| Budget Amount *help |
¥18,460,000 (Direct Cost: ¥14,200,000、Indirect Cost: ¥4,260,000)
Fiscal Year 2009: ¥5,200,000 (Direct Cost: ¥4,000,000、Indirect Cost: ¥1,200,000)
Fiscal Year 2008: ¥6,370,000 (Direct Cost: ¥4,900,000、Indirect Cost: ¥1,470,000)
Fiscal Year 2007: ¥6,890,000 (Direct Cost: ¥5,300,000、Indirect Cost: ¥1,590,000)
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| Research Abstract |
We attempted to develop a new drug delivery system (DDS) targeting specific molecules, such as E-selectin or Thy1, with using anti-E-selectin or anti-Thy1 antibody conjugated bionanocapsule (BNC). The results in this study clearly demonstrated that this nano-device could be a gene deliver system targeting cells expressed these molecules. However, since level of protein expression by transferred Vector-gene was poor, we had to improve the method in the fusion process of BNC and DNA vector. This improvement made it possible to increase protein expression level significantly in vitro. Further in vivo study should be done to achieve clinical application of this DDS.
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