Elucidation of association between retinal ganglion cell death and extracellular matrix in various models of optic nerve degeneration
| Project/Area Number |
19390444
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| Research Category |
Grant-in-Aid for Scientific Research (B)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Ophthalmology
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| Research Institution | Kobe University |
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Principal Investigator |
NEGI Akira Kobe University, 大学院・医学研究科, 教授 (00189359)
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| Co-Investigator(Kenkyū-buntansha) |
NAKAMURA Makoto 神戸大学, 大学院・医学研究科, 講師 (80273788)
KANAMORI Akiyasu 神戸大学, 医学部附属病院, 助教 (10444572)
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| Project Period (FY) |
2007 – 2009
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| Project Status |
Completed (Fiscal Year 2009)
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| Budget Amount *help |
¥11,830,000 (Direct Cost: ¥9,100,000、Indirect Cost: ¥2,730,000)
Fiscal Year 2009: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
Fiscal Year 2008: ¥2,860,000 (Direct Cost: ¥2,200,000、Indirect Cost: ¥660,000)
Fiscal Year 2007: ¥7,150,000 (Direct Cost: ¥5,500,000、Indirect Cost: ¥1,650,000)
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| Keywords | 緑内障 / 糖尿病網膜症 / 視神経変性 / 細胞外基質特性 / 網膜神経節細胞死 / 水チャンネル / アクアポリン / 視神経 / 網膜神経節細胞 / グリア細胞 / アポトーシス / 視神経挫滅 / 慢性高眼圧 / 糖尿病網膜証 / 軸索輸送 |
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| Research Abstract |
There was a substantial difference in magnitude, spatial distribution, and time course of apoptotic death of retinal ganglion cells among three models of optic nerve degeneration induced by diabetes, optic nerve crush, and glaucoma. The changes in aquaporin expression in the retinal ganglion cells and glia in the retina and optic nerve were significantly different among these three models. Besides, the possibility was also demonstrated that the optic nerved degeneration in human glaucoma eyes reflects the scleral biomechanics.
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Report
(4 results)
Research Products
(38 results)
