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Elucidation of the mechanisms sepsis-induced organ dysfunction syndrome in relation to protease-activated receptors(PARs)and vascular endothelial growth factor(VEGF)

Research Project

Project/Area Number 19390456
Research Category

Grant-in-Aid for Scientific Research (B)

Allocation TypeSingle-year Grants
Section一般
Research Field Emergency medicine
Research InstitutionHokkaido University

Principal Investigator

GANDO Satoshi  Hokkaido University, 大学院・医学研究科, 教授 (30125306)

Co-Investigator(Kenkyū-buntansha) MAEDA Seiji  筑波大学, 人間総合科学研究所, 講師 (30282346)
SAWAMURA Atsushi  北海道大学, 大学院・医学研究科, 助教 (00241448)
JESMIN Subrina  国立国際医療センター研究所, 遺伝子診断治療開発研究部, 室長 (60374261)
YAMAGUCHI Naoto  茨城県立医療大学, 保健医療学部, 教授 (40239900)
IEKO Masahiro  北海道医療大学, 歯学部, 教授 (50250436)
Project Period (FY) 2007 – 2008
Project Status Completed (Fiscal Year 2008)
Budget Amount *help
¥18,200,000 (Direct Cost: ¥14,000,000、Indirect Cost: ¥4,200,000)
Fiscal Year 2008: ¥9,100,000 (Direct Cost: ¥7,000,000、Indirect Cost: ¥2,100,000)
Fiscal Year 2007: ¥9,100,000 (Direct Cost: ¥7,000,000、Indirect Cost: ¥2,100,000)
Keywords敗血症 / 臓器不全 / PARs / VEGF
Research Abstract

Lipopolysaccharide(LPS)により発現誘導された「Protease-activated receptors(PARs)がPARs自身による凝固・炎症反応増強機序に加えて、vascular endothelial growth factor(VEGF)の発現誘導あるいはVEGF発現抑制からさらなる炎症反応増強とアポトーシスにより脳、肺臓、肝臓、腎臓等の敗血症性臓器不全発症に深く関わっている」、という仮説を証明した。

Report

(3 results)
  • 2008 Annual Research Report   Final Research Report ( PDF )
  • 2007 Annual Research Report
  • Research Products

    (20 results)

All 2009 2008 2007 Other

All Journal Article (7 results) (of which Peer Reviewed: 7 results) Presentation (12 results) Remarks (1 results)

  • [Journal Article] Expression of 4 protease-activated receptors is associated with increased levels of TNF-alpha, tissue factor, and fibrin in the frontal cortex of endotoxemic rats2009

    • Author(s)
      ジェスミンサブリナ
    • Journal Title

      Thromb Res (印刷中)

    • Related Report
      2008 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Protease-activated receptor 2 (PAR2) blocking peptide counteracts endotoxin-induced inflammation and coagulation and ameliorates renal fibrin deposition in a rat model of acute renal failure2009

    • Author(s)
      ジェスミンサブリナ
    • Journal Title

      Shock (印刷中)

    • Related Report
      2008 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Differential expression,time course and distribution of 4 PARs in rats endotoxin-induced acute lung injury2007

    • Author(s)
      Jesmin S, Gando S, Zaedi S, Sakuraya F.
    • Journal Title

      Inflammation 30

      Pages: 14-27

    • Related Report
      2008 Final Research Report
    • Peer Reviewed
  • [Journal Article] Differential expression, time course and distribution of 4 PARs in rats endotoxin-induced acute lung injury2007

    • Author(s)
      Jesmin S
    • Journal Title

      Inflammation 30

      Pages: 14-27

    • Related Report
      2007 Annual Research Report
    • Peer Reviewed
  • [Journal Article] The activation of neutrophil elastase-mediated fibrinolysis is not sufficient to overcome the fibrinolytic shutdown of disseminated intravascular coagulation associated with systemic inflammation2007

    • Author(s)
      Gando S
    • Journal Title

      Thromb Res 121

      Pages: 67-73

    • Related Report
      2007 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Protease-activated receptor 2(PAR2)blocking peptide counteracts endotoxin-induced inflammation and coagulation and ameliorates renal fibrin deposition in a rat model of acute renal failure

    • Author(s)
      Jesmin S, Gando S, Zaedi S, Prodhn SH, Sawamura A, Miyauchi T, Hiroe M, Yamaguchi N.
    • Journal Title

      Shock (in press)

    • Related Report
      2008 Final Research Report
    • Peer Reviewed
  • [Journal Article] Expression of 4 protease-activated receptors is associated with increased levels of TNF-alpha, tissue factor, and fibrin in the frontal cortex of endotoxemic rats

    • Author(s)
      Jesmin S, Gando S, Zaedi S, Sawamura A, Yamaguchi N.
    • Journal Title

      Thromb Res (in press)

    • Related Report
      2008 Final Research Report
    • Peer Reviewed
  • [Presentation] Time-dependent alterations of VEGF and its signaling molecules in ALI in a rat model of sepsis2008

    • Author(s)
      ジェスミンサブリナ、丸藤哲、ショヘルザエディ、山口直人、小山哲夫、澤村淳
    • Organizer
      第36回日本救急医学会総会
    • Place of Presentation
      札幌
    • Year and Date
      2008-10-14
    • Related Report
      2008 Final Research Report
  • [Presentation] Time-dependent alterations of VEGF and its signaling molecules in ALI in a rat model of sepsis2008

    • Author(s)
      ジェスミンサブリナ
    • Organizer
      第36回日本救急医学会総会
    • Place of Presentation
      札幌ロイトン札幌
    • Year and Date
      2008-10-14
    • Related Report
      2008 Annual Research Report
  • [Presentation] Chronological expression of ET-1 and TNF-α in acute liver injury and its amelioration by PAR2 blockade in a septic rat model2007

    • Author(s)
      ジェスミンサブリナ、菅野正寛、久保田信彦、星野弘勝、早川峰司、澤村淳、丸藤哲
    • Organizer
      第35回日本救急医学会総会・学術集会
    • Place of Presentation
      大阪
    • Year and Date
      2007-10-16
    • Related Report
      2008 Final Research Report
  • [Presentation] PAR2 BP counteracts LPS-induced inflammation and coagulation and ameliorates glomerular fibrin deposition in a rat with ARF2007

    • Author(s)
      ジェスミンサブリナ、菅野正寛、久保田信彦、星野弘勝、早川峰司、澤村淳、丸藤哲
    • Organizer
      第35回日本救急医学会総会・学術集会
    • Place of Presentation
      大阪
    • Year and Date
      2007-10-16
    • Related Report
      2008 Final Research Report
  • [Presentation] PAR2 BP counteracts LPS-induced inflammation and coagulation and ameliorates glomerular fibrin deposition in a rat with ARF2007

    • Author(s)
      ジェスミンサブリナ
    • Organizer
      第35回日本救急医学会総会・学術集会
    • Place of Presentation
      大阪リーガロイヤルホテル
    • Year and Date
      2007-10-16
    • Related Report
      2007 Annual Research Report
  • [Presentation] Chronological expression of ET-1 and TNF-α in acute liver injury and its amelioration by PAR2 blockade in a septic rat model2007

    • Author(s)
      ジェスミンサブリナ
    • Organizer
      第35回日本救急医学会総会・学術集会
    • Place of Presentation
      大阪リーガロイヤルホテル
    • Year and Date
      2007-10-16
    • Related Report
      2007 Annual Research Report
  • [Presentation] Protease-activated receptor 2 blocking peptide counteracts endotoxin-induced inflammation and coagulation and ameliorates glomenular fibrin deposition in a rat model of acute renal failure2007

    • Author(s)
      Gando S, Jesmin S, Zaedi S, Prodhan HS, Sawamura A, Miyauchi T, Yamaguchi N
    • Organizer
      Sepsis 2007. An International Symposium Paris.
    • Place of Presentation
      Paris
    • Year and Date
      2007-09-28
    • Related Report
      2008 Final Research Report
  • [Presentation] Protease-activated receptor 2 blocking peptide counteracts endotoxin-induced inflammation and coagulation and ameliorates glomenular fibrin deposition in a rat model of acute renal failure2007

    • Author(s)
      Gando S
    • Organizer
      Sepsis 2007. An International Symposium Paris
    • Place of Presentation
      Institut Pasteur, Paris
    • Year and Date
      2007-09-28
    • Related Report
      2007 Annual Research Report
  • [Presentation] Effects of protease-activated receptor 2 on the upregulated levels of ET-1 and TNF-α in acute liver injury in a rat model of endotoxemia2007

    • Author(s)
      Sawamura A, Jesmin S, Zaedi S, Prodhan SH, Yamaguchi N, Goto K, Gando Jesmin S, Zaedi S, Togashi H, Sultana SN, Iwashima Y, Yamaguchi N, Hiroe M, Gando S
    • Organizer
      Tenth International Conference on Endothelin
    • Place of Presentation
      Bergamo Italy
    • Year and Date
      2007-09-18
    • Related Report
      2008 Final Research Report
  • [Presentation] Effects of protease-activated receptor 2 on the upregulated levels of ET-1 and TNF-α in acute liver injury in a rat model of endotoxemia2007

    • Author(s)
      Sawamura A
    • Organizer
      Tenth International Conference on Endothelin
    • Place of Presentation
      Centro Congressi "Giovanni XXIII", Bergamo Italy
    • Year and Date
      2007-09-18
    • Related Report
      2007 Annual Research Report
  • [Presentation] Effects of TNF-α blocking peptide on endothelin-1 levels in lungs in endotoxemic rat model2007

    • Author(s)
      awamura A, Jesmin S, Zaedi S, Prodhan SH, Yamaguchi N, Goto K, Gando S
    • Organizer
      Tenth International Conference on Endothelin
    • Place of Presentation
      Bergamo Italy
    • Year and Date
      2007-09-17
    • Related Report
      2008 Final Research Report
  • [Presentation] Effects of TNF-α blocking peptide on endothelin-1 levels in lungs in en dotoxemic rat model2007

    • Author(s)
      Sawamura A
    • Organizer
      Tenth International Conference on Endothelin
    • Place of Presentation
      Centro Congressi "Giovanni XXIII", Bergamo Italy
    • Year and Date
      2007-09-17
    • Related Report
      2007 Annual Research Report
  • [Remarks] Jesmin S, Zaedi S, Togashi H, Sultana SN, Iwashima Y, Yamaguchi N, Hiroe M, Gando S Time-dependent alterations of VEGF and its signaling molecules in acute lung injury in a rat model of sepsis. Time-dependent alterations of VEGF and its signaling molecules in acute lung injury in a rat model of sepsis. Stime-dependent alterations of VEGF and its signaling molecules in acute lung injury in a rat model of sepsis. Shock

    • Related Report
      2008 Final Research Report

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Published: 2007-04-01   Modified: 2021-04-07  

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