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Order-made therapy based on analysis of genetic polymorphism related to cytokine production

Research Project

Project/Area Number 19390457
Research Category

Grant-in-Aid for Scientific Research (B)

Allocation TypeSingle-year Grants
Section一般
Research Field Emergency medicine
Research InstitutionChiba University

Principal Investigator

ODA Shigeto  Chiba University, 大学院・医学研究院, 教授 (90204205)

Co-Investigator(Kenkyū-buntansha) 貞広 智仁  千葉大学, 医学部附属病院, 講師 (00436437)
仲村 将高  千葉大学, 医学研究院, 助教 (30315436)
安部 隆三  千葉大学, 医学部附属病院, 助教 (30375795)
大谷 俊介  千葉大学, 医学部附属病院, 医員 (80375790)
Co-Investigator(Renkei-kenkyūsha) SADAHIRO Tomohito  千葉大学, 医学部附属病院, 講師 (00436437)
NAKAMURA Masataka  千葉大学, 大学院・医学研究院, 助教 (30315436)
WATANABE Eizo  千葉大学, 医学部附属病院, 助教 (40375639)
ABE Ryuzo  千葉大学, 医学部附属病院, 助教 (30375795)
TATEISHI Yoshihisa  千葉大学, 医学部附属病院, 助教 (70375799)
OHTANI Shunsuke  千葉大学, 医学部附属病院, 医員 (80375790)
SHIMADA Tadanaga  千葉大学, 医学部附属病院, 医員 (40436423)
Project Period (FY) 2007 – 2009
Project Status Completed (Fiscal Year 2009)
Budget Amount *help
¥16,380,000 (Direct Cost: ¥12,600,000、Indirect Cost: ¥3,780,000)
Fiscal Year 2009: ¥2,730,000 (Direct Cost: ¥2,100,000、Indirect Cost: ¥630,000)
Fiscal Year 2008: ¥2,730,000 (Direct Cost: ¥2,100,000、Indirect Cost: ¥630,000)
Fiscal Year 2007: ¥10,920,000 (Direct Cost: ¥8,400,000、Indirect Cost: ¥2,520,000)
Keywordsサイトカイン / 遺伝子多型 / 臓器障害 / DNAチップ / 個別化治療 / 予後予測 / 多臓器障害
Research Abstract

It has been widely recognized that a degree of immuno-inflammatory response to insults, such as infection, trauma and surgery varies individually and the difference influences on morbidity and mortality in critically ill patients. The purpose of this study is to identify genetic polymorphisms of protein production related to immuno-inflammatory response, such as cytokines, and to establish order-made therapy based on genetic informations. In this study, we have developed a new DNA-chip which enables to analyze multiple single nucleotide polymorphisms (SNPs) easily and in a short period of time. Then, we first identified two cytokine related SNPs which significantly affect morbidity and mortality in critically ill ICU patients. These SNPs are unique in Japanese population compared to previously reported SNPs in Caucasian. The genetic information analyzed with this DNA-chip would be useful for more precise prediction of outcome in critically ill patients and is essential to establish future order-made therapy.

Report

(4 results)
  • 2009 Annual Research Report   Final Research Report ( PDF )
  • 2008 Annual Research Report
  • 2007 Annual Research Report
  • Research Products

    (30 results)

All 2009 2008 2007

All Journal Article (17 results) (of which Peer Reviewed: 9 results) Presentation (13 results)

  • [Journal Article] Clinical application of cytokine-related gene polymorphism analysis using a newly developed DNA chip in critically ill patients2009

    • Author(s)
      Otani S, Oda S, Sadahiro T, Nakamura M, Watanabe E, Nakada T, Abe R, Tokuhisa T, Hirasawa H
    • Journal Title

      Clinical Biochemistry 42

      Pages: 1387-1393

    • Related Report
      2009 Final Research Report
    • Peer Reviewed
  • [Journal Article] 多臓器不全の発症予知2009

    • Author(s)
      織田成人
    • Journal Title

      感染・炎症・免疫 39

      Pages: 58-60

    • Related Report
      2009 Annual Research Report 2009 Final Research Report
  • [Journal Article] Clinical application of cytokine-related gene polymorphism analysis using a newly developed DNA chip in critically ill patients.2009

    • Author(s)
      Ohtani S, Oda S, Sadahiro H, et al
    • Journal Title

      Clin Biochem 42

      Pages: 1387-1393

    • Related Report
      2009 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Continuous hemodiafiltration with PMMA hemofilter in the treatment of patients with septic shock2008

    • Author(s)
      Nakada T, Oda S, Matsuda K, Sadahiro T, Nakamura M, Abe R, Hirasawa H
    • Journal Title

      Mol Med 14

      Pages: 257-263

    • Related Report
      2009 Final Research Report
    • Peer Reviewed
  • [Journal Article] Continuous hemofiltration with PMMA hemofilter in the treatment of patients with Septic Shock2008

    • Author(s)
      Takaaki Nakada et al
    • Journal Title

      Mol Med 14

      Pages: 257-263

    • Related Report
      2008 Annual Research Report
    • Peer Reviewed
  • [Journal Article] IL-6迅速測定に基づくseptic shockに対するPMMA-CHDFの有効性の検討2008

    • Author(s)
      森田泰正他
    • Journal Title

      医工学治療 20

      Pages: 192-196

    • Related Report
      2008 Annual Research Report
  • [Journal Article] 急性血液浄化法の進歩と今後の展望2008

    • Author(s)
      織田成人
    • Journal Title

      医工学治療 20

      Pages: 217-222

    • Related Report
      2008 Annual Research Report
  • [Journal Article] Surviving Sepsis Campaign guidelines各種治療法の目標達成におけるhypercytokinemia対策の重要性2008

    • Author(s)
      仲村将高他
    • Journal Title

      Shock 23

      Pages: 39-47

    • Related Report
      2008 Annual Research Report
  • [Journal Article] Continuous hemodiafiltration with cytokine-adsorbing hemofilter in the treatment of severe sepsis and septic shock2007

    • Author(s)
      Hirasawa H, Oda S, Matsuda K
    • Journal Title

      Contrib Nephrol 156

      Pages: 365-370

    • Related Report
      2009 Final Research Report 2007 Annual Research Report
    • Peer Reviewed
  • [Journal Article] 自然免疫およびサイトカインに関連した遺伝子多型の敗血症へ及ぼす影響2007

    • Author(s)
      中田孝明, 織田成人, 志賀英敏, 他
    • Journal Title

      日外感染症会誌 4

      Pages: 229-237

    • NAID

      40015525063

    • Related Report
      2009 Final Research Report
    • Peer Reviewed
  • [Journal Article] サイトカインおよび innate immunity 関連遺伝子多型と敗血症2007

    • Author(s)
      中田孝明, 織田成人, 平澤博之
    • Journal Title

      救急医学 31

      Pages: 1400-1410

    • Related Report
      2009 Final Research Report
  • [Journal Article] サイトカイン・ストームにおける genetic polymorphism2007

    • Author(s)
      中田孝明, 織田成人, 渡邉栄三, 他
    • Journal Title

      化学療法の領域 23

      Pages: 1560-1568

    • Related Report
      2009 Final Research Report
  • [Journal Article] Direct hemoperfusion with a cytokine-adsorbing device for the treatment of persistent or severe hypercytokinemia : a pilot study2007

    • Author(s)
      Kobe Y, Oda S, Matsuda K, et al
    • Journal Title

      Blood Purif 25

      Pages: 446-453

    • Related Report
      2009 Final Research Report
    • Peer Reviewed
  • [Journal Article] 自然免疫およびサイトカインに関連した遺伝子多型の敗血症へ及ぼす影響2007

    • Author(s)
      中田 孝明、織田 成人、志賀 英敏, 他
    • Journal Title

      日外感染症会誌 4

      Pages: 229-237

    • NAID

      40015525063

    • Related Report
      2007 Annual Research Report
    • Peer Reviewed
  • [Journal Article] サイトカインおよび血innate immunity関連遺伝子多型と敗血症2007

    • Author(s)
      中田 孝明、織田 成人、平澤 博之
    • Journal Title

      救急医学 31

      Pages: 1400-1410

    • Related Report
      2007 Annual Research Report
  • [Journal Article] サイトカイン・ストームにおけるgenetic polymorphism2007

    • Author(s)
      中田 孝明、織田 成人、渡邉 栄三, 他
    • Journal Title

      化学療法の領域 23

      Pages: 1560-1568

    • Related Report
      2007 Annual Research Report
  • [Journal Article] Direct hemoperfusion with a cutokine-adsorbing device for the treatment of persistent or severe hypercytokinemia:a pilot study2007

    • Author(s)
      Kobe Y, Oda S, Matsuda K, et. al.
    • Journal Title

      Blood Purif 25

      Pages: 446-453

    • Related Report
      2007 Annual Research Report
    • Peer Reviewed
  • [Presentation] 重症患者における炎症反応関連分子に関する遺伝子多型が転帰に及ぼす影響2009

    • Author(s)
      島田忠長, 織田成人, 貞広智仁, 他
    • Organizer
      日本 Shock 学会
    • Place of Presentation
      金沢市
    • Year and Date
      2009-05-30
    • Related Report
      2009 Final Research Report
  • [Presentation] Sepsis 易罹患性及び予後に対する遺伝子多型の影響とその人種間格差2009

    • Author(s)
      渡邉栄三, Buchman TG, 織田成人, 他
    • Organizer
      日本 Shock 学会
    • Place of Presentation
      金沢市
    • Year and Date
      2009-05-30
    • Related Report
      2009 Final Research Report
  • [Presentation] 重症患者における炎症反応関連分子に関する遺伝子多型が転帰に及ぼす影響2009

    • Author(s)
      島田忠長、織田成人、貞広智仁, 他
    • Organizer
      日本Shock学会
    • Place of Presentation
      金沢市
    • Year and Date
      2009-05-30
    • Related Report
      2009 Annual Research Report
  • [Presentation] Sepsis易罹患性及び予後に対する遺伝子多型の影響とその人種間格差2009

    • Author(s)
      渡邉栄三、Buchman TG、織田成人, 他
    • Organizer
      日本Shock学会
    • Place of Presentation
      金沢市
    • Year and Date
      2009-05-30
    • Related Report
      2009 Annual Research Report
  • [Presentation] 敗血症患者における自然免疫に関する遺伝子多型力弐死亡率に与える影響2009

    • Author(s)
      島田忠長他
    • Organizer
      第36回日本集中治療医学会
    • Place of Presentation
      大阪
    • Year and Date
      2009-02-26
    • Related Report
      2008 Annual Research Report
  • [Presentation] 制御困難な高サイトカイン血症を呈するSeptic Shockに対するアフェレシス療法-Double PMMA-CHDFの有効性と適応2008

    • Author(s)
      松村洋輔他
    • Organizer
      第29回日本アフェレシス学会学術大会
    • Place of Presentation
      広島
    • Year and Date
      2008-11-22
    • Related Report
      2008 Annual Research Report
  • [Presentation] 救命困難な Septic Shock に対する血液浄化法の強化~Double PMMA-CHDFの有効性とその適応~2008

    • Author(s)
      松村洋輔, 織田成人, 貞広智仁, 他
    • Organizer
      第19回日本急性血液浄化学会学術集会
    • Place of Presentation
      東京
    • Year and Date
      2008-09-19
    • Related Report
      2009 Final Research Report
  • [Presentation] Accuracy of cytokine-related gene polymorphism analysis with a newly developed DNA chip on critically ill patients2008

    • Author(s)
      Shunsuke Otani et al
    • Organizer
      6th Congress of the International Federation of Shock Society
    • Place of Presentation
      ケルン(ドイツ)
    • Year and Date
      2008-06-30
    • Related Report
      2008 Annual Research Report
  • [Presentation] 高感度DNAチップを用いた新しい一塩基多型 (SNP) 解析法2008

    • Author(s)
      大谷俊介, 織田成人, 仲村将高, 他
    • Organizer
      第35回日本集中治療医学会学術集会
    • Place of Presentation
      東京
    • Year and Date
      2008-02-16
    • Related Report
      2009 Final Research Report
  • [Presentation] 高感度DNAチップを用いた新しい一塩基多型(SNP)解析法2008

    • Author(s)
      大谷 俊介, 織田 成人, 仲村 将高, 他
    • Organizer
      第35回日本集中治療医学会学術集会
    • Place of Presentation
      東京
    • Year and Date
      2008-02-16
    • Related Report
      2007 Annual Research Report
  • [Presentation] 敗血症の病態に関する各種遺伝子多型の検討2007

    • Author(s)
      大谷俊介, 織田成人, 貞広智仁, 他
    • Organizer
      第35回日本救急医学会総会・学術集会
    • Place of Presentation
      大阪
    • Year and Date
      2007-10-17
    • Related Report
      2009 Final Research Report 2007 Annual Research Report
  • [Presentation] Hypercytokinemia 制御困難例に対する血液浄化法の強化2007

    • Author(s)
      仲村将高, 織田成人, 貞広智仁, 他
    • Organizer
      第18回日本急性血液浄化学会学術集会
    • Place of Presentation
      大分市
    • Year and Date
      2007-10-06
    • Related Report
      2009 Final Research Report
  • [Presentation] Hypercytokinemia制御困難例に対する血液浄化法の強化2007

    • Author(s)
      仲村 将高, 織田 成人, 貞広 智仁, 他
    • Organizer
      第18回日本急性血液浄化学会学術集会
    • Place of Presentation
      大分
    • Year and Date
      2007-10-06
    • Related Report
      2007 Annual Research Report

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Published: 2007-04-01   Modified: 2016-04-21  

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