| Project/Area Number |
19390457
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| Research Category |
Grant-in-Aid for Scientific Research (B)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Emergency medicine
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| Research Institution | Chiba University |
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Principal Investigator |
ODA Shigeto Chiba University, 大学院・医学研究院, 教授 (90204205)
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| Co-Investigator(Kenkyū-buntansha) |
貞広 智仁 千葉大学, 医学部附属病院, 講師 (00436437)
仲村 将高 千葉大学, 医学研究院, 助教 (30315436)
安部 隆三 千葉大学, 医学部附属病院, 助教 (30375795)
大谷 俊介 千葉大学, 医学部附属病院, 医員 (80375790)
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| Co-Investigator(Renkei-kenkyūsha) |
SADAHIRO Tomohito 千葉大学, 医学部附属病院, 講師 (00436437)
NAKAMURA Masataka 千葉大学, 大学院・医学研究院, 助教 (30315436)
WATANABE Eizo 千葉大学, 医学部附属病院, 助教 (40375639)
ABE Ryuzo 千葉大学, 医学部附属病院, 助教 (30375795)
TATEISHI Yoshihisa 千葉大学, 医学部附属病院, 助教 (70375799)
OHTANI Shunsuke 千葉大学, 医学部附属病院, 医員 (80375790)
SHIMADA Tadanaga 千葉大学, 医学部附属病院, 医員 (40436423)
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| Project Period (FY) |
2007 – 2009
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| Project Status |
Completed (Fiscal Year 2009)
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| Budget Amount *help |
¥16,380,000 (Direct Cost: ¥12,600,000、Indirect Cost: ¥3,780,000)
Fiscal Year 2009: ¥2,730,000 (Direct Cost: ¥2,100,000、Indirect Cost: ¥630,000)
Fiscal Year 2008: ¥2,730,000 (Direct Cost: ¥2,100,000、Indirect Cost: ¥630,000)
Fiscal Year 2007: ¥10,920,000 (Direct Cost: ¥8,400,000、Indirect Cost: ¥2,520,000)
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| Keywords | サイトカイン / 遺伝子多型 / 臓器障害 / DNAチップ / 個別化治療 / 予後予測 / 多臓器障害 |
|---|
| Research Abstract |
It has been widely recognized that a degree of immuno-inflammatory response to insults, such as infection, trauma and surgery varies individually and the difference influences on morbidity and mortality in critically ill patients. The purpose of this study is to identify genetic polymorphisms of protein production related to immuno-inflammatory response, such as cytokines, and to establish order-made therapy based on genetic informations. In this study, we have developed a new DNA-chip which enables to analyze multiple single nucleotide polymorphisms (SNPs) easily and in a short period of time. Then, we first identified two cytokine related SNPs which significantly affect morbidity and mortality in critically ill ICU patients. These SNPs are unique in Japanese population compared to previously reported SNPs in Caucasian. The genetic information analyzed with this DNA-chip would be useful for more precise prediction of outcome in critically ill patients and is essential to establish future order-made therapy.
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