Pathophysiological analysis for patients with anoxic coma after cardiopulmonary arrest.

• Project/Area Number: 19390459
• Research Category: Grant-in-Aid for Scientific Research (B)
• Allocation Type: Single-year Grants
• Section: 一般
• Research Field: Emergency medicine
• Research Institution: Osaka University
• Principal Investigator: SHIOZAKI Tadahiko Osaka University, 医学系研究科, 助教 (60278687)
• Co-Investigator(Kenkyū-buntansha): SUGIMOTO Hisashi 大阪大学, 名誉教授 (90127241) ; OGURA Hiroshi 大阪大学, 医学系研究科, 講師 (70301265) ; TASAKI Osamu 大阪大学, 医学系研究科, 助教 (90346221) ; MATSUMOTO Naoya 大阪大学, 医学部附属病院, 助教 (50359808) ; 田中 裕 順天堂大学, 医学部, 教授 (90252676)
• Co-Investigator(Renkei-kenkyūsha): TANAKA Hiroshi 順天堂大学, 医学部, 教授 (90252676)
• Project Period (FY): 2007 – 2009
• Project Status: Completed (Fiscal Year 2009)
• Budget Amount: ¥18,200,000 (Direct Cost: ¥14,000,000、Indirect Cost: ¥4,200,000); Fiscal Year 2009: ¥5,460,000 (Direct Cost: ¥4,200,000、Indirect Cost: ¥1,260,000); Fiscal Year 2008: ¥5,460,000 (Direct Cost: ¥4,200,000、Indirect Cost: ¥1,260,000); Fiscal Year 2007: ¥7,280,000 (Direct Cost: ¥5,600,000、Indirect Cost: ¥1,680,000)
• Keywords: 心肺蘇生 / 脳内酸素飽和度 / 脳蘇生 / 蘇生後脳症 / 脳低温療法 / 蘇生後低酸素脳症 / 脳酸素飽和度 / 神経学的予後 / 近赤外線 / 蘇生後脳定 / 脳温度 / ウツタイン様式 / 初期心電図

Research Abstract

In clinical study, we monitored bilateral regional cerebral oxygen saturation using near infrared spectroscopy (the TOS-96) during cardiopulmonary resuscitation continuously just after they arrived at hospital. Our studies suggest that extracorporeal cardiopulmonary resuscitation may improve regional cerebral oxygen saturation in patients with out-of-hospital cardiac arrest and their neurological outcome. In animal studies, using a gerbil model of global ischemia-reperfusion, we assessed the effects of hypothermia on physiological parameters and evaluated the optimal timing for induction of hypothermia to achieve a better survival rate. Under normothermic cerebral ischemia, the survival rate was dramatically decreased by induction of 15 to 20 minutes of ischemia. Induction of hypothermia significantly improved the survival rate only when induction of hypothermia occurred less than 10 minutes after ischemic onset.

Research Products

• [Journal Article] Incidence and outcomes of out-of-hospital cardiac arrest with shockresistant ventricular fibrillation : Data from a large population-based cohort. (2010)
  • Author(s): Sakai T, Tasaki O (3), Sugimoto H (18), 等19名
  • Journal Title: Resuscitation 81 Pages: 956-961
  • Peer Reviewed
• [Journal Article] Evaluation of posttraumatic venous sinus occlusion with CT venography. (2009)
  • Author(s): Fujii Y, Shiozaki T (4), Sugimoto H (8), 等8名
  • Journal Title: J Trauma 66 Pages: 1002-1006
  • Peer Reviewed
• [Journal Article] Comparison of neurological outcomes following witnessed out-of-hospital ventricular fibrillation defibrillated with either biphasic or monophasic automated external defibrillators. (2009)
  • Author(s): Kajino K, Shimazu T, Sugimoto H (9), 等9名
  • Journal Title: Emerg Med J 26 Pages: 492-496
  • Peer Reviewed
• [Journal Article] Prognostic indicators and outcome prediction model for severe traumatic head injury. (2009)
  • Author(s): Tasaki O (1), Shiozaki T (2), Sugimoto H (8), 等8名
  • Journal Title: J Trauma 66 Pages: 304-308
  • Peer Reviewed
• [Journal Article] Evaluation of posttraumatic venous sinus occlusion with CT venography. (2009)
  • Author(s): Fujii Y, Shiozaki T, et al.
  • Journal Title: J Trauma 66 Pages: 1002-1006
  • Peer Reviewed
• [Journal Article] 蘇生後低酸素脳症の頭蓋内圧の変化 (2009)
  • Author(s): 松嶋麻子、塩崎忠彦, 等
  • Journal Title: 脳死・脳蘇生 21 Pages: 67-70
  • Peer Reviewed
• [Journal Article] CTを用いた心肺蘇生時の胸骨圧迫による臓器血流に関する検討 (2009)
  • Author(s): 清水健太郎、塩崎忠彦, 等
  • Journal Title: 脳死・脳蘇生 21 Pages: 63-66
  • Peer Reviewed
• [Journal Article] Evaluation of Posttraumatic Venous Sinus Occlusion With CT Venography (2009)
  • Author(s): Fujii Y, Shiozaki T, et al.
  • Journal Title: J Trauma (In press)
  • Peer Reviewed
• [Journal Article] Prognostic indicators and outcome prediction model for severe traumatic head injury. (2009)
  • Author(s): Tasaki O, Shiozaki T, et al.
  • Journal Title: J Trauma 66 Pages: 304-308
  • Peer Reviewed
• [Journal Article] Subsequent ventricular fibril-lation and survival in out-of-hospital cardiac arrests presenting with PEA or asystole. (2008)
  • Author(s): Kajino K, Shimazu T, Sugimoto H (9), 等9名
  • Journal Title: Resuscitation 79 Pages: 34-40
  • Peer Reviewed
• [Journal Article] Prognostic indicators and outcome prediction model for severe traumatic head injury. (2008)
  • Author(s): Tasaki O, Shiozaki T. et. al.
  • Journal Title: J Trauma (In press)
  • Peer Reviewed
• [Journal Article] 頭部外傷 (2007)
  • Author(s): 塩崎 忠彦
  • Journal Title: 救急医学 31 Pages: 642-646
• [Journal Article] Effects of Timing and Duration of Hypothermia on Survival in an Experimental Gerbil Model of Global Ischemia.
  • Author(s): Noguchi K, Shiozaki T (3), Seiyama A, 等8名
  • Journal Title: Resuscitation in press
  • Peer Reviewed
• [Journal Article] Effectiveness of new "Mobile AED Map" to find and retrieve an AED : a randomized controlled trial.
  • Author(s): Sakai T, Shiozaki T (10), Shimazu T, 等13名
  • Journal Title: Resuscitation in press
  • Peer Reviewed
• [Presentation] Assessment of the benefit of extracorporeal life-support for patients with cardiac arrest in terms of cerebral oxygen saturation. (2010)
  • Author(s): Y Nakahori, K Shimizu, T Shiozaki, M Ohnishi, Y Nakagawa, O Tasaki, H Ogura, Y Kuwagata, T Shimazu
  • Organizer: American heart association resuscitation science symposium.
  • Place of Presentation: Chicago, U.S.A.
• [Presentation] Advanced treatments for Shock-resistant ventricular fibrillation at Critical Care Medical Centers : the Utstein Osaka Project. (2010)
  • Author(s): T Sakai, T Iwami, T Kawamura, T Kitamura, Y Hayashi, T Nishiuchi, Y Ohishi, H Rinka, K Kajino, O Tasaki, T Shimazu
  • Organizer: American heart association resuscitation science symposium.
  • Place of Presentation: Chicago, U.S.A.
• [Presentation] 重症頭部外傷後の植物状態患者はいつ目を覚ますのか? (2009)
  • Author(s): 塩崎忠彦
  • Organizer: 第22回日本脳死・脳蘇生学会
  • Place of Presentation: 横浜
  • Year and Date: 2009-06-26
• [Presentation] Incidence and Outcomes of Out-of-Hospital Cardiac Arrest with Shock-resistant Ventricular Fibrillation in Osaka : Data from a Large Population-based Cohort. (2009)
  • Author(s): T Sakai, T Iwami, K Kajino, O Tasaki, T Nishiuchi, Y Hayashi, H Ikeuchi, A Hiraide, T Irisawa, T Kawamura, H Sugimoto.
  • Organizer: International Resuscitation Science Symposium.
  • Place of Presentation: Osaka, Japan.
  • Year and Date: 2009-03-19
• [Presentation] Effectiveness Of An "AED Map On A Mobile Web" System : A Randomized Controlled Trial. (2009)
  • Author(s): T Sakai, T Iwami, K Kajino, Tetsuhisa K, Chika N, Hiroshi T, Seishiroh M, Takashi K, Taro I, Tasaki O, Shiozaki T, Ogura H, Kuwagata Y
  • Organizer: American Heart Association (AHA) Scientific Sessions
  • Place of Presentation: Orland, U.S.A.
• [Presentation] The sequential changes in rSO-2. during cardio-pulmonary resuscitation. (2009)
  • Author(s): Nakahori Y, Shimizu K, Shiozaki T, Ogura H, Tasaki O, Kuwagata Y, Sugimoto H, Nakamori Y, Fujimi S, Ikeuchi H
  • Organizer: Society of critical care medicine's 38th critical care congress.
  • Place of Presentation: Nashville, Tennessee, U.S.A.
• [Presentation] Prognostic indications and outcome prediction model for patients with return of spontaneous circulation from caldiopulmonary arrest. -OSAKA UTSTEIN PROJECT-. (2009)
  • Author(s): Hayakawa K, Tasaki O, Hamasaki T, Kajino K, Shimizu K, Shiozaki T, Ogura H, Kuwagata Y, Sugimoto H
  • Organizer: Society of critical care medicine's 38th critical care congress.
  • Place of Presentation: Nashville, Tennessee, U.S.A.
• [Presentation] Neurological outcome of cardiac arrest patients treated with percutaneous cardiopulmonary support (PCPS). (2009)
  • Author(s): Shimizu K, Ogura H, Tasaki O, Hayakawa K, Nakahori Y, Kuwagata Y, Sugimoto H
  • Organizer: Society of critical care medicine's 38th critical care congress.
  • Place of Presentation: Nashville, Tennessee, U.S.A.
• [Presentation] 頭部外傷後植物状態患者の意識回復に影響を及ぼす因子は何か? 髄液中各種メディエーターの検討 (2008)
  • Author(s): 塩崎 忠彦
  • Organizer: 日本救急医学会総会
  • Place of Presentation: 札幌
  • Year and Date: 2008-10-14
• [Presentation] Evaluation of posttraumatic venous sinus occlusion with CT venography. (2008)
  • Author(s): Fujii Y, Tasaki O, Yoshiya K, Shiozaki T, Ogura H, Kuwagata Y, Sugimoto H, Sumi Y
  • Organizer: American Association for the Surgery of Trauma 16^(th) Meeting.
  • Place of Presentation: Maui, Hawaii, U.S.A.
• [Presentation] Incidence and Outcomes of Out-of-Hospital Cardiac Arrest with Shock-resistant Ventricular Fibrillation in Osaka : Data from a Large Population-based Cohort. (2008)
  • Author(s): T Sakai, T Iwami, K Kajino, O Tasaki, T Nishiuchi, Y Hayashi, H Ikeuchi, A Hiraide, T Irisawa, T Kawamura, H Sugimoto.
  • Organizer: American Heart Association (AHA) Scientific Sessions
  • Place of Presentation: New Orleans, U.S.A.
• [Presentation] 意識障害患者での下肢廃用性萎縮は電気的筋肉刺激により予防できるか? (2007)
  • Author(s): 塩崎 忠彦
  • Organizer: 日本救急医学会総会
  • Place of Presentation: 大阪
  • Year and Date: 2007-10-17
• [Presentation] Subsequent VF is Associated with Better Outcomes from Out-of-Hospital Cardiac Arrests with Initial Non-shockable Rhythms. population-based Utstein Study In Osaka, Japan. (2007)
  • Author(s): K Kajino, T Iwami, Robert A.Berg, O Tasaki, T Kawamura, H Nonogi, T Nishiuchi, Y Hayashi, H Ikeuchi, H Tanaka, Ti Shimazu, A Hiraide, H Sugimoto
  • Organizer: American Heart Association Scientific Sessions 2007.
  • Place of Presentation: Orlando, U.S.A.
• [Presentation] Evaluation of abdominal blood flow during chest compression in cardiac arrest patients using enhanced computed tomography (CT). (2007)
  • Author(s): K.Shimizu, Y.Oode, H.Ogura, A.Matsushima, O.Tasaki, T.Shiozaki, Y.Kuwagata, T.Shimazu, H.Sugimoto
  • Organizer: American Heart Association Scientific Sessions 2007.
  • Place of Presentation: Orlando, U.S.A.