| Project/Area Number |
19390460
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| Research Category |
Grant-in-Aid for Scientific Research (B)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Emergency medicine
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| Research Institution | Osaka University |
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Principal Investigator |
MATSUMOTO Naoya Osaka University, 医学部・附属病院, 助教 (50359808)
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| Co-Investigator(Kenkyū-buntansha) |
SUGIMOTO Hisashi 大阪大学, 医学系研究科, 名誉教授 (90127241)
KUWAGATA Yasuyuki 大阪大学, 医学系研究科, 准教授 (50273678)
OGURA Hiroshi 大阪大学, 医学系研究科, 講師 (70301265)
SHIOZAKI Tadahiko 大阪大学, 医学系研究科, 助教 (60278687)
TASAKI Osamu 大阪大学, 医学系研究科, 助教 (90346221)
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| Co-Investigator(Renkei-kenkyūsha) |
IDE Chizuka 藍野大学, 医療保健学部, 教授 (70010080)
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| Project Period (FY) |
2007 – 2009
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| Project Status |
Completed (Fiscal Year 2009)
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| Budget Amount *help |
¥18,200,000 (Direct Cost: ¥14,000,000、Indirect Cost: ¥4,200,000)
Fiscal Year 2009: ¥4,550,000 (Direct Cost: ¥3,500,000、Indirect Cost: ¥1,050,000)
Fiscal Year 2008: ¥4,550,000 (Direct Cost: ¥3,500,000、Indirect Cost: ¥1,050,000)
Fiscal Year 2007: ¥9,100,000 (Direct Cost: ¥7,000,000、Indirect Cost: ¥2,100,000)
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| Keywords | 脈絡叢 / 脳脊髄液 / 細胞移植 / 脳梗塞 / 神経保護 / 神経再生 / 成長因子 / 上衣細胞 / 神経幹細胞 / 低酸素侵襲 / ラット / 転写因子 / 遺伝子導入 / 脳虚血損傷 / 分化誘導 |
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| Research Abstract |
We demonstrated that the injection of cultured choroid plexus epithelial cells (CPECs) through cerebrospinal fluid (CSF) suppressed the extension of ischemic brain injury against a rat model of cerebral infarction. Anti-inflammatory, anti-apoptotic and anti-oxidative effects were involved in the neuroprotective mechanisms. It was considered that a variety of neurotrophic and/or growth factors were secreted from the CPECs into the CSF and prevented the ischemic brain injury. In addition, the CPECs transplantation activated neural stem cells, enhancing the neuronal differentiation. In vitro experiments suggested that hypoxic stress itself elicited the ability of CPECs to promote cerebral protection and regeneration.
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