Group A streptococcal proteases degrade human complements and contribute to evasion of innate immunity
| Project/Area Number |
19390463
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| Research Category |
Grant-in-Aid for Scientific Research (B)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Morphological basic dentistry
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| Research Institution | Osaka University |
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Principal Investigator |
TERAO Yutaka Osaka University, 大学院・歯学研究科, 准教授 (50397717)
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| Co-Investigator(Kenkyū-buntansha) |
KAWABATA Shigetada 大阪大学, 大学院・歯学研究科, 教授 (50273694)
NAKATA Masanobu 大阪大学, 大学院・歯学研究科, 助教 (90444497)
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| Project Period (FY) |
2007 – 2008
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| Project Status |
Completed (Fiscal Year 2008)
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| Budget Amount *help |
¥19,630,000 (Direct Cost: ¥15,100,000、Indirect Cost: ¥4,530,000)
Fiscal Year 2008: ¥5,460,000 (Direct Cost: ¥4,200,000、Indirect Cost: ¥1,260,000)
Fiscal Year 2007: ¥14,170,000 (Direct Cost: ¥10,900,000、Indirect Cost: ¥3,270,000)
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| Keywords | 口腔細菌学 / レンサ球菌 / A群レンサ球菌 / 補体 / 好中球 / 免疫回避 / プロテアーゼ / SpeB / ScpA / GAPDH |
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| Research Abstract |
A群レンサ球菌は, 劇症型等の侵襲性疾患を引き起こすことが知られている. 劇症型患者の感染組織では, 好中球の浸潤ならびに貪食能が極度に低下し, A群レンサ球菌の活発な増殖が認められる.そこで, 好中球の貪食と遊走に主要な役割を演じる補体C3b およびC5a が, A群レンサ球菌に分解を受けるのではないかと仮説を立てて研究を推進した.その結果, A群レンサ球菌のSpeB はC3b を分解し, ScpA はGAPDH と協調してC5a を分解することで免疫回避を行い, その後の組織内増殖を可能にしていることが示唆された
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Report
(3 results)
Research Products
(81 results)
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[Journal Article] Infect. Immun.2009
Author(s)
Nakata, M., T. Koller, K. Moritz, D. Ribardo, L. Jonas, K. S. McIver, T. Sumitomo, Y. Terao, S. Kawabata, A. Podbielski and B. Kreikemeyer
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[Journal Article] FEBS Lett.2008
Author(s)
Itsuki ,Y., M. Saeki, H. Nakahara, H. Egusa, Y. Irie, Y. Terao, S. Kawabata, H. Yatani and H. Kamisaki
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[Journal Article] Group A streptococcal cysteine protease degrades C3 (C3b) and contributes to evasion of innate immunity.2008
Author(s)
Terao, Y., Mori, Y., Yamaguchi, M., Shimizu, Y., Ooe, K., Hamada, S. and Kawabata S.
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Journal Title
Journal of Biological Chemistry (印刷中)
Related Report
Peer Reviewed
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[Journal Article] Molecular and biological characterization of histidine triad protein in group A streptococci.2008
Author(s)
Kunitomo, E., Terao, Y., Okamoto, S., Rikimaru, T., Hamada, S., Kawabata, S.
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Journal Title
Microbes and Infections (印刷中)
Related Report
Peer Reviewed
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[Journal Article] Infect Immun.2007
Author(s)
Kreikemeyer, B., M. Nakata, T. Koller, H. Hildisch, V. Kourakos, K. Standar, S. Kawabata, M. O. Glocker and A. Podbielski
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[Presentation]2008
Author(s)
Terao, Y., Y. Mori, M. Yamaguchi, S. Hamada, and S. Kawabata
Organizer
The 8^<th> Awaji International Forum on Infection and Immunity
Place of Presentation
Higashiura, Hyogo, Japan
Related Report
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[Presentation]2008
Author(s)
Terao, Y., Y. Mori, M. Yamaguchi, S. Hamada, and S. Kawabata
Organizer
108^<th> General Meeting of American Society for Microbiology
Place of Presentation
Boston, USA.
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[Presentation]2007
Author(s)
Yamaguchi, M., Y. Terao, Y. Mori, S. Hamada, and S. Kawabata
Organizer
The 107^<th> General Meeting of American Society for Microbiology
Place of Presentation
Toronto, Canada
Related Report
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[Presentation]2007
Author(s)
Nakata, M., D. A. Ribardo, K. S. McIver, S. Kawabata, A. Podbielski, and B. Kreikemeyer
Organizer
The 107^<th> General Meeting of American Society for Microbiology
Place of Presentation
Toronto, Canada
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