| Project/Area Number |
19390464
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| Research Category |
Grant-in-Aid for Scientific Research (B)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Morphological basic dentistry
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| Research Institution | Osaka University |
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Principal Investigator |
WAKISAKA Satoshi Osaka University, 大学院・歯学研究科, 教授 (40158598)
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| Co-Investigator(Kenkyū-buntansha) |
MAEDA Takashi 大阪大学, 大学院・歯学研究科, 講師 (80324789)
HONMA Shiho 大阪大学, 大学院・歯学研究科, 講師 (40372627)
ABE Makoto 大阪大学, 大学院・歯学研究科, 助教 (40448105)
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| Project Period (FY) |
2007 – 2009
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| Project Status |
Completed (Fiscal Year 2009)
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| Budget Amount *help |
¥19,240,000 (Direct Cost: ¥14,800,000、Indirect Cost: ¥4,440,000)
Fiscal Year 2009: ¥3,770,000 (Direct Cost: ¥2,900,000、Indirect Cost: ¥870,000)
Fiscal Year 2008: ¥4,550,000 (Direct Cost: ¥3,500,000、Indirect Cost: ¥1,050,000)
Fiscal Year 2007: ¥10,920,000 (Direct Cost: ¥8,400,000、Indirect Cost: ¥2,520,000)
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| Keywords | 味覚 / 味覚受容器 / 発生 / 再生 / 分化 / 細胞系譜 / 味覚受容関連分子 / 有郭乳頭 / 胃 / 十二指腸 / 低塩分 / 栄養状態 / 味蕾 / 味覚神経 / 神経損傷 / アポトーシス / 味覚受容関連遺伝子 / RT-PCR |
|---|
| Research Abstract |
Palatability improves the quality of life (QOL). The gustatory sensation mostly contribute the palatability. The peripheral gustatory receptor is taste buds, concentrated in lingual papillae and palatal epithelium. The gustatory nerves are excited by basic gustatory stimulation to taste buds. There are 5 basic gustatory stimulation ; salt, acid, sweet, bitter and umami-these basic tastrants have specific receptors. We examined the expression of mRNA for taste-related receptors in developing lingual papilla, and found that mRNA for taste-related receptors expressed prenatal period when the apparent taste buds have not been formed. When sodium intake was restricted, the taste buds cell contributing to reception of salt has changed histochemically. There findings suggest the proper nutrition is important for developing of gustatory system.
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