| Project/Area Number |
19390471
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| Research Category |
Grant-in-Aid for Scientific Research (B)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Functional basic dentistry
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| Research Institution | Tokyo Medical and Dental University |
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Principal Investigator |
OHYA Keiichi Tokyo Medical and Dental University, 医歯学総合研究科, 教授 (10126211)
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| Co-Investigator(Kenkyū-buntansha) |
AOKI Kazuhiro 東京医科歯科大学, 医歯学総合研究科, 准教授 (40272603)
TAKAHASHI Mariko 東京医科歯科大学, 歯学部, 技術職員 (90334440)
自見 英治郎 九州歯科大学, 歯学部・教授, 教授 (40276598)
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| Co-Investigator(Renkei-kenkyūsha) |
JIMI Eijiro 九州歯科大学, 歯学部, 教授 (40276598)
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| Project Period (FY) |
2007 – 2009
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| Project Status |
Completed (Fiscal Year 2009)
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| Budget Amount *help |
¥19,500,000 (Direct Cost: ¥15,000,000、Indirect Cost: ¥4,500,000)
Fiscal Year 2009: ¥3,640,000 (Direct Cost: ¥2,800,000、Indirect Cost: ¥840,000)
Fiscal Year 2008: ¥4,160,000 (Direct Cost: ¥3,200,000、Indirect Cost: ¥960,000)
Fiscal Year 2007: ¥11,700,000 (Direct Cost: ¥9,000,000、Indirect Cost: ¥2,700,000)
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| Keywords | TNF受容体 / 骨吸収 / RANK / RANKL / 破骨細胞 / NF-κB / 骨吸収阻害 / 低Ca食飼育食マウス / NF-kB |
|---|
| Research Abstract |
The cavity-induced allosteric modification (CIAM) compound binds to the cavity located near by the specific loop of the ligand binding site of the TNF receptor and thus inhibits the function of TNF. This study was undertaken to clarify the possibility in which the CIAM compound inhibits the proliferation of the osteoclasts and decreases bone resorption. The CIAM compound inhibited the osteoclast formation and finally increased bone formation. In addition, the compound inhibited the decrease of bone formation which accompanied with the inflammation. These results indicated that the CIAM compound is a new candidate drug both for the inhibitor of bone resorption and for the stimulator of bone formation induced by the inflammatory reactions.
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