Molecular approaches to identify molecules involved in the cell aggregates formation in the skeletal blastema and elucidation of their functional properties
Project/Area Number |
19390475
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Research Category |
Grant-in-Aid for Scientific Research (B)
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Allocation Type | Single-year Grants |
Section | 一般 |
Research Field |
Functional basic dentistry
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Research Institution | Tsurumi University |
Principal Investigator |
NIFUJI Akira Tsurumi University, 歯学部, 教授 (00240747)
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Co-Investigator(Kenkyū-buntansha) |
SHIBATA Tatsuya 鶴見大学, 歯学部, 助教 (90323708)
荒木 良子 放射線医学総合研究所, 先端遺伝子発現研究グループ, 研究員 (40392211)
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Co-Investigator(Renkei-kenkyūsha) |
ARAKI Ryoko 放射線医学総合研究所, 重粒子医科学センター, チームリーダー (40392211)
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Project Period (FY) |
2007 – 2009
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Project Status |
Completed (Fiscal Year 2009)
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Budget Amount *help |
¥19,110,000 (Direct Cost: ¥14,700,000、Indirect Cost: ¥4,410,000)
Fiscal Year 2009: ¥5,980,000 (Direct Cost: ¥4,600,000、Indirect Cost: ¥1,380,000)
Fiscal Year 2008: ¥5,980,000 (Direct Cost: ¥4,600,000、Indirect Cost: ¥1,380,000)
Fiscal Year 2007: ¥7,150,000 (Direct Cost: ¥5,500,000、Indirect Cost: ¥1,650,000)
|
Keywords | 薬理学 / 分化 / 遺伝子 / 発生 / 骨格形成 / 軟骨細胞 / 骨格 |
Research Abstract |
During skeletal development, the skeletal blastema starts from cell aggregates formation in the mesoderm tissue. To understand skeletal tissue formation, it is crucial to elucidate molecular mechanism how cell aggregates are formed. In this study we aimed to establish molecular approaches to identify functional molecules involved in the cell aggregates formation and to analyze their expressions and functions. Through these approaches, we identified and characterized several molecules that may function in the skeletal blastema.
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Report
(4 results)
Research Products
(42 results)
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[Journal Article] Ihh/Gli2 Signaling Promotes Osteoblast Differentiation by Regulating Runx2 Expression and Function2007
Author(s)
Shimoyama A, Wada M, Ikeda F, Hata K, Matsubara T, Nifuji A, Noda M, Amano K, Yamaguchi A, Nishimura R, Yoneda T
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Journal Title
Mol Biol Cell 18(7)
Pages: 2411-8
Related Report
Peer Reviewed
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[Journal Article] Ihh/Gli2 Signaling Promotes Osteoblast Differentiation by Regulating Runx2 Expression and Function.2007
Author(s)
Shimoyama A, Wada M, Ikeda F, Hata K, Matsubara T, Nifuji A, Noda M, Amano K, Yamaguchi A, Nishimura R, Yoneda T
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Journal Title
Mol Biol Cell. 18(7):
Pages: 2411-8
Related Report
Peer Reviewed
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[Book] 解る薬理学2008
Author(s)
二藤彰、浜田節男、坂上宏、李昌一
Total Pages
343
Publisher
学建書院
Related Report
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