A crosstalk between Toll-like receptor and C-type lectin
| Project/Area Number |
19390477
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| Research Category |
Grant-in-Aid for Scientific Research (B)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Pathobiological dentistry/Dental radiology
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| Research Institution | Hokkaido University |
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Principal Investigator |
SHIBATA Kenichiro Hokkaido University, 大学院・歯学研究科, 教授 (50145265)
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| Co-Investigator(Kenkyū-buntansha) |
HASEBE Akira 北海道大学, 大学院・歯学研究科, 助教 (90281815)
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| Project Period (FY) |
2007 – 2009
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| Project Status |
Completed (Fiscal Year 2009)
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| Budget Amount *help |
¥18,980,000 (Direct Cost: ¥14,600,000、Indirect Cost: ¥4,380,000)
Fiscal Year 2009: ¥4,030,000 (Direct Cost: ¥3,100,000、Indirect Cost: ¥930,000)
Fiscal Year 2008: ¥4,160,000 (Direct Cost: ¥3,200,000、Indirect Cost: ¥960,000)
Fiscal Year 2007: ¥10,790,000 (Direct Cost: ¥8,300,000、Indirect Cost: ¥2,490,000)
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| Keywords | 免疫 / 感染 / 炎症 / FSL-1 / TLR2 / DC-SIGN / XS106細胞 / リポアラビノマンナン / MDDC / Man_9(GLcNAc)_2 |
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| Research Abstract |
Hosts recognize microbial invasion and then kill them intracellularily. In this study, we demonstrated that the signal mediated by a sensor that recognize bacterial invasion was suppressed by that by phagocytic receptor.
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Report
(4 results)
Research Products
(24 results)
