Effects of Notch Signaling on the Pulpal Cell Differentiation and the Horizon of Pulpal Regeneration by Regulation of Notch Signaling

• Project/Area Number: 19390481
• Research Category: Grant-in-Aid for Scientific Research (B)
• Allocation Type: Single-year Grants
• Section: 一般
• Research Field: Conservative dentistry
• Research Institution: Tokyo Medical and Dental University
• Principal Investigator: KAWASHIMA Nobuyuki Tokyo Medical and Dental University, 大学院・医歯学総合研究科, 助教 (60272605)
• Co-Investigator(Kenkyū-buntansha): KATSUBE Kenichi 東京医科歯科大学, 大学院・医歯学総合研究科, 講師 (20233760) ; SAKAMOTO Kei 東京医科歯科大学, 大学院・医歯学総合研究科, 助教 (00302886)
• Project Period (FY): 2007 – 2009
• Project Status: Completed (Fiscal Year 2009)
• Budget Amount: ¥16,510,000 (Direct Cost: ¥12,700,000、Indirect Cost: ¥3,810,000); Fiscal Year 2009: ¥2,860,000 (Direct Cost: ¥2,200,000、Indirect Cost: ¥660,000); Fiscal Year 2008: ¥4,160,000 (Direct Cost: ¥3,200,000、Indirect Cost: ¥960,000); Fiscal Year 2007: ¥9,490,000 (Direct Cost: ¥7,300,000、Indirect Cost: ¥2,190,000)
• Keywords: 歯髄細胞 / 象牙芽細胞 / 分化 / Notch / 未分化間葉系細胞 / Hey1 / Notchシグナル / 歯髄細胞分化 / 歯髄再生 / 歯髄 / 石灰化 / 歯胚

Research Abstract

A numerous factors are involved in the course of odontoblastic differentiation. We revealed the importance of Notch signaling in the osteoblastic differentiation, suggesting that the Notch signaling may one of the essential factors to regulate the differentiation of mesenchymal stromal cells into hard tissue forming cells. In the pulp cells, Notch signaling took a central role of odontoblastic differentiation, and active Notch signaling induced pulp cells remained undifferentiated. Hey1 was a major transcriptional factor in the Notch signaling in the osteo/odonto-blastic differentiation, and enforced expression of Hey1 in the pulp cells were disturbed their odontoblastic differentiation.

Research Products

• [Journal Article] MEPE Activated by Furin Promotes Pulpal Cell Adhesion. (2011)
  • Author(s): H.G.Wang, N.Kawashima, T.Iwata, J.Xu, S.Takahashi, T.Sugiyama, H.Suda
  • Journal Title: Jouranal of Dental Research in press
  • Peer Reviewed
• [Journal Article] Osteogenic differentiation of mouse mesenchymal progenitor cell, Kusa-A1 is promoted by mammalian transcriptional repressor Rbp. (2010)
  • Author(s): S.Wang, N.Kawashima, K.Sakamoto, K.Katsube, A.Umezawa, H Suda
  • Journal Title: Biochemical and Biophysical Research Communications 400 Pages: 39-45
  • Peer Reviewed
• [Journal Article] Differentiation of Odontoblasts Is Negatively Regulated by MEPE via Its C-Terminal Fragment. (2010)
  • Author(s): H.G.Wang, N.Kawashima, T.Iwata, J.Xu, S.Takahashi, T.Sugiyama, H.Suda
  • Journal Title: Biochemical and Biophysical Research Communications 398 Pages: 406-12
  • Peer Reviewed
• [Journal Article] Expression of Notch-Signalling-related Genes in Normal and Differentiating Rat Dental Pulp Cells. (2010)
  • Author(s): Sun H, Kawashima N, Xu J, Takahashi S, Suda H
  • Journal Title: Austrarian Endodontic Journal 36 Pages: 54-8
  • Peer Reviewed
• [Journal Article] Expression of Notch-Signalling-related Genes in Normal and Differentiating Rat Dental Pulp Cells (2010)
  • Author(s): Sun H, Kawashima N, Xu J, Takahashi S, Suda H
  • Journal Title: Australian Endodontic Journal (In press)
  • Peer Reviewed
• [Journal Article] Root Canal Medicaments. (2009)
  • Author(s): Kawashima N, Wadachi R, Suda H, Yeng T, Parashos P
  • Journal Title: Int Dent J. 59(1) Pages: 5-11
  • Peer Reviewed
• [Journal Article] Expression of Notch-Signalling-related Genes in Normal and Differentiating Rat Dental Pulp Cells (2009)
  • Author(s): Sun H, Kawashima N, Xu J, Takahashi S, Suda H
  • Journal Title: AEJ (in press)
  • Peer Reviewed
• [Journal Article] Kawashima N, Wadachi R, Suda H, Yeng T, Parashos P. (2009)
  • Author(s): Root Canal Medicaments
  • Journal Title: Int Dent J 59(1) Pages: 5-11
  • Peer Reviewed
• [Journal Article] Contemporary Meaning of Intracanal Medicaments (2009)
  • Author(s): Kawashima N, Wadachi R, Yeng T, Parashos P, Suda H
  • Journal Title: IDJ (in press)
  • Peer Reviewed
• [Journal Article] T Cell Response Mediated by Myeloid Cell-Derived IL-12 Is Responsible for Porphyromonas gingivalis-Induced Periodontitis in IL-10-Deficient Mice. (2008)
  • Author(s): Sasaki H, Suzuki N, Kent R, Kawashima N, Takeda J, Stashenko P
  • Journal Title: The Journal of Immunology 180 Pages: 6193-6198
  • Peer Reviewed
• [Journal Article] Amelogenin positive cells scattered in the interstitial component of odontogenic fibromas. (2008)
  • Author(s): Kabasawa Y, Nagumo K, Takeda Y, Kawashima N, Okada N, Omura K, Yamaguchi A, Katsube K
  • Journal Title: J.Clin.Pathol. 61 Pages: 851-855
  • Peer Reviewed
• [Journal Article] T Cell Response Mediated by Myeloid Cell-Derived IL-12 Is Responsible for Porphyromonas gingivalis-Induced Periodontitis in IL-10-Deficient Mice (2008)
  • Author(s): Sasaki H, Suzuki N, Kent R, Kawashima N, Takeda J, Stashenko P
  • Journal Title: The Journal of Immunology 180 Pages: 6193-6198
  • Peer Reviewed
• [Journal Article] Amelogenin positive cells scattered in the interstitial component of odontogenic fibromas (2008)
  • Author(s): Kabasawa Y, Nagumo K, Takeda Y, Kawashima N, Okada N, Omura K, Yamaguchi A, Katsube K
  • Journal Title: J. Clin 61(Pathol., Jul) Pages: 851-855
  • Peer Reviewed
• [Journal Article] Amelogenin positive cells scattered in the interstitial component of odontogenic fibromas (2008)
  • Author(s): Kabasawa Y, Nagumo K, Takeda Y, Kawashima N, Okada N, Omura K, Yamaguchi A, Katsube K
  • Journal Title: J. Clin. Pathol. 61 Pages: 851-855
  • Peer Reviewed
• [Journal Article] 上顎第一大臼歯・近心第二根管について-超音波チップと実体顕微鏡で処置した症例- (2008)
  • Author(s): 中野貴和子 川島伸之 須田英明
  • Journal Title: 日本歯科保存学会誌 51 Pages: 456-470
  • Peer Reviewed
• [Journal Article] Kinetics of RANKL, RANK and OPG expressions in experimentally-induced rat periapical lesions. (2007)
  • Author(s): Kawashima N., Suzuki N., Yang G., Ohi C., Okuhara S., Kawanishi H., Suda H.
  • Journal Title: Oral Surgery, Oral Medicine, Oral Pathology, Oral Radiology, and Endodontology 103 Pages: 707-711
  • Peer Reviewed
• [Journal Article] Kinetic study of immunohistochemical colocalization of antigen presenting cells and nerve fibers in rat periapical lesions. (2007)
  • Author(s): Yang G, Kawashima N, Kaneko T, Suzuki N, Okiji T, Suda H
  • Journal Title: J.Endodon 33(2) Pages: 132-136
  • Peer Reviewed
• [Journal Article] Differentiation of an ameloblast-lineage cell line (ALC) is induced by Sonic hedgehog signaling. (2007)
  • Author(s): Takahashi S, Kawashima N, Sakamoto K, Nakata A, Kameda T, Sugiyama T, Katsube K, Suda H
  • Journal Title: BBRC 353 Pages: 405-411
  • Peer Reviewed
• [Journal Article] Kinetics of RANKL, RANK and OPG expressions in experimentally-induced rat periapical lesions (2007)
  • Author(s): Kawashima N., Suzuki N., Yang G., Ohi C., Okuhara S., Kawanishi H., Suda H.
  • Journal Title: Oral Surgery, Oral Medicine, Oral Pathology, Oral Radiology, and Endodontology 103 Pages: 707-711
  • Peer Reviewed
• [Journal Article] Kinetic study of immunohistochemical colocalization of antigen presenting cells and nerve fibers in rat periapical lesions (2007)
  • Author(s): Yang G, Kawashima N, Kaneko T, Suzuki N, Okiji T, Suda H J.
  • Journal Title: Endodon 33(2) Pages: 132-136
  • Peer Reviewed
• [Journal Article] Differentiation of an ameloblast-lineage cell line (ALC) is induced by Sonic hedgehog signaling (2007)
  • Author(s): Takahashi S, Kawashima N, Sakamoto K, Nakata A, Kameda T, Sugiyama T, Katsube K, Suda H, BBRC
  • Journal Title: 353 Pages: 405-411
  • Peer Reviewed
• [Presentation] Induction of IL17 synthesis in the experimentally-induced murine periapical lesions. (2010)
  • Author(s): Kawashima N., Xu J., Suzuki N., Zhou M., Wei S., Takimoto K., Koizumi Y., Takahashi S., Suda H.
  • Organizer: 2010 Spring Scientific Meeting of Korean Academy of Endodontics
  • Place of Presentation: BEXCO Busan, Korea
  • Year and Date: 2010-03-27
• [Presentation] Induction of IL17 synthesis in the experimentally-induced murine periapical lesions (2010)
  • Author(s): Kawashima N., et. al.
  • Organizer: Korean Academy of Endodontics, BEXCO Busan, Korea
  • Year and Date: 2010-03-27
• [Presentation] nduction of IL17 synthesis in the experimentally-induced murine periapical lesions (2010)
  • Author(s): 川島伸之, Xu J., 鈴木規元, 周夢宇, Wei S., 瀧本晃陽, 小泉悠, 高橋里美, 須田英明
  • Organizer: Spring Scientific Meeting of Korean Academy of Endodontics
  • Place of Presentation: BEXCO, Busan, Korea
  • Year and Date: 2010-03-27
• [Presentation] 象牙芽細胞分化におけるSp7によるdentin sialophosphoprotein発現誘導 (2010)
  • Author(s): 川島伸之、許セイ、岩田隆紀、周夢宇、瀧本晃陽、小泉悠、大井智恵、高橋里美、鈴木規元、須田英明
  • Organizer: 日本再生医療学会
  • Place of Presentation: 広島国際会議場(口演)
  • Year and Date: 2010-03-18
• [Presentation] 象牙芽細胞分化におけるSp7によるdentin sialophosphoprotein発現誘導 (2010)
  • Author(s): 川島伸之、許〓、岩田隆紀、周夢宇、瀧本晃陽、小泉悠、大井智恵、高橋里美、鈴木規元、須田英明
  • Organizer: 日本再生医療学会
  • Place of Presentation: 広島国際会議場
  • Year and Date: 2010-03-18
• [Presentation] Expression of Mef2c in Murine Odontoblsts. (2010)
  • Author(s): N Kawashima, J Xu, N Suzuki, M Zhou, K Takimoto, Y Koizumi, M Yamamoto, A Salima, S Takahashi, H Suda
  • Organizer: 8th World Endodontic Congress
  • Place of Presentation: in Athens, Greece
• [Presentation] Shh Signaling is Related to BMP and Wnt Signaling in Ameloblast Differentiation. (2010)
  • Author(s): S Takahashi, N Kawashima, K Katsube, T Sugiyama, H Sida
  • Organizer: 8th World Endodontic Congress
  • Place of Presentation: in Athens, Greece
• [Presentation] Wnt Signaling in Odontoblast Differentiation Induced by BMP. (2010)
  • Author(s): Y Koizumi, N Kawashima, K Takimoto, S Takahashi, J Xu, N Suzuki, M Zhou, M Yamamoto, A Salima, T Sugiyama, H Suda
  • Organizer: 8th World Endodontic Congress
  • Place of Presentation: in Athens, Greece
• [Presentation] Analysis of osteoblastic mesenchymal cell adhesion on laser-induced dentin modification. (2010)
  • Author(s): Gombo Bolortuya, Arata Ebihara, Satoshi Watanabe, Tomoo Anjo, Chizuko Kokuzawa, Hidetoshi Saegusa, Nobuyuki Kawashima, Hideaki Suda
  • Organizer: 8th World Endodontic Congress
  • Place of Presentation: in Athens, Greece
• [Presentation] Promotive effects of Sp7 on Dspp expression. (2010)
  • Author(s): N Kawashima, J Xu, T Iwata, S Takahashi, Y Koizumi, K Takimoto, Z Mengyu, C Ohi, N Suzuki, T Sugiyama, H Suda
  • Organizer: 89th IADR General Session & Exhibition in Barcelona
  • Place of Presentation: Spain
• [Presentation] Effects of MMP-3 on Inflammatory Mediator Synthesis from Macrophages. (2010)
  • Author(s): K Takimoto, N Kawashima, M Nakashima, H Nakamura, Y Koizumi, H Suda
  • Organizer: 89th IADR General Session & Exhibition in Barcelona
  • Place of Presentation: Spain
• [Presentation] Effective suppression of periapical lesion expansion by Cathepsin K inhibitor. (2010)
  • Author(s): Suzuki N, Kawashima N, Xu J, Suda H
  • Organizer: 89th IADR General Session & Exhibition in Barcelona
  • Place of Presentation: Spain
• [Presentation] Expression of Vasoactive Intestinal Peptide Receptors in HERS Cells. (2010)
  • Author(s): J Xu, N Kawashima, N Fujiwara, H Harada, H Suda
  • Organizer: 89th IADR General Session & Exhibition in Barcelona
  • Place of Presentation: Spain
• [Presentation] Expression of Sp7 in the rat dental pulp. (2009)
  • Author(s): Kawashima N., Zhou M., Takimoto K., Koizumi Y., Ohi C., Takahashi S., Suzuki N., Suda H.
  • Organizer: 2009 Autumn Scientific Meeting of Korean Academy of Conservative Dentistry, Ramada Plaza
  • Place of Presentation: Jeju, Korea
  • Year and Date: 2009-11-13
• [Presentation] Expression of Sp7 in the rat dental pulp (2009)
  • Author(s): Kawashima N., et. al.
  • Organizer: Korean Academy of Conservative Dentistry
  • Place of Presentation: Ramada Plaza, Jeju, Korea
  • Year and Date: 2009-11-13
• [Presentation] Expression of Sp7 in the rat dental pulp (2009)
  • Author(s): 川島伸之, 周夢宇, 瀧本晃陽, 小泉悠, Ohi C., 高橋里美, 鈴木規元, 須田英明
  • Organizer: Autumn Scientific Meeting of Korean Academy of Conservative Dentistry
  • Place of Presentation: Jeju, Korea
  • Year and Date: 2009-11-13
• [Presentation] 先進医療X線CT画像診断に基づく手術用顕微鏡を用いた歯根端切除手術の治療成績 (2009)
  • Author(s): 岡降知、八幡祥生、中野生和子、花田降周、石村瞳、菊地和泉、鈴木規元、川島伸之、砂川光宏、須田英明
  • Organizer: 日本歯科保存学会秋季大会
  • Place of Presentation: 仙台国際センター 仙台
  • Year and Date: 2009-10-29
• [Presentation] 歯髄細胞におけるOsterix発現 (2009)
  • Author(s): 川島伸之、許セイ、周夢宇、瀧本晃陽、小泉悠、大井知恵、高橋里美、鈴木則元、須田英明
  • Organizer: 日本歯科保存学会秋季大会
  • Place of Presentation: 仙台国際センター 仙台
  • Year and Date: 2009-10-29
• [Presentation] ラット実験的根尖性歯周炎の進展におけるカテプシンK阻害薬の抑制効果 (2009)
  • Author(s): 鈴木則元、川島伸之、許セイ、須田英明
  • Organizer: 日本歯科保存学会秋季大会
  • Place of Presentation: 仙台国際センター 仙台
  • Year and Date: 2009-10-29
• [Presentation] マクロファージのNO産生能に対するMMP-3の影響 (2009)
  • Author(s): 瀧本晃陽、川島伸之、小泉悠、中島美砂子、須田英明
  • Organizer: 日本歯科保存学会秋季大会
  • Place of Presentation: 仙台国際センター 仙台
  • Year and Date: 2009-10-29
• [Presentation] VIP receptor expression in tooth development. (2009)
  • Author(s): Xu J, Kawashima N, Suzuki N, Okuhara S, Wei S, Takahashi S, Zhou M, Koizumi Y, Suda H
  • Organizer: The 15th Asian Pacific Endodontic Confederation poster program 70
  • Place of Presentation: Toshi center Hotel Tokyo Japan
  • Year and Date: 2009-04-25
• [Presentation] Expression of Th17 related cytokines in experimentally-induced rat periapical lesions. (2009)
  • Author(s): Wei S Kawashima N, Suzuki N, Xu J, Takahashi S, Zhou M, Koizumi Y, Suda H
  • Organizer: The 15th Asian Pacific Endodontic Confederation
  • Place of Presentation: Toshi center Hotel Tokyo Japan
  • Year and Date: 2009-04-25
• [Presentation] Expression of Th17 related cytokines in experimentally-induced rat periapical lesions (2009)
  • Author(s): Wei S, 川島伸之, 鈴木規元, Xu J, 高橋里美, 周夢宇, 小泉悠, 須田英明
  • Organizer: Asian Pacific Endodontic Confederation
  • Place of Presentation: Toshi center Hotel Tokyo
  • Year and Date: 2009-04-25
• [Presentation] VIP receptor expression in tooth development (2009)
  • Author(s): Xu J, 川島伸之, 鈴木規元, Okuhara S, Wei S, 高橋里美, 周夢宇, 小泉悠, 須田英明
  • Organizer: Asian Pacific Endodontic Confederation
  • Place of Presentation: Toshi center Hotel Tokyo
  • Year and Date: 2009-04-25
• [Presentation] Notch Signaling in the Dental Pulp (2008)
  • Author(s): Kawashima N., et. al.
  • Organizer: IADR, Metro Toronto Convention Centre
  • Place of Presentation: ON, Canada
  • Year and Date: 2008-07-02
• [Presentation] Keratocystic Odontogenic Tumor : Case Report. (2008)
  • Author(s): Kawashima N, Kabasawa Y, Suda H
  • Organizer: KAE Spring Scientific Meeting 37th Seosuk Hall
  • Place of Presentation: Chosun Univ, Gwangju, Korea
• [Presentation] Notch Signaling in the Dental Pulp. (2008)
  • Author(s): Kawashima N, Takahashi S, Okuhara S, Ohi C, Sun H, Wang H, Xu J, Katsube K, Arany S, Nakata A, Sugiyama T, Suda H,
  • Organizer: ADR General Session & Exhibition Metro Toronto Convention Centre
  • Place of Presentation: ON, Canada
• [Presentation] Processing of Matrix Extracellular Phosphoglycoprotein in Dental Pulp Cells (2008)
  • Author(s): Wang H, Kawashima N, Xu J, Takahashi S, Okuhara S, Iwata T, Suda H
  • Organizer: IADR General Session & Exhibition Metro Toronto Convention Centre
  • Place of Presentation: ON, Canada
• [Presentation] Shh Signaling is Related to BMP Signaling in Ameloblast Differentiation. (2008)
  • Author(s): Takanashi S, Kawashima N, Nakata A, Kameda T, Sugiyama T, Katsube K, Suda H
  • Organizer: ADR General Session & Exhibition Metro Toronto Convention Centre
  • Place of Presentation: ON, Canada
• [Presentation] The effects of Er : YAG laser irradiation on osteoblasts. (2008)
  • Author(s): A. Ebihara, S. Watanabe, H. Saegusa, T. Anjo, N. Kawashima, H.Suda
  • Organizer: IADR General Session & Exhibition Metro Toronto Convention Centre
  • Place of Presentation: ON, Canada
• [Presentation] Role of Mef2c signaling in osteoblast differentiation. (2008)
  • Author(s): N. Kawashima, S. Takahashi, J. Xu, S. Okuhara, H. Wang, C. Ohi, N. Suzuki, H. Suda
  • Organizer: 2008 Autumn Scientific Meeting (130th) of Korean Academy of Conservative Dentistry
  • Place of Presentation: COEX Seoul Korea
• [Presentation] Keratocystic Odontogenic Tumor : Case Report (2008)
  • Author(s): Kawashima N, Kabasawa Y, Suda H
  • Organizer: KAE Spring Scientific Meeting 37th
  • Place of Presentation: Chosun Univ, Gwangju, Korea
• [Presentation] Notch Signaling in the Dental Pulp (2008)
  • Author(s): Kawashima N., Takahashi s., Okuhara S., Ohi C., Sun H., Wnag H., Xu J., Katsube KI, Arany S., Nakata A., Sugiyama T., Suda H.
  • Organizer: IADR General Session & Exhibition
  • Place of Presentation: Metro Toronto Convention Centre, ON, Canada
• [Presentation] Processing of Matrix Extracellular Phosphoglycoprotein in Dental Pulp Cells (2008)
  • Author(s): Wang H., Kawashima N., XU J., Takahashi S., Okuhara s., Iwata T., Suda H.
  • Organizer: IADR General Session & Exhibition
  • Place of Presentation: Metro Toronto Convention Centre, ON, Canada
• [Presentation] Shh Signaling is Related to BMP Signaling in Ameloblast Differentiation (2008)
  • Author(s): Takahashi S., Kawashima N., Nakata A., Kameda T., Sugiyama T., Katsube KI., Suda H.
  • Organizer: IADR General Session &Exhibition
  • Place of Presentation: Metro Toronto Convention Centre, ON, Canada
• [Presentation] Role of Mef2c signaling in osteoblast differentiation (2008)
  • Author(s): Kawashima N., Takahashi s., Okuhara S., Ohi C., Sun H., Wnag H., Xu J., Katsube KI, Arany S., Nakata A., Sugiyama T., Suda H.
  • Organizer: 2008 Autumn Scientific Meeting (130th)of Korean Academy of Conservative Dentistry
  • Place of Presentation: COEX Seoul Korea
• [Presentation] マウス歯髄におけるMEPE発現 (2007)
  • Author(s): 王桿国 川島伸之 許? 高橋里美 奥原滋 須田英明
  • Organizer: 日本歯科保存学雑誌
  • Place of Presentation: 岡山
  • Year and Date: 2007-11-08
• [Presentation] Infiltration of Immunocompetent Cells in Inflammatory Pulpal Tissues Is Mediated by NO Synthesis (2007)
  • Author(s): Nobuyuki KAWASHIMA, Hiromi Nakano-KAWANISHI, Hideaki SUDA
  • Organizer: 歯内療法学会学術大会
  • Place of Presentation: 広島
  • Year and Date: 2007-05-25
• [Presentation] Tooth development in FGF18 deficient mice. (2007)
  • Author(s): Ohi C, Kawashima N, Suda H
  • Organizer: 2007 2008 IADR General Session & Exhibition
  • Place of Presentation: San Aonio
  • Year and Date: 2007-03-24
• [Presentation] Expression of Maml1 in dental pulp cells. (2007)
  • Author(s): Kawashima N., Okuhara S., Takahashi S., Sun H., Wang H., Xu J., Suda H.
  • Organizer: General meeting of European Society of Endodontology
  • Place of Presentation: Istanbul Convention Center
• [Presentation] Detection of pulpal tissue autofluorescence using a confocal laser scanning microscope. (2007)
  • Author(s): Ebihara Arata, Watanabe Satoshi, Saegusa Hidetoshi, Anjo Tomoo, Kawashima Nobuyuki, Suda Hideaki
  • Organizer: General meeting of European Society of Endodontology
  • Place of Presentation: Istanbul Convention Center
• [Presentation] Expression of Maml1 in dental pulp cells (2007)
  • Author(s): Kawashima N., Okuhara S., Takahashi S., Sun H., Wang H., Xu J., Suda H.
  • Organizer: ESE
  • Place of Presentation: Istanbul Convention Center
• [Book] Pathological aspects of pulpal and periapical inflammations in : Orstavik D and Pitt Ford TR editors, Essential Endodontology, Oxford (2007)
  • Author(s): Kawashima N, Suda H
  • Publisher: Blackwell Publishing
• [Book] Essential Endodontology(Orstavik D and Pitt Ford TR editors, Pathological aspects of pulpal and periapical inflammations) (2007)
  • Author(s): Kawashima N, Suda H
  • Publisher: Blackwell Publishing
• [Book] Essential Endodontology (2007)
  • Author(s): Kawashima N, Suda H
  • Total Pages: 748
  • Publisher: Pathological aspects of pulpal and periapical inflammations
• [Patent(Industrial Property Rights)] 歯周病又は根尖性歯周炎の予防又は治療薬 (2009)
  • Inventor(s): 川島伸之, 鈴木規元, 他
  • Industrial Property Rights Holder: 川島伸之, 鈴木規元, 他
  • Filing Date: 2009-09-24