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Development of caries treatment and prevention method by formation of silicon dioxide (silica)

Research Project

Project/Area Number 19390487
Research Category

Grant-in-Aid for Scientific Research (B)

Allocation TypeSingle-year Grants
Section一般
Research Field Conservative dentistry
Research InstitutionKanagawa Dental College

Principal Investigator

TERANAKA Toshio  Kanagawa Dental College, 歯学部, 教授 (60104460)

Co-Investigator(Kenkyū-buntansha) 好野 則夫  東京理科大学, 工学部, 教授 (50084380)
Co-Investigator(Renkei-kenkyūsha) YOSHINO Norio  東京理科大学, 工学部, 教授
Research Collaborator TANAKA Takahiro  神奈川歯科大学, 歯学部, 大学院生
MORI Rie  神奈川歯科大学, 歯学部, 大学院生
IRIYAMA Kouhei  東京理科大学, 工学部, 修士生
SUGAYA Shigenori  東京理科大学, 工学部, 修士生
MATSUDA Chie  東京理科大学, 工学部, 修士生
MIZUTANI Yousuke  東京理科大学, 工学部, 修士生
Project Period (FY) 2007 – 2008
Project Status Completed (Fiscal Year 2008)
Budget Amount *help
¥18,200,000 (Direct Cost: ¥14,000,000、Indirect Cost: ¥4,200,000)
Fiscal Year 2008: ¥4,290,000 (Direct Cost: ¥3,300,000、Indirect Cost: ¥990,000)
Fiscal Year 2007: ¥13,910,000 (Direct Cost: ¥10,700,000、Indirect Cost: ¥3,210,000)
Keywords歯面被覆 / シリカ被膜 / 齲蝕予防 / 齲蝕治療 / 抗菌性シラン / ヘルヒドロポリシロキサン / ペルヒドロポリシロキサン
Research Abstract

歯の表面に付着する細菌の出す酸から歯を守って虫歯を予防できるガラスの薄膜を作る方法を開発した。エナメル質を軽く酸エッチングして液状のガラス成分を塗り、乾いたらその上をオキシドールで濡らして炭酸ガスレーザーを当てると緻密で薄いガラスのフィルムを成膜することができた。また、このガラス薄膜上に強固に結合できる抗菌性、あるいはテフロンのように細菌も付着できないような分子膜を合成することに成功した。

Report

(3 results)
  • 2008 Annual Research Report   Final Research Report ( PDF )
  • 2007 Annual Research Report
  • Research Products

    (36 results)

All 2008 2007 Other

All Journal Article (11 results) (of which Peer Reviewed: 11 results) Presentation (21 results) Remarks (2 results) Patent(Industrial Property Rights) (2 results) (of which Overseas: 2 results)

  • [Journal Article] Synthesis and antibacterial activity of quaternary ammonium salt-type antibacterial agents with a phosphate group2008

    • Author(s)
      Ohta Y、Kondo Y、Kawada K、Teranaka T、Yoshino N
    • Journal Title

      Journal of Oleo Science 57(8)

      Pages: 445-452

    • NAID

      130000055381

    • Related Report
      2008 Final Research Report
    • Peer Reviewed
  • [Journal Article] Synthesis and properties of gemini-type hydrocarbon-fluorocarbon hybrid surfactant2008

    • Author(s)
      Ohno A、Kushiyama A、Kondo Y、TeranakaT、Yoshino N
    • Journal Title

      Journal of Fluorine Chemistry 129(7)

      Pages: 577-582

    • Related Report
      2008 Final Research Report
    • Peer Reviewed
  • [Journal Article] Synthesis of bone formation deriving biosilanes2008

    • Author(s)
      Yoshino N、Nakajima K、Nakamura K、Kondo Y、Ohashi K、Nihei T、Saito M、Teranaka T
    • Journal Title

      Colloids and Surfaces B : Biointerfaces 66(1)

      Pages: 71-96

    • Related Report
      2008 Final Research Report
    • Peer Reviewed
  • [Journal Article] Synthesis and antibacterial activity of quaternary ammonium salt-type antibacterlal agents with a phosphate group.2008

    • Author(s)
      OHTA Yumi
    • Journal Title

      Journal of Oleo Science 57(8)

      Pages: 445-452

    • Related Report
      2008 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Synthesis and properties of gemini-type hydrocarbon-fluorocarbon hybrid surfactants.2008

    • Author(s)
      OHNO Aimi
    • Journal Title

      Journal of Fluorine Chemistrys 129(7)

      Pages: 577-582

    • Related Report
      2008 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Three-body-wear resistance of the experimental composites containing filler treated with hydrophobic silane coupling agents.2008

    • Author(s)
      NIHEI Tomotaro
    • Journal Title

      Dental Materials 24(6)

      Pages: 760-764

    • Related Report
      2008 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Synthesis of bone formation deriving biosilanes.2008

    • Author(s)
      YOSHINO Norio
    • Journal Title

      Colloids and Surfaces B : Biointerfaces 66(1)

      Pages: 71-76

    • Related Report
      2008 Annual Research Report
    • Peer Reviewed
  • [Journal Article] 重合性基およびフルオロアルキル基含有新規ジクロロシランカツプリング剤の接着性2008

    • Author(s)
      二瓶 智太郎
    • Journal Title

      日本歯科保存学雑誌 51(6)

      Pages: 630-638

    • Related Report
      2008 Annual Research Report
    • Peer Reviewed
  • [Journal Article] 重合性基とフルオロアルキル基をもつ新規ジメトキシシランカツプリング剤の合成と接着耐水性2008

    • Author(s)
      鈴木 敏行
    • Journal Title

      歯科材料・器械 28(1)

      Pages: 1-10

    • Related Report
      2008 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Studies on Synthesis, Physical Properties, and Applications of Surface Modifiers Containing a Fluorocarbon Chain2007

    • Author(s)
      Yoshino N
    • Journal Title

      Journal of Oleo Science 7(12)

      Pages: 513-518

    • NAID

      130004650809

    • Related Report
      2008 Final Research Report
    • Peer Reviewed
  • [Journal Article] Studies on Synthesis, Physical Properties, and Applications of Surface Modifiers Containing a Fluorocarbon Chain2007

    • Author(s)
      Yoshino N
    • Journal Title

      オレオサイエンス 7(12)

      Pages: 513-518

    • NAID

      130004650809

    • Related Report
      2007 Annual Research Report
    • Peer Reviewed
  • [Presentation] 歯面改質剤の細胞毒性2008

    • Author(s)
      森梨江、大橋桂、二瓶智太郎、清水統太、近藤行成、好野則夫、寺中敏夫
    • Organizer
      神奈川歯科大学第43回総会
    • Place of Presentation
      横須賀市
    • Year and Date
      2008-12-06
    • Related Report
      2008 Final Research Report
  • [Presentation] 歯面改質剤の細胞毒性2008

    • Author(s)
      森 梨江
    • Organizer
      神奈川歯科大学学会
    • Place of Presentation
      神奈川歯科大学
    • Year and Date
      2008-12-06
    • Related Report
      2008 Annual Research Report
  • [Presentation] 新規シリカコーティング法によるジルコニア接着の改善2008

    • Author(s)
      花岡孝治
    • Organizer
      日本歯科医学会学総会
    • Place of Presentation
      横 浜
    • Year and Date
      2008-11-15
    • Related Report
      2008 Annual Research Report
  • [Presentation] 歯面のシリカコート2008

    • Author(s)
      田中隆博
    • Organizer
      日本歯科医学会学総会
    • Place of Presentation
      横 浜
    • Year and Date
      2008-11-15
    • Related Report
      2008 Annual Research Report
  • [Presentation] 表面改質によるプラークフリー歯面の創製2008

    • Author(s)
      森 梨江
    • Organizer
      日本歯科医学会学総会
    • Place of Presentation
      横 浜
    • Year and Date
      2008-11-15
    • Related Report
      2008 Annual Research Report
  • [Presentation] 新規シリカコーティング法によるジルコニア接着の改善2008

    • Author(s)
      花岡孝治、田中隆博、山口益司、進藤豊彦、寺中敏夫
    • Organizer
      第21回日本歯科医学会学総会
    • Place of Presentation
      横浜市
    • Year and Date
      2008-11-05
    • Related Report
      2008 Final Research Report
  • [Presentation] 歯面のシリカコート2008

    • Author(s)
      田中隆博、花岡孝治、山口益司、進藤豊彦、寺中敏夫
    • Organizer
      第21回日本歯科医学会学総会
    • Place of Presentation
      横浜市
    • Year and Date
      2008-11-05
    • Related Report
      2008 Final Research Report
  • [Presentation] 表面改質によるプラークフリー歯面の創製2008

    • Author(s)
      森梨江、二瓶智太郎、大橋桂、近藤行成、好野則夫、寺中敏夫
    • Organizer
      第21回日本歯科医学会総会
    • Place of Presentation
      横浜市
    • Year and Date
      2008-11-05
    • Related Report
      2008 Final Research Report
  • [Presentation] Effect of New Siliea-coating on Resin Bonding to YZP ceramic2008

    • Author(s)
      HANAOKA Koji
    • Organizer
      International Association for Dental Research
    • Place of Presentation
      Toronto
    • Year and Date
      2008-07-03
    • Related Report
      2008 Annual Research Report
  • [Presentation] Wear resistance of resin-based restorative composites2008

    • Author(s)
      NIHEI Tomotaro
    • Organizer
      International Association for Dental Research
    • Place of Presentation
      Toronto
    • Year and Date
      2008-07-03
    • Related Report
      2008 Annual Research Report
  • [Presentation] フッ化炭素鎖を含む表面処理剤の歯科への応用(XVIII)-各種歯面改質剤の細胞毒性について-2008

    • Author(s)
      森梨江、大橋桂、二瓶智太郎, 近藤行成、好野則夫、寺中敏夫
    • Organizer
      日本歯科保存学会2008年春季学会(第128回)
    • Place of Presentation
      新潟市
    • Year and Date
      2008-06-06
    • Related Report
      2008 Final Research Report
  • [Presentation] フッ化炭素鎖を含む表面処理剤の歯科への応用(XVIII)-各種歯面改質剤の細胞毒性について-2008

    • Author(s)
      森 梨江
    • Organizer
      日本歯科保存学会
    • Place of Presentation
      新 潟
    • Year and Date
      2008-06-05
    • Related Report
      2008 Annual Research Report
  • [Presentation] Modification effect of the novel phosphate-type fluorocarbon-hydrocarbon hybrid surfactant on enamel surface2008

    • Author(s)
      Mori R、Ohashi K、Nihei T、Kondo Y、Yoshino N 、Teranaka T
    • Organizer
      International symposium for adhesive dentistry 2008 in Kanazawa
    • Place of Presentation
      Kanazawa
    • Year and Date
      2008-02-16
    • Related Report
      2008 Final Research Report
  • [Presentation] Silica Coating bya Laser-assisted Rapid Process2007

    • Author(s)
      Hanaoka K, Tanaka T, Yamaguchi M, Shindo T、Teranaka T
    • Organizer
      International dental materials congress
    • Place of Presentation
      Bangkok
    • Year and Date
      2007-11-23
    • Related Report
      2008 Final Research Report
  • [Presentation] Novel ceramic coating on resin composite2007

    • Author(s)
      Tanaka T、Hanaoka K、Yamaguchi M、ShindoT、Teranaka T
    • Organizer
      International dental materials congress
    • Place of Presentation
      Bangkok
    • Year and Date
      2007-11-23
    • Related Report
      2008 Final Research Report 2007 Annual Research Report
  • [Presentation] Silica coating by a Laser-assisted Rapid Process2007

    • Author(s)
      Hanaoka K
    • Organizer
      International dental materials congress
    • Place of Presentation
      Bangkok
    • Year and Date
      2007-11-23
    • Related Report
      2007 Annual Research Report
  • [Presentation] 歯面上へのシリカコートII-レーザーによる急速転換処理-2007

    • Author(s)
      田中隆博、花岡孝治、山口益司、進藤豊彦、寺中敏夫
    • Organizer
      歯科保存学会2007秋季学会(第127回)
    • Place of Presentation
      岡山市
    • Year and Date
      2007-11-09
    • Related Report
      2008 Final Research Report
  • [Presentation] 歯面上へのシリカコートII-レーザーによる急速転換処理-2007

    • Author(s)
      田中隆博
    • Organizer
      日本歯科保存学会2007秋季学会(第127回)
    • Place of Presentation
      岡山市
    • Year and Date
      2007-11-09
    • Related Report
      2007 Annual Research Report
  • [Presentation] フッ化炭素鎖を含む表面処理剤の歯科への応用(XVII)-新規リン酸型ハイブリッド界面活性剤の歯面改質効果-2007

    • Author(s)
      森梨江、大橋桂、二瓶智太郎、近藤行成、好野則夫、寺中敏夫
    • Organizer
      2007年度秋季学会(第127回)日本歯科保存学会
    • Place of Presentation
      岡山
    • Year and Date
      2007-11-08
    • Related Report
      2008 Final Research Report
  • [Presentation] Effect of New Silica-coating on Resin Bonding to YZP ceramic2007

    • Author(s)
      Hanaoka K、Tanaka T、Yamaguchi M、Shindo T 、Teranaka T
    • Organizer
      86^<th> General Session & Exhibition of the IADR
    • Place of Presentation
      Toronto、Canada
    • Year and Date
      2007-07-03
    • Related Report
      2008 Final Research Report
  • [Presentation] 新規シリカコーティング法の接着修復への応用(第2報)-ジルコニア接着耐久性の評価-2007

    • Author(s)
      田中隆博、花岡孝治、山口益司、進藤豊彦、寺中敏夫
    • Organizer
      日本歯科理工学会学術講演会(第49回)
    • Place of Presentation
      札幌市
    • Year and Date
      2007-05-12
    • Related Report
      2008 Final Research Report
  • [Remarks] 寺中敏夫 : 虫歯予防にシリカ被膜、日刊工業新聞、2008年2月14日

    • Related Report
      2008 Final Research Report
  • [Remarks] 寺中敏夫 : う蝕予防、接着に応用-寺中教授ら開発-シリカコーティング技術、日本歯科新聞、2008年3月18日

    • Related Report
      2008 Final Research Report
  • [Patent(Industrial Property Rights)] 歯科用部材およびその製造方法2008

    • Inventor(s)
      寺中敏夫、花岡孝治、山口益司、進藤豊彦
    • Industrial Property Rights Holder
      寺中敏夫、花岡孝治、山口益司、進藤豊彦
    • Filing Date
      2008-12-22
    • Related Report
      2008 Final Research Report
    • Overseas
  • [Patent(Industrial Property Rights)] 歯科用部材およびその製造方法2007

    • Inventor(s)
      寺中敏夫, 他4社
    • Industrial Property Rights Holder
      寺中敏夫, 他4社
    • Filing Date
      2007-04-10
    • Related Report
      2007 Annual Research Report
    • Overseas

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Published: 2007-04-01   Modified: 2016-04-21  

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