| Project/Area Number |
19390488
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| Research Category |
Grant-in-Aid for Scientific Research (B)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
補綴理工系歯学
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| Research Institution | Hokkaido University |
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Principal Investigator |
YOKOYAMA Atsuro Hokkaido University, 大学院・歯学研究科, 教授 (20210627)
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| Co-Investigator(Kenkyū-buntansha) |
AKASAKA Tsukasa 北海道大学, 大学院・歯学研究科, 助教 (00360917)
SATO Yoshinori 東北大学, 大学院・環境科学研究科, 助教 (30374995)
YAMAMOTO Satoru 北海道大学, 大学院・歯学研究科, 助教 (10344524)
YASUDA Motoaki 北海道大学, 大学院・歯学研究科, 准教授 (90239765)
HIGASHINO Fumihiro 北海道大学, 大学院・歯学研究科, 准教授 (50301891)
SHINDO Masanobu 北海道大学, 大学院・歯学研究科, 教授 (20162802)
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| Project Period (FY) |
2007 – 2009
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| Project Status |
Completed (Fiscal Year 2009)
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| Budget Amount *help |
¥18,590,000 (Direct Cost: ¥14,300,000、Indirect Cost: ¥4,290,000)
Fiscal Year 2009: ¥5,330,000 (Direct Cost: ¥4,100,000、Indirect Cost: ¥1,230,000)
Fiscal Year 2008: ¥5,330,000 (Direct Cost: ¥4,100,000、Indirect Cost: ¥1,230,000)
Fiscal Year 2007: ¥7,930,000 (Direct Cost: ¥6,100,000、Indirect Cost: ¥1,830,000)
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| Keywords | カーボンナノチューブ / 三次元スキャホールド / 表面修飾 / 骨芽細胞 / コラーゲン / 骨髄細胞 / 初期接着 / ポリ乳酸 / 生体適合性 / 炎症反応 |
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| Research Abstract |
In this study, we developed 3D collagen scaffolds coated with carbon nanotubes to reconstruct jaw bone. It was shown that initial adhesion and spreading of osteoblastic cells on 3D collagen scaffold was accelerated by CNTs coating, especially center part of scaffold. Also, it was suggested to apply CNTs for reconstruction of jaw bone, because excellent osteoconductivy was observed when 3D collagen scaffolds coated with CNTs were implanted in bone.
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