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Protective effect on stress-related memory deficits by chewing

Research Project

Project/Area Number 19390493
Research Category

Grant-in-Aid for Scientific Research (B)

Allocation TypeSingle-year Grants
Section一般
Research Field 補綴理工系歯学
Research InstitutionSeijoh University

Principal Investigator

WATANABE Kazuko (2009)  Seijoh University, リハビリテーション学部, 教授 (50140413)

渡辺 和子 (渡邊 和子) (2007-2008)  Seijoh University, リハビリテーション学部, 教授 (40158621)

Co-Investigator(Kenkyū-buntansha) KARASAWA Nobuyuki  星城大学, リハビリテーション学部, 教授 (70148287)
KUBO Kin-ya  星城大学, リハビリテーション学部, 教授 (00329492)
ONOZUKA Minoru  神奈川歯科大学, 歯学部, 教授 (90084780)
SASAGURI Kin-ichi  神奈川歯科大学, 歯学部, 講師 (10235286)
KIMU Wanze  神奈川歯科大学, 歯学部, 特別研究員 (50434395)
Project Period (FY) 2007 – 2009
Project Status Completed (Fiscal Year 2009)
Budget Amount *help
¥15,340,000 (Direct Cost: ¥11,800,000、Indirect Cost: ¥3,540,000)
Fiscal Year 2009: ¥3,120,000 (Direct Cost: ¥2,400,000、Indirect Cost: ¥720,000)
Fiscal Year 2008: ¥4,160,000 (Direct Cost: ¥3,200,000、Indirect Cost: ¥960,000)
Fiscal Year 2007: ¥8,060,000 (Direct Cost: ¥6,200,000、Indirect Cost: ¥1,860,000)
Keywordsチューイング / ストレス / 記憶障害・マウス / 拘束ストレス / ストレス性記憶障害 / マウス / 記憶障害
Research Abstract

A new method for measuring method of stress indicator, which is measurable in a slightamount of blood andshort time, had been developed at the beginning. Mild restrain stress induded a alight decrease of leucocyte number and shortening fibrin clotting time , but variability was quite-variable and whole volume of blood was necessary in mice, which is suitable for behavioral analysis. Spontaneous chewing behavior was induced during mild restrain stress and enhanced learning effect in the morris water maze test.

Report

(4 results)
  • 2009 Annual Research Report   Final Research Report ( PDF )
  • 2008 Annual Research Report
  • 2007 Annual Research Report
  • Research Products

    (30 results)

All 2010 2009 2008 2007

All Journal Article (11 results) (of which Peer Reviewed: 8 results) Presentation (14 results) Book (5 results)

  • [Journal Article] Bruxisum affects stress responses in stressed rats.2010

    • Author(s)
      Sato C, Sato S, Takashina H, IshiiH, Onozuka M, Sasaguri K.
    • Journal Title

      Clin Oral Investig 14

      Pages: 153-160

    • Related Report
      2009 Final Research Report
    • Peer Reviewed
  • [Journal Article] Occlusion and brain function : mastication as a prevention of cognitive dysfunction2010

    • Author(s)
      Ono Y、Yamamoto T, Kubo KY, et al
    • Journal Title

      J Oral Rehabil 68

      Pages: 236-248

    • Related Report
      2009 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Chewing under restraint stress inhibits the stress-induced suppression of cell birth in the dentate gyrus of aged SAMP8 mice.2009

    • Author(s)
      Kubo KY, Sasaguri K, Ono Y, Yamamoto T, Takahashi T, Watanabe K, Karasawa N, Onozuka M
    • Journal Title

      Neurosci Lett 463

      Pages: 109-113

    • Related Report
      2009 Final Research Report
    • Peer Reviewed
  • [Journal Article] Effects of chewing in working memory processing2008

    • Author(s)
      Hirano Y, Obata T, Kashikura K, Nonaka H, Tachibana A, Ikehira H, Onozuka M
    • Journal Title

      Neurosci Lett 436

      Pages: 189-92

    • Related Report
      2009 Final Research Report
    • Peer Reviewed
  • [Journal Article] Changes in GFAP-immunoreactive astrocytes-induced by the bite-raised condition in aged SAMP8 mice2008

    • Author(s)
      Ichihashi Y, Arakawa Y, Iinuma M, Tamura Y, Kubo K, Iwaku F, Takahashi T, Karasawa N, Nagatsu I, Onozuka M
    • Journal Title

      Biogenic Amines 22

      Pages: 39-48

    • Related Report
      2009 Final Research Report
    • Peer Reviewed
  • [Journal Article] The bite-raised condition in aged SAMP8 mice induces dendritic spine changes in the hippocampal region2008

    • Author(s)
      Kubo K, Kojo A, Yamamoto T, Onozuka M
    • Journal Title

      Neurosci Lett 441

      Pages: 141-4

    • Related Report
      2009 Final Research Report
    • Peer Reviewed
  • [Journal Article] Chewing ameliorates stress- induced suppre-ssion of hippocampal long-term potentia- tion2008

    • Author(s)
      Ono Y, Kataoka T, Miyake S, Cheng SJ, Tachibana A, Sasaguri KI, Onozuka M
    • Journal Title

      Neuroscience 154

      Pages: 1352-9

    • Related Report
      2009 Final Research Report
    • Peer Reviewed
  • [Journal Article] Occlusal disharmony attenuates glucocortical negative feedback in aged SAMP8 mice2007

    • Author(s)
      Ichihashi Y, Arakawa Y, Iinuma M, Tamura Y, Kubo K, Iwaku F, Sato Y, Onozuka M
    • Journal Title

      Neurosci Lett 427

      Pages: 71-76

    • Related Report
      2009 Final Research Report
  • [Journal Article] Occlusal disharmony induces spatial memory impairment and hippocampal neuron degeneration via stress in SAMP8 mice.2007

    • Author(s)
      Kubo KY, Yamada Y, Iinuma M, Iwaku F, Tamura Y, Watanabe K, Nakamura H, Onozuka M.
    • Journal Title

      Neurosci Lett. 414

      Pages: 188-191

    • Related Report
      2009 Final Research Report
  • [Journal Article] Occlusal disharmony induces spatial memory impairment and hippocam pal neuron degeneration via stress in SAMP82007

    • Author(s)
      Kubo K, et. al.
    • Journal Title

      Neurosci Lett 14

      Pages: 188-191

    • Related Report
      2007 Annual Research Report
    • Peer Reviewed
  • [Journal Article] よく噛む人はボケにくい2007

    • Author(s)
      渡邊和子、小野塚 実
    • Journal Title

      総合臨床 56

      Pages: 2823-2826

    • Related Report
      2007 Annual Research Report
  • [Presentation] Chewing suppresses stress-induced phosphorylation of mitogen-activated protein kinases in the periaqueductal gray2009

    • Author(s)
      Yamada K, Ono Y, Yamamoto T, Onozuka M
    • Organizer
      第32回神経科学会
    • Place of Presentation
      名古屋国際会議場(名古屋)
    • Year and Date
      2009-09-17
    • Related Report
      2009 Final Research Report
  • [Presentation] Chewing is involved in cel generation in the aged hippocampus dentate gurus2009

    • Author(s)
      Kubo K, Sasaguri, KI, Kimura K, Watanabe K, Onozuka M
    • Organizer
      第32回神経科学会
    • Place of Presentation
      名古屋国際会議場(名古屋)
    • Year and Date
      2009-09-17
    • Related Report
      2009 Final Research Report
  • [Presentation] Chewing ameliorates stress- suppressed hippcampal CA1-LTP via activation of histamine H1 receptor2009

    • Author(s)
      Ono Y, Kataoka T, Miyake S, Sasaguri KI, Sato S, Onozuka M
    • Organizer
      第32回神経科学会
    • Place of Presentation
      名古屋国際会議場(名古屋)
    • Year and Date
      2009-09-17
    • Related Report
      2009 Final Research Report
  • [Presentation] Chewing is involved in cell generation in the aged hippocampus dentate gyrus2009

    • Author(s)
      Kubo KY, Sasaguri K, et al
    • Organizer
      第32回日本神経科学大会
    • Place of Presentation
      名古屋国際会議場
    • Year and Date
      2009-09-17
    • Related Report
      2009 Annual Research Report
  • [Presentation] Chewing suppresses stress-induced phosphorylation of mitogen-activated protein kinases in the periaqueductal gray2009

    • Author(s)
      Yamada K, et al
    • Organizer
      第32回日本神経科学大会
    • Place of Presentation
      名古屋国際会議場
    • Year and Date
      2009-09-17
    • Related Report
      2009 Annual Research Report
  • [Presentation] Chewing ameliorates stress-suppressed hippocampal CA1-LTP via acti-vation of histamine H1 receptor2009

    • Author(s)
      Ono Y, et al
    • Organizer
      第32回日本神経科学大会
    • Place of Presentation
      名古屋国際会議場
    • Year and Date
      2009-09-17
    • Related Report
      2009 Annual Research Report
  • [Presentation] Amelioration of stress-reduced CaMKII-dependent hippocampal protein phosphorylation by chewing2008

    • Author(s)
      Iwamoto M, Kato K, Sasagurti TI, Watanabe K, Sato S, Onozuka M
    • Place of Presentation
      東京国際フォーラム(東京)
    • Year and Date
      2008-07-11
    • Related Report
      2009 Final Research Report
  • [Presentation] Amelioration of stress-reduced CaMKII-dependent hippocampal protein phosphorylation by chewing2008

    • Author(s)
      Iwamoto M, et al
    • Organizer
      第31回神経科学大会
    • Place of Presentation
      東京国際フォーラム
    • Year and Date
      2008-07-11
    • Related Report
      2008 Annual Research Report
  • [Presentation] Chewing and amygdaloid response to stress2008

    • Author(s)
      Niwa M, Hirano Y, OtsukaT, Watanabe K, Onozuka M
    • Organizer
      第31回神経科学会
    • Place of Presentation
      東京国際フォーラム(東京)
    • Year and Date
      2008-07-09
    • Related Report
      2009 Final Research Report
  • [Presentation] Chewing and amygdaloid response to stress2008

    • Author(s)
      Niwa M, et al
    • Organizer
      第31回神経科学大会
    • Place of Presentation
      東京国際フォーラム
    • Year and Date
      2008-07-09
    • Related Report
      2008 Annual Research Report
  • [Presentation] Chewing-related neuronal mechanism under stress condition2007

    • Author(s)
      Kim W, Tachibana A, Otsuka T, Hirano Y, Kubo KY, Ono Y, Nakamura H, Karasawa N, Onozuka M, Watanabe K
    • Organizer
      30回日本神経科学大会
    • Place of Presentation
      パシフィコ横浜(横浜)
    • Year and Date
      2007-09-11
    • Related Report
      2009 Final Research Report
  • [Presentation] Ameliorative effect of biting on the stress-attenuated hippocampal memory process : a Morris water Maze study2007

    • Author(s)
      Miyake S, Ono Y, Kataoka T, Kim W, Sasaguri KI, Watanabe K, Sato S, Onozuka M
    • Organizer
      第30回日本神経科学大会
    • Place of Presentation
      パシフィコ横浜(横浜)
    • Year and Date
      2007-09-11
    • Related Report
      2009 Final Research Report
  • [Presentation] Ameliorative effect of biting on the stress-attenuated hippocampal memory process : a CA1-LTP study2007

    • Author(s)
      Ono Y, Miyake S, Kataoka T, Sasaguri K, Sato S, Watanabe K, Onozuka M
    • Organizer
      第30回日本神経科学大会
    • Place of Presentation
      パシフィコ横浜(横浜)
    • Year and Date
      2007-09-11
    • Related Report
      2009 Final Research Report
  • [Presentation] Chewing-related neuronal mechanism under stress condition2007

    • Author(s)
      Kim W, et. al.
    • Organizer
      第30回神経科学学会
    • Place of Presentation
      パシフィコ横浜(横浜)
    • Year and Date
      2007-09-11
    • Related Report
      2007 Annual Research Report
  • [Book] Involvement of dysfunctional mastication in cognitive system deficits in the mouse, In Nover Trends in Brain Science2008

    • Author(s)
      Watanabe K, et al.
    • Publisher
      Springer
    • Related Report
      2009 Final Research Report
  • [Book] Interactions between chewing and brain activity in humans, In Nover Trends in Brain science2008

    • Author(s)
      Onozuka M, Hirano Y, Tachibana A, Kim W, Ono Y, Sasaguri K, Kubo K, Niwa M, Kanematsu K, Watanabe K
    • Publisher
      Springer
    • Related Report
      2009 Final Research Report
  • [Book] Involvement of dysfunctional mastication in cognitive system deficits in the mouse, In Nover Trends in Brain Science2008

    • Author(s)
      Watanabe K, et al
    • Publisher
      Springer
    • Related Report
      2008 Annual Research Report
  • [Book] Interactions between chewing and brain activity in humans, In Nover Trends in Brain Science2008

    • Author(s)
      Onozuka M, et al
    • Publisher
      Springer
    • Related Report
      2008 Annual Research Report
  • [Book] Novel Trends in Brain Science2008

    • Author(s)
      Watanabe K, et. al.
    • Total Pages
      254
    • Publisher
      Springer(Tokyo)
    • Related Report
      2007 Annual Research Report

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Published: 2007-04-01   Modified: 2016-04-21  

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