Development of osteoinductive porous carbonate apataite ceramics
| Project/Area Number |
19390503
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| Research Category |
Grant-in-Aid for Scientific Research (B)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
補綴理工系歯学
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| Research Institution | Asahi University |
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Principal Investigator |
DOI Yutaka Asahi University, 歯学部・歯科理工学分野, 教授 (40116067)
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| Co-Investigator(Kenkyū-buntansha) |
ADACHI Masanori 朝日大学, 歯学部, 准教授 (60076057)
KAMEMIZU Hideo 朝日大学, 歯学部, 講師 (00152877)
KANAYAMA Keichi 朝日大学, 歯学部, 助教 (20454275)
若松 宣一 朝日大学, 歯学部, 講師 (00158594)
飯島 まゆみ 朝日大学, 歯学部, 助教 (80164838)
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| Project Period (FY) |
2007 – 2009
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| Project Status |
Completed (Fiscal Year 2009)
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| Budget Amount *help |
¥19,240,000 (Direct Cost: ¥14,800,000、Indirect Cost: ¥4,440,000)
Fiscal Year 2009: ¥2,210,000 (Direct Cost: ¥1,700,000、Indirect Cost: ¥510,000)
Fiscal Year 2008: ¥5,330,000 (Direct Cost: ¥4,100,000、Indirect Cost: ¥1,230,000)
Fiscal Year 2007: ¥11,700,000 (Direct Cost: ¥9,000,000、Indirect Cost: ¥2,700,000)
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| Keywords | 歯科用材料 / 歯科理工学 / 骨誘導 / 多孔体 / 移植・再生 / 炭酸含有アパタイト / 細胞・組織 / 成長因子 / 生体内吸収性 / 破骨細胞 / 移植・再生医療 |
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| Research Abstract |
Sintered and non-sintered carbonate apatite ceramics with different porosities were prepared and implanted into the skin of dogs to investigate their bioresorbability and also to see if they have an osteoinductive potential or not. At 3 and 6 months postoperatively, the tissues containing materials were subjected to μ-CT analysi before decalcification for light microscopy. Compared to commercially available porous β-TCP, non-sintered CA resorbed to an appreciate extent and in 7 of 16 specimens no CA materials were confirmed. Although not so evident on μ-CT images, newly formed bone was indicated with non-sintered CA ceramics at 6 months.
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Report
(5 results)
Research Products
(46 results)
