| Budget Amount *help |
¥18,980,000 (Direct Cost: ¥14,600,000、Indirect Cost: ¥4,380,000)
Fiscal Year 2009: ¥5,330,000 (Direct Cost: ¥4,100,000、Indirect Cost: ¥1,230,000)
Fiscal Year 2008: ¥4,290,000 (Direct Cost: ¥3,300,000、Indirect Cost: ¥990,000)
Fiscal Year 2007: ¥9,360,000 (Direct Cost: ¥7,200,000、Indirect Cost: ¥2,160,000)
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| Research Abstract |
Establishment of genetic hypoxia imaging is very critical for the treatment of oral cancer. The expression of the human sodium-iodide symporter (hNIS) gene is visualized by positron emission tomography (PET) and single photon emission computed tomography (SPECT). Our group has already established cell lines stably expressing hNIS. We established the cancer cell line stably expressing hNIS (HCT116-hNIS line B), and succeeded in imaging the mouse xenograft model by 99mTcO4 SPECT. In the future, this model will provide a tool to track tumor metastasis in vivo in mice so that the molecular mechanism involved in metastatic cascade will be elucidated.
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