An imaging and drug delivary system for treatment of oral cancer by using ultrasound and nano-bubbles

• Project/Area Number: 19390507
• Research Category: Grant-in-Aid for Scientific Research (B)
• Allocation Type: Single-year Grants
• Section: 一般
• Research Field: Surgical dentistry
• Research Institution: Tohoku University
• Principal Investigator: MORI Shiro Tohoku University, 病院, 講師 (80230069)
• Co-Investigator(Kenkyū-buntansha): 小玉 哲也 東北大学, 先進医工学機構, 准教授 (40271986) ; 小野 栄夫 東北大学, 大学院・医学系研究科, 教授 (20302218)
• Co-Investigator(Renkei-kenkyūsha): KODAMA Tetsuya 東北大学, 医工学研究科, 教授 (40271986) ; ONO Masao 東北大学, 医学系研究科, 教授 (20302218)
• Project Period (FY): 2007 – 2009
• Project Status: Completed (Fiscal Year 2009)
• Budget Amount: ¥18,980,000 (Direct Cost: ¥14,600,000、Indirect Cost: ¥4,380,000); Fiscal Year 2009: ¥5,460,000 (Direct Cost: ¥4,200,000、Indirect Cost: ¥1,260,000); Fiscal Year 2008: ¥5,460,000 (Direct Cost: ¥4,200,000、Indirect Cost: ¥1,260,000); Fiscal Year 2007: ¥8,060,000 (Direct Cost: ¥6,200,000、Indirect Cost: ¥1,860,000)
• Keywords: 口腔癌 / ナノバブル / 超音波 / 画像診断 / 分子導入 / 動物モデル / 腫瘍血管 / 画像構築

Research Abstract

In the present study, we try to develop a three-dementional imaging system and drug delivery system by using nanobubbles and ultrasound for diagnosis and treatment of oral cancer. As a result, we could make three-dementional ultrasound imaging of neovascularization in small tumor, which could not be detectable by using conventional imaging system such as CT or MRI. Moreover, when the treatment experiment of tumor by the drug delivery system that used the nanobubbles and ultrasound was done, the therapeutic gain by this method was able to be confirmed.

Research Products

• [Journal Article] Delivery of Na/I symporter gene into skeletal muscle by using nanobubbles and ultrasound : Visualization of gene expression by positron emission tomography (2010)
  • Author(s): Watanabe Y, Horie S, Funaki Y, Kikuchi Y, Yamazaki H, Ishii K, Mori S, Vassaux G, Kodama T
  • Journal Title: Journal of Nuclear Medicine (in press)
  • Peer Reviewed
• [Journal Article] Morphological study on Acoustic liposome using transmission electron microscopy (2010)
  • Author(s): Kodama T, Tomita N, Horie S, Sax N, Iwasaki H, Suzuki R, Maruyama K, Mori S, Fukumoto M
  • Journal Title: J Electron Microsc (In Press)
  • Peer Reviewed
• [Journal Article] Evaluating the Role of Rheumatoid Factors for the Development of Rheumatoid Arthritis in a Mouse Model with a Newly Established ELISA System (2010)
  • Author(s): Tanaka Y, Komori H, Mori S, Soga Y, Tsubaki T, Terada M, Miyazaki T, Fujino T, Nakamura S, Kanno H, Sawasaki T, Endo Y, Nose M
  • Journal Title: Tohoku J Exp Med 220(3) Pages: 199-206
  • NAID: 10027083539
  • Peer Reviewed
• [Journal Article] Morphological study on Acoustic liposome using transmission electron microscopy (2010)
  • Author(s): Kodama T, et al.
  • Journal Title: J Electron Microsc (未定, In press)
  • Peer Reviewed
• [Journal Article] Evaluating the Role of Rheumatoid Factors for the Development of Rheumatoid Arthritis in a Mouse Model with a Newly Established ELISA System (2010)
  • Author(s): Tanaka Y, et al.
  • Journal Title: Tohoku J Exp Med 220 Pages: 199-206
  • Peer Reviewed
• [Journal Article] Delivery of Na/I symporter gene into skeletal muscle by using nanobubbles and ultrasound : Visualization of gene expression by positron emission tomography (2010)
  • Author(s): Watanabe Y, et al.
  • Journal Title: Journal of Nuclear Medicine (未定, In press)
  • Peer Reviewed
• [Journal Article] Periodontal Gene Transfer by Ultrasound and Nano-/Microbubbles (2009)
  • Author(s): R. Chen, Chiba M, Mori S, Fukumoto M, Kodama T
  • Journal Title: J Dent Res 88(11) Pages: 1008-1013
  • Peer Reviewed
• [Journal Article] Periodontal Gene Transfer by Ultrasound and Nano-/Microbubbles (2009)
  • Author(s): Chen R, et al.
  • Journal Title: J Dent Res 88 Pages: 1008-1013
  • Peer Reviewed
• [Journal Article] (2009)
  • Author(s): Komori H, et al.
  • Journal Title: Chemical Pollution in Indochina ; Contamination Status, Ecosystem Impact and Remediation Technology(Tokai University Press) Pages: 160-167
• [Journal Article] Herpes simplex virus thymidine kinase-mediated suicide gene therapy using nano/microbubbles and ultrasound (2008)
  • Author(s): Aoi A, Watanabe Y, Mori S, Takahashi M, Vassaux G, Kodama T
  • Journal Title: Ultrasound Med Biol 34(3) Pages: 425-34
  • Peer Reviewed
• [Journal Article] A novel recombinant congenic mouse strain developing arthritis with enthesopathy (2008)
  • Author(s): Mori S, Tanda N, Ito MR, Oishi H, Tsubaki T, Komori H, Zhang MC, Ono M, Nishimura M, Nose M
  • Journal Title: Pathol Int 58(7) Pages: 407-414
  • NAID: 10027377068
  • Peer Reviewed
• [Journal Article] Low-intensity ultrasound and microbubbles enhance the antitumor effect of cisplatin (2008)
  • Author(s): Watanabe Y, Aoi A, Horie S, Tomita N, Mori S, Morikawa H, Matsumura Y, Vassaux G, Kodama T
  • Journal Title: Cancer Sci 99(12) Pages: 2525-2531
  • NAID: 10024014712
  • Peer Reviewed
• [Journal Article] Loss of heterozygosity of the PTH/PTHrP type 1 receptor in oral squamous cell carcinoma (2008)
  • Author(s): Miyashita H, Mori S, Fukumoto Y, Sato A, Fukumoto M, Kawamura H
  • Journal Title: Molecular Medicine Reports 1 Pages: 821-825
  • Peer Reviewed
• [Journal Article] Herpes simplex virus thymidine kinase-mediated suicide genetherapy using nano / microbubbles and ultrasound (2008)
  • Author(s): Atsuko Aoi, et.al.
  • Journal Title: Ultrasound Med Biol 34 Pages: 425-434
  • Peer Reviewed
• [Journal Article] A novel recombinant congenic mouse strain developing arthritis with enthesopathy (2008)
  • Author(s): Shiro Mori, et.al.
  • Journal Title: Pathol Int 58 Pages: 407-414
  • NAID: 10027377068
  • Peer Reviewed
• [Journal Article] Low-intensity ultrasound and microbubbles enhance the antitumor effect of cisplatin (2008)
  • Author(s): Yukiko Watanabe, et.al.
  • Journal Title: Cancer Science 99 Pages: 2525-2531
  • Peer Reviewed
• [Journal Article] Loss of heterozygosity of the PTH / PTHrP type 1 receptor in oral squamous cell carcinoma (2008)
  • Author(s): Hitoshi Miyashita
  • Journal Title: Molecular Medicine Reports 1 Pages: 821-825
  • Peer Reviewed
• [Journal Article] 高周波超音波イメージングシステムによるシスプラチン抗腫瘍効果の定量化 (2008)
  • Author(s): 小玉哲也, 他
  • Journal Title: 第46回日本生体医工学会大会プログラム・抄録集 46 Pages: 277-277
• [Journal Article] マウス骨格筋でのNa/I symporter(NIS)遺伝子発現の可視化 (2008)
  • Author(s): 渡邊夕紀子, 他
  • Journal Title: 日本機械学会2008年度年次大会講演論文集 2 Pages: 23-24
• [Journal Article] 下顎骨に発生した平滑筋肉腫の1例 (2008)
  • Author(s): 大木宏介, 他
  • Journal Title: 東北大歯誌 27 Pages: 57-63
  • Peer Reviewed
• [Journal Article] Herpes simplex virus thymidine kinase-mediated suicide gene therapy using nano/microbubbles and ultrasound (2008)
  • Author(s): Aoi A, Watanabe Y, Mori S, et. al.
  • Journal Title: Ultrasound Med Biol 34 Pages: 425-434
  • Peer Reviewed
• [Journal Article] Autosomal loci associated with a sex-related difference in the development of autoimmune phenotypes in a lupus model (2007)
  • Author(s): Misu N, Zhang MC, Mori S, Miyazaki T, Furukawa H, Sasaki T, Nose M, Ono M
  • Journal Title: Eur J Immunol 37(10) Pages: 2787-2796
  • Peer Reviewed
• [Journal Article] A non-MHC locus determines tissue-specificity in the pathogenic process underlying synovial proliferation in a mouse arthropathy model (2007)
  • Author(s): Zhang MC, Mori S, Date F, Furukawa H, Ono M
  • Journal Title: Ann Rheum Dis 66 Pages: 242-245
  • Peer Reviewed
• [Journal Article] ナノバブルと超音波を用いたDDS:骨橋筋への応用 (2007)
  • Author(s): 小玉哲也, 青井あつ子, 渡邊夕紀子, 小野栄夫, 森 士朗
  • Journal Title: 日本機械学会2007年度年次大会講演論文集 2 Pages: 151-152
  • Peer Reviewed
• [Journal Article] シスプラチンを使った抗腫瘍効果:高周波による定量化 (2007)
  • Author(s): 冨田典子, 渡邊夕紀子, 堀江佐知子, 小野栄夫, 森 士朗, 小玉哲也
  • Journal Title: 日本機械学会2007年度年次大会講演論文集 2 Pages: 155-156
  • Peer Reviewed
• [Presentation] Targeted gene delivery using nanobubble and ultrasound (2010)
  • Author(s): Horie S, Watanabe Y, Chen R, Mori S, Matsumura Y, Kodama T
  • Organizer: The 5th International Symposium on Medical, Bio -and Nano-Electronics
  • Place of Presentation: Sendai, Japan
• [Presentation] PET imaging of Na/I symporter gene expression induced by nanobubbles and ultrasound (2010)
  • Author(s): Watanabe Y, Horie S, Funaki Y, Kikuchi Y, Yamazaki H, Ishii K, Mori S, Kodama T
  • Organizer: The 5th International Symposium on Medical, Bio- and Nano-Electronics
  • Place of Presentation: Sendai, Japan
• [Presentation] Observation for angiogenesis of liver metastases in preclinical models (2010)
  • Author(s): Chen R, YWatanabe Y, Li L, Horie S, Mori S, Fukumoto M, Kodama T.
  • Organizer: The 5th International Symposium on Medical, Bio-and Nano-Electronics
  • Place of Presentation: Sendai, Japan
• [Presentation] Four-dimensional high-frequency ultrasound imaging system for early detection of lymph node micro-metastasis (2010)
  • Author(s): Li L, Horie S, CHEN R, Watanabe Y, Baba T, Sax N, Sakamoto M, Mori S, Takahashi S, Kodama T.
  • Organizer: The 5th International Symposium on Medical, Bio- and Nano-Electronics
  • Place of Presentation: Sendai, Japan
• [Presentation] TEM observation and analysis of echogenic nano-bubbles (2010)
  • Author(s): Sax N, Horie S, Li L, Chen R, Watanabe Y, Mori S, Kodama T.
  • Organizer: The 5th International Symposium on Medical, Bio- and Nano-Electronics
  • Place of Presentation: Sendai, Japan
• [Presentation] Volumetric and angiogenetic imaging system by using nanobubbles and high-frequency ultrasound for evaluation of the antitumor effect by cisplatin (2010)
  • Author(s): Yagishita Y, Takata Y, Ohki K, Miyashita H, Morikawa H, Sakamoto M, Mori S, Kawamura H, Kodama T.
  • Organizer: The 5th International Symposium on Medical, Bio-and Nano-Electronics
  • Place of Presentation: Sendai, Japan
• [Presentation] Ultrasound molecular imaging of lymph node metastasis with nano/microbubbles (2010)
  • Author(s): Li L, Chen R, Horie S, Watanabe Y, Baba T, Sax N, Sakamoto M, Mori S, Takahashi S, Kodama T.
  • Organizer: International Symposium of AIDS and Tuberculosis (ISAT2010)
  • Place of Presentation: Sendai, Japan
• [Presentation] Physical characterization of acoustic liposomes (2010)
  • Author(s): Sax N, Horie S, Li L, Chen R, Watanabe Y, Mori S, Kodama T.
  • Organizer: International Symposium of AIDS and Tuberculosis (ISAT2010)
  • Place of Presentation: Sendai, Japan
• [Presentation] Ultrasound molecular imaging of lymph node metastasis with nano/microbubbles (ISAT2010) (2010)
  • Author(s): 李麗, et al.
  • Organizer: International Symposium of AIDS and Tuberculosis
  • Place of Presentation: Sendai
• [Presentation] Physical characterization of acoustic liposomes (2010)
  • Author(s): Sax N, et al.
  • Organizer: International Symposium of AIDS and Tuberculosis (ISAT2010)
  • Place of Presentation: Sendai
• [Presentation] Targeted gene delivery using nanobubble and ultrasound (2010)
  • Author(s): 堀江佐知子, et al.
  • Organizer: The 5th International Symposium on Medical, Bio- and Nano-Electronics
  • Place of Presentation: Sendai
• [Presentation] PET imaging of Na/I symporter gene expression induced by nanobubbles and ultrasound (2010)
  • Author(s): 渡邊夕紀子, et al.
  • Organizer: The 5th International Symposium on Medical, Bio- and Nano-Electronics
  • Place of Presentation: Sendai
• [Presentation] Observation for angiogenesis of liver metastases in preclinical models (2010)
  • Author(s): Chen R, et al.
  • Organizer: The 5th International Symposium on Medical, Bio- and Nano-Electronics
  • Place of Presentation: Sendai
• [Presentation] Four-dimensional high-frequency ultrasound imaging system for early detection of lymph node micro-metastasis (2010)
  • Author(s): 李麗, et al.
  • Organizer: The 5th International Symposium on Medical, Bio- and Nano-Electronics
  • Place of Presentation: Sendai
• [Presentation] TEM observation and analysis of echogenic nano-bubbles (2010)
  • Author(s): Sax N, et al.
  • Organizer: The 5th International Symposium on Medical, Bio- and Nano-Electronics
  • Place of Presentation: Sendai
• [Presentation] Volumetric and angiogenetic imaging system by using nanobubbles and high-frequency ultrasound for evaluation of the antitumor effect by cisplatin (2010)
  • Author(s): Yagishita Y, et al.
  • Organizer: The 5th International Symposium on Medical, Bio- and Nano-Electronics
  • Place of Presentation: Sendai
• [Presentation] 超音波分子イメージング法による新しいリンパ節転移早期診断法の開発 (2009)
  • Author(s): 李麗, 他
  • Organizer: 第6回東北大学バイオサイエンスシンポジウムおよび第14回学際ライフサイエンスシンポジウム
  • Place of Presentation: 仙台
  • Year and Date: 2009-06-16
• [Presentation] 音響照射圧を用いたターゲッティング分子導入法の開発 (2009)
  • Author(s): 堀江佐知子, 他
  • Organizer: 第6回東北大学バイオサイエンスシンポジウムおよび第14回学際ライフサイエンスシンポジウム
  • Place of Presentation: 仙台
  • Year and Date: 2009-06-16
• [Presentation] ナノバブルと超音波を利用した遺伝子導入法:マウスを使用したPETによる遺伝子発現の可視化.講演要旨集212頁 (2009)
  • Author(s): 渡邊夕紀子, 他
  • Organizer: 第6回東北大学バイオサイエンスシンポジウムおよび第14回学際ライフサイエンスシンポジウム
  • Place of Presentation: 仙台
  • Year and Date: 2009-06-16
• [Presentation] リンパ節転移早期診断に関する三次元高周波超音波イメージング (2009)
  • Author(s): 李麗, 他
  • Organizer: 日本超音波医学会東北地方会第37回学術集会
  • Place of Presentation: 仙台
  • Year and Date: 2009-03-15
• [Presentation] 表在性膀胱がんに対する新しい遺伝子治療法の開発 (2009)
  • Author(s): 堀江佐知子, 他
  • Organizer: 日本超音波医学会東北地方会第37回学術集会
  • Place of Presentation: 仙台
  • Year and Date: 2009-03-15
• [Presentation] Three-dimentional high-frequency ultrasound imaging for early diagnosis of lymph node metastasis combined with microbubbles (2009)
  • Author(s): Li L, Horie S, Chen R, Watanabe Y, Sakamoto M, Mori S, Takahashi S, Kodama T.
  • Organizer: The 3rd East Asian Pacific Student Workshop on Nano-Biomedical Engineering
  • Place of Presentation: Engineering Auditorium, National University of Singapore, Singapore
• [Presentation] ナノバブルと高周波超音波画像診断装置の遠隔地口腔診断への応用 (2009)
  • Author(s): 森士朗, 他
  • Organizer: 第54回日本口腔外科学総会
  • Place of Presentation: 札幌
• [Presentation] Novel approach to early diagnosis of lymph node metastasis with ultrasonic molecular imaging (2009)
  • Author(s): Li L, Horie S, Chen R, Watanabe Y, Mori S, Ono M, Sakamoto M, Takahashi S, Kodama T
  • Organizer: 第68回本癌学会総会
  • Place of Presentation: 横浜
• [Presentation] ナノバブルと超音波を用いた口腔癌リアルタイム画像診断システムの開発に向けての検討 (2009)
  • Author(s): 森士朗, 他
  • Organizer: 第33回日本頭頸部癌学会
  • Place of Presentation: 札幌
• [Presentation] Immunohistochemical localization of CD134 ligand, CD137 ligand, GITR ligand and BAFF in Sjogren's syndrome-like autoimmune sialadenitis of MRL/lpr mice (2009)
  • Author(s): Saito K, et al.
  • Organizer: The 3^<rd> International Symposium for Interface Oral Health Science in SENDAI
  • Place of Presentation: Sendai
• [Presentation] 関節強直症マウスのゲノム解析と顎変形症疾患モデル動物としての可能性についての検討 (2009)
  • Author(s): 高田陽子, 他
  • Organizer: 第19回日本顎変形症学会総会
  • Place of Presentation: 仙台
• [Presentation] ナノバブルと超音波を用いた抗腫瘍分子導入システムによる抗腫瘍効果に関する検討 (2009)
  • Author(s): 宮下仁, 他
  • Organizer: 第33回日本頭頸部癌学会
  • Place of Presentation: 札幌
• [Presentation] ナノバブルと超音波を用いた口腔癌画像診断システムの診断精度に関する検討 (2009)
  • Author(s): 大木宏介, 他
  • Organizer: 第33回日本頭頸部癌学会
  • Place of Presentation: 札幌
• [Presentation] ナノバブルと超音波を用いた口腔癌診断システムの遠隔地医療への応用 (2009)
  • Author(s): 森士朗, 他
  • Organizer: 第35回(社)日本口腔外科学会北日本地方会
  • Place of Presentation: 旭川
• [Presentation] ナノバブルを用いたリンパ節転移診断に関する三次元高周波超音波イメージング法の開発 (2009)
  • Author(s): 李麗, 他
  • Organizer: 日本機械学会第21回バイオエンジニアリング講演会
  • Place of Presentation: 札幌
• [Presentation] 表在性膀胱がんへの遺伝子治療法の開発 (2009)
  • Author(s): 堀江佐知子, 他
  • Organizer: 第48回日本生体医工学会大会
  • Place of Presentation: 東京
• [Presentation] ^<124>Iを使用したNIS遺伝子発現イメージング法の開発:超音波とナノバブルを利用した遺伝子デリバリー (2009)
  • Author(s): 渡邊夕紀子, 他
  • Organizer: 第25回日本DDS学会
  • Place of Presentation: 東京
• [Presentation] ナノバブルを用いた超音波によるリンパ節転移早期診断システムの研究開発 (2009)
  • Author(s): 李麗, 他
  • Organizer: 第25回日本DDS学会
  • Place of Presentation: 東京
• [Presentation] 表在性膀胱がんに対する薬剤送達法の開発 (2009)
  • Author(s): 堀江佐知子, 他
  • Organizer: 日本機械学会2009年度年次大会
  • Place of Presentation: 盛岡
• [Presentation] 臨床試験を目指した肝転移モデルの非侵襲的観察 (2009)
  • Author(s): 陳鋭, 他
  • Organizer: 日本機械学会2009年度年次大会
  • Place of Presentation: 盛岡
• [Presentation] 口腔癌治療のためのナノバブルと超音波を用いた抗腫瘍効果増強法に関する検討 (2009)
  • Author(s): 宮下仁, 他
  • Organizer: 第54回(社)日本口腔外科学総会
  • Place of Presentation: 札幌
• [Presentation] ナノバブルと高周波超音波画像診断装置の遠隔地口腔診断への応用 (2009)
  • Author(s): 森士朗, 他
  • Organizer: 第54回(社)日本口腔外科学総会
  • Place of Presentation: 札幌
• [Presentation] ナノバブルと超音波を用いた高周波超音波画像診断装置による微小転移検出に関する検討 (2009)
  • Author(s): 大木宏介, 他
  • Organizer: 第54回(社)日本口腔外科学総会
  • Place of Presentation: 札幌
• [Presentation] 新しい関節強直症モデルマウスのゲノム解析 (2009)
  • Author(s): 高田陽子, 他
  • Organizer: 第54回(社)日本口腔外科学総会
  • Place of Presentation: 札幌
• [Presentation] Three-dimentional high-frequency ultrasound imaging for early diagnosis of lymph node metastasis combined with microbubble (2009)
  • Author(s): 李麗, et al.
  • Organizer: The 3rd East Asian Pacific Student Workshop on Nano-Biomedical Engineering
  • Place of Presentation: Singapore
• [Presentation] ナノ・マイクロバブルと超音波によるシスプラチンの抗腫瘍効果の増強 (2008)
  • Author(s): 渡邊夕紀子, 他
  • Organizer: 日本超音波医学会第36回東北地方会学術集会
  • Place of Presentation: 山形
  • Year and Date: 2008-09-21
• [Presentation] Evaluation of cisplatin-induced antitumor effect with contrast-enhanced high-frequency ultrasound (2008)
  • Author(s): Tomita N, Horie S, Watanabe Y, Ooswa F, Sakuma M, Chen R, Ohki K, Morikawa H, Mori S, Ono M, Kodama T
  • Organizer: 11th International Symposium on Advanced Biomedical Ultrasound
  • Place of Presentation: Sendai, Japan
  • Year and Date: 2008-03-07
• [Presentation] Evaluation of cisplatin-Induced antitumor effect with contrast-enhanced high-frequency ultrasound (2008)
  • Author(s): Noriko Tomita, S Horie, Y Watanabe, F Ooswa, M Sakuma, R Chen, K Ohki, H Morikawa, S Mori, M Ono, T Kodama
  • Organizer: 11th International Symposium on Advanced Biomedical Ultrasound
  • Place of Presentation: Sendai
  • Year and Date: 2008-03-07
• [Presentation] Local gene delivery system of nano/microbubbles-enhanced ultrasound aimed for treatment of gingival tumor (2008)
  • Author(s): Chen R, Chiba M, Watanabe Y, Horie S, Tomita N, Fukumoto M, Mori S, Kodama T.
  • Organizer: 2008 International Conference on Frontiers of Dental and Craniofacial Research
  • Place of Presentation: Beijing International Convention Center (BICC), Beijing, China
• [Presentation] Development of diagnostic imaging system for regional lymph node micrometastasis with high-frequency ultrasound (2008)
  • Author(s): Tomita N, Horie S, Oosawa F, Rui C, Watanabe Y, Morikawa H, Ohki K, Fukumoto M, Mori S, Kodama T.
  • Organizer: 2008 IEEE International Ultrasonics Symposium (IUS)
  • Place of Presentation: Beijing International Convention Center (BICC), Beijing, China
• [Presentation] Contrast-Enhanced High-Frequency Ultrasound Imaging of Liver Metastases in Preclinical Models (2008)
  • Author(s): Chen R, Tomita N, Baba T, Oosawa F, Watanabe Y, Horie S, Mori S, Fukumoto M, Kodama T.
  • Organizer: 2008 IEEE International Ultrasonics Symposium (IUS)
  • Place of Presentation: Beijing International Convention Center (BICC), Beijing, China
• [Presentation] ナノバブルと超音波を用いた口腔癌の治療のための新しい画像診断・分子導入システム (2008)
  • Author(s): 森士朗, 他
  • Organizer: 第53回日本口腔外科学総会
  • Place of Presentation: 徳島
• [Presentation] Bladder cancer therapy using nanobubbles and two different intensities of ultrasound (2008)
  • Author(s): Horie S, Watanabe Y, Chen R, Tomita N, Oosawa F, Fujisawa S, Ono M, Fukumoto M, Mori S, Matsumura Y, Kodama T.
  • Organizer: The 2008 Nanomedicine Conference
  • Place of Presentation: Hotel Eden Roc, Sant Feliu de Guixols, Spain
• [Presentation] 口腔癌の診断・治療のためのナノバブルと超音波を用いた画像診断・分子導入システムの開発 (2008)
  • Author(s): 森士朗, 他
  • Organizer: 第32回日本頭頸部癌学会
  • Place of Presentation: 東京
• [Presentation] Bladder cancer therapy using nanobubbles and two different intensities of ultrasound (2008)
  • Author(s): Horie S, et.al.
  • Organizer: The 2008 Nanomedicine Conference.
  • Place of Presentation: Sant Feliu de Guixols, Spain
• [Presentation] Local gene delivery system of nano / microbubbles-enhanced ultrasound aimed for treatment of gingival tumor (2008)
  • Author(s): Chen R, et.al.
  • Organizer: 2008 International Conference on Frontiers of Dental and Craniofacial Research
  • Place of Presentation: Beijing, China
• [Presentation] Development of diagnostic imaging system for regional lymphnode micrometastasis with high-frequency ultrasound (2008)
  • Author(s): Tomita N, et.al.
  • Organizer: 2008 IEEE International Ultrasoni Symposium (IUS).
  • Place of Presentation: Beijing, China
• [Presentation] Contrast-Enhanced High-Frequency Ultrasound Imaging of Liver Metastases in Preclinical Models (2008)
  • Author(s): Chen R, et.al.
  • Organizer: 2008 IEEE International Ultrasonics Symposium (IUS).
  • Place of Presentation: Beijing, China
• [Presentation] 上顎歯肉に転移したエクリン汗孔癌の1例 (2008)
  • Author(s): 栗原淳, 他
  • Organizer: 第34回(社)日本口腔外科学会北日本地方会
  • Place of Presentation: 新潟
• [Presentation] ナノバブルを用いた腫瘍血管造影法による口腔癌早期診断システムモデルの開発 (2008)
  • Author(s): 大木宏介, 他
  • Organizer: 第32回日本頭頸部癌学会
  • Place of Presentation: 東京
• [Presentation] ナノバブル超音波システムを用いた抗癌剤および抗腫瘍分子の導入による新たな癌治療法の開発 (2008)
  • Author(s): 宮下仁, 他
  • Organizer: 第32回日本頭頸部癌学会
  • Place of Presentation: 東京
• [Presentation] 高周波超音波イメージングシステムによるシスプラチン抗腫瘍効果の定量化 (2008)
  • Author(s): 小玉哲也, 他
  • Organizer: 第46回日本生体医工学会大会
  • Place of Presentation: 神戸
• [Presentation] マウス骨格筋でのNa/I symporter(NIS)遺伝子発現の可視化 (2008)
  • Author(s): 渡邊夕紀子, 他
  • Organizer: 日本機械学会2008年度年次大会
  • Place of Presentation: 横浜
• [Presentation] 歯周組織への遺伝子導入を目指した新しい非ウイルス法の開発 (2008)
  • Author(s): 陳鋭, 他
  • Organizer: 日本実験力学2008年度年次講演会
  • Place of Presentation: 札幌
• [Presentation] ナノバブルと超音波を用いた口腔癌の治療のための新しい画像診断・分子導入システム (2008)
  • Author(s): 森士朗, 他
  • Organizer: 第53回(社)日本口腔外科学総会
  • Place of Presentation: 徳島
• [Presentation] ナノバブルと超音波を用いた腫瘍血管造影法による口腔癌診断システムモデルの開発 (2008)
  • Author(s): 大木宏介, 他
  • Organizer: 第53回(社)日本口腔外科学総会
  • Place of Presentation: 徳島
• [Presentation] ナノバブル超音波を用いた抗癌剤および抗腫瘍分子の導入による新たな癌治療法の開発 (2008)
  • Author(s): 宮下仁, 他
  • Organizer: 第53回(社)日本口腔外科学総会
  • Place of Presentation: 徳島
• [Presentation] ナノバブルを用いた肝転移診断に関する三次元高周波超音波イメージング (2008)
  • Author(s): 陳鋭, 他
  • Organizer: 第67回日本癌学会学術総会
  • Place of Presentation: 名古屋
• [Presentation] 膀胱がん治療のための新しい薬剤到達法の開発 (2008)
  • Author(s): 堀江佐知子, 他
  • Organizer: 第67回日本癌学会学術総会
  • Place of Presentation: 名古屋
• [Presentation] 癌痺痛緩和およびPETによるイメージング (2008)
  • Author(s): 渡蓬夕紀子, 他
  • Organizer: 第67回日本癌学会学術総会
  • Place of Presentation: 名古屋
• [Presentation] 高周波超音波を利用した新しいリンパ節内微小転移診断システムの開発 (2008)
  • Author(s): 冨田典子, 他
  • Organizer: 第67回日本癌学会学術総会
  • Place of Presentation: 名古屋
• [Presentation] 口腔扁平上皮癌細胞株(SAS)からの放射線耐性細胞株の樹立とその特性 (2008)
  • Author(s): 中川浩伸, 他
  • Organizer: 第67回日本癌学会学術総会
  • Place of Presentation: 名古屋
• [Presentation] 高周波超音波イメージングシステムを用いた所属リンパ節転移画像診断システムの開発 (2008)
  • Author(s): 冨田典子, 他
  • Organizer: 第46回日本癌治療学会総会
  • Place of Presentation: 名古屋
• [Presentation] ナノバブルと超音波を用いた膀胱がんへの遺伝子導入法の開発 (2008)
  • Author(s): 堀江佐知子, 他
  • Organizer: 第46回日本癌治療学会総会
  • Place of Presentation: 名古屋
• [Presentation] A genetic mode of regulation for the growth correlation of mandible and craniomaxilla in mice (2008)
  • Author(s): Maya Sakamoto, et.al.
  • Organizer: The 7th Asian Congress of Oral and Maxillofacial Radiology and The 13th Conference of Clinical Diagnosis of JSOMR
  • Place of Presentation: Nara, Japan
• [Presentation] A case of mandibular ossifying fibroma showed an increased FDG uatake in the FDG-PET / CT (2008)
  • Author(s): Kojima I, et.al.
  • Organizer: The 7th Asian Congress of Oral and Maxillofacial Radiology and The 13^<th> Conference of Clinical Diagnosis of JSOMR
  • Place of Presentation: Nara, Japan
• [Presentation] ナノバブルと超音波を使用したPositron Emission Tomography(PET)によるNa/I symporter(NIS) 遺伝子発現の可視化 (2007)
  • Author(s): 渡邊夕紀子, 堀江佐知子, 冨田典子, 佐久間基成, 大澤ふき, 陳鋭, 菊地洋平, 田代学, 森士朗, 船木善仁, 山崎浩道, 石井慶造, 小濱泰昭, 小野栄夫, 伊藤正敏, 小玉哲也
  • Organizer: 東北大学イノベーションフェア2007
  • Place of Presentation: 仙台市
  • Year and Date: 2007-10-05
• [Presentation] ナノバブルと高周波超音波による腫瘍内血管の三次元画像の構築 (2007)
  • Author(s): 冨田典子, 堀江佐知子, 渡邊夕紀子, 大澤ふき, 佐久間基成, 陳鋭, 船本健一, 福本学, 大木宏介, 森士朗, 早瀬敏幸, 小玉哲也
  • Organizer: 東北大学イノベーションフェア2007in仙台
  • Place of Presentation: 仙台市
  • Year and Date: 2007-10-05
• [Presentation] High frequency ultrasound for analysis of antitumor effects (2007)
  • Author(s): Horie S, Tomita N, Watanabe Y, Osawa F, Sakuma M, Cehn R, Funamoto K, Fukumoto M, Oki K, Mori S, Hayase T, Kodama T.
  • Organizer: SMIT 2007
  • Place of Presentation: Sendai
• [Presentation] Three-dimensional image of intratumoral neovascular constructed with high-frequency contrast-enhanced micro-ultrasound (2007)
  • Author(s): Tomita N, Horie S, Watanabe Y, Funamoto K, Hayase T, Oki K, Morikawa H, Ono M, Mori S, Kodama T.
  • Organizer: SMIT 2007
  • Place of Presentation: Sendai
• [Presentation] ソノポレーションによる遺伝子導入効率:気泡特性に対する検討 (2007)
  • Author(s): 小玉哲也, 青井あつ子, 渡邊夕紀子, 堀江佐知子, 冨田典子, 小野栄夫, 森 士朗
  • Organizer: 日本超音波医学会第80回学術集会
  • Place of Presentation: 鹿児島
• [Presentation] ナノバブルと超音波を用いたDDS:骨格筋への応用 (2007)
  • Author(s): 小玉哲也, 青井あつ子, 渡邊夕紀子, 小野栄夫, 森 士朗
  • Organizer: 日本機械学会2007年度年次大会
  • Place of Presentation: 吹田市
• [Presentation] シスプラチンを使った抗腫瘍効果:高周波による定量化 (2007)
  • Author(s): 冨田典子, 渡邊夕紀子, 堀江佐知子, 小野栄夫, 森 士朗, 小玉哲也
  • Organizer: 日本機械学会2007年度年次大会
  • Place of Presentation: 吹田市
• [Presentation] 高周波超音波画像診断による抗腫瘍効果の評価 (2007)
  • Author(s): 堀江佐知子, 冨田典子, 渡邊夕紀子, 大木宏介, 森川秀広, 森 士朗, 小野栄夫, 小玉哲也
  • Organizer: 第66回日本癌学会学術総会
  • Place of Presentation: 横浜市
• [Presentation] ナノバブルと高周波超音波による腫瘍内血管の三次元画像の構築 (2007)
  • Author(s): 冨田典子, 堀江佐知子, 渡邊夕紀子, 船本健一, 早瀬敏幸, 大木宏介, 森川秀広, 小野栄夫, 森 士朗, 小玉哲也
  • Organizer: 第66回日本癌学会学術総会
  • Place of Presentation: 横浜市
• [Book] Chemical Pollution in Indochina ; Contamination Status, Ecosystem Impact and Remediation Technology(Ed. By Suzuki S and Takada H.) (2009)
  • Author(s): Komori H, Soga Y, Mori S, Nose M
  • Publisher: Tokai University Press
• [Book] Genetic Analysis of Arsenic Toxicities Using an Experimental Mouse Model. In Chemical Pollution in Indochina ; Contamination Status, Ecosystem Impact and Remediation Technology (2009)
  • Author(s): Hiroaki Komori, et.al.
  • Publisher: Tokai University Press
• [Patent(Industrial Property Rights)] 超音波発生用プローブ (2007)
  • Inventor(s): 小玉哲也, 森士朗
  • Industrial Property Rights Holder: 国立大学法人東北大学、日本素材株式会社、株式会社マテリアル仙台
  • Filing Date: 2007-04-10
  • Overseas