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Development of cancer-targeted liposome with viral proteins

Research Project

Project/Area Number 19390508
Research Category

Grant-in-Aid for Scientific Research (B)

Allocation TypeSingle-year Grants
Section一般
Research Field Surgical dentistry
Research InstitutionChiba University

Principal Investigator

UZAWA Katsuhiro  Chiba University, 大学院・医学研究院, 准教授 (30302558)

Co-Investigator(Kenkyū-buntansha) SHIRASAWA Hiroshi  千葉大学, 大学院・医学研究院, 教授 (00216194)
SHIIBA Masashi  千葉大学, 大学院・医学研究院, 講師 (20301096)
BUKAWA Hiroki  筑波大学, 医学部・臨床医学系, 教授 (80173558)
SAITO Kengo  千葉大学, 大学院・医学研究院, 助教 (70451755)
Project Period (FY) 2007 – 2009
Project Status Completed (Fiscal Year 2009)
Budget Amount *help
¥18,850,000 (Direct Cost: ¥14,500,000、Indirect Cost: ¥4,350,000)
Fiscal Year 2009: ¥4,290,000 (Direct Cost: ¥3,300,000、Indirect Cost: ¥990,000)
Fiscal Year 2008: ¥3,900,000 (Direct Cost: ¥3,000,000、Indirect Cost: ¥900,000)
Fiscal Year 2007: ¥10,660,000 (Direct Cost: ¥8,200,000、Indirect Cost: ¥2,460,000)
Keywords臨床腫瘍学 / 低病原性ウイルス / ウイルスカプシド / 腫瘍特異的吸着 / リポソーム / 腫瘍特異性 / リボソーム / drug delivery system / シンドビスウイルス
Research Abstract

Targeted liposomes can be broadly defined as liposomes that are engineered to interact with a particular population of cells with the objective of delivering a payload or increasing their retention within the targeted cell population. We previously identifided a Sindbis virus (SIN) strain which preferentially infects several cancers in vitro and in vivo without side effects. In this study, we have developed a cisplatin-encapsulating cancer-targeted liposome with the SIN protein and evaluated its cytotoxicity to cancers in vitro and in vivo. In vitro, the cisplatin-encapsulating cancer-targeted liposome has exhibited higher cytotoxicity to cancer cells than the cisplatin-encapsulating non-targeted liposome. Mice injected with the cisplatin-encapsulating cancer-targeted liposome displayed rapid tumor regression. Thus, this finding that a cisplatin-encapsulating cancer-targeted liposome with the SIN protein selectively fused with cancer cells and sensitized cancer cells suggested the application of this cancer-targeted lipsome to cancer therapy.

Report

(4 results)
  • 2009 Annual Research Report   Final Research Report ( PDF )
  • 2008 Annual Research Report
  • 2007 Annual Research Report
  • Research Products

    (9 results)

All 2010 2009 2008

All Journal Article (4 results) (of which Peer Reviewed: 4 results) Presentation (4 results) Patent(Industrial Property Rights) (1 results)

  • [Journal Article] Oncolytic virotherapy for oral squamous cell carcinoma using replication-competent viruses2009

    • Author(s)
      Saito K, Shirasawa H, Isegawa N, Shiiba M, Uzawa K, Tanzawa H
    • Journal Title

      Oral Oncology 45(12)

      Pages: 1021-7

    • Related Report
      2009 Final Research Report
    • Peer Reviewed
  • [Journal Article] Oncolytic activity of Sindbis virus in human oral squamous carcinoma cells2009

    • Author(s)
      Saito K, Uzawa K, Kasamatsu A, Shinozuka K, Sakuma K, Yamatoji M, Shiiba M, Shino Y, Shirasawa H, Tanzawa H
    • Journal Title

      Br J Cancer 101(4)

      Pages: 684-90

    • Related Report
      2009 Final Research Report
    • Peer Reviewed
  • [Journal Article] Oncolytic virotherapy for oral squamous cell carcinoma using replication-competent viruses.2009

    • Author(s)
      齋藤謙悟、白澤浩、丹沢秀樹, ほか3名
    • Journal Title

      Oral Oncology 45

      Pages: 1021-27

    • Related Report
      2009 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Oncolytic activity of Sindbis virus in human oral squamous carcinom a cells.2009

    • Author(s)
      齋藤謙悟、白澤浩、丹沢秀樹, ほか3名
    • Journal Title

      British Journal of Cancer 101

      Pages: 684-690

    • Related Report
      2009 Annual Research Report
    • Peer Reviewed
  • [Presentation] The effect of a cisplatin-encapsulating cancer-targeted lipsome with viral proteins on cancer cells 68^<th>2009

    • Author(s)
      Saito K., Shirasawa H., Uzawa K., Tanzawa H.
    • Organizer
      Annual Meeting of the japanese Cancer Association
    • Place of Presentation
      Yokohama
    • Year and Date
      2009-10-03
    • Related Report
      2009 Final Research Report
  • [Presentation] The effect of a cisplatin-encapsulating cancer-targeted lipsome with viral proteins on cancer cells2009

    • Author(s)
      齋藤謙悟
    • Organizer
      第68回 日本癌学会総会
    • Place of Presentation
      横浜
    • Year and Date
      2009-10-03
    • Related Report
      2009 Annual Research Report
  • [Presentation] Targeted lipsome with viral proteins for cancer cells2008

    • Author(s)
      齋藤謙悟
    • Organizer
      第67回癌学会総会
    • Place of Presentation
      名古屋国際会議場
    • Year and Date
      2008-10-28
    • Related Report
      2008 Annual Research Report
  • [Presentation] Oncolytic activity of sindbis virus for oral cancer cells2008

    • Author(s)
      Saito k., Shirasawa H., Shiiba M., Uzawa K., Tanzawa H
    • Organizer
      3th World Congress on Advances in Oncology and 11th International Symposium on Molecular Medicine
    • Place of Presentation
      Greece Krete
    • Related Report
      2009 Final Research Report
  • [Patent(Industrial Property Rights)] 腫瘍特異性を有する新型リポソーム2010

    • Inventor(s)
      鵜沢一弘, 齋藤謙悟, 丹沢秀樹, 白澤浩, 山本惠司, 森部久仁一, 椎葉正史
    • Industrial Property Rights Holder
      千葉大学
    • Industrial Property Number
      2010-086071
    • Filing Date
      2010-04-02
    • Related Report
      2009 Final Research Report

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Published: 2007-04-01   Modified: 2016-04-21  

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