Strategic development of a novel implant system to achieve bone regeneration without cell transplantation
Project/Area Number |
19390509
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Research Category |
Grant-in-Aid for Scientific Research (B)
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Allocation Type | Single-year Grants |
Section | 一般 |
Research Field |
Surgical dentistry
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Research Institution | The University of Tokyo |
Principal Investigator |
TAKATO Tsuyoshi The University of Tokyo, 医学部附属病院, 教授 (90171454)
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Co-Investigator(Kenkyū-buntansha) |
CHIKADU Daichi 東京大学, 医学部附属病院, 講師 (30343122)
OGASAWARA Toru 東京大学, 医学部附属病院, 講師 (20359623)
NISHIYAMA Nobuhiro 東京大学, 大学院・医学系研究科, 准教授 (10372385)
TEI Yuichi 東京大学, 大学院・医学系研究科, 教授 (30345053)
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Project Period (FY) |
2007 – 2009
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Project Status |
Completed (Fiscal Year 2009)
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Budget Amount *help |
¥18,200,000 (Direct Cost: ¥14,000,000、Indirect Cost: ¥4,200,000)
Fiscal Year 2009: ¥4,680,000 (Direct Cost: ¥3,600,000、Indirect Cost: ¥1,080,000)
Fiscal Year 2008: ¥4,160,000 (Direct Cost: ¥3,200,000、Indirect Cost: ¥960,000)
Fiscal Year 2007: ¥9,360,000 (Direct Cost: ¥7,200,000、Indirect Cost: ¥2,160,000)
|
Keywords | 再生医療 / 骨再生 / 人工骨 / 移植・再生医療 / 再生医学 / シグナル伝達 / トランスレーショナルリサーチ / 骨再生療法 / 化合物スクリーニング / 化合物デリバリーシステム / インクジェットプリンター / Colla1GFP / 骨再生インプラント / 三次元造形法 / 骨分化シグナル / siRNA / ナノ送達システム |
Research Abstract |
This study aims to develop a novel bone regeneration system which helps or substitutes for cell transplantation. Among three pillars for regenerative medicine, we tried to improve two factors : "signal" and "scaffold". The combined use of nano-carriers and biomaterials induced the activation of osteogenic signal in cells around bone defect sites, which enabled bone regeneration without cell transplantation. In addition, we developed a technique for three-dimensional imaging followed by rapid prototyping to generate tailor-made artificial bone that fitted into defect sites.
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Report
(4 results)
Research Products
(51 results)
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[Journal Article] Maxillofacial reconstruction using custom-made artificial bones fabricated by inkjet printing technology2009
Author(s)
Saijo H, Igawa K, Kanno Y, Mori Y, Kondo K, Shimizu K, Suzuki S, Chikazu D, Iino M, Anzai M, Sasaki N, Chung UI, Takato T.
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Journal Title
J Artif Organs 12(3)
Pages: 200-5
NAID
Related Report
Peer Reviewed
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[Journal Article] Development of high-throughput screening system for osteogenic drugs using a cell-based sensor2008
Author(s)
Hojo H., Igawa K., Ohba S., Yano F., Nakajima K., Komiyama Y., Ikeda T., Lichtler AC., Woo JT., Yonezawa T., Takato T., Chung UI.
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Journal Title
Biochem Biophys Res Commun 14 ; 376 (2)
Pages: 375-9
Related Report
Peer Reviewed
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[Journal Article] Patchedl haploinsufficiency increases adult bone mass and modulates Gli3 repressor activity2008
Author(s)
Ohba, S., Kawaguchi, H., Kugimiya, F., Ogasawara, T., Kawamura, N., Saito, T., Ikeda, T., Fujii, K., Miyajima, T., Kuramochi, A., Miyashita, T., Oda, H., Nakamura, K., Takato, T., Chung, U.I.
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Journal Title
Dev Cell 14
Pages: 689-69
Related Report
Peer Reviewed
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[Journal Article] A novel osteogenic helioxanthin-derivative acts in a BMP-dependent manner2007
Author(s)
Ohba S., Nakajima K., Komiyama Y., Kugimiya F., Igawa K., Itaka K., Moro T., Nakamura K., Kawaguchi H., Takato T., Chung U. I.
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Journal Title
Biochem Biophys Res Commun 357(4)
Pages: 854-860
Related Report
Peer Reviewed
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[Presentation] Cyclooxygenase-2は膜性骨の骨折治癒における key factor である2009
Author(s)
近津大地, 藤川由美子, 末永英之, 杉山円, 古賀陽子, 阿部雅修, 西條英人, 森良之, 飯野光喜, 高戸毅
Organizer
第54回日本口腔外科学会総会
Place of Presentation
札幌コンベンションセンター, 北海道
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[Presentation] Development of high-throughput screening system for osteogenic drugs using cell-based sensor2008
Author(s)
Hojo H., Igawa K., Ohba S., Yano F., Nakajima N., Komiyama K., Ikeda T., Lichtler AC., Woo JT., Yonezawa Y, Takato T., Chung UI.
Organizer
30th annual meeting of the American Society for Bone and Mineral Research
Place of Presentation
Montreal, Quebec, Canada
Related Report
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[Presentation] Improvement in Wound Healing by a Novel Synthetic Collagen-gel Dressing in Diabetic Mice2008
Author(s)
Chikazu D., Taguchi T., Koyama H., Hikiji H.., Fujihara H., Suenaga H., Saijo H., Mori Y., Iino M., Takato T.
Organizer
8th Asian Congress on Oral and Maxillofacial Surgery
Place of Presentation
Bangkok, Thailand
Related Report
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[Presentation] Patched1機能不全による Hedgehog シグナルの活性化は, Runx2のDNA結合・転写活性を競合阻害している抑制型Gli3産生を低下させることによって骨量を増加させる2007
Author(s)
大庭伸介, 藤井克則, 宮島剛, 倉持朗, 宮下俊之, 織田弘美, 中村耕三, 高戸毅, 川口浩, 鄭雄一
Organizer
第25回日本骨代謝学会
Place of Presentation
大阪
Related Report
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[Presentation] Tailor-made tricalcium phosphate bone implant directly fabricated by a three-dimensional ink-jet printer2007
Author(s)
Igawa K., Mochizuki M., Sugimori O., Shimizu K., Yamazawa K., Kawaguchi H., Nakamura K., Takato T., Nishimura R., Suzuki S., Anzai M., Chung U.I., Sasaki N.
Organizer
The 45th Annual Meeting of the Japanese Society for Artificial Organs and the 2nd Meeting of the International Federation for Artificial Organs
Place of Presentation
Osaka
Related Report
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