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Optimization of bone substitutes in dental field

Research Project

Project/Area Number 19390513
Research Category

Grant-in-Aid for Scientific Research (B)

Allocation TypeSingle-year Grants
Section一般
Research Field Surgical dentistry
Research InstitutionTokyo Medical and Dental University

Principal Investigator

KASUGAI Shohei  Tokyo Medical and Dental University, 医歯学総合研究科, 教授 (70161049)

Co-Investigator(Kenkyū-buntansha) KONDO Hisatomo  東京医科歯科大学, 医歯学総合研究科, 助教 (70343150)
KURODA Shinji  東京医科歯科大学, 歯学部附属病院, 助教 (50323689)
小田 茂  東京医科歯科大学, 大学院・医歯学総合研究科, 講師 (70160869)
朝日奈 泉  長崎大学, 医歯薬学総合研究科, 教授 (30221039)
松田 聡  兵庫県立大学, 工学研究科, 准教授 (40316047)
Project Period (FY) 2007 – 2009
Project Status Completed (Fiscal Year 2009)
Budget Amount *help
¥19,240,000 (Direct Cost: ¥14,800,000、Indirect Cost: ¥4,440,000)
Fiscal Year 2009: ¥3,510,000 (Direct Cost: ¥2,700,000、Indirect Cost: ¥810,000)
Fiscal Year 2008: ¥5,460,000 (Direct Cost: ¥4,200,000、Indirect Cost: ¥1,260,000)
Fiscal Year 2007: ¥10,270,000 (Direct Cost: ¥7,900,000、Indirect Cost: ¥2,370,000)
Keywords骨補填材 / ハイドロキシアパタイト / TCP / シンバスタチン / 骨 / 骨再生 / 骨造成 / 再生 / α-TCP / スタチン / BMP
Research Abstract

Various calcium phosphate materials of different forms, which are resorbable or not resorbable, have been used as bone substitutes. However, autologous bone graft is still a gold standard for bone augmentation. Although bone substitutes, which are currently available, function as scaffold for bone regeneration and although they are osteo-conductive, they do not stimulate bone formation. The purpose of this project is to develop bone substitutes, which exchange to real bone stimulating bone formation. Firstly, we developed hydroxyapatite (HA) fiber material of 15μm diameter and demonstrated that this material exchanges to bone without inhibiting bone regeneration in animal experiments. Secondary, we developed the bone substitute by combining α-TCP, which is resorbable material, and simvastatin, which is an inhibitor of cholesterol synthesis. We observed that this bone substitute stimulates bone formation and exchanges to bone in animal experiments. Furthermore, efficacy and safety of this bone substitute were confirmed in clinical study. The two bone substitutes, which were developed in this project, would be potentially effective in dental field compared to the ones, which are clinically used.

Report

(4 results)
  • 2009 Annual Research Report   Final Research Report ( PDF )
  • 2008 Annual Research Report
  • 2007 Annual Research Report
  • Research Products

    (114 results)

All 2010 2009 2008 2007 Other

All Journal Article (46 results) (of which Peer Reviewed: 19 results) Presentation (63 results) Book (4 results) Remarks (1 results)

  • [Journal Article] Differentiation of bone marrow stromal cells into osteoblasts in a self-assembling peptide hydrogel : in vitro and in vivo studies2010

    • Author(s)
      Ozeki M, Kuroda S, Kon K, Kasugai S.
    • Journal Title

      J Biomater Appl (Epub ahead of print)

    • Related Report
      2009 Final Research Report
  • [Journal Article] Molecular and tissue responses in the healing of rat calvarial defects after local application of simvastatin combined with alpha tricalcium phosphate2010

    • Author(s)
      Nyan M, Miyahara T, Noritake K, Hao J, Rodriguez R, Kuroda S, Kasugai S.
    • Journal Title

      Journal of Biomedical Materials Research Part B ; Applied Biomaterials 93(1)

      Pages: 65-73

    • Related Report
      2009 Final Research Report
  • [Journal Article] Effects of alpha-tricalcium phosphate containing simvastatin on alveolar ridge augmentation2010

    • Author(s)
      Maruo K, Sato D, Machida T, Kasugai S.
    • Journal Title

      Journal of Oral Tissue Enigineering 7(3)

      Pages: 143-152

    • NAID

      130004456613

    • Related Report
      2009 Final Research Report
  • [Journal Article] Effect of hydroxyapatite fiber material on rat incisor socket healing2010

    • Author(s)
      Machida T, Nyan M, Kon K, Maruo K, Sato H, Kasugai S.
    • Journal Title

      Journal of Oral Tissue Enigineering 7(3)

      Pages: 153-162

    • NAID

      130004456614

    • Related Report
      2009 Final Research Report
  • [Journal Article] Effects of alpha-tricalcium phosphate containing simvastatin on alveolar ridge augmentation.2010

    • Author(s)
      Maruo K, Sato D, Machida T, Kasugai S.
    • Journal Title

      Journal of Oral Tissue Enigineering 7(3)

      Pages: 143-152

    • NAID

      130004456613

    • Related Report
      2009 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Molecular and tissue responses in the healing of rat calvarial defects after local application of simvastatin combined with alpha tricalcium phosphate.2010

    • Author(s)
      Nyan M, Miyahara T, Noritake K, Hao J, Rodriguez R, Kuroda S, Kasugai S.
    • Journal Title

      Journal of Biomedical Materials Research Part B ; Applied Biomaterials 93(1)

      Pages: 65-73

    • Related Report
      2009 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Differentiation of bone marrow stromal cells into osteoblasts in a self-assembling peptide hydrogel : in vitro and in vivo studies.2010

    • Author(s)
      Ozeki M, Kuroda S, Kon K, Kasugai S.
    • Journal Title

      J Biomater Appl (in press)

    • Related Report
      2009 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Regeneration of bone and tendon/ligament-like tissue induced by gene transfer of bone morphogenetic protein-12 in a rat bone defect.2010

    • Author(s)
      Kuroda S, Goto N, Suzuki M, Kaneda K, Ohya K, Shimokawa H, Kasugai S.
    • Journal Title

      Journal of Tissue Engineering (in press)

    • Related Report
      2009 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Bone augmentation ability of autogenous bone graft particles with different sizes : a histological and micro-computed tomography study2009

    • Author(s)
      Kon K, Shiota M, Ozeki M, Yamashita Y, Kasugai S.
    • Journal Title

      Clinical Oral Implants Research 20(11)

      Pages: 1240-6

    • Related Report
      2009 Final Research Report
  • [Journal Article] Fully functional bioengineered tooth replacement as an organ replacement therapy2009

    • Author(s)
      Ikeda E, Morita R, Nakao K, Ishida K, Nakamura T, Takano-Yamamoto T, Ogawa M, Mizuno M, Kasugai S, Tsuji T.
    • Journal Title

      Proc Natl Acad Sci USA. 106(32)

      Pages: 13475-80

    • Related Report
      2009 Final Research Report
  • [Journal Article] Effects of cholesterol-bearing pullulan (CHP)-nanogels in combination with prostaglandin El on wound healing2009

    • Author(s)
      Kobayashi H, Katakura O, Morimoto N, Akiyoshi K, Kasugai S
    • Journal Title

      Journal of Biomedical Material Research, Part B : Applied Biomaterials 91(1)

      Pages: 55-60

    • Related Report
      2009 Final Research Report
  • [Journal Article] Effects of granule size and surface properties of red algae-derived resorbable hydroxyapatite on new bone bormation2009

    • Author(s)
      Nakamura T, Shiota M, Kihara H, Yamashita Y, Kasugai S.
    • Journal Title

      Journal of Oral Tissue Engineering 6(3)

      Pages: 167-179

    • Related Report
      2009 Final Research Report
  • [Journal Article] Hydroxyapatite fiber material for bone tissue engineering Journal of Oral Tissue2009

    • Author(s)
      Okabayashi S, Takayama K, Kuroda S, Kanai T, Fujii S, Sato M, Kasugai S.
    • Journal Title

      Engineering 6(3)

      Pages: 180-188

    • Related Report
      2009 Final Research Report
  • [Journal Article] The target cells of parathyroid hormone (PTH) anabolic effect in bone are immature cells of osteoblastic lineage2009

    • Author(s)
      Kondo H, Amizuka N, Kihara H, Furuya J, Kuroda S, Ozawa S, Ohya K, Kasugai S.
    • Journal Title

      Journal of Oral Tissue Engineering 7(1)

      Pages: 2-14

    • NAID

      130004456600

    • Related Report
      2009 Final Research Report
  • [Journal Article] Hydroxyapatite fiber materialwith BMP-2 gene induces ectopic bone formation2009

    • Author(s)
      Oda M, Kuroda S, Kondo H, Kasugai S.
    • Journal Title

      Journal of Biomedical Material Research, Part B : Applied Biomaterials 90(1)

      Pages: 101-9

    • Related Report
      2009 Final Research Report
  • [Journal Article] Effects of the combination with alpha-tricalcium phosphate and simvastatin on bone regeneration2009

    • Author(s)
      Nyan M, Sato D, Kihara H, Machida T, Ohya K, Kasugai S.
    • Journal Title

      Clinical Oral Implant Research 20(3)

      Pages: 280-7

    • Related Report
      2009 Final Research Report
  • [Journal Article] 歯科領域での骨の再生の基礎と臨床 : 歯科インプラント治療と骨造成2009

    • Author(s)
      春日井昇平
    • Journal Title

      東京都歯科医師会雑誌 57(9)

      Pages: 447-454

    • Related Report
      2009 Final Research Report
  • [Journal Article] Effects of the combination with alpha-tricalcium phosphate and simvastatin on bone regeneration2009

    • Author(s)
      Nyan M, Sato D, Kihara H, Machida T, Ohya K, Kasugai S
    • Journal Title

      Clinical Oral Implant Research 20(3)

      Pages: 280-287

    • Related Report
      2009 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Hydroxyapatite fiber materialwith BMP-2 gene induces ectopic bone formation.2009

    • Author(s)
      Oda M, Kuroda S, Kondo H, Kasugai S.
    • Journal Title

      Journal of Biomedical Material Research, Part B : Applied Biomaterials 90(1)

      Pages: 101-109

    • Related Report
      2009 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Hydroxyapatite fiber material for bone tissue engineering2009

    • Author(s)
      Okabayashi S, Takayama K, Kuroda S, Kanai T, Fujii S, Sato M, Kasugai S.
    • Journal Title

      Journal of Oral Tissue Engineering 6(3)

      Pages: 180-188

    • NAID

      130004941154

    • Related Report
      2009 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Effects of granule size and surface properties of red algae-derived resorbable hydroxyapatite on new bone bormation.2009

    • Author(s)
      Nakamura T, Shiota M, Kihara H, Yamashita Y, Kasugai S.
    • Journal Title

      Journal of Oral Tissue Engineering 6(3)

      Pages: 167-179

    • Related Report
      2009 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Effects of cholesterol-bearing pullulan (CHP)-nanogels in combination with prostaglandin El on wound healing.2009

    • Author(s)
      Kobayashi H, Katakura O, Morimoto N, Akiyoshi K, Kasugai S
    • Journal Title

      Journal of Biomedical Material Research, Part B : Applied Biomaterials 91(1)

      Pages: 55-60

    • Related Report
      2009 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Bone augmentation ability of autogenous bone graft particles with different sizes : a histological and micro-computed tomography study.2009

    • Author(s)
      Kon K, Shiota M, Ozeki M, Yamashita Y, Kasugai S.
    • Journal Title

      Clinical Oral Implants Research 20(11)

      Pages: 1240-1246

    • Related Report
      2009 Annual Research Report
    • Peer Reviewed
  • [Journal Article] BMP-2 and VEGF transfection to human periosteal cells enhances osteoblast differentiation and bone formation2008

    • Author(s)
      Samee M, Kasugai S, Kondo H, Ohya K, Shimokawa H, Kuroda S.
    • Journal Title

      Journal of Pharmacological Sciences 108(1)

      Pages: 18-31

    • Related Report
      2009 Final Research Report
  • [Journal Article] Effects of prostaglandin El application on rat incisal sockets2008

    • Author(s)
      Iino G, Hishimura K, Omura K, Kasugai S.
    • Journal Title

      International Journal of Oral Maxillofacial Implants 23(5)

      Pages: 835-40

    • Related Report
      2009 Final Research Report
  • [Journal Article] Relevance of resonance frequency analysis to evaluate dental implant stability : Simulation and histomorphometrical animal experiments2008

    • Author(s)
      Ito Y, Sato D, Yoneda S, Ito D, Kondo H, Kasugai S.
    • Journal Title

      Clinical Oral Implant Research 19(1)

      Pages: 9-14

    • Related Report
      2009 Final Research Report
  • [Journal Article] Is sodium alginate an alternative hemostatic material in the tooth extraction socket?2008

    • Author(s)
      Kaneda K, Kuroda S, Goto N, Sato D, Ohya K, Kasugai K.
    • Journal Title

      Journal of Oral Tissue Engineering 5(3)

      Pages: 127-133

    • NAID

      110006665905

    • Related Report
      2009 Final Research Report
  • [Journal Article] 歯科領域における再生・再構築医療のためのバイオマテリアル 骨形成を促進する化合物を含む吸収性骨補填材2008

    • Author(s)
      春日井昇平
    • Journal Title

      バイオマテリアル 26(3)

      Pages: 13-18

    • Related Report
      2009 Final Research Report
  • [Journal Article] 歯周病研究の新展開と治療戦略 スタチンを用いた歯槽骨再建2008

    • Author(s)
      春日井昇平
    • Journal Title

      炎症と免疫 16(2)

      Pages: 201-206

    • Related Report
      2009 Final Research Report 2007 Annual Research Report
  • [Journal Article] Relevance of resonance frequency analysis to evaluate dental implant stability : Simulation and histomorphometrical animal experiments.2008

    • Author(s)
      Ito Y, Sato D, Yoneda S, Ito D, Kondo H, Kasugai S.
    • Journal Title

      Clinical Oral Implant Research 19(1)

      Pages: 9-14

    • Related Report
      2008 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Is Sodium Alginate an Alternative Hemostatic Material in the Tooth Extraction Socket?2008

    • Author(s)
      Kaneda K, Kuroda S, Goto N, Sato D, Ohya K, Kasugai S.
    • Journal Title

      Journal of Oral Tissue Engineering 5(3)

      Pages: 127-133

    • NAID

      110006665905

    • Related Report
      2008 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Effects of prostaglandin El application on rat incisal sockets.2008

    • Author(s)
      lino G, Hishimura K, Omura K, Kasugai S.
    • Journal Title

      International Journal of Oral Maxillofacial Implants 23(5)

      Pages: 835-840

    • Related Report
      2008 Annual Research Report
    • Peer Reviewed
  • [Journal Article] BMP-2 and VEGF transfection to human periosteal cells enhances osteoblast differentiation and bone formation.2008

    • Author(s)
      Samee M, Kasugai S, Kondo H, Ohya K, Shimokawa H, Kuroda S.
    • Journal Title

      Journal of Pharmacological Sciences 108(1)

      Pages: 18-31

    • Related Report
      2008 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Effects of Vascular endothelial growth factor (VEGF) on neovascularization and osteogenesis in areas of poor blood supply : histological study on the rabbit skulls2007

    • Author(s)
      Sakuyama A, Shiota M, Fujimori T, Yamashita Y, Kasugai S.
    • Journal Title

      Journal of Oral Tissue Engineering 5(2)

      Pages: 71-80

    • NAID

      110006571212

    • Related Report
      2009 Final Research Report
  • [Journal Article] in vitro Evaluation of short-term storage solution for bone grafts in dental implant surgery2007

    • Author(s)
      Kanai T, Kondo H, Yoneda S, Ito D, Kuroda S, Kasugai S.
    • Journal Title

      Journal of Oral Tissue Engineering 4(3)

      Pages: 121-128

    • NAID

      130004456575

    • Related Report
      2009 Final Research Report
  • [Journal Article] Preliminary studies of in vivo and ex vivo implantation accompanied by transgenes2007

    • Author(s)
      Kuroda S, Endo M, Samee M, Kondo H, Kasugai S.
    • Journal Title

      Journal of Oral Tissue Engineering 4(3)

      Pages: 143-148

    • NAID

      130004456578

    • Related Report
      2009 Final Research Report
  • [Journal Article] Bone formation with the combination of simvastatin and calcium sulfate in critical-sized rat calvarial defect2007

    • Author(s)
      Nyan M, Sato D, Oda M, Machida T, Kobayashi H, Nakamura T, Kasugai S.
    • Journal Title

      Journal of Pharmacological Science 104(4)

      Pages: 384-6

    • NAID

      10024315383

    • Related Report
      2009 Final Research Report
  • [Journal Article] Preliminary studies of in vivo and ex vivo implantations accompanied by transgenes2007

    • Author(s)
      Kuroda S, Endo M Samee M Kondo H, Kasugai S.
    • Journal Title

      Journal of Oral Tissue Engineering 4(3)

      Pages: 143-148

    • NAID

      130004456578

    • Related Report
      2009 Final Research Report
  • [Journal Article] Histological and histomorphometrical comparative study of the degradation and osteoconductive characteristics of alpha-and beta-tricalcium phosphate (TCP) in block grafts2007

    • Author(s)
      Yamada M, Shiota M, Yamashita Y, Kasugai S.
    • Journal Title

      Journal of Biomedical Material Research, Part B : Applied Biomaterials 82(1)

      Pages: 139-48

    • Related Report
      2009 Final Research Report
  • [Journal Article] Bone increase in rat tibiae by local administration of amino-terminally truncated rhFGF-4(73-206)2007

    • Author(s)
      Kuroda S. Kondo H, Ohya K, Kasugai S.
    • Journal Title

      Tissue Engineering 13(2)

      Pages: 415-22

    • Related Report
      2009 Final Research Report
  • [Journal Article] Effects of Vascular endothelial growth factor (VEGF) on neovascularization and osteogenesis in areas of poor blood supply: histological study on the rabbitskulls2007

    • Author(s)
      Sakuyama A, Shiota M, Fujimori T, Yamashita Y, Kasugai S.
    • Journal Title

      Journal of Oral Tissue Engineering 5(2)

      Pages: 71-80

    • Related Report
      2007 Annual Research Report
    • Peer Reviewed
  • [Journal Article] in vitro Evaluation of short-term storage solution for bone grafts in dentalimplant surgery.2007

    • Author(s)
      Kanai T, Kondo H, Yoneda S, Ito D, Kuroda S, Kasugai S.
    • Journal Title

      Journal of Oral Tissue Engineering 4(3)

      Pages: 121-128

    • Related Report
      2007 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Bone formation with the combination of simvastatin and calcium sulfate in critical-sized rat calvarial defect.2007

    • Author(s)
      Nyan M, Sato D, Oda M, Machida T, Kobayashi H, Nakamura T, Kasugai S.
    • Journal Title

      Journal of Pharmacological Science 104(4)

    • NAID

      10024315383

    • Related Report
      2007 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Histological and histomorphometrical comparative study of the degradation and osteoconductive characteristics of alpha-and beta-tricalcium phosphate (TCP) in block grafts.2007

    • Author(s)
      Yamada M, Shiota M, Yamashita Y, Kasugai S.
    • Journal Title

      Journal of Biomedical Material Research, Part B: Applied Biomaterials 82(1)

      Pages: 139-48

    • Related Report
      2007 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Bone increase in rat tibiae by local administration of amino-terminally truncated rhFGF-4 (73-206).2007

    • Author(s)
      Kuroda S. Kondo H, Ohya K, Kasugai S.
    • Journal Title

      Tissue Engineering 13(2)

      Pages: 415-22

    • Related Report
      2007 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Regeneration of bone and tendon/ligament-like tissue induced by gene transfer of bone morphogenetic protein-12 in a rat bone defect

    • Author(s)
      Kuroda S, Goto N, Suzuki M, Kaneda K, Ohya K, Shimokawa H, Kasugai S.
    • Journal Title

      Journal of Tissue Engineering (in press)

    • Related Report
      2009 Final Research Report
  • [Presentation] Evaluating osteoconductiviry of alpha-TCT, beta-TCP and HA with or without combination with simvastatin2010

    • Author(s)
      Hisham Rojbani, Myat Nyan, 大谷啓一, 春日井昇平
    • Organizer
      第9回日本再生医療学会総会
    • Place of Presentation
      広島国際会議場 広島
    • Related Report
      2009 Final Research Report
  • [Presentation] Local application of EGCG for bone regeneration2010

    • Author(s)
      Reena Rodriguez, 近藤尚知, Myat Nyan, Hao Jia, 宮原宇将, 大谷啓一, 春日井昇平
    • Organizer
      第9回日本再生医療学会総会
    • Place of Presentation
      広島国際会議場 広島
    • Related Report
      2009 Final Research Report
  • [Presentation] Novel GBR membrane consisting of cholesterol-bearing pullulan nanogel2010

    • Author(s)
      Miyahara T, Nyan M, Nagayama T, Hao J, Rodoriguez R, Yamamoto Y, Shimoda A, Kuroda S, Tachikawa N, Shiota M, Akiyoshi K, Kasugai S
    • Organizer
      The 25^<th> Annual Meeting of Academy of Osseointegration
    • Place of Presentation
      Walt Disney World Dolphin Resort Hotel, Orland, USA
    • Related Report
      2009 Final Research Report
  • [Presentation] Osteoclast response to a thin sputtered hydroxyapatite coating.2010

    • Author(s)
      Hao Jia、黒田真司、大谷啓一、青木秀希、春日井昇平
    • Organizer
      第9回日本再生医療学会総会
    • Place of Presentation
      広島国際会議場 広島
    • Related Report
      2009 Annual Research Report
  • [Presentation] Evaluating osteoconductiviry of alpha-TCT, beta-TCP and HA with or without combination with simvastatin.2010

    • Author(s)
      Hisham Rojbani, Myat Nyan, 大谷啓一, 春日井昇平
    • Organizer
      第9回日本再生医療学会総会
    • Place of Presentation
      広島国際会議場 広島
    • Related Report
      2009 Annual Research Report
  • [Presentation] Local application of EGCG for bone regeneration.2010

    • Author(s)
      Reena Rodriguez, 近藤尚知、Myat Nyan, Hao Jia, 宮原宇将、大谷啓一、春日井昇平
    • Organizer
      第9回日本再生医療学会総会
    • Place of Presentation
      広島国際会議場 広島
    • Related Report
      2009 Annual Research Report
  • [Presentation] Evaluation of a new design of soft tissue and periosteal distraction.2010

    • Author(s)
      Osama Zakaria, 今一裕、春日井昇平
    • Organizer
      第9回日本再生医療学会総会
    • Place of Presentation
      広島国際会議場 広島
    • Related Report
      2009 Annual Research Report
  • [Presentation] An in vitro study of osteoblast differentiation on surface modified Y-TZP zirconia.2010

    • Author(s)
      Srilatha Bhargava, 黒田真司、Hao Jia、Myat Nyan、大谷啓一、青木秀希、春日井昇平
    • Organizer
      第9回日本再生医療学会総会
    • Place of Presentation
      広島国際会議場 広島
    • Related Report
      2009 Annual Research Report
  • [Presentation] Novel GBR membrane consisting of cholesterol-bearing pullulan nanogel.2010

    • Author(s)
      宮原宇将, Nyan M, Nagayama T, Hao J, Rodoriguez R, Yamamoto Y, Shimoda A, 黒田真司, Tachikawa N, 塩田真, Akiyoshi K, 春日井昇平
    • Organizer
      The 25^<th> Annual Meeting of Academy of Osseointegration
    • Place of Presentation
      Walt Disney World Dolphin Resort Hotel, Orland, USA
    • Related Report
      2009 Annual Research Report
  • [Presentation] インプラント治療に必要な 骨補填材2009

    • Author(s)
      春日井昇平
    • Organizer
      第7回日本再生歯科医学会総会・学術大会
    • Place of Presentation
      九州歯科大学
    • Year and Date
      2009-09-12
    • Related Report
      2009 Final Research Report
  • [Presentation] インプラント治療に必要な骨補填材.2009

    • Author(s)
      春日井昇平
    • Organizer
      第7回日本再生歯科医学会総会・学術大会
    • Place of Presentation
      九州歯科大学 小倉
    • Year and Date
      2009-09-12
    • Related Report
      2009 Annual Research Report
  • [Presentation] 歯科医療の現状と将来:歯科インプラント治療と再生医療との関わり.2009

    • Author(s)
      春日井昇平
    • Organizer
      岩手大学歯学部オープンリサーチプロジェクト難治性歯科疾患克服に向けたCell Therapyの基礎構築とDentistryの育成 シンポジウム 再生医療の現状と将来
    • Place of Presentation
      岩手医科大学循環器医療センター 盛岡
    • Year and Date
      2009-07-25
    • Related Report
      2009 Annual Research Report
  • [Presentation] 吸収性HAファイバーの骨造成への応用2009

    • Author(s)
      木村純一, 塩田真, 今一裕, 藤井政樹, 町田哲, 佐藤仁, 藤井茂夫, 春日井昇平
    • Organizer
      第74回口腔病学会学術大会
    • Place of Presentation
      東京医科歯科大学 東京
    • Related Report
      2009 Annual Research Report 2009 Final Research Report
  • [Presentation] Four year clinical observation of thin hydroxyapatite-coated implant2009

    • Author(s)
      Kasugai S, Shiota M, Tachikawa N, Kondo H, Kuroda S, Fujimori T, Munakata M, Nakata H, Kobayashi H.
    • Organizer
      18^<th> Annual Scientific Meeting of European Association for Osseointegration
    • Place of Presentation
      Grimaldi Forum, Monaco
    • Related Report
      2009 Final Research Report
  • [Presentation] シンバスタチンを含有する alpha-TCP の骨補填材としての有効性 : 臨床研究2009

    • Author(s)
      上野憲秀, 近藤尚知, 鬼原英道, 佐藤大輔, 春日井昇平
    • Organizer
      第39回日本口腔インプラント学会学術大会
    • Place of Presentation
      大阪国際会議場、大阪
    • Related Report
      2009 Final Research Report
  • [Presentation] Osteoblast and osteoclast responses to a thin sputtered hydroxyapatite coating2009

    • Author(s)
      Hao J, Kuroda S, Shimokawa H, Ohya K, Aoki H. Kasugai S.
    • Organizer
      2nd Meeting of IADR Pan Asian Pacific Federation (PAPF) and the 1st Meeting of IADR Asia/Pacific Region (APR)
    • Place of Presentation
      Wuhan, China
    • Related Report
      2009 Final Research Report
  • [Presentation] Vertical bone augmentation by space creation2009

    • Author(s)
      Nyan M, Miyahara T, Noritake K, Jia H, Rodriguez R, Kasugai S.
    • Organizer
      2nd Meeting of IADR Pan Asian Pacific Federation (PAPF) and the 1st Meeting of IADR Asia/Pacific Region (APR)
    • Place of Presentation
      Wuhan, China
    • Related Report
      2009 Final Research Report
  • [Presentation] Bone regeneration by combination of green tea catechin and alpha-TCP2009

    • Author(s)
      Rodriguez R, Kondo H, Nyan M, Hao J, Zakaria O, Miyahara T, Ohya K, Kasugai S.
    • Organizer
      nd Meeting of IADR Pan Asian Pacific Federation (PAPF) and the 1st Meeting of IADR Asia/Pacific Region (APR)
    • Place of Presentation
      Wuhan, China
    • Related Report
      2009 Final Research Report
  • [Presentation] Effects of simvastatin and alpha-tricalcium phosphate combination on the early healing of bone defects2009

    • Author(s)
      Nyan M, Machida T, Noritake K, Miyahara T, Kuroda S, Kasugai S.
    • Organizer
      Annual World Dental Congress of FDI
    • Place of Presentation
      Suntec International Convention and Exhibition Centre, Singapore
    • Related Report
      2009 Final Research Report
  • [Presentation] 骨形成促進作用を示す吸収性の骨補填材2009

    • Author(s)
      春日井昇平
    • Organizer
      第27回日本骨代謝学会総会・学術大会 シンポジウム 歯周組織と骨の再生
    • Place of Presentation
      大阪国際会議場 大阪
    • Related Report
      2009 Final Research Report
  • [Presentation] Prosthesis or regeneration? : Dental implant vs. tissue-engineered tooth2009

    • Author(s)
      Kasugai S.
    • Organizer
      The 2^<nd> Thailand International Conference on Oral Biology, Biology of Mineralized Tissue
    • Place of Presentation
      Chulalongkorm University, Bangkok, Thailand
    • Related Report
      2009 Final Research Report
  • [Presentation] Bone substitute of alpha-TCP containing simvastatin : Clinical study2009

    • Author(s)
      Ueno N, Sato D, Nyan M, Kondo H, Kasugai S.
    • Organizer
      24^<th> Annual Meeting of Academy of Osseointegration
    • Place of Presentation
      San Diego Convention Center, San Diego, USA
    • Related Report
      2009 Final Research Report
  • [Presentation] Gelatin hydrogel membrane for bone regeneration2009

    • Author(s)
      Noritake K, Kuroda S, Nyan M, Tabata Y, Kasugai S.
    • Organizer
      The 55th Annual Meeting of the Orthopaedic Research Society
    • Place of Presentation
      Las Vegas, NA, USA
    • Related Report
      2009 Final Research Report
  • [Presentation] Interference of osterix in adipogenesis of rat bone marrow stromal cells2009

    • Author(s)
      Kuroda S, Noritake K, Hao J, Kondo H, Kasugai S.
    • Organizer
      The 55th Annual Meeting of the Orthopaedic Research Society
    • Place of Presentation
      Las Vegas, NA, USA
    • Related Report
      2009 Final Research Report
  • [Presentation] 上顎洞底が近接する上顎臼歯欠損部に対するインプラント治療のガイドライン.シンポジウム 口腔インプラントの臨床エビデンスはどのくらい整ったのか 診療ガイドラインの策定に向けて2009

    • Author(s)
      春日井昇平
    • Organizer
      第39回日本口腔インプラント学会学術大会
    • Place of Presentation
      大阪国際会議場、大阪
    • Related Report
      2009 Annual Research Report
  • [Presentation] シンバスタチンを含有するalpha-TCPの骨補填材としての有効性:臨床研究.2009

    • Author(s)
      上野憲秀、近藤尚知、鬼原英道、佐藤大輔、春日井昇平
    • Organizer
      第39回日本口腔インプラント学会学術大会
    • Place of Presentation
      大阪国際会議場、大阪
    • Related Report
      2009 Annual Research Report
  • [Presentation] Split crestと骨移植によって上顎前歯部にインプラント治療をおこなった一症例2009

    • Author(s)
      武山秀子、黒田真司、長田紀子、則武加奈子、春日井昇平
    • Organizer
      第39回日本口腔インプラント学会学術大会
    • Place of Presentation
      大阪国際会議場、大阪
    • Related Report
      2009 Annual Research Report
  • [Presentation] 骨形成促進作用を示す吸収性の骨補填材.2009

    • Author(s)
      春日井昇平
    • Organizer
      第27回日本骨代謝学会総会・学術大会 シンポジウム 歯周組織と骨の再生
    • Place of Presentation
      大阪国際会議場 大阪
    • Related Report
      2009 Annual Research Report
  • [Presentation] Prosthesis or regeneration? : Dental implant vs. tissue-engineered tooth.2009

    • Author(s)
      春日井昇平
    • Organizer
      The 2^<nd> Thailand International Conference on Oral Biology, Biology of Mineralized Tissue
    • Place of Presentation
      Chulalongkorm University, Bangkok, Thailand
    • Related Report
      2009 Annual Research Report
  • [Presentation] Bone substitute of alpha-TCP containing simvastatin : Clinical study2009

    • Author(s)
      Ueno N, Sato D, Nyan M, KondoH, Kasugai.
    • Organizer
      The 24^<th> Annual Meeting of Academy of Osseointegration
    • Place of Presentation
      Convention Center, San Diego, USA
    • Related Report
      2008 Annual Research Report
  • [Presentation] Bone substitute in dental implant treatment2008

    • Author(s)
      Kasugai S.
    • Place of Presentation
      Khonkaen University, Thailand
    • Year and Date
      2008-01-07
    • Related Report
      2009 Final Research Report
  • [Presentation] 骨形形成を促進する化合物を含む吸収性骨補填材2008

    • Author(s)
      春日井昇平
    • Organizer
      日本バイオマテリアル学会シンポジウム2008
    • Place of Presentation
      東京大学 東京
    • Related Report
      2009 Final Research Report
  • [Presentation] Dental implant treatment in the near future : Prosthesis or regeneration?2008

    • Author(s)
      Kasugai S.
    • Organizer
      第4回日中歯科医学会
    • Place of Presentation
      西安 中華人民共和国
    • Related Report
      2009 Final Research Report
  • [Presentation] Particle size effect on augmented bone volume in autologous graft2008

    • Author(s)
      Kon K, Shiota M, Ozeki M, Kimura J, Kasugai S.
    • Organizer
      The 17^<th> Annual Scientific Meeting of European Association of Osseointegration
    • Place of Presentation
      PKIN Convention Center, Warsaw, Poland
    • Related Report
      2009 Final Research Report
  • [Presentation] Combination with alpha-tricalcium phosphate and simvastatin stimulates bone regeneration2008

    • Author(s)
      Nyan M, Kihara H, Machida T, Ueno H, Kasugai S.
    • Organizer
      The 17^<th> Annual Scientific Meeting of European Association of Osseointegration
    • Place of Presentation
      PKIN Convention Center, Warsaw, Poland
    • Related Report
      2009 Final Research Report
  • [Presentation] 繊維性ハイドロキシアパタイト材料がラット抜歯窩治癒に及ぼす影響 : 放射線学的評価2008

    • Author(s)
      町田哲, 丸尾勝一郎, 佐藤仁, 春日井昇平
    • Organizer
      シンポジウム 第38回日本口腔インプラント学会学術大会
    • Place of Presentation
      東京フォーラム 東京
    • Related Report
      2009 Final Research Report
  • [Presentation] 超薄膜ハイドロキシアパタイトコーティングインプラント周囲における新生骨形成 : ビーグル犬における早期負荷の組織観察2008

    • Author(s)
      藤森達也, 塩田真, 春日井昇平, 作山葵
    • Organizer
      シンポジウム 第38回日本口腔インプラント学会学術大会
    • Place of Presentation
      東京フォーラム 東京
    • Related Report
      2009 Final Research Report
  • [Presentation] 骨形成促進作用を示す骨補填材. シンポジウム Periodontal Tissue Engineering の現状と将来展望2008

    • Author(s)
      春日井昇平
    • Organizer
      第29回日本炎症・再生医学会
    • Place of Presentation
      都市センターホテル 東京
    • Related Report
      2009 Final Research Report
  • [Presentation] 歯科インプラント治療と再生医療の融合2008

    • Author(s)
      春日井昇平
    • Organizer
      第7回日本再生医療学会総会
    • Place of Presentation
      名古屋国際会議場
    • Related Report
      2009 Final Research Report
  • [Presentation] Hydoroxyapatite fiber material as bone substitute : Clinical study for sinus elevation2008

    • Author(s)
      Sato M, Fujii S, Amagasa T, Kasugai S.
    • Organizer
      The 23^<rd> Annual Meeting of Academy of Osseointegration
    • Place of Presentation
      The Hynes Convention Center, Boston, USA
    • Related Report
      2009 Final Research Report
  • [Presentation] 歯科インプラント治療と再生医療の融合.2008

    • Author(s)
      春日井昇平
    • Organizer
      第7回日本再生医療学会総会
    • Place of Presentation
      名古屋国際会議場
    • Related Report
      2007 Annual Research Report
  • [Presentation] 血液供給不足部位へのVEGFの応用による血管ならびに骨新生に関する組織学的研究.2008

    • Author(s)
      藤森達也、作山葵、塩田真、春日井昇平
    • Organizer
      第27回日本口腔インプラント学会関東・甲信越支部学術大会
    • Place of Presentation
      都市センター 東京
    • Related Report
      2007 Annual Research Report
  • [Presentation] Hydoroxyapatite fiber material as bone substitute: Clinical study for sinus elevarion.2008

    • Author(s)
      Sato M, Fujii S, Amagasa T, Kasugai S
    • Organizer
      The 23rd Annual Meeting of Academy of Osseointegration
    • Place of Presentation
      The Hynes Convention Center, Boston, USA
    • Related Report
      2007 Annual Research Report
  • [Presentation] Clinical trial of thin hydroxyapatite-coated one-piece implant.2008

    • Author(s)
      Kasugai S, Ochi M, Shiota M, Hirose Y, Tachikawa N, Kuniyasu H, Kondo H, Matubara H, Kuroda S, Taira H, Hujimori T, Murata M, Kitajo H, Kusano K.
    • Organizer
      The 23rd Annual Meeting of Academy of Osseointegration
    • Place of Presentation
      The Hynes Convention Center, Boston, USA
    • Related Report
      2007 Annual Research Report
  • [Presentation] New bone substitute in dental implant treatment2007

    • Author(s)
      Kasugai S.
    • Organizer
      The 9^<th> Implantological and Dental Day
    • Place of Presentation
      Intercontinental Hotel, Brno, Czech Republic
    • Year and Date
      2007-12-01
    • Related Report
      2009 Final Research Report
  • [Presentation] New bone substitute in dental implant treatment.2007

    • Author(s)
      Kasugai S
    • Organizer
      The 9th Implantological and Dental Day
    • Place of Presentation
      Intercontinental Hotel, Brno, Czech Republic
    • Year and Date
      2007-12-01
    • Related Report
      2007 Annual Research Report
  • [Presentation] 歯科インプラント治療の現状と限界:歯の再生医療への期待.2007

    • Author(s)
      春日井昇平
    • Organizer
      東京理科大学シンポジウム
    • Place of Presentation
      秋葉原コンベンションセンター 東京
    • Year and Date
      2007-11-12
    • Related Report
      2007 Annual Research Report
  • [Presentation] Alpha-TCP containing simvastatin as bone substitute : Animal and clinical studies2007

    • Author(s)
      Sato D, Ueno N, Nyan M, Kasugai S.
    • Organizer
      The 16^<th> Annual Scientific Meeting of European Association for Osseointegration (EAO)
    • Place of Presentation
      Barcelona Convention Center, Barcelona, Spain
    • Related Report
      2009 Final Research Report
  • [Presentation] Hydroxyapatite fiber material for bone tissue engineering2007

    • Author(s)
      Okabayashi S, Kasugai S.
    • Organizer
      The 16^<th> Annual Scientific Meeting of European Association for Osseointegration (EAO)
    • Place of Presentation
      Barcelona Convention Center, Barcelona, Spain
    • Related Report
      2009 Final Research Report
  • [Presentation] Application of simvastatin to tooth sockets of rats for bone augmentation2007

    • Author(s)
      Nishimura K, Sato D, Kondo H, Kasugai S.
    • Organizer
      The 16^<th> Annual Scientific Meeting of European Association for Osseointegration (EAO)
    • Place of Presentation
      Barcelona Convention Center, Barcelona, Spain
    • Related Report
      2009 Final Research Report
  • [Presentation] 繊維性ハイドロキシアパタイト材料とBMP-2遺伝子による異所性骨形成の誘導2007

    • Author(s)
      小田充匡, 近藤尚知, 黒田真司, 春日井昇平
    • Organizer
      第5回日本再生歯科医学会学術大会
    • Place of Presentation
      東京歯科大学水道橋病院 東京
    • Related Report
      2009 Final Research Report
  • [Presentation] 超薄膜ハイドロキシアパタイト (HA) コーティングインプラントの臨床試験2007

    • Author(s)
      春日井昇平, 越智守生, 塩田真, 廣瀬由紀人, 立川敬子, 國安宏哉, 近藤尚知, 松原秀樹, 黒田真司, 平博彦, 藤森達也, 村田勝, 北所弘行, 草野薫
    • Organizer
      第37回日本口腔インプラント学会学術大会
    • Place of Presentation
      熊本
    • Related Report
      2009 Final Research Report
  • [Presentation] 骨欠損部に適用した植物性ハイドロキシアパタイト顆粒の吸収と新生骨形成2007

    • Author(s)
      中村貴弘, 鬼原英道, 塩田真, 春日井昇平
    • Organizer
      第37回日本口腔インプラント学会学術大会
    • Place of Presentation
      熊本
    • Related Report
      2009 Final Research Report
  • [Presentation] 自家骨とβ-TCPを用いた上顎洞底挙上術後の移植骨体積変化のX線学的検討.2007

    • Author(s)
      相澤 悟、丸川恵理子、依田泰、塚原宏泰、立川敬子、春日井昇平、小村健
    • Organizer
      第11回日本顎顔面インプラント学会学術大会
    • Place of Presentation
      日本歯科大学新潟生命歯学部 新潟
    • Related Report
      2007 Annual Research Report
  • [Presentation] 当科におけるサイナスリフト症例の臨床的検討.2007

    • Author(s)
      高藤恭子、立川敬子、大庭容子、塩田真、春日井昇平
    • Organizer
      第11回日本顎顔面インプラント学会学術大会
    • Place of Presentation
      日本歯科大学新潟生命歯学部 新潟
    • Related Report
      2007 Annual Research Report
  • [Presentation] Alpha-TCP containing simvastatin as bone substitute: Animal and clinical studies.2007

    • Author(s)
      Sato D, Ueno N, Nyan M, Kasugai S
    • Organizer
      The 16th Annual Scientific Meeting of European Association for Osseointegration (EAO)
    • Place of Presentation
      Barcelona Convention Center, Barcelona, Spain
    • Related Report
      2007 Annual Research Report
  • [Presentation] Hydroxyapatite fiber material for bone tissue engineering.2007

    • Author(s)
      Okabayashi S, Kasugai S.
    • Organizer
      The 16th Annual Scientific Meeting of European Association for Osseointegration (EAO)
    • Place of Presentation
      Barcelona Convention Center, Barcelona, Spain
    • Related Report
      2007 Annual Research Report
  • [Presentation] Application of simvastatin to tooth sockets of rats for bone augmentation.2007

    • Author(s)
      Nishimurra K, Sato D, Kondo H, Kasugai S.
    • Organizer
      The 16th Annual Scientific Meeting of European Association for Osseointegration (EAO)
    • Place of Presentation
      Barcelona Convention Center, Barcelona, Spain
    • Related Report
      2007 Annual Research Report
  • [Presentation] Downstream signal transactivation by FGF-4/Osx transgene partially imitates changes of BMP-2 induced osteogenic transcription, factors in NIH3T3 cells.2007

    • Author(s)
      Kuroda S, Samee M, Kondo H, Kasugai S.
    • Organizer
      The 29th Meeting of American Society for Bone and Mineral Research.
    • Place of Presentation
      Honolulu, Hawaii, USA
    • Related Report
      2007 Annual Research Report
  • [Presentation] 繊維性ハイドロキシアパタイト材料とBMP-2遺伝子による異所性骨形成の誘導.2007

    • Author(s)
      小田充匡、近藤尚知、黒田真司、春日井昇平.
    • Organizer
      第5回日本再生歯科医学会学術大会
    • Place of Presentation
      東京歯科大学水道橋病院東京
    • Related Report
      2007 Annual Research Report
  • [Presentation] 超薄膜ハイドロキシアパタイト(HA)コーティングインプラントの臨床試験.2007

    • Author(s)
      春日井昇平、越智守生、塩田真、廣瀬由紀人、立川敬子、國安宏哉、近藤尚知、松原秀樹、黒田真司、平博彦、藤森達也、村田勝、北所弘行、草野薫.
    • Organizer
      第37回日本口腔インプラント学会学術大会
    • Place of Presentation
      熊本
    • Related Report
      2007 Annual Research Report
  • [Presentation] 骨欠損部に適用した植物性ハイドロキシアパタイト顆粒の吸収と新生骨形成.2007

    • Author(s)
      中村貴弘、鬼原英道、塩田真、春日井昇平.
    • Organizer
      第37回日本口腔インプラント学会学術大会
    • Place of Presentation
      熊本
    • Related Report
      2007 Annual Research Report
  • [Presentation] ペプチドハイドロゲルを用いたラット骨髄細胞の3次元培養2007

    • Author(s)
      尾関真帆、黒田真司、春日井昇平
    • Organizer
      第49回歯科基礎医学会学術大会ならびに総会
    • Place of Presentation
      北海道大学学術交流会館札幌
    • Related Report
      2007 Annual Research Report
  • [Book] インプラント治療の現状と最近の進歩 : 再生医療との関わり. Minimally Intervention 時代の歯科知識 (吉山昌宏, 伊藤博夫, 十河基文編)2009

    • Author(s)
      春日井昇平
    • Publisher
      永末書店
    • Related Report
      2009 Final Research Report
  • [Book] 細胞増殖のためのバイオマテリアルの利用 再生部位確保膜歯周組織 (GTR). 患者まで届いている再生誘導治療 (田畑泰彦 編)2009

    • Author(s)
      春日井昇平
    • Publisher
      株式会社メディカルドウ
    • Related Report
      2009 Final Research Report
  • [Book] 欠損補綴のオプション インプラント治療. 現代のパーシャルデンチャー (野首孝祠, 五十嵐順正 編)2008

    • Author(s)
      春日井昇平
    • Publisher
      クインテッセンス出版
    • Related Report
      2009 Final Research Report
  • [Book] 口腔における再生医療. 口と歯の事典 (高戸毅, 天笠光雄, 葛西一貴, 古郷幹彦, 須佐見隆史, 鈴木茂彦, 谷口尚, 新美成二 編)2008

    • Author(s)
      春日井昇平
    • Publisher
      朝倉書店
    • Related Report
      2009 Final Research Report
  • [Remarks]

    • URL

      http://www.tmd.ac.jp/grad/mfc/mfc-J.htm

    • Related Report
      2009 Annual Research Report

URL: 

Published: 2007-04-01   Modified: 2016-04-21  

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