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Study of technique of vascular anastomosis and monitoring of blood flow for improving rates of free tissue transplantation

Research Project

Project/Area Number 19390519
Research Category

Grant-in-Aid for Scientific Research (B)

Allocation TypeSingle-year Grants
Section一般
Research Field Surgical dentistry
Research InstitutionKyushu University

Principal Investigator

SASAGURI Masaaki  九州大学, 大学病院, 准助教 (00225898)

Co-Investigator(Kenkyū-buntansha) NAKAMURA Seiji  九州大学, 歯学研究科, 教授 (60189040)
ISOGAI Noritaka  近畿大学, 医学研究科, 教授 (90203067)
MITSUYASU Takeshi  九州大学, 大学病院, 助教 (00380519)
Project Period (FY) 2007 – 2010
Project Status Completed (Fiscal Year 2010)
Budget Amount *help
¥8,710,000 (Direct Cost: ¥6,700,000、Indirect Cost: ¥2,010,000)
Fiscal Year 2010: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
Fiscal Year 2009: ¥2,210,000 (Direct Cost: ¥1,700,000、Indirect Cost: ¥510,000)
Fiscal Year 2008: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
Fiscal Year 2007: ¥3,120,000 (Direct Cost: ¥2,400,000、Indirect Cost: ¥720,000)
Keywords遊離組織移植 / 微小血管吻合 / 皮弁血流 / 血管吻合
Research Abstract

The purpose of this study is to establish vascular anastomosis technique and postoperative management method for improving the success rate of free tissue transplantation with microvascular anastomosis.
(1)Disturbance of blood flow due to differences in condition of vascular anastomosis : Thrombogenic anastomosis led to disturbance of blood flow at a high rate. Anticoagulation therapy with subcutaneous heparin administration could not suppress the thrombus formation in the cases of experimental thrombogenic anastomosis. Flexion of the blood vessel pattern did not affect the blood flow failure.
(2)The blood flow disturbance and the ischemic time of the flap : With the extension of the time of flap ischemia, the incidence of failure of blood flow was increased. The blood flow obstruction was suppressed by heparin treatment to the flap during ischemia of the flap.
(3) Postoperative blood flows of the flaps were observed using a laser Doppler flowmetry(LDF) in the cases of oral cavity reconstruction by free tissue transplantation. The averageblood flow rate in the flaps gradually increased after the operation, and then became stable untilday 3. In addition, after PGE1 administration, the flap blood flow increased by 30-40% and increase in blood flow was sustained for 3-4 hours. In this way, the changes in blood flow in postoperative flap, it was found to give a uniform pattern. On the other hand, resulted in failure of blood flow in patients after surgery, blood flow patterns were different. Careful monitoring of the flaps by LDF may provide significant information for quickly identifying circulation disturbances in the flaps prior to macroscopic change of the flap

Report

(6 results)
  • 2010 Annual Research Report   Final Research Report ( PDF )
  • 2009 Annual Research Report   Self-evaluation Report ( PDF )
  • 2008 Annual Research Report
  • 2007 Annual Research Report
  • Research Products

    (9 results)

All 2011 2009 2008

All Journal Article (2 results) (of which Peer Reviewed: 1 results) Presentation (7 results)

  • [Journal Article] Postoperative changes of blood flow in free microvascular flaps transferred for reconstruction of oral cavity2011

    • Author(s)
      Eiji Mitate, Masaaki Sasaguri, Kazunari Oobu, Takeshi Mitsuyasu, Akihiko Tanaka, Takahiro Kiyosue, Seiji Nakamura
    • Journal Title

      Effects of intravenous infusion of prostaglandin E1 Asian Journal of Oral and Maxillofacial Surgery

      Volume: 23(3) Pages: 113-116

    • Related Report
      2010 Final Research Report
  • [Journal Article] Postoperative changes of blood flow in free microvascular flaps transferred for reconstruction of oral cavity : Effect of intravaneous infusion of prostaglandin E12011

    • Author(s)
      Eitate Mitate, Masaaki Sasaguri, et.al.
    • Journal Title

      Asian Journal of Oral and Maxillofacial Surgery

      Volume: (in press)

    • Related Report
      2010 Annual Research Report
    • Peer Reviewed
  • [Presentation] 顎口腔領域遊離組織移植における血行障害の原因についての検討2009

    • Author(s)
      笹栗正明, 光安岳志, 飯田和政, 北村亮二, 中村誠司
    • Organizer
      第54回日本口腔外科学会総会
    • Place of Presentation
      札幌市
    • Year and Date
      2009-10-10
    • Related Report
      2009 Self-evaluation Report
  • [Presentation] 顎口腔領域遊離組織移植における血行障害の原因についての検討2009

    • Author(s)
      笹栗正明、光安岳志, 他7名
    • Organizer
      第54回日本口腔外科学会学術大会総会
    • Place of Presentation
      札幌市
    • Year and Date
      2009-10-10
    • Related Report
      2009 Annual Research Report
  • [Presentation] 顎口腔領域遊離組織移植における血行障害の原因についての検討2009

    • Author(s)
      笹栗正明、光安岳志、飯田政和、見立英史他5名
    • Organizer
      第回日本口腔外科学会総会
    • Place of Presentation
      札幌
    • Related Report
      2010 Final Research Report
  • [Presentation] 遊離組織移植術後血流障害症例におけるレーザー血流計測について2008

    • Author(s)
      見立英史、笹栗正明、大部一成、光安岳志、清末崇裕、中村誠司
    • Organizer
      第76回日本口腔外科学会九州地方会
    • Place of Presentation
      宮崎市
    • Year and Date
      2008-09-06
    • Related Report
      2010 Final Research Report
  • [Presentation] 遊離組織移植術後の血流計測について-血流障害症例についての検討-2008

    • Author(s)
      見立英史、笹栗正明、大部一成、光安岳志、清末崇裕、中村誠司
    • Organizer
      第12回九州地区口腔癌研究会
    • Place of Presentation
      宮崎市
    • Year and Date
      2008-09-05
    • Related Report
      2010 Final Research Report
  • [Presentation] 遊離組織移植後血流障害症例におけるレーザー血流計測2008

    • Author(s)
      見立英史, 笹栗正明, 大部一成, 光安岳志, 田中昭彦, 清末崇裕, 中村誠司
    • Organizer
      第76回日本口腔外科学会九州地方会
    • Place of Presentation
      宮崎市
    • Year and Date
      2008-09-05
    • Related Report
      2009 Self-evaluation Report
  • [Presentation] 遊離組織移植後の血流計測について-血流障害症例についての検討-2008

    • Author(s)
      見立英史, 笹栗正明, 大部一成, 光安岳志, 田中昭彦, 清末崇裕, 中村誠司
    • Organizer
      第12回九州口腔癌治療研究会
    • Place of Presentation
      宮崎市
    • Year and Date
      2008-09-05
    • Related Report
      2009 Self-evaluation Report

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Published: 2007-04-01   Modified: 2016-04-21  

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