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The basic and clinical study for the personalized oral cancer therapy

Research Project

Project/Area Number 19390523
Research Category

Grant-in-Aid for Scientific Research (B)

Allocation TypeSingle-year Grants
Section一般
Research Field Surgical dentistry
Research InstitutionMeikai University

Principal Investigator

FUKUDA Masakatsu  Meikai University, 歯学部, 講師 (10311614)

Co-Investigator(Kenkyū-buntansha) KUSAMA Kaoru  明海大学, 歯学部, 教授 (20130479)
SAKASHITA Hideaki  明海大学, 歯学部, 教授 (10178551)
Project Period (FY) 2007 – 2009
Project Status Completed (Fiscal Year 2009)
Budget Amount *help
¥16,770,000 (Direct Cost: ¥12,900,000、Indirect Cost: ¥3,870,000)
Fiscal Year 2009: ¥4,810,000 (Direct Cost: ¥3,700,000、Indirect Cost: ¥1,110,000)
Fiscal Year 2008: ¥4,160,000 (Direct Cost: ¥3,200,000、Indirect Cost: ¥960,000)
Fiscal Year 2007: ¥7,800,000 (Direct Cost: ¥6,000,000、Indirect Cost: ¥1,800,000)
Keywords頭頸部悪性腫瘍 / 遺伝子変異 / NF-κB / p53 / ING / アポトーシス / NF-кB
Research Abstract

Human oral squamous cell carcinoma (HOSCC) is the most common malignant tumor in the oral cavity, and that frequent alteration of p53 tumor suppressor gene is associated with the development of HOSCC, especially in 30% to 50% of that. The p33^<ING1b> has a close relationship with p53 and that neither p53 nor p33^<ING1b> alone can cause cell growth inhibition, which prompted us to investigate their potential role in oral carcinogenesis. Furthermore, Nuclear factor-κB (NF-κB) has key roles in inflammation, immune response, tumorigenesis and protection against apoptosis. It has recently been reported that the function of NF-κB is regulated by p53. In this study, to determine whether the p33^<ING1b> isoform plays a role in chemosentivity of HOSCC, we investigated the effect of p33^<ING1b> overexpression on taxol-induced apoptosis and the activation of caspases in HOSCC cells. Previous experimental evidences indicated that p33^<ING1b> functionally cooperates with p53 in controlling cell growth, senescence and apoptosis. The p33^<ING1b> may cooperate with p53 in taxol-induced apoptosis of the HOSCC. To test this hypothesis, the HOSCC cell lines, contained wild-type p53 and mutant p53, were employed to examine the enhancement ofapoptosis by p33^<ING1b> overexpression and its mechanism. We found that overexpression of exogenous p33^<ING1b> in wild-type p53 cell line can dramatically promote taxol-induced apoptosis.

Report

(4 results)
  • 2009 Annual Research Report   Final Research Report ( PDF )
  • 2008 Annual Research Report
  • 2007 Annual Research Report
  • Research Products

    (25 results)

All 2010 2009 2008 2007

All Journal Article (13 results) (of which Peer Reviewed: 13 results) Presentation (12 results)

  • [Journal Article] IL-23 promotes growth and proliferation in human squamous cell carcinoma of the oral cavity.2010

    • Author(s)
      MASAKATSU FUKUDA, MASAHIRO EHARA, SEIJI SUZUKI, YOSHIHIRO OHMORI, HIDEAKI SAKASHITA
    • Journal Title

      International Journal of Oncology (in press)

    • Related Report
      2009 Final Research Report
    • Peer Reviewed
  • [Journal Article] Tumor suppressor p33ING1b enhances taxol-induced apoptosis in human squamous cell carcinoma of the oral cavity.2010

    • Author(s)
      FUKUDA Masakatsu, SAKASHITA Hideaki
    • Journal Title

      Hospital Dentistry & Oral-Maxillofacial Surgery 21.2

      Pages: 91-9

    • Related Report
      2009 Final Research Report
    • Peer Reviewed
  • [Journal Article] Expression of hypoxia-inducible factor-1αin squamous cell carcinoma of the oral cavity.2010

    • Author(s)
      FUKUDA Masakatsu, SAKASHITA Hideaki
    • Journal Title

      Hospital Dentistry & Oral-Maxillofacial Surgery 21.2

      Pages: 85-90

    • Related Report
      2009 Final Research Report
    • Peer Reviewed
  • [Journal Article] Interleukin-23 and its receptors expression in human squamous cell carcinoma of the oral cavity.2010

    • Author(s)
      Masakatsu Fukuda, Masahiro Ehara, Seiji Suzuki, Hideaki Sakashita
    • Journal Title

      Molecular Medicine Reports 3

      Pages: 89-93

    • Related Report
      2009 Final Research Report
    • Peer Reviewed
  • [Journal Article] Interleukin-23 and its receptors expression in human squamous cell carcinoma of the oral cavity2010

    • Author(s)
      Masakatsu FUKUDA, et al.
    • Journal Title

      Molecular Medicine Reports 3

      Pages: 89-93

    • Related Report
      2009 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Tumor suppressor p33^<INGIb> enhances taxol-induced apoptosis in human squamous cell carcinoma of the oral cavity2010

    • Author(s)
      FUKUDA Masakatsu, et al.
    • Journal Title

      Hospital Dentistry & Oral-Maxillofacial Surgery 21

      Pages: 91-96

    • Related Report
      2009 Annual Research Report
    • Peer Reviewed
  • [Journal Article] IL-23 promotes growth and proliferation in human squamous cell carcinoma of the oral cavity2010

    • Author(s)
      MASAKATSU FUKUDA, et al.
    • Journal Title

      International Journal of Oncology 36

      Pages: 1355-1365

    • Related Report
      2009 Annual Research Report
    • Peer Reviewed
  • [Journal Article] imetidine inhibits salivary gland tumor cell adhesion to neural cells and induces apoptosis by blocking NCAM expression.2008

    • Author(s)
      Masakatsu Fukuda, Kaoru Kusama, Hideaki Sakashita
    • Journal Title

      BMC Cancer 8(1)

      Pages: 376-376

    • Related Report
      2009 Final Research Report
    • Peer Reviewed
  • [Journal Article] Loss of CYLD might be associated with development of salivary gland tumors.2008

    • Author(s)
      Fukuda M., Hiroi M., Suzuki S., Ohmori Y., Sakashita H.
    • Journal Title

      Oncol. Rep. 19

      Pages: 1421-1427

    • Related Report
      2009 Final Research Report
    • Peer Reviewed
  • [Journal Article] Cimetidine inhibits salivary gland tumor cell adhesion to neural cells and induces apoptosis by blocking NCAM expression.2008

    • Author(s)
      Fukuda M
    • Journal Title

      BMC Cancer 8(1) : 376(webのためなし)

    • Related Report
      2008 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Loss of CYLD might be associated with development of salivary gland tumors2008

    • Author(s)
      Masakatsu FUKUDA
    • Journal Title

      Oncol. Rep. (in press)

    • Related Report
      2007 Annual Research Report
    • Peer Reviewed
  • [Journal Article] 唾液腺悪性腫瘍の増殖・進展メカニズムに関する研究-cimetidineの及ぼす影響について-2007

    • Author(s)
      南弘子・福田正勝・草間薫・坂下英明
    • Journal Title

      日本口腔科学会雑誌 第56巻第3号

      Pages: 263-274

    • NAID

      10019565627

    • Related Report
      2009 Final Research Report
    • Peer Reviewed
  • [Journal Article] 唾液腺悪性腫瘍の増殖・進展メカニズムに関する研究-cimetidineの及ぼす影響について-2007

    • Author(s)
      南 弘子
    • Journal Title

      日本口腔科学会雑誌 第56巻

      Pages: 263-274

    • Related Report
      2007 Annual Research Report
    • Peer Reviewed
  • [Presentation] 口腔扁平上皮癌におけるhypoxia-inducible factor-1α(HIF-1α)の発現について.2009

    • Author(s)
      福田正勝, 奥結香, 鈴木正二, 坂下英明
    • Organizer
      第54回日本口腔外科学会学術総会
    • Place of Presentation
      札幌コンベンションセンター
    • Related Report
      2009 Final Research Report
  • [Presentation] Expression of hypoxia-inducible factor-1αin squamous cell carcinoma of the oral cavity.2009

    • Author(s)
      Masakatsu Fukuda, Kaoru Kusama, Hideaki Sakashita
    • Organizer
      第68回日本癌学会学術総会
    • Place of Presentation
      パシフィコ横浜
    • Related Report
      2009 Final Research Report
  • [Presentation] Interleukin (IL)-23 promotes growth and proliferating activity of head and neck cancer.2008

    • Author(s)
      Masakatsu Fukuda, Kaoru Kusama, Hideaki Sakashita
    • Organizer
      第67回日本癌学会学術総会
    • Place of Presentation
      名古屋国際会議場
    • Related Report
      2009 Final Research Report
  • [Presentation] Interleukin (IL)-23は口腔癌の成長および増殖活性を促進する2008

    • Author(s)
      福田正勝, 中野みゆき, 鈴木正二, 草間薫, 坂下英明
    • Organizer
      第53回日本口腔外科学会学術総会
    • Place of Presentation
      アスティ徳島
    • Related Report
      2009 Final Research Report
  • [Presentation] Expression of hypoxia-inducible factor-1α in squamous cell carcinoma of the oral cavity2008

    • Author(s)
      Masakatsu Fukuda
    • Organizer
      第68回日本癌学会学術総会
    • Place of Presentation
      パシフィコ横浜
    • Related Report
      2009 Annual Research Report
  • [Presentation] Interleukin(IL)-23は口腔癌の成長および増殖活性を促進する2008

    • Author(s)
      福田正勝
    • Organizer
      第53回日本口腔外科学会学術総会
    • Place of Presentation
      アスティ徳島
    • Related Report
      2008 Annual Research Report
  • [Presentation] Interleukin(IL)-23 promotes growth and proliferating activity of head and neck cancer2008

    • Author(s)
      Masakatsu Fukuda
    • Organizer
      第67回日本癌学会学術総会
    • Place of Presentation
      名古屋国際会議場
    • Related Report
      2008 Annual Research Report
  • [Presentation] CYLD regulates NF-κB and its related factors expression in salivary gland tumors2007

    • Author(s)
      Masakatsu Fukuda
    • Organizer
      89^<th> AAOMS Annual Meeting
    • Place of Presentation
      Honolulu, Hawaii
    • Year and Date
      2007-08-13
    • Related Report
      2007 Annual Research Report
  • [Presentation] CYLD regulates NF-κB and its related factors expression in salivary gland tumors.2007

    • Author(s)
      Masakatsu Fukuda, Yuka Oku, Seiji Suzuki, Kaoru Kusama, Hideaki Sakashita
    • Organizer
      89th AAOMS Annual Meeting, Scientific Sessions and Exhibition in conjunction with the Japanese Society of Oral and Maxillofacial Surgeons and the Korean Association of Oral and Maxillofacial Surgeons, Hawaii Convention Center
    • Place of Presentation
      Honolulu, Hawaii
    • Related Report
      2009 Final Research Report
  • [Presentation] Cimetidine Inhibits Salivary Gland Tumor Cell Adhesion to Neural Cells and Induces Apoptosis by Blocking NCAM Expression.2007

    • Author(s)
      Masakatsu Fukuda, Kaoru Kusama, Hideaki Sakashita
    • Organizer
      第66回日本癌学会学術総会
    • Place of Presentation
      パシフィコ横浜
    • Related Report
      2009 Final Research Report
  • [Presentation] CYLDは唾液腺腫瘍におけるNF-κBとその関連因子の発現を調節する2007

    • Author(s)
      福田正勝, 奥結香, 鈴木正二, 草間薫, 坂下英明
    • Organizer
      第52回日本口腔外科学会学術総会
    • Place of Presentation
      名古屋国際会議場
    • Related Report
      2009 Final Research Report
  • [Presentation] CYLD regulates NF-κB-related factors expression in salivary gland tumors.2007

    • Author(s)
      Masakatsu Fukuda, Seiji Suzuki, Kaoru Kusama, Hideaki Sakashita
    • Organizer
      13th International Congress of Mucosal Immunology (ICMI)
    • Place of Presentation
      Tokyo, Japan
    • Related Report
      2009 Final Research Report

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Published: 2007-04-01   Modified: 2016-04-21  

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