The study on regeneration of dental enamel using synthetic phosphorylated polypeptides
| Project/Area Number |
19390533
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| Research Category |
Grant-in-Aid for Scientific Research (B)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Orthodontic/Pediatric dentistry
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| Research Institution | Kanagawa Dental College |
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Principal Investigator |
SHINJI Hisaaki Kanagawa Dental College, 歯学部, 准教授 (00147993)
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| Co-Investigator(Kenkyū-buntansha) |
KURATA Shigeaki 神奈川歯科大学, 歯学部, 准教授 (20104333)
OHKAWA Kousaku 信州大学, 繊維学部, 准教授 (60291390)
YAMAGUCHI Mina 神奈川歯科大学, 歯学部, 助教 (10386849)
木本 茂成 神奈川歯科大学, 歯学部, 教授 (90205013)
山本 浩之 信州大学, 繊維学部, 名誉教授 (60021151)
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| Co-Investigator(Renkei-kenkyūsha) |
YAMAMOTO Hiroyuki 神奈川歯科大学, 歯学部, 客員教授 (60021151)
KIMOTO Shigenari 神奈川歯科大学, 歯学部, 教授 (90205013)
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| Project Period (FY) |
2007 – 2009
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| Project Status |
Completed (Fiscal Year 2009)
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| Budget Amount *help |
¥17,160,000 (Direct Cost: ¥13,200,000、Indirect Cost: ¥3,960,000)
Fiscal Year 2009: ¥3,640,000 (Direct Cost: ¥2,800,000、Indirect Cost: ¥840,000)
Fiscal Year 2008: ¥5,200,000 (Direct Cost: ¥4,000,000、Indirect Cost: ¥1,200,000)
Fiscal Year 2007: ¥8,320,000 (Direct Cost: ¥6,400,000、Indirect Cost: ¥1,920,000)
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| Keywords | ポリホスホセリン / 歯質 / 石灰化 / ナノファイバー / ホスホセリン |
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| Research Abstract |
Phosphorylated polypeptides (protein) has been successful in chemical synthesis in our laboratory. Also, the synthetic phosphorylated polypeptides were adsorbed on the surface of tooth enamel, and then the hydroxyapatite (hard tissues of teeth, bone etc.) was made by deposition of calcium. These results were suggested a possibility for tooth cavity restoration or pit and fissure modification of teeth (sealant) as a new dental treatment method, making a great deal of contribution to the dental profession.
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Report
(4 results)
Research Products
(98 results)
