Molecular genetics study of gutter-shaped root (GSR) in inbred mice using RNAi analysis.
| Project/Area Number |
19390534
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| Research Category |
Grant-in-Aid for Scientific Research (B)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Orthodontic/Pediatric dentistry
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| Research Institution | Tsurumi University |
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Principal Investigator |
ASADA Yoshinobu Tsurumi University, 歯学部, 教授 (20184145)
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| Co-Investigator(Kenkyū-buntansha) |
IDAIRA Yayoi 鶴見大学, 歯学部, 助教 (40200018)
INOUE Hiroko 鶴見大学, 歯学部, 講師 (50367306)
MISHIMA Kenji 鶴見大学, 歯学部, 准教授 (50275343)
SAITO Ichiro 鶴見大学, 歯学部, 教授 (60147634)
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| Project Period (FY) |
2007 – 2009
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| Project Status |
Completed (Fiscal Year 2009)
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| Budget Amount *help |
¥18,460,000 (Direct Cost: ¥14,200,000、Indirect Cost: ¥4,260,000)
Fiscal Year 2009: ¥2,730,000 (Direct Cost: ¥2,100,000、Indirect Cost: ¥630,000)
Fiscal Year 2008: ¥3,770,000 (Direct Cost: ¥2,900,000、Indirect Cost: ¥870,000)
Fiscal Year 2007: ¥11,960,000 (Direct Cost: ¥9,200,000、Indirect Cost: ¥2,760,000)
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| Keywords | 樋状根 / Real time PCR / Gene Chip / QTL解析 / Shh遺伝子 / Recombinant / inbred mice / マイクロアレイ法 / SHH pathway / AKXLマウス / 近交系マウス / Neuropeptide Y |
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| Research Abstract |
A detailed study using Quantitative trait locus (QTL) analysis, microarray and Real time PCR revealed that gutter-shaped root (GSR) formation in the C57L/J mice is strongly controlled by the genetic factor(s). It is well known that Shh signaling pathway is associated with the extension of the epithelial diaphragm (ED). It is suggested that the arrested development of ED in the C57L/J mice is caused by the fall of expression level of the Shh gene at 11days after birth. We concluded that GSR formationin the C57L/J mice is regulated by signaling factors such as Shh pathway.
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Report
(4 results)
Research Products
(12 results)
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[Journal Article] The Zinc transporter SLC39A13/ZIP13 is required for connective Tissue development; its involvement in BMP/TGF-βsignaling pathways2008
Author(s)
Fukada T, Civic N, Furuichi T, Shimoda S, Mishima K, Higashiyama H, Idaira Y, Asada Y, Kitamura H, Yamasaki S, Hojyo S, Nakayama M, Ohara O, Koseki H, Santos, H.G. Bonafe L, Ha-Vinh R, Zankl A, Unger S, Kraenzlin, M.E. Beckmann J.S., Saito I, Rivolta C, IFukada T, Civic N, Furuichi T, Shim
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Related Report
Peer Reviewed
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