Metabolome analysis of oral biofilm using CE-TOFMS and its application possibility as an oral health indicator

• Project/Area Number: 19390539
• Research Category: Grant-in-Aid for Scientific Research (B)
• Allocation Type: Single-year Grants
• Section: 一般
• Research Field: Social dentistry
• Research Institution: Tohoku University
• Principal Investigator: TAKAHASHI Nobuhiro Tohoku University, 大学院・歯学研究科, 教授 (60183852)
• Co-Investigator(Kenkyū-buntansha): HANADA Nobuhiro 鶴見大学, 歯学部, 教授 (70180916) ; KOSEKI Takeyoshi 東北大学, 大学院・歯学研究科, 教授 (80291128) ; SENPUKU Hidenobu 国立感染症研究所, 細菌第一部, 室長 (20250186) ; SATO Takuichi 東北大学, 大学院・歯学研究科, 講師 (10303132) ; SAKAMOTO Mitsuo 独立行政法人理化学研究所, 微生物材料開発室, 協力研究員 (50321766)
• Project Period (FY): 2007 – 2009
• Project Status: Completed (Fiscal Year 2009)
• Budget Amount: ¥15,470,000 (Direct Cost: ¥11,900,000、Indirect Cost: ¥3,570,000); Fiscal Year 2009: ¥3,120,000 (Direct Cost: ¥2,400,000、Indirect Cost: ¥720,000); Fiscal Year 2008: ¥2,990,000 (Direct Cost: ¥2,300,000、Indirect Cost: ¥690,000); Fiscal Year 2007: ¥9,360,000 (Direct Cost: ¥7,200,000、Indirect Cost: ¥2,160,000)
• Keywords: 歯学 / バイオフィルム / メタボローム / 微生物 / 微生物叢

Research Abstract

Metabolome analysis for the representative plaque bacteria and human oral biofilm using a capillary electrophoresis equipped with a time-of-flight mass spectrometer was established. By this method, a new finding was obtained about the pentose-phosphate pathway and the Kreb's tricarboxylic acid cycle, as well as the Embden-Meyerhof-Parnas pathway. In addition, the metabolome analysis was applicable to a very small amount of oral biofilm. These results suggest that the metabolome data can be used as an indicator of oral health status.

Research Products

• [Journal Article] Metabolomics of supragingival plaque and oral bacteria (2010)
  • Author(s): Takahashi N, 3名中筆頭
  • Journal Title: J Dent Res (印刷中)
  • Peer Reviewed
• [Journal Article] Profiling of subgingival plaque biofilm microflora from periodontally healthy subjects and from subjects with periodontitis using quantitative real-time PCR (2010)
  • Author(s): Sato T, 4名中2番目, Takahashi N, 4名中4番目
  • Journal Title: J Periodontal Res 45(3) Pages: 389-395
  • Peer Reviewed
• [Journal Article] Tooth loss and intakes of nutrients and foods : a nationwide survey of Japanese dentists (2010)
  • Author(s): Hanada N, 9名中8番目
  • Journal Title: Community Dent Oral Epidemiol 38(1) Pages: 43-49
  • Peer Reviewed
• [Journal Article] Unique functions of hydroxyapatite with mutans streptococci adherence (2010)
  • Author(s): Hanada N, 9名中7番目, Senpuku H, 9名中9番目
  • Journal Title: Quintessence Int 41(1)
  • Peer Reviewed
• [Journal Article] Hsp60 and 16S rRNA gene sequence relationships among species of the genus Bacteroides with the finding that Bacteroides suis and Bacteroides tectus are heterotypic synonyms of Bacteroides pyogenes (2010)
  • Author(s): Sakamoto M, 3名中筆頭
  • Journal Title: Int J Syst Evol Microbiol (in press)
  • Peer Reviewed
• [Journal Article] Slackia equolifaciens sp. nov., a human intestinal bacterium capable of producing equol (2010)
  • Author(s): Sakamoto M, 5名中3番目
  • Journal Title: Int J Syst Evol Microbiol (in press)
  • Peer Reviewed
• [Journal Article] Prevotella aurantiaca sp. nov., isolated from the human oral cavity (2010)
  • Author(s): Sakamoto M, 3名中筆頭
  • Journal Title: Int J Syst Evol Microbiol 60(3) Pages: 500-503
  • Peer Reviewed
• [Journal Article] Lactobacillus similis sp. nov., isolated from fermented cane molasses (2010)
  • Author(s): Sakamoto M, 3名中2番目
  • Journal Title: Int J Syst Evol Microbiol 60(1) Pages: 187-190
  • Peer Reviewed
• [Journal Article] Profiling of subgingival plaque biofilm microflora from periodontally healthy subjects and from subjects with periodontitis using quantitative real-time PCR (2010)
  • Author(s): Yuki Abiko
  • Journal Title: J Periodontal Res 45(印刷中)
  • Peer Reviewed
• [Journal Article] (2010)
  • Author(s): Yoko Sakuma
  • Journal Title: Interface Oral Health Science 2009(Springer, New York) Pages: 215-216
• [Journal Article] (2010)
  • Author(s): Yasuhisa Takeuchi
  • Journal Title: Interface Oral Health Science 2009(Springer, New York) Pages: 230-231
• [Journal Article] (2010)
  • Author(s): Yuki Abiko
  • Journal Title: Interface Oral Health Science 2009(Springer, New York) Pages: 240-242
• [Journal Article] (2010)
  • Author(s): Kazuhiro Hashimoto
  • Journal Title: Interface Oral Health Science 2009(Springer, New York) Pages: 243-244
• [Journal Article] (2010)
  • Author(s): Ryo Komori
  • Journal Title: Interface Oral Health Science 2009(Springer, New York) Pages: 248-249
• [Journal Article] (2010)
  • Author(s): Jumpei Washio
  • Journal Title: Interface Oral Health Science 2009(Springer, New York) Pages: 250-251
• [Journal Article] (2010)
  • Author(s): Kazuko Nakajo
  • Journal Title: Interface Oral Health Science 2009(Springer, New York) Pages: 267-268
• [Journal Article] (2010)
  • Author(s): Hitomi Domon
  • Journal Title: Interface Oral Health Science 2009(Springer, New York) Pages: 269-270
• [Journal Article] (2010)
  • Author(s): Takuichi Sato
  • Journal Title: Interface Oral Health Science 2009(Springer, New York) Pages: 273-274
• [Journal Article] (2010)
  • Author(s): Masatoshi Takahashi
  • Journal Title: Interface Oral Health Science 2009(Springer, New York) Pages: 283-285
• [Journal Article] Transient acid-impairment of growth ability of oral Streptococcus, Actinomyces, and Lactobacillus: a possible ecological determinant in dental plaque (2009)
  • Author(s): Takahashi N, 4名中4番目
  • Journal Title: Oral Microbiol Immunol 24(4) Pages: 319-324
  • Peer Reviewed
• [Journal Article] Fluoride released from glass-ionomer cement is responsible to inhibit the acid production of caries-related oral streptococci (2009)
  • Author(s): Takahashi N, 6名中6番目
  • Journal Title: Dent Mater 25(6) Pages: 703-708
  • Peer Reviewed
• [Journal Article] Effects of alpha-amylase and its inhibitors on acid production from cooked starch by oral streptococci (2009)
  • Author(s): Takahashi N, 7名中7番目
  • Journal Title: Caries Res 43(1) Pages: 17-24
  • Peer Reviewed
• [Journal Article] 口腔バイオフィルム細菌叢生態系から見た齲蝕と歯周炎―予防のための「パラダイムシフト」― (2009)
  • Author(s): 高橋信博, 単独筆頭
  • Journal Title: 歯界展望「特集 未来歯科医学に向けて」 114(3) Pages: 564-568
• [Journal Article] 3.A longitudinal study of the relationship between diet intake and dental caries and periodontal disease in elderly Japanese subjects (2009)
  • Author(s): Hanada N, 4名中3番目
  • Journal Title: Gerodontology 26(2) Pages: 130-136
  • Peer Reviewed
• [Journal Article] Construction of a dental caries prediction model by data mining (2009)
  • Author(s): Hanada N, 8名中8番目
  • Journal Title: J Oral Sci 51(1) Pages: 61-68
  • NAID: 130000666181
  • Peer Reviewed
• [Journal Article] Longitudinal evaluation of multi-phasic, odontological and nutritional associations in dentists (LEMONADE Study) : study design and profile of nationwide cohort participants at baseline (2009)
  • Author(s): Hanada N, 8名中7番目
  • Journal Title: J Epidemiol 19(2) Pages: 72-80
  • NAID: 10027650444
  • Peer Reviewed
• [Journal Article] Relationship between root caries and alveolar bone loss in the first wet-rice agriculturalists of the Yayoi period in Japan (2009)
  • Author(s): Hanada N, 9名中7番目
  • Journal Title: Arch Oral Biol 54(2) Pages: 192-200
  • Peer Reviewed
• [Journal Article] E2F-1-deficient NOD/SCID mice developed showing decreased saliva production (2009)
  • Author(s): Senpuku H, 12名中12番目
  • Journal Title: Exp Biol Med (Maywood) 234(12) Pages: 1525-1536
  • Peer Reviewed
• [Journal Article] Inhibiting effects of Enterococcus faecium non-biofilm strain on Streptococcus mutans biofilm formation (2009)
  • Author(s): Senpuku H, 7名中7番目
  • Journal Title: J Microbiol Immunol Infect 42(3) Pages: 188-196
  • Peer Reviewed
• [Journal Article] Effects of IgY against Candida albicans and Candida spp. adherence and biofilm formation (2009)
  • Author(s): Senpuku H, 10名中10番目
  • Journal Title: Jpn J Infect Dis 62(5) Pages: 337-342
  • Peer Reviewed
• [Journal Article] The role of anti-PAc (361-386) peptide SIgA antibody in professional oral hygiene of the elderly (2009)
  • Author(s): Senpuku H, 5名中5番目
  • Journal Title: Gerodontology 26(4) Pages: 259-267
  • Peer Reviewed
• [Journal Article] Role of lysine in interaction between surface protein peptides of Streptococcus gordonii and agglutinin peptide (2009)
  • Author(s): Senpuku H, 5名中5番目
  • Journal Title: Oral Microbiol Immunol 24(2) Pages: 162-169
  • Peer Reviewed
• [Journal Article] Inhibiting effects of Streptococcus salivarius on competence-stimulating peptide-dependent biofilm formation by Streptococcus mutans (2009)
  • Author(s): Senpuku H, 8名中8番目
  • Journal Title: Oral Microbiol Immunol 24(2) Pages: 152-161
  • Peer Reviewed
• [Journal Article] E2F1-deficient NOD/SCID mice are an experimental model for dry mouth (2009)
  • Author(s): Senpuku H, 6名中5番目
  • Journal Title: J Med Invest 56 Suppl Pages: 260-261
  • NAID: 130004822609
  • Peer Reviewed
• [Journal Article] Parabacteroides gordonii sp. nov., isolated from human blood cultures (2009)
  • Author(s): Sakamoto M, 7名中筆頭
  • Journal Title: Int J Syst Evol Microbiol 59(Pt 11) Pages: 2843-2847
  • Peer Reviewed
• [Journal Article] Butyricimonas synergistica gen. nov., sp. nov. and Butyricimonas virosa sp. nov., butyric acid-producing bacteria in the family 'Porphyromonadaceae' isolated from rat faeces (2009)
  • Author(s): Sakamoto M, 6名中筆頭
  • Journal Title: Int J Syst Evol Microbiol 59(7) Pages: 1748-1753
  • Peer Reviewed
• [Journal Article] Diversity of spirochetes in endodontic infections (2009)
  • Author(s): Sakamoto M, 4名中筆頭
  • Journal Title: J Clin Microbiol 47(5) Pages: 1352-1357
  • Peer Reviewed
• [Journal Article] Prevotella falsenii sp. nov., a Prevotella intermedia-like organism isolated from monkey dental plaque (2009)
  • Author(s): Sakamoto M, 7名中筆頭
  • Journal Title: Int J Syst Evol Microbiol 59(2) Pages: 319-322
  • Peer Reviewed
• [Journal Article] Fluoride released from glass-ionomer cement is responsible to inhibit the acid production of caries-related oral streptococci (2009)
  • Author(s): Kazuko Nakajo
  • Journal Title: Dent Mater 25 Pages: 703-708
  • Peer Reviewed
• [Journal Article] Transient acid-impairment of growth ability of oral Streptococcus, Actinomyces, and Lactobacillus : a possible ecological determinant in dental plaque (2009)
  • Author(s): Masahiko Horiuchi
  • Journal Title: Oral Microbiol Immunol 24 Pages: 319-324
  • Peer Reviewed
• [Journal Article] Effects of alpha-amylase and its inhibitors on acid production from cooked starch by oral streptococci (2009)
  • Author(s): Aizawa S
  • Journal Title: Caries Res 43 Pages: 17-24
  • Peer Reviewed
• [Journal Article] Fluoride released from glass-ionomer cement is responsible to inhibit the acid production of caries-related oral streptococci (2009)
  • Author(s): Nakajo K
  • Journal Title: Dental Materials 25(印刷中)
  • Peer Reviewed
• [Journal Article] Caries ecology revisited : microbial dynamics and the caries process (2008)
  • Author(s): Takahashi N, 2名中筆頭
  • Journal Title: Caries Res 42(6) Pages: 409-418
  • Peer Reviewed
• [Journal Article] Chairside-evaluation of pH-lowering activity and lactic acid production of dental plaque : Correlation with caries-experience and incidence in preschool children (2008)
  • Author(s): Takahashi N, 3名中3番目
  • Journal Title: Quintessence Int 39(2) Pages: 151-158
  • Peer Reviewed
• [Journal Article] Mutual induction of noncollagenous bone proteins at the interface between epithelial cells and fibroblasts from human periodontal ligament (2008)
  • Author(s): Takahashi N, 6名中4番目
  • Journal Title: J Periodontal Res 43(1) Pages: 64-75
  • Peer Reviewed
• [Journal Article] 歯の健康力, う蝕予防ツールとしてのトクホ食品―これまでとこれから― (2008)
  • Author(s): 高橋信博, 単独筆頭
  • Journal Title: Food Style 21 Pages: 26-29
• [Journal Article] Longitudinal study on the relationship between serum albumin and periodontal disease (2008)
  • Author(s): Hanada N, 6名中5番目
  • Journal Title: J Clin Periodontol 35(4) Pages: 291-296
  • Peer Reviewed
• [Journal Article] Heparin inhibits osteoclastic differentiation and function (2008)
  • Author(s): Koseki T, 8名中7番目
  • Journal Title: J Cell Biochem 103(6) Pages: 1707-1717
  • Peer Reviewed
• [Journal Article] Role of activated natural killer cells in oral diseases (2008)
  • Author(s): Senpuku H, 5名中5番目
  • Journal Title: Jpn J Infect Dis 61(6) Pages: 469-474
  • Peer Reviewed
• [Journal Article] Differential expression of the Smb bacteriocin in Streptococcus mutans isolates (2008)
  • Author(s): Senpuku H, 8名中8番目
  • Journal Title: Antimicrob Agents Chemother 52(8) Pages: 2742-2749
  • Peer Reviewed
• [Journal Article] Opr86 is essential for viability and is a potential candidate for a protective antigen against biofilm formation by Pseudomonas aeruginosa (2008)
  • Author(s): Senpuku H, 10名中4番目
  • Journal Title: J Bacteriol 190(11) Pages: 3969-3978
  • Peer Reviewed
• [Journal Article] Impact of routine oral care on opportunistic pathogens in the institutionalized elderly (2008)
  • Author(s): Senpuku H, 5名中2番目
  • Journal Title: J Med Dent Sci 55(1) Pages: 7-13
  • NAID: 110006826895
  • Peer Reviewed
• [Journal Article] Glycosylation of the OMP85 homolog of Porphyromonas gingivalis and its involvement in biofilm formation (2008)
  • Author(s): Senpuku H, 8名中8番目
  • Journal Title: Biochem Biophys Res Commun 365(4) Pages: 784-789
  • Peer Reviewed
• [Journal Article] Molecular analysis of the root canal microbiota associated with endodontic treatment failures (2008)
  • Author(s): Sakamoto M, 4名中筆頭
  • Journal Title: Oral Microbiol Immunol 23(4) Pages: 275-281
  • Peer Reviewed
• [Journal Article] Caries ecology revisited : microbial dynamics and the caries process (2008)
  • Author(s): Takahashi N
  • Journal Title: Caries Res 42 Pages: 409-418
  • Peer Reviewed
• [Journal Article] Chairside-evaluation of pH-lowering activity and lactic acid production of dental plaque: Correlation with caries-experience and incidence in preschool children (2008)
  • Author(s): Shimizu K
  • Journal Title: Quintessence Int 39 Pages: 151-158
  • Peer Reviewed
• [Journal Article] Mutual induction of noncollagenous bone proteins at the interface between epithelial cells and fibroblasts from human periodontal ligament (2008)
  • Author(s): Shimonishi M
  • Journal Title: J Periodontal Res 43 Pages: 64-75
  • Peer Reviewed
• [Journal Article] In vitro differentiation of epithelial cells cultured from human periodontal ligament (2007)
  • Author(s): Takahashi N, 7名中4番目
  • Journal Title: J Periodontal Res 42(5) Pages: 456-465
  • Peer Reviewed
• [Journal Article] Profiling of bacterial flora in crevices around titanium orthodontic anchor plates (2007)
  • Author(s): Sato T, 5名中2番目, Takahashi N, 5名中5番目
  • Journal Title: Clin Oral Implants Res 18(1) Pages: 21-26
  • Peer Reviewed
• [Journal Article] Nested PCR for the sensitive detection of cariogenic bacteria (2007)
  • Author(s): Sato T, 6名中筆頭, Takahashi N, 6名中6番目
  • Journal Title: Cariology Today 3-4 Pages: 17-20
  • Peer Reviewed
• [Journal Article] Surface properties of resin composite materials relative to biofilm formation (2007)
  • Author(s): Hanada N, 7名中5番目
  • Journal Title: Dent Mater J 26(5) Pages: 613-622
  • NAID: 110006402818
  • Peer Reviewed
• [Journal Article] Renal function and periodontal disease in elderly Japanese (2007)
  • Author(s): Hanada N, 4名中3番目
  • Journal Title: J Periodontol 78(7) Pages: 1241-1248
  • Peer Reviewed
• [Journal Article] Effects of oral care on development of oral mucositis and microorganisms in patients with esophageal cancer (2007)
  • Author(s): Senpuku H, 7名中5番目
  • Journal Title: Jpn J Infect Dis 60(1) Pages: 23-28
  • Peer Reviewed
• [Journal Article] A new portable sulfide monitor with a zinc-oxide semiconductor sensor for daily use and field study (2007)
  • Author(s): Koseki T, 6名中5番目
  • Journal Title: J Dent. 35(7) Pages: 552-7
  • Peer Reviewed
• [Journal Article] Potential role of high molecular weight hyaluronan in the anti-Candida activity of human oral epithelial cells (2007)
  • Author(s): Koseki T, 8名中6番目
  • Journal Title: Med Mycol 45(1) Pages: 73-79
  • Peer Reviewed
• [Journal Article] Role of salivary tumour necrosis factor alpha in HIV-positive patients with oral manifestations (2007)
  • Author(s): Senpuku H, 6名中6番目
  • Journal Title: Int J STD AIDS 18(8) Pages: 565-569
  • Peer Reviewed
• [Journal Article] Relationships of anti-PAc (361-386) peptide salivary IgA antibody, eosinophils and basophils with periodontal status in the elderly (2007)
  • Author(s): Senpuku H, 7名中筆頭
  • Journal Title: FEMS Immunol Med Microbiol 49(1) Pages: 84-90
  • Peer Reviewed
• [Journal Article] Prevotella pleuritidis sp. nov., isolated from pleural fluid (2007)
  • Author(s): Sakamoto M, 6名中筆頭
  • Journal Title: Int J Syst Evol Microbiol 57(8) Pages: 1725-1728
  • Peer Reviewed
• [Journal Article] Bacteroides coprophilus sp. nov., isolated from human faeces (2007)
  • Author(s): Sakamoto M, 6名中4番目
  • Journal Title: Int J Syst Evol Microbiol 57(6) Pages: 1323-1326
  • Peer Reviewed
• [Journal Article] Prevotella copri sp. nov. and Prevotella stercorea sp. nov., isolated from human faeces (2007)
  • Author(s): Sakamoto M, 5名中3番目
  • Journal Title: Int J Syst Evol Microbiol 57(5) Pages: 941-946
  • Peer Reviewed
• [Journal Article] Barnesiella viscericola gen. nov., sp. nov., a novel member of the family Porphyromonadaceae isolated from chicken caecum (2007)
  • Author(s): Sakamoto M, 3名中筆頭
  • Journal Title: Int J Syst Evol Microbiol 57(2) Pages: 342-346
  • Peer Reviewed
• [Journal Article] Parabacteroides johnsonii sp. nov., isolated from human faeces (2007)
  • Author(s): Sakamoto M, 3名中筆頭
  • Journal Title: Int J Syst Evol Microbiol 57(2) Pages: 293-296
  • Peer Reviewed
• [Journal Article] Bacterial reduction and persistence after endodontic treatment procedures (2007)
  • Author(s): Sakamoto M, 4名中筆頭
  • Journal Title: Oral Microbiol Immunol 22(1) Pages: 19-23
  • Peer Reviewed
• [Journal Article] Profiling of bacterial flora in crevices around titanium orthodontic anchor plates (2007)
  • Author(s): Sato R
  • Journal Title: Clin Oral Implants Res 18 Pages: 21-26
  • Peer Reviewed
• [Journal Article] In vitro differentiation of epithelialcells cultured from human periodontal ligament (2007)
  • Author(s): Shimonishi M
  • Journal Title: J Periodontal Res 42 Pages: 456-465
  • Peer Reviewed
• [Presentation] ISFETによるバイオフィルム-マテリアルインターフェイス環境測定 (2010)
  • Author(s): 真柳弦
  • Organizer: 第5回高機能インターフェイス科学カンファレンス
  • Place of Presentation: 仙台
  • Year and Date: 2010-03-14
• [Presentation] 特定保健用食品開発(う蝕)の課題と展望 (2009)
  • Author(s): 高橋信博
  • Organizer: 2009年JADRシンポジウム「特定保健用食品と口腔保健」
  • Place of Presentation: 横浜
  • Year and Date: 2009-11-21
• [Presentation] CE-TOFMSを用いたプラークバイオフィルムの糖代謝メタボローム解析 (2009)
  • Author(s): 鷲尾純平, 高橋信博, 2名中2番目
  • Organizer: 第58回日本口腔衛生学会・総会
  • Place of Presentation: 岐阜
  • Year and Date: 2009-10-10
• [Presentation] CE-TOFMSを用いたプラークバイオフィルムの糖代謝メタボローム解析 (2009)
  • Author(s): 鷲尾純平
  • Organizer: 第58回日本口腔衛生学会
  • Place of Presentation: 岐阜
  • Year and Date: 2009-10-10
• [Presentation] 齲蝕学-過去・現在・未来- (2009)
  • Author(s): 高橋信博
  • Organizer: 第58回日本口腔衛生学会(自由集会2)
  • Place of Presentation: 岐阜
  • Year and Date: 2009-10-09
• [Presentation] CE-TOFMSを用いた Streptococcus mutans および Actinomyces naeslundii の糖代謝メタボローム解析 (2009)
  • Author(s): 鷲尾純平, 高橋信博, 3名中3番目
  • Organizer: 第51回歯科基礎医学会学術大会
  • Place of Presentation: 新潟
  • Year and Date: 2009-09-10
• [Presentation] CE-TOFMSを用いたStreptococcus mutansおよびActinomyces naeslundiiの糖代謝メタボローム解析 (2009)
  • Author(s): 鷲尾純平
  • Organizer: 第51回歯科基礎医学会学術大会
  • Place of Presentation: 新潟
  • Year and Date: 2009-09-10
• [Presentation] 口腔バイオフィルムのメタボローム解析の試み～何がいるかから、何をしているかへ～ (2009)
  • Author(s): 鷲尾純平, 高橋信博, 3名中3番目
  • Organizer: 第51回歯科基礎医学会学術大会サテライトシンポジウム
  • Place of Presentation: 新潟
  • Year and Date: 2009-09-09
• [Presentation] Metabolic activity of oral microbial ecosystem in health and disease (2009)
  • Author(s): Takahashi N, 単独筆頭
  • Organizer: The 1st Tohoku-Forsyth Symposium
  • Place of Presentation: Boston, USA
  • Year and Date: 2009-03-10
• [Presentation] Metabolic activity of oral microbial ecosystem in health and disease (2009)
  • Author(s): Takahashi N
  • Organizer: The 1st Tohoku-Forsyth Symposium
  • Place of Presentation: ボストン(アメリカ)
  • Year and Date: 2009-03-10
• [Presentation] インターフェイス口腔健康科学とは (2009)
  • Author(s): 高橋信博
  • Organizer: 第54回東北大学歯学会
  • Place of Presentation: 仙台
  • Year and Date: 2009-02-27
• [Presentation] Interface Oral Health Science-A concept of future dental research from Tohoku University Graduate School of Dentistry- (2009)
  • Author(s): Takahashi N
  • Organizer: 第3回インターフェイス口腔健康科学国際シンポジウム
  • Place of Presentation: 名古屋
  • Year and Date: 2009-01-15
• [Presentation] う蝕関連口腔細菌の糖代謝メタボローム解析 : 糖代謝機能の類似と相違 (2009)
  • Author(s): 鷲尾純平, 高橋信博, 3名中3番目
  • Organizer: 第82回日本生化学大会
  • Place of Presentation: 神戸
• [Presentation] Short-term inhibition of plaque acidogenicity by NaF-mouthrinse and fluoride retention within dental plaque (2009)
  • Author(s): Takahashi N, 6名中筆頭, Nakajo K, Asanoumi T, Shibata A, Yagishita Y, Washio J
  • Organizer: ORCA 2009
  • Place of Presentation: Budapest, Hungary
• [Presentation] う蝕関連口腔細菌の糖代謝メタボローム解析:糖代謝機能の類似と相違 (2009)
  • Author(s): 鷲尾純平
  • Organizer: 第82回日本生化学大会
  • Place of Presentation: 神戸
• [Presentation] Ecological dynamics of caries-associated oral biofilm : involvement of mutans streptococci and non-mutans bacteria, Symposium 1 "Oral Biofilm Today" (2008)
  • Author(s): Takahashi N, 単独筆頭
  • Organizer: The 56th Annual Meeting of Japanese Association for Dental Research
  • Place of Presentation: Nagoya
  • Year and Date: 2008-11-29
• [Presentation] Ecological dynamics of caries-associated oral biofilm : involvement of mutans streptococci and non-mutans bacteria (2008)
  • Author(s): Takahashi N
  • Organizer: 第56回国際歯科研究学会日本部会(シンポジウム1)
  • Place of Presentation: 名古屋
  • Year and Date: 2008-11-29
• [Presentation] Plaque pH telemetry method of tooth friendly international and Japanese dental FOSHU (2008)
  • Author(s): Takahashi N, 単独筆頭
  • Organizer: Workshop on Oral Health
  • Place of Presentation: 北京, 中国
  • Year and Date: 2008-11-10
• [Presentation] Plaque pH telemetry method of tooth friendly international and Jananese dental FOSHU (2008)
  • Author(s): Takahashi N
  • Organizer: Workshop on Oral Health
  • Place of Presentation: 北京
  • Year and Date: 2008-11-10
• [Presentation] 細菌代謝コントロールによる口腔疾患予防戦略-フッ化物が有する静菌作用とその生化学的メカニズム- (2008)
  • Author(s): 中條和子
  • Organizer: 第50回歯科基礎医学会学術大会サテライトシンポジウム
  • Place of Presentation: 東京
  • Year and Date: 2008-09-23
• [Presentation] う蝕予防ツールとしてのトクホ食品〜これまでとこれから〜 (2008)
  • Author(s): 高橋信博
  • Organizer: 第13回国際食品素材/添加物展・会議
  • Place of Presentation: 東京
  • Year and Date: 2008-05-23
• [Presentation] 口腔環境中の乳酸はVeillonellαの硫化水素産生を促進する (2007)
  • Author(s): 鷲尾純平
  • Organizer: 第56回日本口腔衛生学会
  • Place of Presentation: 千葉
  • Year and Date: 2007-10-04
• [Presentation] 口腔Veillonellaはcystathionine β-synthase様活性を持ちシステインから硫化水素を産生する (2007)
  • Author(s): 鷲尾純平
  • Organizer: 第49回歯科基礎医学会学術大会
  • Place of Presentation: 札幌
  • Year and Date: 2007-08-30
• [Presentation] 舌苔と口臭―舌苔常在細菌の口臭産生への関与― (2007)
  • Author(s): 鷲尾純平, 佐藤拓一, 4名中2番目, 高橋信博, 4名中4番目
  • Organizer: 第49回歯科基礎医学会学術大会サテライトシンポジウム
  • Place of Presentation: 札幌
  • Year and Date: 2007-08-29
• [Presentation] Effects of pH and lactate on the production of hydrogen sulfide by oral Veillonella (2007)
  • Author(s): Washo J
  • Organizer: 7th International Conference of the International Society for Breath Odor Research
  • Place of Presentation: 米国シカゴ
  • Year and Date: 2007-08-23
• [Presentation] 舌苔構成細菌と口臭―舌苔常在菌による口臭の産生― (2007)
  • Author(s): 鷲尾純平, 高橋信博, 2名中2番目
  • Organizer: 口鼻臭臨床研究会 第2回学術集会シンポジウム
  • Place of Presentation: 名古屋
  • Year and Date: 2007-06-24
• [Presentation] 東北地方の地域歯科保健推進に向けた東北大学の取り組み―東北大学地域歯科保健推進室の設置― (2007)
  • Author(s): 小関健由, 8名中筆頭, 高橋信博, 8名中3番目
  • Organizer: 第19回日本口腔衛生学会・東北地方会
  • Place of Presentation: 仙台
  • Year and Date: 2007-05-26
• [Book] Interface Oral Health Science 2009(T. Sasano and O. Suzuki (eds.)) (2010)
  • Author(s): Takahashi N, 5名中3番目
  • Publisher: Springer
• [Book] Interface Oral Health Science 2009(T. Sasano and O. Suzuki (eds.)) (2010)
  • Author(s): Takahashi N, 6名中6番目
  • Publisher: Springer
• [Book] Interface Oral Health Science 2009(T. Sasano and O. Suzuki (eds.)) (2010)
  • Author(s): Takahashi N, 4名中4番目
  • Publisher: Springer
• [Book] Interface Oral Health Science 2009(T. Sasano and O. Suzuki (eds.)) (2010)
  • Author(s): Takahashi N, 5名中5番目
  • Publisher: Springer
• [Book] クイズう蝕&歯周病の基礎知識100 (2009)
  • Author(s): 高橋信博(監修 : 伊藤中編集 : 渡部勝/長山和枝)
  • Publisher: クインテッセンス出版株式会社
• [Book] う蝕学―チェアサイドの予防と回復のプログラム―, (田上順次, 花田信弘, 桃井保子(編)) (2008)
  • Author(s): 高橋信博, 単独筆頭
  • Publisher: 永末書店
• [Book] シンプル生化学改訂第5版,(林典夫, 廣野治子(編)) (2008)
  • Author(s): 高橋信博, 単独筆頭
  • Publisher: 南江堂
• [Book] う蝕学-チェアサイドの予防と回復のプログラム- (2008)
  • Author(s): 高橋信博
  • Publisher: 末長書店
• [Book] Interface Oral Health Science 2007(M. Watanabe and O. Okuno (eds.)) (2007)
  • Author(s): Takahashi N, 3名中3番目
  • Publisher: Springer
• [Book] Interface Oral Health Science 2007(M. Watanabe and O. Okuno (eds.)) (2007)
  • Author(s): Takahashi N, 5名中5番目
  • Publisher: Springer
• [Book] Interface Oral Health Science 2007(M. Watanabe and O. Okuno (eds.)) (2007)
  • Author(s): Takahashi N, 4名中4番目
  • Publisher: Springer
• [Book] Interface Oral Health Science 2007(M. Watanabe and O. Okuno (eds.)) (2007)
  • Author(s): Takahashi N, 6名中6番目
  • Publisher: Springer
• [Book] Interface Oral Health Science 2007(M. Watanabe and O. Okuno (eds.)) (2007)
  • Author(s): Sato T, 4名中2番目, Takahashi N, 4名中4番目
  • Publisher: Springer
• [Book] Interface Oral Health Science 2007 (2007)
  • Author(s): Washio J
  • Publisher: Springer, Tokyo
• [Book] Interface Oral Health Science 2007 (2007)
  • Author(s): Abiko Y
  • Publisher: Springer, Tokyo
• [Book] Interface Oral Health Science 2007 (2007)
  • Author(s): Matsuyama J
  • Publisher: Springer, Tokyo
• [Book] Interface Oral Health Science 2007 (2007)
  • Author(s): Miyasawa-Hori H
  • Publisher: Springer, Tokyo
• [Book] Interface Oral Health Science 2007 (2007)
  • Author(s): Aizawa S
  • Publisher: Springer, Tokyo
• [Book] Interface Oral Health Science 2007 (2007)
  • Author(s): Nakajo K
  • Publisher: Springer, Tokyo
• [Book] Interface Oral Health Science 2007 (2007)
  • Author(s): Ito Y
  • Publisher: Springer, Tokyo
• [Book] Interface Oral Health Science 2007 (2007)
  • Author(s): Sato T
  • Publisher: Springer, Tokyo
• [Book] Interface Oral Health Science 2007 (2007)
  • Author(s): Masaki M
  • Publisher: Springer, Tokyo
• [Book] Interface Oral Health Science 2007 (2007)
  • Author(s): Miyoshi Y
  • Publisher: Springer, Tokyo
• [Remarks] ホームページ等
• [Patent(Industrial Property Rights)] バイオフィルム抑制型抗菌性チタン合金 (2008)
  • Inventor(s): 高橋正敏, 中條和子, 奥野攻, 高橋信博, 菊地聖史, 高田雄京, 佐々木啓一
  • Industrial Property Rights Holder: 高橋正敏, 中條和子, 奥野攻, 高橋信博, 菊地聖史, 高田雄京, 佐々木啓一
  • Industrial Property Number: 2008-294012
  • Filing Date: 2008-11-18