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Metabolome analysis of oral biofilm using CE-TOFMS and its application possibility as an oral health indicator

Research Project

Project/Area Number 19390539
Research Category

Grant-in-Aid for Scientific Research (B)

Allocation TypeSingle-year Grants
Section一般
Research Field Social dentistry
Research InstitutionTohoku University

Principal Investigator

TAKAHASHI Nobuhiro  Tohoku University, 大学院・歯学研究科, 教授 (60183852)

Co-Investigator(Kenkyū-buntansha) HANADA Nobuhiro  鶴見大学, 歯学部, 教授 (70180916)
KOSEKI Takeyoshi  東北大学, 大学院・歯学研究科, 教授 (80291128)
SENPUKU Hidenobu  国立感染症研究所, 細菌第一部, 室長 (20250186)
SATO Takuichi  東北大学, 大学院・歯学研究科, 講師 (10303132)
SAKAMOTO Mitsuo  独立行政法人理化学研究所, 微生物材料開発室, 協力研究員 (50321766)
Project Period (FY) 2007 – 2009
Project Status Completed (Fiscal Year 2009)
Budget Amount *help
¥15,470,000 (Direct Cost: ¥11,900,000、Indirect Cost: ¥3,570,000)
Fiscal Year 2009: ¥3,120,000 (Direct Cost: ¥2,400,000、Indirect Cost: ¥720,000)
Fiscal Year 2008: ¥2,990,000 (Direct Cost: ¥2,300,000、Indirect Cost: ¥690,000)
Fiscal Year 2007: ¥9,360,000 (Direct Cost: ¥7,200,000、Indirect Cost: ¥2,160,000)
Keywords歯学 / バイオフィルム / メタボローム / 微生物 / 微生物叢
Research Abstract

Metabolome analysis for the representative plaque bacteria and human oral biofilm using a capillary electrophoresis equipped with a time-of-flight mass spectrometer was established. By this method, a new finding was obtained about the pentose-phosphate pathway and the Kreb's tricarboxylic acid cycle, as well as the Embden-Meyerhof-Parnas pathway. In addition, the metabolome analysis was applicable to a very small amount of oral biofilm. These results suggest that the metabolome data can be used as an indicator of oral health status.

Report

(4 results)
  • 2009 Annual Research Report   Final Research Report ( PDF )
  • 2008 Annual Research Report
  • 2007 Annual Research Report
  • Research Products

    (127 results)

All 2010 2009 2008 2007 Other

All Journal Article (75 results) (of which Peer Reviewed: 63 results) Presentation (27 results) Book (23 results) Remarks (1 results) Patent(Industrial Property Rights) (1 results)

  • [Journal Article] Metabolomics of supragingival plaque and oral bacteria2010

    • Author(s)
      Takahashi N, 3名中筆頭
    • Journal Title

      J Dent Res (印刷中)

    • Related Report
      2009 Final Research Report
    • Peer Reviewed
  • [Journal Article] Profiling of subgingival plaque biofilm microflora from periodontally healthy subjects and from subjects with periodontitis using quantitative real-time PCR2010

    • Author(s)
      Sato T, 4名中2番目, Takahashi N, 4名中4番目
    • Journal Title

      J Periodontal Res 45(3)

      Pages: 389-395

    • Related Report
      2009 Final Research Report
    • Peer Reviewed
  • [Journal Article] Tooth loss and intakes of nutrients and foods : a nationwide survey of Japanese dentists2010

    • Author(s)
      Hanada N, 9名中8番目
    • Journal Title

      Community Dent Oral Epidemiol 38(1)

      Pages: 43-49

    • Related Report
      2009 Final Research Report
    • Peer Reviewed
  • [Journal Article] Unique functions of hydroxyapatite with mutans streptococci adherence2010

    • Author(s)
      Hanada N, 9名中7番目, Senpuku H, 9名中9番目
    • Journal Title

      Quintessence Int 41(1)

    • Related Report
      2009 Final Research Report
    • Peer Reviewed
  • [Journal Article] Hsp60 and 16S rRNA gene sequence relationships among species of the genus Bacteroides with the finding that Bacteroides suis and Bacteroides tectus are heterotypic synonyms of Bacteroides pyogenes2010

    • Author(s)
      Sakamoto M, 3名中筆頭
    • Journal Title

      Int J Syst Evol Microbiol (in press)

    • Related Report
      2009 Final Research Report
    • Peer Reviewed
  • [Journal Article] Slackia equolifaciens sp. nov., a human intestinal bacterium capable of producing equol2010

    • Author(s)
      Sakamoto M, 5名中3番目
    • Journal Title

      Int J Syst Evol Microbiol (in press)

    • Related Report
      2009 Final Research Report
    • Peer Reviewed
  • [Journal Article] Prevotella aurantiaca sp. nov., isolated from the human oral cavity2010

    • Author(s)
      Sakamoto M, 3名中筆頭
    • Journal Title

      Int J Syst Evol Microbiol 60(3)

      Pages: 500-503

    • Related Report
      2009 Final Research Report
    • Peer Reviewed
  • [Journal Article] Lactobacillus similis sp. nov., isolated from fermented cane molasses2010

    • Author(s)
      Sakamoto M, 3名中2番目
    • Journal Title

      Int J Syst Evol Microbiol 60(1)

      Pages: 187-190

    • Related Report
      2009 Final Research Report
    • Peer Reviewed
  • [Journal Article] Profiling of subgingival plaque biofilm microflora from periodontally healthy subjects and from subjects with periodontitis using quantitative real-time PCR2010

    • Author(s)
      Yuki Abiko
    • Journal Title

      J Periodontal Res 45(印刷中)

    • Related Report
      2009 Annual Research Report
    • Peer Reviewed
  • [Journal Article]2010

    • Author(s)
      Yoko Sakuma
    • Journal Title

      Interface Oral Health Science 2009(Springer, New York)

      Pages: 215-216

    • Related Report
      2009 Annual Research Report
  • [Journal Article]2010

    • Author(s)
      Yasuhisa Takeuchi
    • Journal Title

      Interface Oral Health Science 2009(Springer, New York)

      Pages: 230-231

    • Related Report
      2009 Annual Research Report
  • [Journal Article]2010

    • Author(s)
      Yuki Abiko
    • Journal Title

      Interface Oral Health Science 2009(Springer, New York)

      Pages: 240-242

    • Related Report
      2009 Annual Research Report
  • [Journal Article]2010

    • Author(s)
      Kazuhiro Hashimoto
    • Journal Title

      Interface Oral Health Science 2009(Springer, New York)

      Pages: 243-244

    • Related Report
      2009 Annual Research Report
  • [Journal Article]2010

    • Author(s)
      Ryo Komori
    • Journal Title

      Interface Oral Health Science 2009(Springer, New York)

      Pages: 248-249

    • Related Report
      2009 Annual Research Report
  • [Journal Article]2010

    • Author(s)
      Jumpei Washio
    • Journal Title

      Interface Oral Health Science 2009(Springer, New York)

      Pages: 250-251

    • Related Report
      2009 Annual Research Report
  • [Journal Article]2010

    • Author(s)
      Kazuko Nakajo
    • Journal Title

      Interface Oral Health Science 2009(Springer, New York)

      Pages: 267-268

    • Related Report
      2009 Annual Research Report
  • [Journal Article]2010

    • Author(s)
      Hitomi Domon
    • Journal Title

      Interface Oral Health Science 2009(Springer, New York)

      Pages: 269-270

    • Related Report
      2009 Annual Research Report
  • [Journal Article]2010

    • Author(s)
      Takuichi Sato
    • Journal Title

      Interface Oral Health Science 2009(Springer, New York)

      Pages: 273-274

    • Related Report
      2009 Annual Research Report
  • [Journal Article]2010

    • Author(s)
      Masatoshi Takahashi
    • Journal Title

      Interface Oral Health Science 2009(Springer, New York)

      Pages: 283-285

    • Related Report
      2009 Annual Research Report
  • [Journal Article] Transient acid-impairment of growth ability of oral Streptococcus, Actinomyces, and Lactobacillus: a possible ecological determinant in dental plaque2009

    • Author(s)
      Takahashi N, 4名中4番目
    • Journal Title

      Oral Microbiol Immunol 24(4)

      Pages: 319-324

    • Related Report
      2009 Final Research Report
    • Peer Reviewed
  • [Journal Article] Fluoride released from glass-ionomer cement is responsible to inhibit the acid production of caries-related oral streptococci2009

    • Author(s)
      Takahashi N, 6名中6番目
    • Journal Title

      Dent Mater 25(6)

      Pages: 703-708

    • Related Report
      2009 Final Research Report
    • Peer Reviewed
  • [Journal Article] Effects of alpha-amylase and its inhibitors on acid production from cooked starch by oral streptococci2009

    • Author(s)
      Takahashi N, 7名中7番目
    • Journal Title

      Caries Res 43(1)

      Pages: 17-24

    • Related Report
      2009 Final Research Report
    • Peer Reviewed
  • [Journal Article] 口腔バイオフィルム細菌叢生態系から見た齲蝕と歯周炎―予防のための「パラダイムシフト」―2009

    • Author(s)
      高橋信博, 単独筆頭
    • Journal Title

      歯界展望「特集 未来歯科医学に向けて」 114(3)

      Pages: 564-568

    • Related Report
      2009 Final Research Report
  • [Journal Article] 3.A longitudinal study of the relationship between diet intake and dental caries and periodontal disease in elderly Japanese subjects2009

    • Author(s)
      Hanada N, 4名中3番目
    • Journal Title

      Gerodontology 26(2)

      Pages: 130-136

    • Related Report
      2009 Final Research Report
    • Peer Reviewed
  • [Journal Article] Construction of a dental caries prediction model by data mining2009

    • Author(s)
      Hanada N, 8名中8番目
    • Journal Title

      J Oral Sci 51(1)

      Pages: 61-68

    • NAID

      130000666181

    • Related Report
      2009 Final Research Report
    • Peer Reviewed
  • [Journal Article] Longitudinal evaluation of multi-phasic, odontological and nutritional associations in dentists (LEMONADE Study) : study design and profile of nationwide cohort participants at baseline2009

    • Author(s)
      Hanada N, 8名中7番目
    • Journal Title

      J Epidemiol 19(2)

      Pages: 72-80

    • NAID

      10027650444

    • Related Report
      2009 Final Research Report
    • Peer Reviewed
  • [Journal Article] Relationship between root caries and alveolar bone loss in the first wet-rice agriculturalists of the Yayoi period in Japan2009

    • Author(s)
      Hanada N, 9名中7番目
    • Journal Title

      Arch Oral Biol 54(2)

      Pages: 192-200

    • Related Report
      2009 Final Research Report
    • Peer Reviewed
  • [Journal Article] E2F-1-deficient NOD/SCID mice developed showing decreased saliva production2009

    • Author(s)
      Senpuku H, 12名中12番目
    • Journal Title

      Exp Biol Med (Maywood) 234(12)

      Pages: 1525-1536

    • Related Report
      2009 Final Research Report
    • Peer Reviewed
  • [Journal Article] Inhibiting effects of Enterococcus faecium non-biofilm strain on Streptococcus mutans biofilm formation2009

    • Author(s)
      Senpuku H, 7名中7番目
    • Journal Title

      J Microbiol Immunol Infect 42(3)

      Pages: 188-196

    • Related Report
      2009 Final Research Report
    • Peer Reviewed
  • [Journal Article] Effects of IgY against Candida albicans and Candida spp. adherence and biofilm formation2009

    • Author(s)
      Senpuku H, 10名中10番目
    • Journal Title

      Jpn J Infect Dis 62(5)

      Pages: 337-342

    • Related Report
      2009 Final Research Report
    • Peer Reviewed
  • [Journal Article] The role of anti-PAc (361-386) peptide SIgA antibody in professional oral hygiene of the elderly2009

    • Author(s)
      Senpuku H, 5名中5番目
    • Journal Title

      Gerodontology 26(4)

      Pages: 259-267

    • Related Report
      2009 Final Research Report
    • Peer Reviewed
  • [Journal Article] Role of lysine in interaction between surface protein peptides of Streptococcus gordonii and agglutinin peptide2009

    • Author(s)
      Senpuku H, 5名中5番目
    • Journal Title

      Oral Microbiol Immunol 24(2)

      Pages: 162-169

    • Related Report
      2009 Final Research Report
    • Peer Reviewed
  • [Journal Article] Inhibiting effects of Streptococcus salivarius on competence-stimulating peptide-dependent biofilm formation by Streptococcus mutans2009

    • Author(s)
      Senpuku H, 8名中8番目
    • Journal Title

      Oral Microbiol Immunol 24(2)

      Pages: 152-161

    • Related Report
      2009 Final Research Report
    • Peer Reviewed
  • [Journal Article] E2F1-deficient NOD/SCID mice are an experimental model for dry mouth2009

    • Author(s)
      Senpuku H, 6名中5番目
    • Journal Title

      J Med Invest 56 Suppl

      Pages: 260-261

    • NAID

      130004822609

    • Related Report
      2009 Final Research Report
    • Peer Reviewed
  • [Journal Article] Parabacteroides gordonii sp. nov., isolated from human blood cultures2009

    • Author(s)
      Sakamoto M, 7名中筆頭
    • Journal Title

      Int J Syst Evol Microbiol 59(Pt 11)

      Pages: 2843-2847

    • Related Report
      2009 Final Research Report
    • Peer Reviewed
  • [Journal Article] Butyricimonas synergistica gen. nov., sp. nov. and Butyricimonas virosa sp. nov., butyric acid-producing bacteria in the family 'Porphyromonadaceae' isolated from rat faeces2009

    • Author(s)
      Sakamoto M, 6名中筆頭
    • Journal Title

      Int J Syst Evol Microbiol 59(7)

      Pages: 1748-1753

    • Related Report
      2009 Final Research Report
    • Peer Reviewed
  • [Journal Article] Diversity of spirochetes in endodontic infections2009

    • Author(s)
      Sakamoto M, 4名中筆頭
    • Journal Title

      J Clin Microbiol 47(5)

      Pages: 1352-1357

    • Related Report
      2009 Final Research Report
    • Peer Reviewed
  • [Journal Article] Prevotella falsenii sp. nov., a Prevotella intermedia-like organism isolated from monkey dental plaque2009

    • Author(s)
      Sakamoto M, 7名中筆頭
    • Journal Title

      Int J Syst Evol Microbiol 59(2)

      Pages: 319-322

    • Related Report
      2009 Final Research Report
    • Peer Reviewed
  • [Journal Article] Fluoride released from glass-ionomer cement is responsible to inhibit the acid production of caries-related oral streptococci2009

    • Author(s)
      Kazuko Nakajo
    • Journal Title

      Dent Mater 25

      Pages: 703-708

    • Related Report
      2009 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Transient acid-impairment of growth ability of oral Streptococcus, Actinomyces, and Lactobacillus : a possible ecological determinant in dental plaque2009

    • Author(s)
      Masahiko Horiuchi
    • Journal Title

      Oral Microbiol Immunol 24

      Pages: 319-324

    • Related Report
      2009 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Effects of alpha-amylase and its inhibitors on acid production from cooked starch by oral streptococci2009

    • Author(s)
      Aizawa S
    • Journal Title

      Caries Res 43

      Pages: 17-24

    • Related Report
      2008 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Fluoride released from glass-ionomer cement is responsible to inhibit the acid production of caries-related oral streptococci2009

    • Author(s)
      Nakajo K
    • Journal Title

      Dental Materials 25(印刷中)

    • Related Report
      2008 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Caries ecology revisited : microbial dynamics and the caries process2008

    • Author(s)
      Takahashi N, 2名中筆頭
    • Journal Title

      Caries Res 42(6)

      Pages: 409-418

    • Related Report
      2009 Final Research Report
    • Peer Reviewed
  • [Journal Article] Chairside-evaluation of pH-lowering activity and lactic acid production of dental plaque : Correlation with caries-experience and incidence in preschool children2008

    • Author(s)
      Takahashi N, 3名中3番目
    • Journal Title

      Quintessence Int 39(2)

      Pages: 151-158

    • Related Report
      2009 Final Research Report
    • Peer Reviewed
  • [Journal Article] Mutual induction of noncollagenous bone proteins at the interface between epithelial cells and fibroblasts from human periodontal ligament2008

    • Author(s)
      Takahashi N, 6名中4番目
    • Journal Title

      J Periodontal Res 43(1)

      Pages: 64-75

    • Related Report
      2009 Final Research Report
    • Peer Reviewed
  • [Journal Article] 歯の健康力, う蝕予防ツールとしてのトクホ食品―これまでとこれから―2008

    • Author(s)
      高橋信博, 単独筆頭
    • Journal Title

      Food Style 21

      Pages: 26-29

    • Related Report
      2009 Final Research Report
  • [Journal Article] Longitudinal study on the relationship between serum albumin and periodontal disease2008

    • Author(s)
      Hanada N, 6名中5番目
    • Journal Title

      J Clin Periodontol 35(4)

      Pages: 291-296

    • Related Report
      2009 Final Research Report
    • Peer Reviewed
  • [Journal Article] Heparin inhibits osteoclastic differentiation and function2008

    • Author(s)
      Koseki T, 8名中7番目
    • Journal Title

      J Cell Biochem 103(6)

      Pages: 1707-1717

    • Related Report
      2009 Final Research Report
    • Peer Reviewed
  • [Journal Article] Role of activated natural killer cells in oral diseases2008

    • Author(s)
      Senpuku H, 5名中5番目
    • Journal Title

      Jpn J Infect Dis 61(6)

      Pages: 469-474

    • Related Report
      2009 Final Research Report
    • Peer Reviewed
  • [Journal Article] Differential expression of the Smb bacteriocin in Streptococcus mutans isolates2008

    • Author(s)
      Senpuku H, 8名中8番目
    • Journal Title

      Antimicrob Agents Chemother 52(8)

      Pages: 2742-2749

    • Related Report
      2009 Final Research Report
    • Peer Reviewed
  • [Journal Article] Opr86 is essential for viability and is a potential candidate for a protective antigen against biofilm formation by Pseudomonas aeruginosa2008

    • Author(s)
      Senpuku H, 10名中4番目
    • Journal Title

      J Bacteriol 190(11)

      Pages: 3969-3978

    • Related Report
      2009 Final Research Report
    • Peer Reviewed
  • [Journal Article] Impact of routine oral care on opportunistic pathogens in the institutionalized elderly2008

    • Author(s)
      Senpuku H, 5名中2番目
    • Journal Title

      J Med Dent Sci 55(1)

      Pages: 7-13

    • NAID

      110006826895

    • Related Report
      2009 Final Research Report
    • Peer Reviewed
  • [Journal Article] Glycosylation of the OMP85 homolog of Porphyromonas gingivalis and its involvement in biofilm formation2008

    • Author(s)
      Senpuku H, 8名中8番目
    • Journal Title

      Biochem Biophys Res Commun 365(4)

      Pages: 784-789

    • Related Report
      2009 Final Research Report
    • Peer Reviewed
  • [Journal Article] Molecular analysis of the root canal microbiota associated with endodontic treatment failures2008

    • Author(s)
      Sakamoto M, 4名中筆頭
    • Journal Title

      Oral Microbiol Immunol 23(4)

      Pages: 275-281

    • Related Report
      2009 Final Research Report
    • Peer Reviewed
  • [Journal Article] Caries ecology revisited : microbial dynamics and the caries process2008

    • Author(s)
      Takahashi N
    • Journal Title

      Caries Res 42

      Pages: 409-418

    • Related Report
      2008 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Chairside-evaluation of pH-lowering activity and lactic acid production of dental plaque: Correlation with caries-experience and incidence in preschool children2008

    • Author(s)
      Shimizu K
    • Journal Title

      Quintessence Int 39

      Pages: 151-158

    • Related Report
      2007 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Mutual induction of noncollagenous bone proteins at the interface between epithelial cells and fibroblasts from human periodontal ligament2008

    • Author(s)
      Shimonishi M
    • Journal Title

      J Periodontal Res 43

      Pages: 64-75

    • Related Report
      2007 Annual Research Report
    • Peer Reviewed
  • [Journal Article] In vitro differentiation of epithelial cells cultured from human periodontal ligament2007

    • Author(s)
      Takahashi N, 7名中4番目
    • Journal Title

      J Periodontal Res 42(5)

      Pages: 456-465

    • Related Report
      2009 Final Research Report
    • Peer Reviewed
  • [Journal Article] Profiling of bacterial flora in crevices around titanium orthodontic anchor plates2007

    • Author(s)
      Sato T, 5名中2番目, Takahashi N, 5名中5番目
    • Journal Title

      Clin Oral Implants Res 18(1)

      Pages: 21-26

    • Related Report
      2009 Final Research Report
    • Peer Reviewed
  • [Journal Article] Nested PCR for the sensitive detection of cariogenic bacteria2007

    • Author(s)
      Sato T, 6名中筆頭, Takahashi N, 6名中6番目
    • Journal Title

      Cariology Today 3-4

      Pages: 17-20

    • Related Report
      2009 Final Research Report
    • Peer Reviewed
  • [Journal Article] Surface properties of resin composite materials relative to biofilm formation2007

    • Author(s)
      Hanada N, 7名中5番目
    • Journal Title

      Dent Mater J 26(5)

      Pages: 613-622

    • NAID

      110006402818

    • Related Report
      2009 Final Research Report
    • Peer Reviewed
  • [Journal Article] Renal function and periodontal disease in elderly Japanese2007

    • Author(s)
      Hanada N, 4名中3番目
    • Journal Title

      J Periodontol 78(7)

      Pages: 1241-1248

    • Related Report
      2009 Final Research Report
    • Peer Reviewed
  • [Journal Article] Effects of oral care on development of oral mucositis and microorganisms in patients with esophageal cancer2007

    • Author(s)
      Senpuku H, 7名中5番目
    • Journal Title

      Jpn J Infect Dis 60(1)

      Pages: 23-28

    • Related Report
      2009 Final Research Report
    • Peer Reviewed
  • [Journal Article] A new portable sulfide monitor with a zinc-oxide semiconductor sensor for daily use and field study2007

    • Author(s)
      Koseki T, 6名中5番目
    • Journal Title

      J Dent. 35(7)

      Pages: 552-7

    • Related Report
      2009 Final Research Report
    • Peer Reviewed
  • [Journal Article] Potential role of high molecular weight hyaluronan in the anti-Candida activity of human oral epithelial cells2007

    • Author(s)
      Koseki T, 8名中6番目
    • Journal Title

      Med Mycol 45(1)

      Pages: 73-79

    • Related Report
      2009 Final Research Report
    • Peer Reviewed
  • [Journal Article] Role of salivary tumour necrosis factor alpha in HIV-positive patients with oral manifestations2007

    • Author(s)
      Senpuku H, 6名中6番目
    • Journal Title

      Int J STD AIDS 18(8)

      Pages: 565-569

    • Related Report
      2009 Final Research Report
    • Peer Reviewed
  • [Journal Article] Relationships of anti-PAc (361-386) peptide salivary IgA antibody, eosinophils and basophils with periodontal status in the elderly2007

    • Author(s)
      Senpuku H, 7名中筆頭
    • Journal Title

      FEMS Immunol Med Microbiol 49(1)

      Pages: 84-90

    • Related Report
      2009 Final Research Report
    • Peer Reviewed
  • [Journal Article] Prevotella pleuritidis sp. nov., isolated from pleural fluid2007

    • Author(s)
      Sakamoto M, 6名中筆頭
    • Journal Title

      Int J Syst Evol Microbiol 57(8)

      Pages: 1725-1728

    • Related Report
      2009 Final Research Report
    • Peer Reviewed
  • [Journal Article] Bacteroides coprophilus sp. nov., isolated from human faeces2007

    • Author(s)
      Sakamoto M, 6名中4番目
    • Journal Title

      Int J Syst Evol Microbiol 57(6)

      Pages: 1323-1326

    • Related Report
      2009 Final Research Report
    • Peer Reviewed
  • [Journal Article] Prevotella copri sp. nov. and Prevotella stercorea sp. nov., isolated from human faeces2007

    • Author(s)
      Sakamoto M, 5名中3番目
    • Journal Title

      Int J Syst Evol Microbiol 57(5)

      Pages: 941-946

    • Related Report
      2009 Final Research Report
    • Peer Reviewed
  • [Journal Article] Barnesiella viscericola gen. nov., sp. nov., a novel member of the family Porphyromonadaceae isolated from chicken caecum2007

    • Author(s)
      Sakamoto M, 3名中筆頭
    • Journal Title

      Int J Syst Evol Microbiol 57(2)

      Pages: 342-346

    • Related Report
      2009 Final Research Report
    • Peer Reviewed
  • [Journal Article] Parabacteroides johnsonii sp. nov., isolated from human faeces2007

    • Author(s)
      Sakamoto M, 3名中筆頭
    • Journal Title

      Int J Syst Evol Microbiol 57(2)

      Pages: 293-296

    • Related Report
      2009 Final Research Report
    • Peer Reviewed
  • [Journal Article] Bacterial reduction and persistence after endodontic treatment procedures2007

    • Author(s)
      Sakamoto M, 4名中筆頭
    • Journal Title

      Oral Microbiol Immunol 22(1)

      Pages: 19-23

    • Related Report
      2009 Final Research Report
    • Peer Reviewed
  • [Journal Article] Profiling of bacterial flora in crevices around titanium orthodontic anchor plates2007

    • Author(s)
      Sato R
    • Journal Title

      Clin Oral Implants Res 18

      Pages: 21-26

    • Related Report
      2007 Annual Research Report
    • Peer Reviewed
  • [Journal Article] In vitro differentiation of epithelialcells cultured from human periodontal ligament2007

    • Author(s)
      Shimonishi M
    • Journal Title

      J Periodontal Res 42

      Pages: 456-465

    • Related Report
      2007 Annual Research Report
    • Peer Reviewed
  • [Presentation] ISFETによるバイオフィルム-マテリアルインターフェイス環境測定2010

    • Author(s)
      真柳弦
    • Organizer
      第5回高機能インターフェイス科学カンファレンス
    • Place of Presentation
      仙台
    • Year and Date
      2010-03-14
    • Related Report
      2009 Annual Research Report
  • [Presentation] 特定保健用食品開発(う蝕)の課題と展望2009

    • Author(s)
      高橋信博
    • Organizer
      2009年JADRシンポジウム「特定保健用食品と口腔保健」
    • Place of Presentation
      横浜
    • Year and Date
      2009-11-21
    • Related Report
      2009 Annual Research Report
  • [Presentation] CE-TOFMSを用いたプラークバイオフィルムの糖代謝メタボローム解析2009

    • Author(s)
      鷲尾純平, 高橋信博, 2名中2番目
    • Organizer
      第58回日本口腔衛生学会・総会
    • Place of Presentation
      岐阜
    • Year and Date
      2009-10-10
    • Related Report
      2009 Final Research Report
  • [Presentation] CE-TOFMSを用いたプラークバイオフィルムの糖代謝メタボローム解析2009

    • Author(s)
      鷲尾純平
    • Organizer
      第58回日本口腔衛生学会
    • Place of Presentation
      岐阜
    • Year and Date
      2009-10-10
    • Related Report
      2009 Annual Research Report
  • [Presentation] 齲蝕学-過去・現在・未来-2009

    • Author(s)
      高橋信博
    • Organizer
      第58回日本口腔衛生学会(自由集会2)
    • Place of Presentation
      岐阜
    • Year and Date
      2009-10-09
    • Related Report
      2009 Annual Research Report
  • [Presentation] CE-TOFMSを用いた Streptococcus mutans および Actinomyces naeslundii の糖代謝メタボローム解析2009

    • Author(s)
      鷲尾純平, 高橋信博, 3名中3番目
    • Organizer
      第51回歯科基礎医学会学術大会
    • Place of Presentation
      新潟
    • Year and Date
      2009-09-10
    • Related Report
      2009 Final Research Report
  • [Presentation] CE-TOFMSを用いたStreptococcus mutansおよびActinomyces naeslundiiの糖代謝メタボローム解析2009

    • Author(s)
      鷲尾純平
    • Organizer
      第51回歯科基礎医学会学術大会
    • Place of Presentation
      新潟
    • Year and Date
      2009-09-10
    • Related Report
      2009 Annual Research Report
  • [Presentation] 口腔バイオフィルムのメタボローム解析の試み~何がいるかから、何をしているかへ~2009

    • Author(s)
      鷲尾純平, 高橋信博, 3名中3番目
    • Organizer
      第51回歯科基礎医学会学術大会サテライトシンポジウム
    • Place of Presentation
      新潟
    • Year and Date
      2009-09-09
    • Related Report
      2009 Annual Research Report 2009 Final Research Report
  • [Presentation] Metabolic activity of oral microbial ecosystem in health and disease2009

    • Author(s)
      Takahashi N, 単独筆頭
    • Organizer
      The 1st Tohoku-Forsyth Symposium
    • Place of Presentation
      Boston, USA
    • Year and Date
      2009-03-10
    • Related Report
      2009 Final Research Report
  • [Presentation] Metabolic activity of oral microbial ecosystem in health and disease2009

    • Author(s)
      Takahashi N
    • Organizer
      The 1st Tohoku-Forsyth Symposium
    • Place of Presentation
      ボストン(アメリカ)
    • Year and Date
      2009-03-10
    • Related Report
      2008 Annual Research Report
  • [Presentation] インターフェイス口腔健康科学とは2009

    • Author(s)
      高橋信博
    • Organizer
      第54回東北大学歯学会
    • Place of Presentation
      仙台
    • Year and Date
      2009-02-27
    • Related Report
      2008 Annual Research Report
  • [Presentation] Interface Oral Health Science-A concept of future dental research from Tohoku University Graduate School of Dentistry-2009

    • Author(s)
      Takahashi N
    • Organizer
      第3回インターフェイス口腔健康科学国際シンポジウム
    • Place of Presentation
      名古屋
    • Year and Date
      2009-01-15
    • Related Report
      2008 Annual Research Report
  • [Presentation] う蝕関連口腔細菌の糖代謝メタボローム解析 : 糖代謝機能の類似と相違2009

    • Author(s)
      鷲尾純平, 高橋信博, 3名中3番目
    • Organizer
      第82回日本生化学大会
    • Place of Presentation
      神戸
    • Related Report
      2009 Final Research Report
  • [Presentation] Short-term inhibition of plaque acidogenicity by NaF-mouthrinse and fluoride retention within dental plaque2009

    • Author(s)
      Takahashi N, 6名中筆頭, Nakajo K, Asanoumi T, Shibata A, Yagishita Y, Washio J
    • Organizer
      ORCA 2009
    • Place of Presentation
      Budapest, Hungary
    • Related Report
      2009 Final Research Report
  • [Presentation] う蝕関連口腔細菌の糖代謝メタボローム解析:糖代謝機能の類似と相違2009

    • Author(s)
      鷲尾純平
    • Organizer
      第82回日本生化学大会
    • Place of Presentation
      神戸
    • Related Report
      2009 Annual Research Report
  • [Presentation] Ecological dynamics of caries-associated oral biofilm : involvement of mutans streptococci and non-mutans bacteria, Symposium 1 "Oral Biofilm Today"2008

    • Author(s)
      Takahashi N, 単独筆頭
    • Organizer
      The 56th Annual Meeting of Japanese Association for Dental Research
    • Place of Presentation
      Nagoya
    • Year and Date
      2008-11-29
    • Related Report
      2009 Final Research Report
  • [Presentation] Ecological dynamics of caries-associated oral biofilm : involvement of mutans streptococci and non-mutans bacteria2008

    • Author(s)
      Takahashi N
    • Organizer
      第56回国際歯科研究学会日本部会(シンポジウム1)
    • Place of Presentation
      名古屋
    • Year and Date
      2008-11-29
    • Related Report
      2008 Annual Research Report
  • [Presentation] Plaque pH telemetry method of tooth friendly international and Japanese dental FOSHU2008

    • Author(s)
      Takahashi N, 単独筆頭
    • Organizer
      Workshop on Oral Health
    • Place of Presentation
      北京, 中国
    • Year and Date
      2008-11-10
    • Related Report
      2009 Final Research Report
  • [Presentation] Plaque pH telemetry method of tooth friendly international and Jananese dental FOSHU2008

    • Author(s)
      Takahashi N
    • Organizer
      Workshop on Oral Health
    • Place of Presentation
      北京
    • Year and Date
      2008-11-10
    • Related Report
      2008 Annual Research Report
  • [Presentation] 細菌代謝コントロールによる口腔疾患予防戦略-フッ化物が有する静菌作用とその生化学的メカニズム-2008

    • Author(s)
      中條和子
    • Organizer
      第50回歯科基礎医学会学術大会サテライトシンポジウム
    • Place of Presentation
      東京
    • Year and Date
      2008-09-23
    • Related Report
      2008 Annual Research Report
  • [Presentation] う蝕予防ツールとしてのトクホ食品〜これまでとこれから〜2008

    • Author(s)
      高橋信博
    • Organizer
      第13回国際食品素材/添加物展・会議
    • Place of Presentation
      東京
    • Year and Date
      2008-05-23
    • Related Report
      2008 Annual Research Report
  • [Presentation] 口腔環境中の乳酸はVeillonellαの硫化水素産生を促進する2007

    • Author(s)
      鷲尾純平
    • Organizer
      第56回日本口腔衛生学会
    • Place of Presentation
      千葉
    • Year and Date
      2007-10-04
    • Related Report
      2007 Annual Research Report
  • [Presentation] 口腔Veillonellaはcystathionine β-synthase様活性を持ちシステインから硫化水素を産生する2007

    • Author(s)
      鷲尾純平
    • Organizer
      第49回歯科基礎医学会学術大会
    • Place of Presentation
      札幌
    • Year and Date
      2007-08-30
    • Related Report
      2007 Annual Research Report
  • [Presentation] 舌苔と口臭―舌苔常在細菌の口臭産生への関与―2007

    • Author(s)
      鷲尾純平, 佐藤拓一, 4名中2番目, 高橋信博, 4名中4番目
    • Organizer
      第49回歯科基礎医学会学術大会サテライトシンポジウム
    • Place of Presentation
      札幌
    • Year and Date
      2007-08-29
    • Related Report
      2009 Final Research Report
  • [Presentation] Effects of pH and lactate on the production of hydrogen sulfide by oral Veillonella2007

    • Author(s)
      Washo J
    • Organizer
      7th International Conference of the International Society for Breath Odor Research
    • Place of Presentation
      米国シカゴ
    • Year and Date
      2007-08-23
    • Related Report
      2007 Annual Research Report
  • [Presentation] 舌苔構成細菌と口臭―舌苔常在菌による口臭の産生―2007

    • Author(s)
      鷲尾純平, 高橋信博, 2名中2番目
    • Organizer
      口鼻臭臨床研究会 第2回学術集会シンポジウム
    • Place of Presentation
      名古屋
    • Year and Date
      2007-06-24
    • Related Report
      2009 Final Research Report
  • [Presentation] 東北地方の地域歯科保健推進に向けた東北大学の取り組み―東北大学地域歯科保健推進室の設置―2007

    • Author(s)
      小関健由, 8名中筆頭, 高橋信博, 8名中3番目
    • Organizer
      第19回日本口腔衛生学会・東北地方会
    • Place of Presentation
      仙台
    • Year and Date
      2007-05-26
    • Related Report
      2009 Final Research Report
  • [Book] Interface Oral Health Science 2009(T. Sasano and O. Suzuki (eds.))2010

    • Author(s)
      Takahashi N, 5名中3番目
    • Publisher
      Springer
    • Related Report
      2009 Final Research Report
  • [Book] Interface Oral Health Science 2009(T. Sasano and O. Suzuki (eds.))2010

    • Author(s)
      Takahashi N, 6名中6番目
    • Publisher
      Springer
    • Related Report
      2009 Final Research Report
  • [Book] Interface Oral Health Science 2009(T. Sasano and O. Suzuki (eds.))2010

    • Author(s)
      Takahashi N, 4名中4番目
    • Publisher
      Springer
    • Related Report
      2009 Final Research Report
  • [Book] Interface Oral Health Science 2009(T. Sasano and O. Suzuki (eds.))2010

    • Author(s)
      Takahashi N, 5名中5番目
    • Publisher
      Springer
    • Related Report
      2009 Final Research Report
  • [Book] クイズう蝕&歯周病の基礎知識1002009

    • Author(s)
      高橋信博(監修 : 伊藤中編集 : 渡部勝/長山和枝)
    • Publisher
      クインテッセンス出版株式会社
    • Related Report
      2008 Annual Research Report
  • [Book] う蝕学―チェアサイドの予防と回復のプログラム―, (田上順次, 花田信弘, 桃井保子(編))2008

    • Author(s)
      高橋信博, 単独筆頭
    • Publisher
      永末書店
    • Related Report
      2009 Final Research Report
  • [Book] シンプル生化学改訂第5版,(林典夫, 廣野治子(編))2008

    • Author(s)
      高橋信博, 単独筆頭
    • Publisher
      南江堂
    • Related Report
      2009 Final Research Report
  • [Book] う蝕学-チェアサイドの予防と回復のプログラム-2008

    • Author(s)
      高橋信博
    • Publisher
      末長書店
    • Related Report
      2007 Annual Research Report
  • [Book] Interface Oral Health Science 2007(M. Watanabe and O. Okuno (eds.))2007

    • Author(s)
      Takahashi N, 3名中3番目
    • Publisher
      Springer
    • Related Report
      2009 Final Research Report
  • [Book] Interface Oral Health Science 2007(M. Watanabe and O. Okuno (eds.))2007

    • Author(s)
      Takahashi N, 5名中5番目
    • Publisher
      Springer
    • Related Report
      2009 Final Research Report
  • [Book] Interface Oral Health Science 2007(M. Watanabe and O. Okuno (eds.))2007

    • Author(s)
      Takahashi N, 4名中4番目
    • Publisher
      Springer
    • Related Report
      2009 Final Research Report
  • [Book] Interface Oral Health Science 2007(M. Watanabe and O. Okuno (eds.))2007

    • Author(s)
      Takahashi N, 6名中6番目
    • Publisher
      Springer
    • Related Report
      2009 Final Research Report
  • [Book] Interface Oral Health Science 2007(M. Watanabe and O. Okuno (eds.))2007

    • Author(s)
      Sato T, 4名中2番目, Takahashi N, 4名中4番目
    • Publisher
      Springer
    • Related Report
      2009 Final Research Report
  • [Book] Interface Oral Health Science 20072007

    • Author(s)
      Washio J
    • Publisher
      Springer, Tokyo
    • Related Report
      2007 Annual Research Report
  • [Book] Interface Oral Health Science 20072007

    • Author(s)
      Abiko Y
    • Publisher
      Springer, Tokyo
    • Related Report
      2007 Annual Research Report
  • [Book] Interface Oral Health Science 20072007

    • Author(s)
      Matsuyama J
    • Publisher
      Springer, Tokyo
    • Related Report
      2007 Annual Research Report
  • [Book] Interface Oral Health Science 20072007

    • Author(s)
      Miyasawa-Hori H
    • Publisher
      Springer, Tokyo
    • Related Report
      2007 Annual Research Report
  • [Book] Interface Oral Health Science 20072007

    • Author(s)
      Aizawa S
    • Publisher
      Springer, Tokyo
    • Related Report
      2007 Annual Research Report
  • [Book] Interface Oral Health Science 20072007

    • Author(s)
      Nakajo K
    • Publisher
      Springer, Tokyo
    • Related Report
      2007 Annual Research Report
  • [Book] Interface Oral Health Science 20072007

    • Author(s)
      Ito Y
    • Publisher
      Springer, Tokyo
    • Related Report
      2007 Annual Research Report
  • [Book] Interface Oral Health Science 20072007

    • Author(s)
      Sato T
    • Publisher
      Springer, Tokyo
    • Related Report
      2007 Annual Research Report
  • [Book] Interface Oral Health Science 20072007

    • Author(s)
      Masaki M
    • Publisher
      Springer, Tokyo
    • Related Report
      2007 Annual Research Report
  • [Book] Interface Oral Health Science 20072007

    • Author(s)
      Miyoshi Y
    • Publisher
      Springer, Tokyo
    • Related Report
      2007 Annual Research Report
  • [Remarks] ホームページ等

    • Related Report
      2009 Final Research Report
  • [Patent(Industrial Property Rights)] バイオフィルム抑制型抗菌性チタン合金2008

    • Inventor(s)
      高橋正敏, 中條和子, 奥野攻, 高橋信博, 菊地聖史, 高田雄京, 佐々木啓一
    • Industrial Property Rights Holder
      高橋正敏, 中條和子, 奥野攻, 高橋信博, 菊地聖史, 高田雄京, 佐々木啓一
    • Industrial Property Number
      2008-294012
    • Filing Date
      2008-11-18
    • Related Report
      2009 Final Research Report

URL: 

Published: 2007-04-01   Modified: 2016-04-21  

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