| Project/Area Number |
19390539
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| Research Category |
Grant-in-Aid for Scientific Research (B)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Social dentistry
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| Research Institution | Tohoku University |
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Principal Investigator |
TAKAHASHI Nobuhiro Tohoku University, 大学院・歯学研究科, 教授 (60183852)
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| Co-Investigator(Kenkyū-buntansha) |
HANADA Nobuhiro 鶴見大学, 歯学部, 教授 (70180916)
KOSEKI Takeyoshi 東北大学, 大学院・歯学研究科, 教授 (80291128)
SENPUKU Hidenobu 国立感染症研究所, 細菌第一部, 室長 (20250186)
SATO Takuichi 東北大学, 大学院・歯学研究科, 講師 (10303132)
SAKAMOTO Mitsuo 独立行政法人理化学研究所, 微生物材料開発室, 協力研究員 (50321766)
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| Project Period (FY) |
2007 – 2009
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| Project Status |
Completed (Fiscal Year 2009)
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| Budget Amount *help |
¥15,470,000 (Direct Cost: ¥11,900,000、Indirect Cost: ¥3,570,000)
Fiscal Year 2009: ¥3,120,000 (Direct Cost: ¥2,400,000、Indirect Cost: ¥720,000)
Fiscal Year 2008: ¥2,990,000 (Direct Cost: ¥2,300,000、Indirect Cost: ¥690,000)
Fiscal Year 2007: ¥9,360,000 (Direct Cost: ¥7,200,000、Indirect Cost: ¥2,160,000)
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| Keywords | 歯学 / バイオフィルム / メタボローム / 微生物 / 微生物叢 |
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| Research Abstract |
Metabolome analysis for the representative plaque bacteria and human oral biofilm using a capillary electrophoresis equipped with a time-of-flight mass spectrometer was established. By this method, a new finding was obtained about the pentose-phosphate pathway and the Kreb's tricarboxylic acid cycle, as well as the Embden-Meyerhof-Parnas pathway. In addition, the metabolome analysis was applicable to a very small amount of oral biofilm. These results suggest that the metabolome data can be used as an indicator of oral health status.
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