Impaired scaffold formation of AQP5 during aging : in the relation with mastication and swallowing
| Project/Area Number |
19390540
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| Research Category |
Grant-in-Aid for Scientific Research (B)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Social dentistry
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| Research Institution | The University of Tokushima |
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Principal Investigator |
ISHIKAWA Yasuko The University of Tokushima, 大学院・ヘルスバイオサイエンス研究部, 准教授 (40144985)
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| Co-Investigator(Kenkyū-buntansha) |
OKAMURA Ko 大阪大学, 大学院・医学研究科, 助教 (50437381)
SHONO Masayuki 徳島大学, 大学院・ヘルスバイオサイエンス研究部, 技術職員 (60380101)
中江 良子 徳島大学, 大学院・ヘルスバイサイエンス研究部, 助教 (80127844)
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| Project Period (FY) |
2007 – 2009
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| Project Status |
Completed (Fiscal Year 2009)
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| Budget Amount *help |
¥18,590,000 (Direct Cost: ¥14,300,000、Indirect Cost: ¥4,290,000)
Fiscal Year 2009: ¥4,030,000 (Direct Cost: ¥3,100,000、Indirect Cost: ¥930,000)
Fiscal Year 2008: ¥5,460,000 (Direct Cost: ¥4,200,000、Indirect Cost: ¥1,260,000)
Fiscal Year 2007: ¥9,100,000 (Direct Cost: ¥7,000,000、Indirect Cost: ¥2,100,000)
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| Keywords | 社会歯科学 / 水チャネル / アクアポリン / 老化 / ラフト / 咀嚼 / 嚥下 / 細胞内情報伝達系 / 基盤分子 |
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| Research Abstract |
In order to spend a sane social life with the high quality even if we grow old, we investigate mechanism of pathogenesis of xerostomia caused by aging in relation with AQP5 and scaffold proteins. We developed a diagnostic kit of xerostomia using AQP5 in saliva. We examined whether the impaired mastication/swallowing ability linked decreasing the value that we obtained with the kit. The decreasing of AQP5 trafficking and the enhancement of AQP5 mistrafficking to basal plasma membrane were improved by administration of plant ceramide.
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Report
(4 results)
Research Products
(44 results)
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[Journal Article] Identification of aquaporin-5 and lipid rafts in human resting saliva and their release into cevimeline-stimulated saliva2009
Author(s)
Yan Pan, Fusako Iwata, Di Wang, Masahiro Munaguchi, Keiko Ooga, Yasukazu Oomoto, Masaaki Takai, Gota Cho, Jinsen Kang, Masayuki Shono, Xue-jun Li, Ko Okamura, Toyoki Mori, Yasuko Ishikawa
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Journal Title
Biochimica Et Biophysica Acta Vol.1790
Pages: 49-56
Related Report
Peer Reviewed
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[Journal Article] Effect of iron-querceti n complex on reduction of nitrite in in vitro and in vivo systems.2008
Author(s)
Hideki Ohnishi, Satoshi Iwanaga, Kazuyoshi Kawazoe, Keisuke Ishikawa, Sakiko Orino, Shuhci Tomita, Koichiro Tsuchiya, Yasuhisa Kanematsu, Nagakatsu Harada, Kazuhiro Mori, Tomoko Tsuchihnshi, Yasuko Ishikawa Toshiaki Tamaki
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Journal Title
journal of Agricultural and Food Chemistry vol.56
Pages: 10092-10098
Related Report
Peer Reviewed
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