| Project/Area Number |
19390541
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| Research Category |
Grant-in-Aid for Scientific Research (B)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Social dentistry
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| Research Institution | Kyushu University |
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Principal Investigator |
YAMASHITA Yoshihisa Kyushu University, 大学院・歯学研究院, 教授 (20192403)
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| Co-Investigator(Kenkyū-buntansha) |
NAKANO Yoshio 九州大学, 大学院・歯学研究院, 准教授 (80253459)
SHIMAZAKI Yoshihiro 九州大学, 大学院・歯学研究院, 准教授 (10291519)
SHIOTA Susumiu 九州大学, 大学院・歯学研究院, 助教 (00150467)
KIYOHARA Yutaka 九州大学, 大学院・医学研究院, 教授 (80161602)
IIDA Mitsuo 九州大学, 大学院・医学研究院, 教授 (00127961)
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| Project Period (FY) |
2007 – 2009
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| Project Status |
Completed (Fiscal Year 2009)
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| Budget Amount *help |
¥18,850,000 (Direct Cost: ¥14,500,000、Indirect Cost: ¥4,350,000)
Fiscal Year 2009: ¥6,760,000 (Direct Cost: ¥5,200,000、Indirect Cost: ¥1,560,000)
Fiscal Year 2008: ¥5,720,000 (Direct Cost: ¥4,400,000、Indirect Cost: ¥1,320,000)
Fiscal Year 2007: ¥6,370,000 (Direct Cost: ¥4,900,000、Indirect Cost: ¥1,470,000)
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| Keywords | 口腔フローラ / T-RFLP / 口腔疾患 / 全身の健康 / 16S rRNA遺伝子 / 網羅的解析 / 口腔の健康 / 口腔細菌叢 / 唾液検査 |
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| Research Abstract |
In this study, oral microflora was examined in relationship to periodontitis and malodor, and was further analyzed with febrile days and pneumonia in institutionalized elderly. To characterize the composition of oral microflora, chromosomal DNA was extracted from bacteria in saliva or tongue coat and Terminal-Restriction Fragment Length Polymorphism analysis was carried out using the extracted bacterial DNA as template. The results indicated that T-RFLP pattern of salivary bacteria was closely associated with the prevalence of periodontitis and malodor. In addition, T-RFLP pattern in tongue coat was also associated with febrile days and pneumonia in institutionalized elderly.
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