Development of preventive measures against systemic diseases caused by oral biofilm
| Project/Area Number |
19390543
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| Research Category |
Grant-in-Aid for Scientific Research (B)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Social dentistry
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| Research Institution | Kagoshima University |
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Principal Investigator |
OHO Takahiko Kagoshima University, 大学院・医歯学総合研究科, 教授 (50160940)
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| Co-Investigator(Kenkyū-buntansha) |
YAMAGUCHI Taihei 鹿児島大学, 大学院・医歯学総合研究科, 准教授 (80230358)
KITADA Katsuhiro 鹿児島大学, 大学院・医歯学総合研究科, 助教 (90195264)
NAGATA Emi 鹿児島大学, 医学部・歯学部附属病院, 助教 (00304816)
YOSHIDA Yasuo 岩手医科大学, 歯学部, 准教授 (10315096)
SATOU Setsuko 鹿児島大学, 医学部・歯学部附属病院, 講師 (70145514)
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| Project Period (FY) |
2007 – 2009
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| Project Status |
Completed (Fiscal Year 2009)
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| Budget Amount *help |
¥17,680,000 (Direct Cost: ¥13,600,000、Indirect Cost: ¥4,080,000)
Fiscal Year 2009: ¥4,290,000 (Direct Cost: ¥3,300,000、Indirect Cost: ¥990,000)
Fiscal Year 2008: ¥4,420,000 (Direct Cost: ¥3,400,000、Indirect Cost: ¥1,020,000)
Fiscal Year 2007: ¥8,970,000 (Direct Cost: ¥6,900,000、Indirect Cost: ¥2,070,000)
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| Keywords | 歯学 / 微生物 / 感染症 / 歯垢 |
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| Research Abstract |
Mechanisms of systemic diseases caused by oral biofilm were examined to develop new preventive methods against the diseases. Interaction between oral streptococci recovered from abscess lesion and salivary proteins was clarified. Human aortic endothelial cells were invaded by oral streptococci recovered from infective endocarditis and produced more inflammatory cytokines than non-invaded cells. Oral opportunistic bacteria recovered from pneumonia lesion showed capability to bind to saliva-coated endotracheal tubes and cuffs.
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Report
(4 results)
Research Products
(30 results)
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[Journal Article] Molecular and Enzymatic Characterization of βC-S lyase in Streptococcus constellatus.2008
Author(s)
Yoshida, Y., Ito, S., Sasaki, T., Kishi, M., Kurota, M., Suwabe, A., Kunimatsu, K., H. Kato
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Journal Title
Oral Microbiol. Immunol. 23
Pages: 245-253
Related Report
Peer Reviewed
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