Comprehensive study to explore new physiologically active proteins in the snake venoms in the tropical and subtropical regions
| Project/Area Number |
19406002
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| Research Category |
Grant-in-Aid for Scientific Research (B)
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| Allocation Type | Single-year Grants |
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| Section | 海外学術 |
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| Research Field |
Biological pharmacy
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| Research Institution | Meiji Pharmaceutical University |
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Principal Investigator |
MORITA Takashi Meiji Pharmaceutical University, 薬学部, 客員研究員 (90128108)
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| Co-Investigator(Kenkyū-buntansha) |
YAMAZAKI Yasuo 明治薬科大学, 薬学部, 助教 (30308621)
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| Project Period (FY) |
2007 – 2010
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| Project Status |
Completed (Fiscal Year 2010)
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| Budget Amount *help |
¥7,670,000 (Direct Cost: ¥5,900,000、Indirect Cost: ¥1,770,000)
Fiscal Year 2010: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
Fiscal Year 2009: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
Fiscal Year 2008: ¥2,080,000 (Direct Cost: ¥1,600,000、Indirect Cost: ¥480,000)
Fiscal Year 2007: ¥2,210,000 (Direct Cost: ¥1,700,000、Indirect Cost: ¥510,000)
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| Keywords | 生理活性 / 蛋白質 / プロテアーゼインヒビター / 神経毒蛋白質 / VEGF / タンパク質 / プロテオーム |
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| Research Abstract |
We have performed to study a diverse range of interesting proteins such as procoagulants, anticoagulants, platelet agonists, and platelet antagonists in the venoms of venomous snakes in the both tropical and sub-tropical region. In addition, we have comprehensively studied on the search, isolation, characterization of new C-type lectin-like proteins, cysteine-rich secretory proteins (CRISPs). We finally isolated and characterized more than ten structurally and functionally novel proteins with anticoagulant, antiplatelet or VEGF-activities. These molecules are known to exhibit potent and unique biological activities.
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Report
(6 results)
Research Products
(53 results)
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[Journal Article] Snake venom vascular endothelial growth factors (VEGF-Fs) exclusively vary their structures and functions among species2009
Author(s)
Yamazaki, Y., Matsunaga, Y., Tokunaga, Y., Obayashi, S., Saito, M., Morita, T.
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Journal Title
J.Biol.Chem. 284
Pages: 9885-9891
Related Report
Peer Reviewed
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[Journal Article] Adenovirus serotype 5 hexon mediates liver gene transter.2008
Author(s)
Waddington SN, McVey JH, Bhella D, Parker AL, Barker K, Atoda H, Pink R, Buckley SMK, Greig JA, Denby L, Custers J, Morita T, Francischetti IMB, Monteiro RQ, Barouch DH, Rooijen NV, Napoli C, Havenga MJE, Nicklin SA, Baker AH
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Journal Title
Related Report
Peer Reviewed
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[Journal Article] Involvement of the snake toxin receptor CLEC-2, in podoplanin-mediated platelet activation, by cancer cells2007
Author(s)
Suzuki-Inoue K, Kato Y, Inoue O, Kaneko MK, Mishima K, Yatomi Y, Yamazaki Y, Narimatsu H, Ozaki Y
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Journal Title
J.Biol.Chem. 282
Pages: 25993-26001
Related Report
Peer Reviewed
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