| Budget Amount *help |
¥16,770,000 (Direct Cost: ¥12,900,000、Indirect Cost: ¥3,870,000)
Fiscal Year 2009: ¥5,720,000 (Direct Cost: ¥4,400,000、Indirect Cost: ¥1,320,000)
Fiscal Year 2008: ¥5,070,000 (Direct Cost: ¥3,900,000、Indirect Cost: ¥1,170,000)
Fiscal Year 2007: ¥5,980,000 (Direct Cost: ¥4,600,000、Indirect Cost: ¥1,380,000)
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| Research Abstract |
Garcinia vilersiana is medium size tree and commonly used for traditional medicinal purposes in Vietnam. In this study, we investigated the ability of Garcinia vilersiana extract to activate transcription factor Nrf2 in RAW264.7 cells. We found that Garcinia vilersiana bark extract activates Nrf2, leading to increase in antioxidant response element (ARE) binding activity and transcriptional activation of ARE. Garcinia vilersiana bark extract was also found to induce heme oxygenase-1 (HO-1) protein expression, suggesting that the drug action of Garcinia vilersiana may be attributable to activation of Nrf2-HO-1 signaling.
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