| Project/Area Number |
19406006
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| Research Category |
Grant-in-Aid for Scientific Research (B)
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| Allocation Type | Single-year Grants |
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| Section | 海外学術 |
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| Research Field |
Human pathology
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| Research Institution | The University of Tokyo |
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Principal Investigator |
FUKAYAMA Masashi The University of Tokyo, 大学院・医学系研究科, 教授 (70281293)
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| Co-Investigator(Kenkyū-buntansha) |
柴原 純二 東京大学, 医学部附属病院, 助教 (60334380)
森川 鉄平 東京大学, 大学院・医学系研究科, 助教 (80451772)
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| Co-Investigator(Renkei-kenkyūsha) |
SHIBAHARA Junji 東京大学, 医学部附属病院, 助教 (60334380)
MORIKAWA Teppei 東京大学, 大学院・医学系研究科, 助教 (80451772)
OTA Satoshi 東京大学, 大学院・医学系研究科, 講師 (90324342)
GOTO Akiteru 東京大学, 大学院・医学系研究科, 助教 (90317090)
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| Project Period (FY) |
2007 – 2010
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| Project Status |
Completed (Fiscal Year 2010)
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| Budget Amount *help |
¥15,210,000 (Direct Cost: ¥11,700,000、Indirect Cost: ¥3,510,000)
Fiscal Year 2010: ¥3,250,000 (Direct Cost: ¥2,500,000、Indirect Cost: ¥750,000)
Fiscal Year 2009: ¥3,250,000 (Direct Cost: ¥2,500,000、Indirect Cost: ¥750,000)
Fiscal Year 2008: ¥3,250,000 (Direct Cost: ¥2,500,000、Indirect Cost: ¥750,000)
Fiscal Year 2007: ¥5,460,000 (Direct Cost: ¥4,200,000、Indirect Cost: ¥1,260,000)
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| Keywords | SV40 / DNAウイルス / 悪性中皮腫 / 髄膜腫 / 分子疫学 / 日本 / アジア / PCR / メチル化 |
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| Research Abstract |
The significance of SV40 as an oncogenic vrus was evaluated in mesothelioma and menigioma of Japan, Korea, and Taiwan by PCR of SV40-DNA. PQ, SV and NK fragments of SV40-DNA were amplified in 7, 0 and 0 cases of 35 Japanese mesotheliomas, Four Korean and five Taiwan mesotheliomas showed no amplification of three fragments of SV40. On the other hand, NK fragments were amplified in low frequencies, 3.1% (5/159) in Japanese and 2.5% (6/244) in Korean meningiomas. SV40 has little relationship with mesotheliomas in Japan, Korea, and Taiwan. On the other hand, SV40 has definite relationship with menngiomas in Japan and Korea with low frequencies, suggesting necessity for further molecular epidemiologies on this topic.
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