Polymorphism in drug resistant genes of Plasmodium falciparum

• Project/Area Number: 19406011
• Research Category: Grant-in-Aid for Scientific Research (B)
• Allocation Type: Single-year Grants
• Section: 海外学術
• Research Field: Parasitology (including Sanitary zoology)
• Research Institution: Nagasaki University
• Principal Investigator: UEMURA Haruki Nagasaki University, 熱帯医学研究所, 講師 (60184975)
• Co-Investigator(Kenkyū-buntansha): ICHINOSE Yoshio 長崎大学, 熱帯医学研究所, 教授 (70176296) ; KANEKO Satoshi 長崎大学, 熱帯医学研究所, 教授 (00342907)
• Research Collaborator: ISOZUMI Rie 長崎大学, 熱帯医学研究所, COE研究員
• Project Period (FY): 2007 – 2009
• Project Status: Completed (Fiscal Year 2009)
• Budget Amount: ¥15,210,000 (Direct Cost: ¥11,700,000、Indirect Cost: ¥3,510,000); Fiscal Year 2009: ¥3,770,000 (Direct Cost: ¥2,900,000、Indirect Cost: ¥870,000); Fiscal Year 2008: ¥3,640,000 (Direct Cost: ¥2,800,000、Indirect Cost: ¥840,000); Fiscal Year 2007: ¥7,800,000 (Direct Cost: ¥6,000,000、Indirect Cost: ¥1,800,000)
• Keywords: 熱帯熱マラリア原虫 / 薬剤耐性 / pfcrt遺伝子 / pfmdr 1遺伝子 / pfdhfr遺伝子 / pfdhps遺伝子 / ベトナム / インドネシア / pfdhs遺伝子 / ベトナム:イラン:ミャンマー:インドネシア:ケニア / pfmdrl遺伝子 / pfmdr1遺伝子 / インドネシア;ミャンマー:ベトナム:ケニア

Research Abstract

Due to the wide spread of resistant malaria parasites to commonly used anti-malarial drugs, ACTs (Artemisinin-based Combination Therapies) are recommended as the first line treatment therapies in many malaria countries. From the comparison of polymorphisms in Plasmodium falciparum genotypes, we observed a tendency of decreasing mutant alleles of pfcrt and pfmdr 1 genes in Vietnam parasites. We assume it would be effect of introduction and usage of artemisinin and its derivatives in this country.

Research Products

• [Journal Article] Longitudinal survey of Plasmodium falciparum infection in Vietnam: Characteristics of antimalarial resistance and their reflecting factors. (2010)
  • Author(s): Rie Isozumi, Haruki Uemura, Le Duc Dao, Truong Van Hanh, Nguyen Duc Giang, Ha Viet Vien, Bui Quang Phuc, Nguyen Van Tuan, Shusuke Nakazawa
  • Journal Title: J Clin Microbiol. 48(1) Pages: 70-77
  • Peer Reviewed
• [Journal Article] Longitudinal survey of Plasmodium falciparum infection in Vietnam : Characteristics of antimalarial resistance and their associated factors (2010)
  • Author(s): Isozumi R., Uemura H., Dao LD., Hanh TV., Giang ND., 他
  • Journal Title: Journal of Clinical Microbiology 48 Pages: 70-77
  • NAID: 120006984534
  • Peer Reviewed
• [Journal Article] First record of Anopheles balabacensis from western Sumbawa Island, Indonesia. (2009)
  • Author(s): Maekawa Y, Sunahara T, Dachlan YP, Yotoranoto S, Basuki S, Uemura H, Kanbara H, Takagi M
  • Journal Title: J Am Mosq Control Assoc. 25(2) Pages: 203-5
  • NAID: 120006983655
  • Peer Reviewed
• [Journal Article] Detection of K76T Mutation in pfcrt Gene as an Applicable Genetic Marker for Prediction of Chloroquine Resistant falciparum Malaria in Isolates from an Endemic District of Iran. (2008)
  • Author(s): AR Esmaeili Rastaghi, M Nateghpour, M Assmar, MR Razavi, H Kanbara, H Uemura, SR Naddaf, H Keshavarz, A Raeisi, M Mohebali
  • Journal Title: Iranian J Parasitol Vol.3,No.2 Pages: 48-56
• [Presentation] ベトナムBinh Phuoc省で採取された熱帯熱マラリア原虫の縦断的網羅的薬剤耐性遺伝子解析(pfcrt, pfmdr 1) (2009)
  • Author(s): 五十棲理恵
  • Organizer: 第78回日本寄生虫学会大会
  • Place of Presentation: 東京
  • Year and Date: 2009-03-28
• [Presentation] Polymorphism in pfcrt and pfmdr1 genes of malaria parasite populations in Binh Phuoc, Vietnam. (2008)
  • Author(s): H. Uemura
  • Organizer: XVIIth International Congress for Tropical Medicine and Malaria
  • Place of Presentation: Cheju, Korea
• [Presentation] Polymorphism in pfcrt and pfmdrl genes of malaria parasite populations in Binh Phuoc, Vietnam (2008)
  • Author(s): Uemura H., et al
  • Organizer: XVIIth International Congress for Tropical Medicine and Malaria
  • Place of Presentation: Cheju, Korea
• [Remarks] 長崎大学熱帯医学研究所原虫学分野
  • URL: http://www.tm.nagasaki-u.ac.jp/nekken/research/protozoology.html