• Search Research Projects
  • Search Researchers
  • How to Use
  1. Back to previous page

Polymorphism in drug resistant genes of Plasmodium falciparum

Research Project

Project/Area Number 19406011
Research Category

Grant-in-Aid for Scientific Research (B)

Allocation TypeSingle-year Grants
Section海外学術
Research Field Parasitology (including Sanitary zoology)
Research InstitutionNagasaki University

Principal Investigator

UEMURA Haruki  Nagasaki University, 熱帯医学研究所, 講師 (60184975)

Co-Investigator(Kenkyū-buntansha) ICHINOSE Yoshio  長崎大学, 熱帯医学研究所, 教授 (70176296)
KANEKO Satoshi  長崎大学, 熱帯医学研究所, 教授 (00342907)
Research Collaborator ISOZUMI Rie  長崎大学, 熱帯医学研究所, COE研究員
Project Period (FY) 2007 – 2009
Project Status Completed (Fiscal Year 2009)
Budget Amount *help
¥15,210,000 (Direct Cost: ¥11,700,000、Indirect Cost: ¥3,510,000)
Fiscal Year 2009: ¥3,770,000 (Direct Cost: ¥2,900,000、Indirect Cost: ¥870,000)
Fiscal Year 2008: ¥3,640,000 (Direct Cost: ¥2,800,000、Indirect Cost: ¥840,000)
Fiscal Year 2007: ¥7,800,000 (Direct Cost: ¥6,000,000、Indirect Cost: ¥1,800,000)
Keywords熱帯熱マラリア原虫 / 薬剤耐性 / pfcrt遺伝子 / pfmdr 1遺伝子 / pfdhfr遺伝子 / pfdhps遺伝子 / ベトナム / インドネシア / pfdhs遺伝子 / ベトナム:イラン:ミャンマー:インドネシア:ケニア / pfmdrl遺伝子 / pfmdr1遺伝子 / インドネシア;ミャンマー:ベトナム:ケニア
Research Abstract

Due to the wide spread of resistant malaria parasites to commonly used anti-malarial drugs, ACTs (Artemisinin-based Combination Therapies) are recommended as the first line treatment therapies in many malaria countries. From the comparison of polymorphisms in Plasmodium falciparum genotypes, we observed a tendency of decreasing mutant alleles of pfcrt and pfmdr 1 genes in Vietnam parasites. We assume it would be effect of introduction and usage of artemisinin and its derivatives in this country.

Report

(4 results)
  • 2009 Annual Research Report   Final Research Report ( PDF )
  • 2008 Annual Research Report
  • 2007 Annual Research Report
  • Research Products

    (8 results)

All 2010 2009 2008 Other

All Journal Article (4 results) (of which Peer Reviewed: 3 results) Presentation (3 results) Remarks (1 results)

  • [Journal Article] Longitudinal survey of Plasmodium falciparum infection in Vietnam: Characteristics of antimalarial resistance and their reflecting factors.2010

    • Author(s)
      Rie Isozumi, Haruki Uemura, Le Duc Dao, Truong Van Hanh, Nguyen Duc Giang, Ha Viet Vien, Bui Quang Phuc, Nguyen Van Tuan, Shusuke Nakazawa
    • Journal Title

      J Clin Microbiol. 48(1)

      Pages: 70-77

    • Related Report
      2009 Final Research Report
    • Peer Reviewed
  • [Journal Article] Longitudinal survey of Plasmodium falciparum infection in Vietnam : Characteristics of antimalarial resistance and their associated factors2010

    • Author(s)
      Isozumi R., Uemura H., Dao LD., Hanh TV., Giang ND., 他
    • Journal Title

      Journal of Clinical Microbiology 48

      Pages: 70-77

    • NAID

      120006984534

    • Related Report
      2009 Annual Research Report
    • Peer Reviewed
  • [Journal Article] First record of Anopheles balabacensis from western Sumbawa Island, Indonesia.2009

    • Author(s)
      Maekawa Y, Sunahara T, Dachlan YP, Yotoranoto S, Basuki S, Uemura H, Kanbara H, Takagi M
    • Journal Title

      J Am Mosq Control Assoc. 25(2)

      Pages: 203-5

    • NAID

      120006983655

    • Related Report
      2009 Final Research Report
    • Peer Reviewed
  • [Journal Article] Detection of K76T Mutation in pfcrt Gene as an Applicable Genetic Marker for Prediction of Chloroquine Resistant falciparum Malaria in Isolates from an Endemic District of Iran.2008

    • Author(s)
      AR Esmaeili Rastaghi, M Nateghpour, M Assmar, MR Razavi, H Kanbara, H Uemura, SR Naddaf, H Keshavarz, A Raeisi, M Mohebali
    • Journal Title

      Iranian J Parasitol Vol.3,No.2

      Pages: 48-56

    • Related Report
      2009 Final Research Report
  • [Presentation] ベトナムBinh Phuoc省で採取された熱帯熱マラリア原虫の縦断的網羅的薬剤耐性遺伝子解析(pfcrt, pfmdr 1)2009

    • Author(s)
      五十棲理恵
    • Organizer
      第78回日本寄生虫学会大会
    • Place of Presentation
      東京
    • Year and Date
      2009-03-28
    • Related Report
      2009 Final Research Report
  • [Presentation] Polymorphism in pfcrt and pfmdr1 genes of malaria parasite populations in Binh Phuoc, Vietnam.2008

    • Author(s)
      H. Uemura
    • Organizer
      XVIIth International Congress for Tropical Medicine and Malaria
    • Place of Presentation
      Cheju, Korea
    • Related Report
      2009 Final Research Report
  • [Presentation] Polymorphism in pfcrt and pfmdrl genes of malaria parasite populations in Binh Phuoc, Vietnam2008

    • Author(s)
      Uemura H., et al
    • Organizer
      XVIIth International Congress for Tropical Medicine and Malaria
    • Place of Presentation
      Cheju, Korea
    • Related Report
      2008 Annual Research Report
  • [Remarks] 長崎大学熱帯医学研究所原虫学分野

    • URL

      http://www.tm.nagasaki-u.ac.jp/nekken/research/protozoology.html

    • Related Report
      2009 Final Research Report

URL: 

Published: 2007-04-01   Modified: 2016-04-21  

Information User Guide FAQ News Terms of Use Attribution of KAKENHI

Powered by NII kakenhi