| Project/Area Number |
19406011
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| Research Category |
Grant-in-Aid for Scientific Research (B)
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| Allocation Type | Single-year Grants |
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| Section | 海外学術 |
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| Research Field |
Parasitology (including Sanitary zoology)
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| Research Institution | Nagasaki University |
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Principal Investigator |
UEMURA Haruki Nagasaki University, 熱帯医学研究所, 講師 (60184975)
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| Co-Investigator(Kenkyū-buntansha) |
ICHINOSE Yoshio 長崎大学, 熱帯医学研究所, 教授 (70176296)
KANEKO Satoshi 長崎大学, 熱帯医学研究所, 教授 (00342907)
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| Research Collaborator |
ISOZUMI Rie 長崎大学, 熱帯医学研究所, COE研究員
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| Project Period (FY) |
2007 – 2009
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| Project Status |
Completed (Fiscal Year 2009)
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| Budget Amount *help |
¥15,210,000 (Direct Cost: ¥11,700,000、Indirect Cost: ¥3,510,000)
Fiscal Year 2009: ¥3,770,000 (Direct Cost: ¥2,900,000、Indirect Cost: ¥870,000)
Fiscal Year 2008: ¥3,640,000 (Direct Cost: ¥2,800,000、Indirect Cost: ¥840,000)
Fiscal Year 2007: ¥7,800,000 (Direct Cost: ¥6,000,000、Indirect Cost: ¥1,800,000)
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| Keywords | 熱帯熱マラリア原虫 / 薬剤耐性 / pfcrt遺伝子 / pfmdr 1遺伝子 / pfdhfr遺伝子 / pfdhps遺伝子 / ベトナム / インドネシア / pfdhs遺伝子 / ベトナム:イラン:ミャンマー:インドネシア:ケニア / pfmdrl遺伝子 / pfmdr1遺伝子 / インドネシア;ミャンマー:ベトナム:ケニア |
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| Research Abstract |
Due to the wide spread of resistant malaria parasites to commonly used anti-malarial drugs, ACTs (Artemisinin-based Combination Therapies) are recommended as the first line treatment therapies in many malaria countries. From the comparison of polymorphisms in Plasmodium falciparum genotypes, we observed a tendency of decreasing mutant alleles of pfcrt and pfmdr 1 genes in Vietnam parasites. We assume it would be effect of introduction and usage of artemisinin and its derivatives in this country.
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