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Molecular epidemiology study on carcinogenic mechanism of Epstein-Barr-associated nasopharyngeal carcinoma and modification by environmental factors in southern China

Research Project

Project/Area Number 19406021
Research Category

Grant-in-Aid for Scientific Research (B)

Allocation TypeSingle-year Grants
Section海外学術
Research Field Hygiene
Research InstitutionMie University

Principal Investigator

MURATA Mariko  Mie University, 大学院・医学系研究科, 教授 (10171141)

Co-Investigator(Kenkyū-buntansha) OIKAWA Shinji  三重大学, 大学院・医学系研究科, 准教授 (10277006)
HIRAKU Yusuke  三重大学, 医学系研究科, 講師 (30324510)
MA Nei  鈴鹿医療科学大学, 保健衛生学部, 教授 (30263015)
Project Period (FY) 2007 – 2009
Project Status Completed (Fiscal Year 2009)
Budget Amount *help
¥16,900,000 (Direct Cost: ¥13,000,000、Indirect Cost: ¥3,900,000)
Fiscal Year 2009: ¥4,940,000 (Direct Cost: ¥3,800,000、Indirect Cost: ¥1,140,000)
Fiscal Year 2008: ¥5,720,000 (Direct Cost: ¥4,400,000、Indirect Cost: ¥1,320,000)
Fiscal Year 2007: ¥6,240,000 (Direct Cost: ¥4,800,000、Indirect Cost: ¥1,440,000)
Keywords中国南部 / Epstein-Barrウィルス / 上咽頭癌 / 8-ニトログアニン / 炎症 / 8-ハイドロキシデオキシグアノシン / DNAメチル化 / Ras-related associated with diabetes(RRAD) / がん抑制遺伝子 / エピジェネティック異常 / ubiquitin carboxyl-terminal hydrolase L1(UCHL1) / メチル化特異的PCR / 中国南部地域 / 感染・炎症関連発がん / 誘導型一酸化窒素合成酵素 / 8-oxodG / バイオマーカー
Research Abstract

Epstein-Barr virus-infected nasopharyngeal carcinoma (NPC) is an important health problem in southern China. We obtained serum and biopsy specimens of nasopharyngeal tissues from NPC patients in southern China. We performed double immunofluorescent staining to examine the formation of nitrative and oxidative DNA lesions (8-nitroguanine, and 8-oxo-7,8-dihydro-2'-deoxyguanosine (8-oxodG)) in these specimens. DNA lesions were observed in cancer cells and inflammatory cells of NPC patients. Intensive immunoreactivity of iNOS was detected in the cytoplasm of cancer cells. Nuclear accumulation of EGFR and STAT3 activation by IL-6 may play the key role in iNOS expression and resultant DNA damage, leading to EBV-mediated NPC. The serum level of 8-oxodG in the NPC patients was significantly higher than that in the control. Promoter hypermethylation of Ras-related associated with diabetes (RRAD) was detected in all six NPC cell lines and most of primary NPC tissues. These findings may provide a strategy for preventing the development of NPC.

Report

(4 results)
  • 2009 Annual Research Report   Final Research Report ( PDF )
  • 2008 Annual Research Report
  • 2007 Annual Research Report
  • Research Products

    (71 results)

All 2010 2009 2008 2007 Other

All Journal Article (29 results) (of which Peer Reviewed: 29 results) Presentation (40 results) Book (2 results)

  • [Journal Article] Nitrative and oxidative DNA damage as potential survival biomarkers for nasopharyngeal carcinoma.2010

    • Author(s)
      Huang Y-J., Zhang B-B., Ma N., Murata M., Tang A-z., Huang G-W.
    • Journal Title

      Med Oncol (in press)

    • Related Report
      2009 Final Research Report
    • Peer Reviewed
  • [Journal Article] The role of iNOS-mediated DNA damage in infection-and asbestos-induced carcinogenesis2010

    • Author(s)
      Hiraku Y., Kawanishi S., Ichinose T., Murata M.
    • Journal Title

      Ann. NY Acad. Sci (in press)

    • Related Report
      2009 Final Research Report
    • Peer Reviewed
  • [Journal Article] DNA damage and estrogenic activity induced by the environmental pollutant 2-nitrotoluene and its metabolite. Environ.2010

    • Author(s)
      Watanabe C., Egami T., Midorikawa K., Hiraku Y., Oikawa S., Kawanishi S., Murata M.
    • Journal Title

      Health Prev. Med (in press)

    • Related Report
      2009 Final Research Report
    • Peer Reviewed
  • [Journal Article] Formation of 8-nitroguanine, a nitrative DNA lesion, in inflammation-related carcinogenesis and its significance, Environ.2010

    • Author(s)
      Hiraku Y.
    • Journal Title

      Health Prev. Med (in press)

    • Related Report
      2009 Final Research Report
    • Peer Reviewed
  • [Journal Article] Role of Peroxisome Proliferator-activated Receptor-alpha in Hepatobiliary Injury Induced by Ammonium Perfluorooctanoate in Mouse Liver2010

    • Author(s)
      Minata M, Harada KH, KarrMa N.A, Hitomi T, Hirosawa M, Murata M, Gonzalez FJ, Koizumi A.
    • Journal Title

      Ind Health 48(1)

      Pages: 96-107

    • Related Report
      2009 Final Research Report
    • Peer Reviewed
  • [Journal Article] Prognostic significance of nitrative DNA damage in infection-and inflammation-related carcinogenesis2010

    • Author(s)
      Hiraku Y., Kawanishi S.
    • Journal Title

      In: Nitric Oxide and Cancer: Prognosis, Prevention and Therapy(Springer, New York, NY, USA) (in press)

    • Related Report
      2009 Final Research Report
    • Peer Reviewed
  • [Journal Article] Role of Peroxisome Proliferator-activated Receptor-alpha in Hepatobiliary Injury Induced by Ammonium Perfluorooctanoate in Mouse Liver2010

    • Author(s)
      Minata M, et. al.
    • Journal Title

      Ind Health 48(1)

      Pages: 96-107

    • Related Report
      2009 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Immunohistochemical analysis of 8-nitroguanine, a nitrative DNA lesion, in relation to inflammation-associated carcinogenesis2009

    • Author(s)
      Hiraku Y., Kawanishi, S.
    • Journal Title

      Methods. Mol. Biol 512

      Pages: 3-3

    • Related Report
      2009 Final Research Report
    • Peer Reviewed
  • [Journal Article] Proteomic identification of carbonylated proteins in the monkey hippocampus after ischemia-reperfusion.2009

    • Author(s)
      Oikawa S, Yamada T, Minohata T, Kobayashi H, Furukawa A, Tada-Oikawa S, Hiraku Y, Murata M, Kikuchi M, Yamashima T.
    • Journal Title

      Free Radic Biol Med 46

      Pages: 1472-1477

    • Related Report
      2009 Final Research Report
    • Peer Reviewed
  • [Journal Article] The mechanisms of oxidative DNA damage and apoptosis induced by norsalsolinol, an endogenous tetrahydroisoquinoline derivative associated with Parkinson's disease.2009

    • Author(s)
      Kobayashi H, Fukuhara K, Tada-Oikawa S, Yada Y, Hiraku Y, Murata M, Oikawa S.
    • Journal Title

      J Neurochem 108(2)

      Pages: 397-407

    • Related Report
      2009 Final Research Report
    • Peer Reviewed
  • [Journal Article] Proteomic identification of carbonylated proteins in the monkey hippocampus after ischemia-reperfusion2009

    • Author(s)
      Oikawa S, et al.
    • Journal Title

      Free Radic Biol Med. 46

      Pages: 1472-1477

    • Related Report
      2009 Annual Research Report
    • Peer Reviewed
  • [Journal Article] The mechanisms of oxidative DNA damage and apoptosis induced by norsalsolinol, an endogenous tetrahydroisoquinoline derivative associated with Parkinson's disease2009

    • Author(s)
      Kobayashi H, et al.
    • Journal Title

      J Neurochem 108(2)

      Pages: 397-407

    • Related Report
      2009 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Proteomic identification of carbonylated proteins in the monkey hippocampus after ischemia-reperfusion.2009

    • Author(s)
      Oikawa S, et al.
    • Journal Title

      Free Radic Biol Med (in press)

    • Related Report
      2008 Annual Research Report
    • Peer Reviewed
  • [Journal Article] The mechanisms of oxiidative DNA damage and apoptosis induced by norsalsolinol, an endogenous tetrahydroisoquinoline derivative associated with Parkinson's disease.2009

    • Author(s)
      Kobayashi H, et al.
    • Journal Title

      J Neurochem 108(2)

      Pages: 397-407

    • Related Report
      2008 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Reactive nitrogen species-dependent DNA damage in EBV-associated nasopharyngeal carcinoma: the relation to STAT3 activation and EGFR expression.2008

    • Author(s)
      Ma N., Kawanishi M, Hiraku Y, Murata M, Huang GW, Huang Y, Luo DZ, Mo WG, Fukui Y, Kawanishi S.
    • Journal Title

      Int J Cancer 122(11)

      Pages: 2517-25

    • Related Report
      2009 Final Research Report
    • Peer Reviewed
  • [Journal Article] Urinary 8-oxo-7, 8-dihydro-2'-deoxyguanosine in patients with parasite infection and the effect of anti-parasitic drug in relation to cholangiocarcinogenesis.2008

    • Author(s)
      Thanan R., Murata M, Pinlaor S, Sithithaworn P, Khuntikeo N, Tangkanakul W, Hiraku Y, Oikawa S, Yongvanit P, Kawanishi S.
    • Journal Title

      Cancer Epidemiol Biomarkers Prev 17(3)

      Pages: 518-24

    • Related Report
      2009 Final Research Report
    • Peer Reviewed
  • [Journal Article] Critical role of hydrogen peroxide in the differential susceptibility of Th1 and Th2 cells to tributyltin-induced apoptosis.2008

    • Author(s)
      Tada-Oikawa S, Kato T, Kuribayashi K, Nishino K, Murata M, Kawanishi S.
    • Journal Title

      Biochem Pharmacol 75(2)

      Pages: 552-61

    • Related Report
      2009 Final Research Report
    • Peer Reviewed
  • [Journal Article] Reactive nitrogen species-dependent DNA damage in EBV-associated nasopharyngeal carcinoma: the relation to STAT3 activation and EGFR expression.2008

    • Author(s)
      Ma N., Kawanishi M, Hiraku Y, Murata M, Huang GW, Huang Y, Luo DZ, Mo WG, Fukui Y, Kawanishi Y
    • Journal Title

      International Journal of Cancer 122(11)

      Pages: 2517-25

    • Related Report
      2009 Final Research Report
    • Peer Reviewed
  • [Journal Article] Reactive nitrogen species-dependent DNA damage in EBV-associated nasopharyngeal carcinoma : the relation to STAT3 activation and EGFR expression.2008

    • Author(s)
      Ma. N, et al.
    • Journal Title

      Int J Cancer. 122(11)

      Pages: 2517-25

    • Related Report
      2008 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Urinary 8-oxoo-7, 8-dihydro-2'-dexyguanosine in patients with parasite infection and the effeect of anti-parasitic drug in relation to cholangiocarcinogenesis.2008

    • Author(s)
      R. Thanan, et al.
    • Journal Title

      Cancer Epidemiol Biomarkers 17(3)

      Pages: 518-24

    • Related Report
      2008 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Critical role of hydrogen peroxide in the differential susceptibility of Th1 and Th2 cells to tributyltin-induced apoptosis.2008

    • Author(s)
      Tada-Oikawa S, et al.
    • Journal Title

      Biochem Pharmacol. 75(2)

      Pages: 552-61

    • Related Report
      2008 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Reactive nitrogen species-dependent DNA damage in EBV-associated nasopharyngeal carcinoma: the relation to STAT3 activation and EGFR expression2008

    • Author(s)
      N. Ma, M. Kawanishi, Y. Hiraku, M. Murata, C-W. Huang, Y. Huang, D-Z. Luo, W.-G.Mo, Y. Fukui, S. Kawanishi
    • Journal Title

      International Journal of Cancer (印刷中)

    • Related Report
      2007 Annual Research Report
    • Peer Reviewed
  • [Journal Article] 8-Nitroguanine as a potential biomarker for progression of malignant fibrous histiocytoma, a model of inflammation-related cancer.2007

    • Author(s)
      Hoki Y, Murata M, Hiraku Y, Ma N., Matsumine A, Uchida A, Kawanishi S.
    • Journal Title

      Oncol Rep 8(5)

      Pages: 1165-9

    • Related Report
      2009 Final Research Report
    • Peer Reviewed
  • [Journal Article] Nitrative and oxidative DNA damage in cervical intraepithelial neoplasia associated with huMa N. papilloma virus infection.2007

    • Author(s)
      Hiraku Y, Tabata T, Ma N., Murata M, Ding X, Kawanishi S.
    • Journal Title

      Cancer Sci 98(7)

      Pages: 964-72

    • Related Report
      2009 Final Research Report
    • Peer Reviewed
  • [Journal Article] iNOS-dependent DNA damage in patients with malignant fibrous histiocytoma in relation to prognosis.2007

    • Author(s)
      Hoki Y, Hiraku Y, Ma N., Murata M, Matsumine A, Nagahama M, Shintani K, Uchida A, Kawanishi S.
    • Journal Title

      Cancer Sci 98(2)

      Pages: 163-8

    • Related Report
      2009 Final Research Report
    • Peer Reviewed
  • [Journal Article] Nitrative and oxidative DNA damage in cervical intraepithelial neoplasia associated with huMa N. papilloma virus infection.2007

    • Author(s)
      Hiraku Y, Tabata T, Ma N., Murata M, Ding X, Kawanishi S
    • Journal Title

      Cancer Science 98(7)

      Pages: 249-257

    • Related Report
      2009 Final Research Report
    • Peer Reviewed
  • [Journal Article] 8-Nitroguanine as a potential biomarker for progression of malignant fibrous histiocytoma,a model of inflammation-related cancer2007

    • Author(s)
      Hoki Y, Murata M, Hiraku Y, Ma N, Matsumine A, Uchida A, Kawanishi S
    • Journal Title

      Oncology Report 8巻5号

      Pages: 1165-1169

    • Related Report
      2007 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Nitrative and oxidative DNA damage in cervical intraepithelial neoplasia associated with human papilloma virus infection2007

    • Author(s)
      Hiraku Y, Tabata T, Ma N, Murata M, Ding X, Kawanishi S.
    • Journal Title

      Cancer Science 98巻7号

      Pages: 964-72

    • Related Report
      2007 Annual Research Report
    • Peer Reviewed
  • [Journal Article] iNOS-dependent DNA damage in patients with malignant fibrous histiocytoma in relation to prognosis2007

    • Author(s)
      Hoki Y, Hiraku Y, Ma N, Murata M, Matsumine A, Nagahama M, Shintani K, Uchida A, Kawanishi S.
    • Journal Title

      Cancer Science 98巻2号

      Pages: 163-168

    • Related Report
      2007 Annual Research Report
    • Peer Reviewed
  • [Presentation] カーボンブラックによる細胞内DNA損傷の解析2009

    • Author(s)
      平工雄介, 村田真理子
    • Organizer
      日本産業衛生学会東海地方会
    • Place of Presentation
      名古屋市
    • Year and Date
      2009-11-14
    • Related Report
      2009 Annual Research Report
  • [Presentation] The role of iNOS-mediated DNA damage in inflammation-related carcinogenesis2009

    • Author(s)
      Yusuke Hiraku, Shosuke Kawanishi, Takamichi Ichinose, Mariko Murata
    • Organizer
      4th International Conference on Oxidative/Nitrosative Stress and Disease
    • Place of Presentation
      New York, USA
    • Related Report
      2009 Final Research Report
  • [Presentation] ブアバン・スーシボン, ラオスにおける生活習慣病の現状と有害金属汚染について2009

    • Author(s)
      翠川裕, 中村哲, 翠川薫, 村田真理子
    • Organizer
      第50回日本熱帯医学会大会総会
    • Place of Presentation
      沖縄市
    • Related Report
      2009 Final Research Report
  • [Presentation] Identification of protein carbonyls in liver tissues of patients with liver fluke-induced cholangiocarcinoma2009

    • Author(s)
      Raynoo Thanan, Mariko Murata, Yusuke Hiraku, Shinji Oikawa, Shosuke Kawanishi
    • Organizer
      第68回日本癌学会総会
    • Place of Presentation
      横浜市
    • Related Report
      2009 Annual Research Report 2009 Final Research Report
  • [Presentation] Hypermethylation of RRAD promoter in nasopharyngeal carcinoma.2009

    • Author(s)
      Yingxi Mo, Kaoru Midorikawa, Ning Ma, Yusuke Hiraku, Shinji Oikawa, Mariko Murata
    • Organizer
      第68回日本癌学会総会
    • Place of Presentation
      横浜市
    • Related Report
      2009 Final Research Report
  • [Presentation] 感染症および関連発がんにおける酸化ストレスの役割, 酸化ストレス連携研究会ミニシンポジウム2009

    • Author(s)
      村田真理子
    • Organizer
      第79回日本衛生学会総会
    • Place of Presentation
      東京
    • Related Report
      2009 Final Research Report
  • [Presentation] 東南アジアにおける生活習慣病の現状と有害金属汚染について2009

    • Author(s)
      翠川薫, Bouavanh Southivong, 翠川裕, 中村哲, 村田真理子
    • Organizer
      第79回日本衛生学会学術総会
    • Place of Presentation
      東京
    • Related Report
      2009 Final Research Report
  • [Presentation] Hypermethylation of UCHL1 promoter in nasopharyngeal carcinoma2009

    • Author(s)
      Zhe Zhang, Guang-wu Huang, Libo Yan, Xiaoying Zhou, Yingxi Mo, Ning Ma, Yusuke Hiraku, Shinji Oikawa, Mariko Murata
    • Organizer
      第8回分子予防環境医学研究会
    • Place of Presentation
      東京
    • Related Report
      2009 Final Research Report 2008 Annual Research Report
  • [Presentation] Hypermethylation of RRAD promoter in nasopharyngeal carcinoma2009

    • Author(s)
      Yingxi Mo, et al.
    • Organizer
      第68回日本癌学会総会
    • Place of Presentation
      横浜市
    • Related Report
      2009 Annual Research Report
  • [Presentation] ラオスにおける生活習慣病の現状と有害金属汚染について2009

    • Author(s)
      翠川裕, 外
    • Organizer
      第50回日本熱帯医学会大会総会
    • Place of Presentation
      沖縄市
    • Related Report
      2009 Annual Research Report
  • [Presentation] がん化学予防剤アスピリンの代謝物によるDNA損傷機構2009

    • Author(s)
      及川伸二, 外
    • Organizer
      日本環境変異原学会第38回大会
    • Place of Presentation
      静岡市
    • Related Report
      2009 Annual Research Report
  • [Presentation] 2-nitrotolueneと代謝物による遺伝子損傷性とエストロゲン活性の検討2009

    • Author(s)
      渡邊千草, 外
    • Organizer
      第79回日本衛生学会総会
    • Place of Presentation
      東京
    • Related Report
      2008 Annual Research Report
  • [Presentation] 感染症および関連発がんにおける酸化ストレスの役割2009

    • Author(s)
      村田真理子
    • Organizer
      第79回日本衛生学会総会、酸化ストレス連携研究会ミニシンポジウム
    • Place of Presentation
      東京
    • Related Report
      2008 Annual Research Report
  • [Presentation] 虚血再還流サル黒質における酸化損傷タンパク質のプロテオミクス解析2009

    • Author(s)
      小林果, 外
    • Organizer
      第79回日本衛生学会総会
    • Place of Presentation
      東京
    • Related Report
      2008 Annual Research Report
  • [Presentation] Nitrative and oxidative DNA damage via chronic inflammation by liver fluke infection; in relation to cholangiocarcinoma development. Fifth International Conference Biology2008

    • Author(s)
      Mariko Murata, Yusuke Hiraku, Shinji Oikawa, Ning Ma, Shosuke Kawanishi
    • Organizer
      The 5th International Conference on the Biology, Chemistry and Therapeutic Applications of Nitric Oxide
    • Place of Presentation
      Bregenz, Austria
    • Related Report
      2009 Final Research Report
  • [Presentation] Formation of 8-nitroguanine, a nitrative DNA lesion, in patients infected with oncogenic viruses, HPV and EBV2008

    • Author(s)
      Yusuke Hiraku, Mariko Murata, Ning Ma, Shosuke Kawanishi
    • Organizer
      The 5th International Conference on the Biology, Chemistry and Therapeutic Applications of Nitric Oxide
    • Place of Presentation
      Bregenz, Austria
    • Related Report
      2009 Final Research Report
  • [Presentation] Formation of 8-nitroguanine, a nitrative DNA lesion, in patients with EBV-associated nasopharyngeal carcinoma2008

    • Author(s)
      平工雄介, 村田真理子, 川西正祐
    • Organizer
      第67回日本癌学会総会
    • Place of Presentation
      名古屋市
    • Related Report
      2009 Final Research Report
  • [Presentation] Oxidative DNA damage induced by a metabolite of tamoxifen, an anti-breast cancer drug; in relation to carcinogenicity.2008

    • Author(s)
      Mariko Murata, Yusuke Hiraku, Shinji Oikawa, Kiyoshi Fukuhara, Shosuke Kawanishi
    • Organizer
      第67回日本癌学会総会
    • Place of Presentation
      名古屋
    • Related Report
      2009 Final Research Report
  • [Presentation] EBウイルス感染による上咽頭癌患者におけるニトロ化DNA損傷2008

    • Author(s)
      平工雄介, 馬寧, 村田真理子, Guang-Wu Huang, Yuanjiao Huang, Dian-Zhong Luo, Wei-Guang Mo, 川西正祐
    • Organizer
      第8回日本NO学会学術集会
    • Place of Presentation
      仙台市
    • Related Report
      2009 Final Research Report
  • [Presentation] タイ肝吸虫感染者および胆管癌患者における酸化ストレスマーカー8-oxo-7, 8-dihydro-2'-deoxyguanosineの有用性の検討2008

    • Author(s)
      村田真理子, 平工雄介, 及川伸二, 川西正祐
    • Organizer
      第78回日本衛生学会総会
    • Place of Presentation
      熊本市
    • Related Report
      2009 Final Research Report
  • [Presentation] Mechanism of Oxidative DNA Damage and Apoptosis Induced by Dorubicin through Generation of Reactive Oxygen Species.2008

    • Author(s)
      Mizutani H, et al.
    • Organizer
      EHRLICH II, 2nd World Conference on Magic Bullets
    • Place of Presentation
      Nurnberg, Germany
    • Related Report
      2008 Annual Research Report
  • [Presentation] Nitrative and oxidative DNA damage via chronic inflammation by liver fluke infection ; in relation to cholangiocarcinoma development. Fifth International Conference Biology2008

    • Author(s)
      Mariko Murata, et al.
    • Organizer
      The 5th International Conference on the Biology, Chemistry and Therapeutic Applications of Nitric Oxlde
    • Place of Presentation
      Bregenz, Austria
    • Related Report
      2008 Annual Research Report
  • [Presentation] Formation of 8-nitroguanine, a nitrative DNA lesion, in patients infected with oncogenic viruses. HPV and EBV2008

    • Author(s)
      Yusuke Hiraku, et al.
    • Organizer
      The 5th International Conference on the Biology, Chemistry and Therapeutic Applications of Nitric Oxide
    • Place of Presentation
      Bregenz, Austria
    • Related Report
      2008 Annual Research Report
  • [Presentation] Metal-mediated DNA damage induced by methylene blue in relation to the carcinogenicity (メチレンブルーによる金属依存性DNA損傷:発がん性との関連)2008

    • Author(s)
      平工雄介, 外
    • Organizer
      日本環境変異原学会第37回大会
    • Place of Presentation
      宜野湾市
    • Related Report
      2008 Annual Research Report
  • [Presentation] 環境汚染物質2-nitrotolueneによる発がん機構の検討2008

    • Author(s)
      渡邊千草, 外
    • Organizer
      日本環境変異原学会第37回大会
    • Place of Presentation
      宜野湾市
    • Related Report
      2008 Annual Research Report
  • [Presentation] 環境化学物質の酸化ストレス作用を介した免疫修飾作用に基づく気道過敏症増悪作用機構2008

    • Author(s)
      小端久美, 外
    • Organizer
      日本環境変異原学会第37回大会
    • Place of Presentation
      宜野湾市
    • Related Report
      2008 Annual Research Report
  • [Presentation] Formation of 8-nitroguanine, a nitrative DNA lesion, in patients with EBV-associated nasopharyngeal carcinoma (EBウイルス感染による上咽頭癌患者におけるニトロ化DNA損傷塩基8-ニトログアニンの生成)2008

    • Author(s)
      平工雄介, 村田真理子
    • Organizer
      第67回日本癌学会総会
    • Place of Presentation
      名古屋市
    • Related Report
      2008 Annual Research Report
  • [Presentation] Oxidative DNA damage induced by a metabolite of tamoxifen, an anti-breast cancer drug ; in relation to carcinogenicity.2008

    • Author(s)
      Mariko Murata, et al.
    • Organizer
      第67回日本癌学会総会
    • Place of Presentation
      名古屋市
    • Related Report
      2008 Annual Research Report
  • [Presentation] Nitrative and oxidative DNA damage by activation of oncogenic K-ras in mice.2008

    • Author(s)
      Shiho Ohnishi, et al.
    • Organizer
      第67回日本癌学会総会
    • Place of Presentation
      名古屋市
    • Related Report
      2008 Annual Research Report
  • [Presentation] アスベスト曝露マウス肺におけるDNA損傷塩基8-ニトログアニンの生成(第2報)免疫組織化学法における染色性の定量的解析2008

    • Author(s)
      平工雄介, 村田真理子
    • Organizer
      第81回日本産業衛生学会
    • Place of Presentation
      札幌市
    • Related Report
      2008 Annual Research Report
  • [Presentation] EBウイルス感染による上咽頭癌患者におけるニトロ化DNA損傷2008

    • Author(s)
      平工雄介, 外
    • Organizer
      第8回目本NO学会学術集会
    • Place of Presentation
      仙台市
    • Related Report
      2008 Annual Research Report
  • [Presentation] アスベスト気管内投与マウスの肺組織におけるDNA損傷塩基8-ニトログアニンの生成2007

    • Author(s)
      平工 雄介、村田 真理子、川西 正祐
    • Organizer
      日本産業衛生学会東海地方会
    • Place of Presentation
      愛知県名古屋市
    • Year and Date
      2007-11-17
    • Related Report
      2007 Annual Research Report
  • [Presentation] Dietary supplementation with coenzyme Q 10 decreases urinary level of 8-hydroxydeoxyguanosine in healthy subjects2007

    • Author(s)
      Kimiko Ito, Mariko Murata
    • Organizer
      Asian Conference on Environmental Mutagens & 36th Annual Meeting of The Japanese Environmental Mutagen Society
    • Place of Presentation
      北九州市
    • Related Report
      2009 Final Research Report
  • [Presentation] Ma Nganese enhances oxidative damage to cellular and isolated DNA induced by a coffee polyphenol, chlorogenic acid2007

    • Author(s)
      Mariko Murata, Yusuke Hiraku, Shinji Oikawa, Shosuke Kawanishi
    • Organizer
      European Meeting 2007 of the Society for Free Radical Research
    • Place of Presentation
      Portugal
    • Related Report
      2009 Final Research Report
  • [Presentation] プロテオーム解析によるタイ肝吸虫関連胆管癌におけるcytokeratin 19の検出2007

    • Author(s)
      村田真理子, 古川絢子, 平工雄介, 及川伸二, 川西正祐
    • Organizer
      第66回日本癌学会学術総会
    • Place of Presentation
      横浜
    • Related Report
      2009 Final Research Report
  • [Presentation] Formation of 8-nitroguanine and 8-oxo-7, 8-dihydro-2-deoxyguanosine by nitric oxide (NO) and superoxide (0_2)2007

    • Author(s)
      Shiko Takeuchi, Mariko Murata, Shinji Oikawa, Yusuke Hiraku, Shosuke Kawanishi
    • Organizer
      第1回アジア環境変異原学会・日本環境変異原学会第36回大会
    • Place of Presentation
      福岡県北九州市
    • Related Report
      2007 Annual Research Report
  • [Presentation] Formation of 8-nitroguanine, a nitrative DNA lesion, in the lung of mice exposed to asbestos(アスベスト曝露マウス肺におけるニトロ化DNA損傷塩基8-ニトログアニンの生成)2007

    • Author(s)
      平工 雄介、市瀬 孝道、馬 寧、吉田 成一、定金 香里、村田 真理子、川西 正祐
    • Organizer
      第1回アジア環境変異原学会・日本環境変異原学会第36回大会
    • Place of Presentation
      福岡県北九州市
    • Related Report
      2007 Annual Research Report
  • [Presentation] LPSによるニトロ化DNA損傷の分子機構: 感染・炎症関連発がんとの関連2007

    • Author(s)
      平工 雄介、及川(多田) 佐枝子、Somchai Pinlaor、馬 寧、村田 真理子、Raynoo Thanan, Puangrat Yongvanit、川西 正祐
    • Organizer
      第7回日本NO学会学術集会
    • Place of Presentation
      滋賀県大津市
    • Related Report
      2007 Annual Research Report
  • [Presentation] アスベスト曝露マウス肺におけるDNA損傷塩基8-ニトログアニンの生成2007

    • Author(s)
      平工 雄介、村田 真理子、川西 正祐
    • Organizer
      第80回日本産業衛生学会
    • Place of Presentation
      大阪府大阪市
    • Related Report
      2007 Annual Research Report
  • [Presentation] Formation of 8-nitroguanine and 8-oxo-7, 8-dihydro-2'-deoxyguanosine by nitric oxide (NO) and superoxide (O2-)

    • Author(s)
      Shiko Takeuchi, Mariko Murata, Shinji Oikawa, Yusuke Hiraku, Shosuke Kawanishi
    • Organizer
      1st Asian Conference on Environmental Mutagens & 36th Annual Meeting of The Japanese Environmental Mutagen Society
    • Place of Presentation
      Kitakyushu, Japan
    • Related Report
      2009 Final Research Report
  • [Book] 腫瘍薬学(第1章がんの生物学)2010

    • Author(s)
      村田哲也, 村田真理子, (川西正祐, 他編)
    • Publisher
      南山堂
    • Related Report
      2009 Final Research Report
  • [Book] 第5章子どもの病気とその予防、子どもの保健-理論と実践-(第6版)2010

    • Author(s)
      谷口アキ, 村田真理子
    • Publisher
      日本小児医事出版社
    • Related Report
      2009 Final Research Report

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Published: 2007-04-01   Modified: 2016-04-21  

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