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Comparative global sero-epidemiological study between the birth-cohort prevalence rate of hepatitis virus and the mortality caused by hepatocellular carcinoma

Research Project

Project/Area Number 19406022
Research Category

Grant-in-Aid for Scientific Research (B)

Allocation TypeSingle-year Grants
Section海外学術
Research Field Hygiene
Research InstitutionHiroshima University

Principal Investigator

TANAKA Junko  Hiroshima University, 大学院・医歯薬学総合研究科, 教授 (70155266)

Co-Investigator(Kenkyū-buntansha) KATAYAMA Keiko  広島大学, 大学院・医歯薬学総合研究科, 講師 (50304415)
YOSHIZAWA Hiroshi  広島大学, 大学院・医歯薬学総合研究科, 名誉教授 (30109954)
Research Collaborator BUSCH Michael  Director California University, Blood System Research Institute, Professor
MERPHY Edward  Senior Investigator California University, Blood System Research Institute, Professor
LUDMILA ZENEVSKAIA  Kiev Municipal Blood Center, Director
EDWARD Manza  Kiev Municipal Blood Center, System administrator
LELIE Nico  Novartis Vaccines and Diagnostics SAS, Senior Director Scientific Affairs
CLARKE Anne  International Plasma Fractionation Association in Nertherland, Director
SOMANA Svay  Ministry of Health of Kingdom of Cambodia, Vice-chief
OLLONE Lim  Ministry of Health of Kingdom of Cambodia, Chief
TABUCHI Ayako  広島大学, 大学院・医歯薬学総合研究科, 社会人大学院生
GOMBOJAV Bayasgalan  広島大学, 非常勤研究員
MIZUI Masaaki  広島県血液センター, 部長
MATSUO Junko  広島大学, 大学院・医歯薬学総合研究科, 助教 (70570232)
Project Period (FY) 2007 – 2009
Project Status Completed (Fiscal Year 2009)
Budget Amount *help
¥16,900,000 (Direct Cost: ¥13,000,000、Indirect Cost: ¥3,900,000)
Fiscal Year 2009: ¥3,250,000 (Direct Cost: ¥2,500,000、Indirect Cost: ¥750,000)
Fiscal Year 2008: ¥6,110,000 (Direct Cost: ¥4,700,000、Indirect Cost: ¥1,410,000)
Fiscal Year 2007: ¥7,540,000 (Direct Cost: ¥5,800,000、Indirect Cost: ¥1,740,000)
Keywords肝がん対策 / HCV抗体陽性率 / 肝がん死亡率 / 肝炎ウイルス罹患率 / 国際情報交換 / アメリカ / ウクライナ共和国 / カンボジア王国 / 日本:アメリカ:ウクライナ:カンボジア王国 / 国際研究者交流 / 日本:アメリカ:ウクライナ:スウェーデン / 日本:アメリカ:ウクライナ
Research Abstract

We studied to clarify the relativity between the age of developing HCC and the duration of infection with hepatitis viruses based on the data of the prevalence rate of hepatitis viruses and the mortality rate of hepatocellular carcinoma (HCC). We could offer and construct the evidence of the liver cancer control measures in each country through this study results. The hepatitis B surface antigen positivity rate and anti-HCV prevalence and the liver cancer mortality rate according to the age class acquired data from the United States and the Ukraine were calculated. On the other hand, in cooperation with the Kingdom of Cambodia Ministry of Health we began the pilot study in the one of the Asia country, where the detailed survey about hepatitis viral infection has not done yet. We had made the basement to clarify the prevalence rate and the incidence rate of thehepatitis viruses in Asia.

Report

(4 results)
  • 2009 Annual Research Report   Final Research Report ( PDF )
  • 2008 Annual Research Report
  • 2007 Annual Research Report
  • Research Products

    (37 results)

All 2010 2009 2008 2007

All Journal Article (18 results) (of which Peer Reviewed: 7 results) Presentation (14 results) Book (5 results)

  • [Journal Article] Regular surveillance by imaging for early detection and better prognosis of hepatocellular carcinoma in patients infected with hepatitis C virus2010

    • Author(s)
      Noda I, Kitamoto M, Nakahara H, Hayashi R, Okimoto T, Monzen Y, Yamada H, Imagawa M, Hiraga N, Tanaka J, Chayama K
    • Journal Title

      Journal of Gastroenterology 45

      Pages: 105-112

    • NAID

      10027214070

    • Related Report
      2009 Annual Research Report
    • Peer Reviewed
  • [Journal Article] 肝癌発生の疫学2009

    • Author(s)
      田中純子, 片山惠子
    • Journal Title

      内科 104巻

      Pages: 614-620

    • Related Report
      2009 Final Research Report
  • [Journal Article] 肝がん予防策としてのウイルス性肝炎対策の効果2009

    • Author(s)
      田中純子
    • Journal Title

      公衆衛生 73巻

      Pages: 894-899

    • Related Report
      2009 Final Research Report
  • [Journal Article] 透析患者のウイルス肝炎の起源院内感染とその予防策2009

    • Author(s)
      片山恵子, 田中純子
    • Journal Title

      臨牀透析 25

      Pages: 51-58

    • Related Report
      2009 Annual Research Report
  • [Journal Article] 肝癌発生の疫学2009

    • Author(s)
      田中純子, 片山惠子
    • Journal Title

      内科 104

      Pages: 614-620

    • Related Report
      2009 Annual Research Report
  • [Journal Article] 肝がん予防策としてのウイルス性肝炎対策の効果2009

    • Author(s)
      田中純子
    • Journal Title

      公衆衛生 73

      Pages: 894-899

    • Related Report
      2009 Annual Research Report
  • [Journal Article] Incidence rates of hepatitis B and C virus infections among blood donors in Hiroshima, Japan, during 10 years from 1994 to 20042008

    • Author(s)
      Tanaka J, Mizui M, Nagakami H, Katayama K, Tabuchi A, Komiya Y, Miyakawa Y, Yoshizawa H
    • Journal Title

      Intervirology 51

      Pages: 33-41

    • Related Report
      2009 Final Research Report
    • Peer Reviewed
  • [Journal Article] ウイルス肝炎の疫学わが国の肝炎ウイルス罹患状況と推定キャリア数2008

    • Author(s)
      田中純子
    • Journal Title

      Medical Practice 25巻

      Pages: 1726-1733

    • Related Report
      2009 Final Research Report
  • [Journal Article] HCV感染の疫学の変化:現況と将来2008

    • Author(s)
      田中純子, 片山惠子, 田渕文子, 吉澤浩司
    • Journal Title

      肝胆膵 57巻

      Pages: 707-715

    • Related Report
      2009 Final Research Report
  • [Journal Article] A novel hepatitis B virus surface antigen immunoassay as sensitive as hepatitis B virus nucleic acid testing in detecting early infection2008

    • Author(s)
      Matsubara N
    • Journal Title

      Transfusion 80

      Pages: 2064-2068

    • Related Report
      2008 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Titration of hepatitis B virus infectivity In the sera of pre-acute and late acute phases of HBV infection : Transmission experiments to chimeric mice with human liver repopulated hepatocytes2008

    • Author(s)
      Tabuchi A
    • Journal Title

      Journal of Medical Virology 80

      Pages: 2064-2068

    • Related Report
      2008 Annual Research Report
    • Peer Reviewed
  • [Journal Article] ウイルス肝炎の疫学 わが国の肝炎ウイルス罹患状況と推定キャリア数2008

    • Author(s)
      田中純子
    • Journal Title

      Medical Practice 25

      Pages: 1726-1733

    • Related Report
      2008 Annual Research Report
  • [Journal Article] 透析医療施設におけるHCV感染対策2008

    • Author(s)
      田中純子
    • Journal Title

      感染制御 4

      Pages: 464-470

    • Related Report
      2008 Annual Research Report
  • [Journal Article] HCV感染の疫学の変化 : 現況と将来2008

    • Author(s)
      田中純子
    • Journal Title

      肝胆膵 57

      Pages: 707-715

    • Related Report
      2008 Annual Research Report
  • [Journal Article] Incidence Rates of Hepatitis B and C Virus Infections among Blood Donors in Hiroshima, Japan, during 10 Years from 1994 to 20042008

    • Author(s)
      Tanaka J
    • Journal Title

      Intervirology 51

      Pages: 33-41

    • Related Report
      2007 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Minimum infectious dose of hepatitis B virus in chimpanzees and difference in the dynamics of viremia between genotype A and genotype C.2008

    • Author(s)
      Komiya Y
    • Journal Title

      Transfusion 48

      Pages: 286-294

    • Related Report
      2007 Annual Research Report
    • Peer Reviewed
  • [Journal Article] b型肝炎ウイルス(HBV)感染の疫学-年齢別, 地域別にみたHBVキャリアの分布-2007

    • Author(s)
      田中純子
    • Journal Title

      Expert Opinion on Hepatitis B 4

      Pages: 6-9

    • Related Report
      2009 Final Research Report
  • [Journal Article] Liver disease in hepatitis C virus carriers identified at blood donation and their outcomes with or without interferon treatment: Study on 1019 carriers followed for 5-10 years2007

    • Author(s)
      Mizui M
    • Journal Title

      Hepatology Research 37

      Pages: 994-1001

    • NAID

      10019796200

    • Related Report
      2007 Annual Research Report
    • Peer Reviewed
  • [Presentation] Comparative global sero-epidemi- ological study between the birth- cohort prevalence rate of hepatitis C virus and the mortality caused by hepatocellular carcinoma2010

    • Author(s)
      Bayasgalan G, Akita T, Tabuchi A, Matsuo J, Mizui M, Katayama K, Tanaka J
    • Organizer
      国際疫学会西太平洋地域学術会議(The Joint Scientific Meeting of IEA Western Pacific Region and Japan Epidemi- ological Association)
    • Place of Presentation
      埼玉
    • Year and Date
      2010-01-09
    • Related Report
      2009 Final Research Report
  • [Presentation] Serological epidemiological study about hepatitis B virus infection at nine hemodialysis hospitals in Hiroshima2010

    • Author(s)
      田渕文子, 松尾順子, 片山恵子, 田中純子
    • Organizer
      国際疫学会西太平洋地域学術会議 (The Joint Scientific Meeting of IEA Western Pacific Region and Japan Epidemiological Association)
    • Place of Presentation
      埼玉県立大学(埼玉県)
    • Year and Date
      2010-01-09
    • Related Report
      2009 Annual Research Report
  • [Presentation] Comparative global sero-epidemiological study between the birth-cohort prevalence rate of hepatitis C virus and the mortality caused by hepatocellular carcinoma2010

    • Author(s)
      Bayasgalan G, Akita T, Tabuchi A, Matsuo J, Mizui M, Katayama K, Tanaka J
    • Organizer
      国際疫学会西太平洋地域学術会議 (The Joint Scientific Meeting of IEA Western Pacific Region and Japan Epidemiological Association)
    • Place of Presentation
      埼玉県立大学(埼玉県)
    • Year and Date
      2010-01-09
    • Related Report
      2009 Annual Research Report
  • [Presentation] 広島県内9透析医療施設における血液透析患者のHBV感染に関する血清学的疫学調査2009

    • Author(s)
      田渕文子, 松尾順子, 片山恵子, 田中純子, 広島県透析患者肝炎 study group
    • Organizer
      第7回日本予防医学会学術総会
    • Place of Presentation
      千葉大学西千葉キャンパスけやき会館 (千葉県)
    • Year and Date
      2009-12-13
    • Related Report
      2009 Annual Research Report
  • [Presentation] B型肝炎ウイルス感染防御能としてのHBs抗体価の定量-ヒト肝細胞置換キメラマウスを用いた感染実験-2009

    • Author(s)
      片山恵子, 松尾順子, 田渕文子, 田中純子
    • Organizer
      第39回 日本肝臓学会西部会
    • Place of Presentation
      米子市文化ホール(鳥取県)
    • Year and Date
      2009-12-04
    • Related Report
      2009 Annual Research Report
  • [Presentation] 我が国のB型肝炎ウイルス(HBV)感染の疫学2009

    • Author(s)
      田中純子
    • Organizer
      DDW-Japan2009 第13回 日本肝臓学会大会
    • Place of Presentation
      国立京都国際会館(京都府)
    • Year and Date
      2009-10-16
    • Related Report
      2009 Annual Research Report
  • [Presentation] 広島県における肝疾患診療連携拠点病院の役割と病診連携2009

    • Author(s)
      高橋祥一, 田中純子, 茶山一彰
    • Organizer
      DDW-Japan2009 第13回 日本肝臓学会大会ワークショップ
    • Place of Presentation
      グランドプリンスホテル京都(京都府)
    • Year and Date
      2009-10-14
    • Related Report
      2009 Annual Research Report
  • [Presentation] 我が国の肝がん撲滅を目指した肝炎ウイルス検診5年間の成果2008

    • Author(s)
      田中純子
    • Organizer
      第6回 日本予防医学会学術総会
    • Place of Presentation
      東京都
    • Year and Date
      2008-11-30
    • Related Report
      2008 Annual Research Report
  • [Presentation] B型肝炎ウイルスの感染早期及び後期における血清中HBV感染量の測定 : ヒト肝細胞置換キメラマウスを用いた感染実験2008

    • Author(s)
      田渕文子
    • Organizer
      第6回 日本予防医学会学術総会
    • Place of Presentation
      東京都
    • Year and Date
      2008-11-30
    • Related Report
      2008 Annual Research Report
  • [Presentation] わが国の肝がん撲滅を目ざした肝炎ウイルス検診5年間の成果、有効性と展望2008

    • Author(s)
      田中純子
    • Organizer
      第12回 日本肝臓学会大会 ワークショップ
    • Place of Presentation
      東京都
    • Year and Date
      2008-10-02
    • Related Report
      2008 Annual Research Report
  • [Presentation] Experimental transmission of HBV to susceptible model animals-Summary of the present status and perspectives-2008

    • Author(s)
      Yoshizawa H
    • Organizer
      IPFA/PEI(The 15th Workshop on “Surveillanceand Screening of Blood Borne Pathogens")
    • Place of Presentation
      オーストリア・ウィーン
    • Year and Date
      2008-05-14
    • Related Report
      2008 Annual Research Report
  • [Presentation] Experimental transmission of HCV to human hepatocyte trans planted chimera mice to examine the neutralizing activity of HCIG (candidate) fractionated from human pooled plasma with high titer of anti-HCVenv antibody2008

    • Author(s)
      Yoshizawa H
    • Organizer
      IPFA/PEI (The 15th Workshop on "Surveillance and Screening of Blood Borne Pathogens")
    • Place of Presentation
      オーストリア・ウィーン
    • Year and Date
      2008-05-13
    • Related Report
      2008 Annual Research Report
  • [Presentation] 献血者集団におけるHBV・HCV新規感染率からみた一般集団におけるincidenceの推定2007

    • Author(s)
      田中純子
    • Organizer
      第5回日本予防医会
    • Place of Presentation
      鹿児島県 指宿市
    • Year and Date
      2007-11-24
    • Related Report
      2007 Annual Research Report
  • [Presentation] Liver disease in hepatitis C virus carriers found at the occasion of blood donation and outcomes with or without interferon treatment: A study on 1019 carriers followed for5-10 years2007

    • Author(s)
      Tanaka J
    • Organizer
      DDW2007
    • Place of Presentation
      Washington DC., USA
    • Year and Date
      2007-05-21
    • Related Report
      2007 Annual Research Report
  • [Book] 透析療法ネクストVIII 感染症対策(肝炎ウイルス感染発生時の対処と再発防止策:p92-98)2009

    • Author(s)
      田中純子, 吉澤浩司
    • Total Pages
      133
    • Publisher
      医学図書出版株式会社
    • Related Report
      2009 Annual Research Report
  • [Book] 肝炎のインターフェロン治療 up to date 2009 節目検診と肝炎・肝がん対策2008

    • Author(s)
      田中純子
    • Publisher
      日本メディカルセンター
    • Related Report
      2008 Annual Research Report
  • [Book] 我が国における肝硬変の疫学, 最新医学別冊新しい診断と治療のABC44消化器6肝硬変2007

    • Author(s)
      田中純子
    • Publisher
      最新医学社(東京)
    • Related Report
      2009 Final Research Report
  • [Book] Congenital and Other Related Infectious Diseases of the Newborn Perinatal Hepatitis B Virus Infection in Japan2007

    • Author(s)
      Koyama T
    • Publisher
      Elsevier B.V.
    • Related Report
      2007 Annual Research Report
  • [Book] 最新医学別冊 新しい診断と治療のABC44 消化器6 肝硬変2007

    • Author(s)
      田中純子
    • Publisher
      最新医学社
    • Related Report
      2007 Annual Research Report

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Published: 2007-04-01   Modified: 2016-04-21  

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