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Investigation of disease susceptibility genes associated with intractable intraocular inflammation with racial differences and development of new antioxidant therapy

Research Project

Project/Area Number 19406028
Research Category

Grant-in-Aid for Scientific Research (B)

Allocation TypeSingle-year Grants
Section海外学術
Research Field Ophthalmology
Research InstitutionHokkaido University

Principal Investigator

OHNO Shigeaki  Hokkaido University, 大学院・医学研究科, 特任教授 (50002382)

Co-Investigator(Kenkyū-buntansha) ISHIDA Susumu  北海道大学, 大学院・医学研究科, 教授 (10245558)
YOSHIDA Kazuhiko  北海道大学, 大学病院, 講師 (90281807)
NAMBA Kenichi  北海道大学, 大学病院, 助教 (70333599)
KITAICHI Nobuyoshi  北海道大学, 大学病院, 助教 (40431366)
TAGAWA Yoshitsugu  北海道大学, 大学院・医学研究科, 准教授 (40109426)
ONOE Kazunori  北海道大学, 遺伝子病制御研究所, 教授 (40002117)
水木 信久  横浜市立大学, 医学部, 教授 (90336579)
猪子 英俊  東海大学, 医学部, 教授 (10101932)
Co-Investigator(Renkei-kenkyūsha) MIZUKI Nobuhisa  横浜市立大学, 医学部, 教授 (90336579)
INOKO Hidetoshi  東海大学, 医学部, 教授 (10101932)
Project Period (FY) 2007 – 2009
Project Status Completed (Fiscal Year 2009)
Budget Amount *help
¥16,900,000 (Direct Cost: ¥13,000,000、Indirect Cost: ¥3,900,000)
Fiscal Year 2009: ¥4,810,000 (Direct Cost: ¥3,700,000、Indirect Cost: ¥1,110,000)
Fiscal Year 2008: ¥4,810,000 (Direct Cost: ¥3,700,000、Indirect Cost: ¥1,110,000)
Fiscal Year 2007: ¥7,280,000 (Direct Cost: ¥5,600,000、Indirect Cost: ¥1,680,000)
Keywords疾患感受性遺伝子 / ベーチェット病 / 難治性内眼炎 / アデノウイルス角結膜炎 / 分子疫学 / アスタキサンチン
Research Abstract

In GWAS studies in Behcet disease, 2 new genes and HLA-B*510101 were found. In Vogt-Koyanagi-Harada disease, HLA-DRB1*0405 and several genetic associations were also found. Virological studies revealed 2 new human adenoviruses (HAdV 53 and 54). One of the carotenoids, astaxanthin showed significant increase of choroidal blood flow. DHMEQ, a new NF-κB blocker also showed significant suppression of experimental uveoretinitis.

Report

(4 results)
  • 2009 Annual Research Report   Final Research Report ( PDF )
  • 2008 Annual Research Report
  • 2007 Annual Research Report
  • Research Products

    (118 results)

All 2009 2008 2007 Other

All Journal Article (69 results) (of which Peer Reviewed: 69 results) Presentation (49 results)

  • [Journal Article] Lack of association between toll-like receptor 4 gene polymorphisms and sarcoidosis-related uveitis in Japan2009

    • Author(s)
      Asukata Y, Ota M, Meguro A, Katsuyama Y, Ishihara M, Namba K, Kitaichi N, Morimoto S, Kaburaki T, Ando Y, Takenaka S, Inoko H, Ohno S, Mizuki N
    • Journal Title

      Mol Vis VOL. 15

      Pages: 14-20

    • Related Report
      2009 Final Research Report
    • Peer Reviewed
  • [Journal Article] Evaluation of PTPN22 polymorphisms and Vogt-Koyanagi-Harada disease in Japanese patients2009

    • Author(s)
      Horie Y, Kitaichi N, Katsuyama Y, Yoshida K, Miura T, Ota M, Asukata Y, Inoko H, Mizuki N, Ishida S, Ohno S
    • Journal Title

      Mol Vis VOL. 15

      Pages: 1115-1119

    • NAID

      120001415121

    • Related Report
      2009 Final Research Report
    • Peer Reviewed
  • [Journal Article] Association of TLR4 polymorphisms with Behcet's disease in a Korean population2009

    • Author(s)
      Horie Y, Neguro A Ota M, Kitaichi N, Katsuyama Y, Takemoto Y, Namba K, Yoshida K, Song Y W, ParkK S, Lee E B, Inoko H, Mizuki N, Ohno S
    • Journal Title

      Rheumatology VOL. 48

      Pages: 638-642

    • Related Report
      2009 Final Research Report
    • Peer Reviewed
  • [Journal Article] Investigation of the association between the GLC3A locus andnormal tension glaucoma in Japanese patients by microsatellite analysis2009

    • Author(s)
      Kamio M, Meguro A, Ota M, Nomura N, Kashiwagi K, Mabuchi F, Iijima H, Kawase K, Yamamoto T, Nakamura M, Negi A, Sagara T, Nishida T, Inatani M, Tanihara H, Aihara M, Araie M, Fukuchi T, Abe H, Higashide T, Sugiyama K, Kanamoto T, Kiuchi Y, Iwase A, Ohno S,Inoko H, Mizuki N
    • Journal Title

      Clin Ophthalmol VOL. 3

      Pages: 183-188

    • Related Report
      2009 Final Research Report
    • Peer Reviewed
  • [Journal Article] Proliferative diabetic retinopathy with lymphocyte-rich epiretinal membrane associated with poor visual prognosis2009

    • Author(s)
      Kase S, Saito W, Ohno S, Ishida S
    • Journal Title

      Invest Ophthalmol Vis Sci VOL. 50

      Pages: 5909-5912

    • Related Report
      2009 Final Research Report
    • Peer Reviewed
  • [Journal Article] Low prevalence of juvenile-onset Behcet's diease with uveitis in east/south Asian people2009

    • Author(s)
      Kitaichi N, Miyazaki A, Stanford MR, Iwata D, Chams H, Ohno S
    • Journal Title

      Br J Ophthalmol VOL. 93

      Pages: 1428-1430

    • Related Report
      2009 Final Research Report
    • Peer Reviewed
  • [Journal Article] Clinical features of intraocular inflammation in Hokkaido, Japan2009

    • Author(s)
      Kitamei H, Kitaichi N, Namba K, Kotake S, Goda C, Kitamura M, Miyazaki A, Ohno S
    • Journal Title

      Acta Ophthalmol VOL. 87

      Pages: 424-428

    • Related Report
      2009 Final Research Report
    • Peer Reviewed
  • [Journal Article] Association of microsatellite polymorphisms of the GPDS1 locus with normal tension glaucoma in the Japanese population2009

    • Author(s)
      Nakamura K, Ota M, Meguro A, Nomura N, Kashiwagi K, Mabuchi F, Iijima H, Kawase K, Yamamoto T, Nakamura M,Negi A, Sagara T, Nishida T, Inatani M, Tanihara H, Aihara M, Araie M, Fukuchi T, Abe H Higashide T, Sugiyama K, Kanamoto T, Kiuchi Y, Iwase A, Ohno S, Inoko H, Mizuki N
    • Journal Title

      Clin Ophthalmol VOL. 3

      Pages: 307-312

    • Related Report
      2009 Final Research Report
    • Peer Reviewed
  • [Journal Article] New susceptibility locus for high myopia is linked to the uromodulin-like 1 (UMODL1) gene region on chromosome 21q22.32009

    • Author(s)
      Nishizaki R, Ota M, Inoko H, Meguro A, Shiota T, Okada E, Mok J, Oka A, Ohno S, Mizuki N
    • Journal Title

      Eye VOL. 23

      Pages: 222-229

    • Related Report
      2009 Final Research Report
    • Peer Reviewed
  • [Journal Article] Investigation of the association between toll-like receptor 2 gene polymorphisms and Behcet's disease in Japanese patients2009

    • Author(s)
      Tomiyama R, Meguro A, Ota M, Katsuyama Y, Nishide T, Uemoto R, Iijima Y, Ohno S, Inoko H, Mizuki N
    • Journal Title

      VOL. 70

      Pages: 41-44

    • Related Report
      2009 Final Research Report
    • Peer Reviewed
  • [Journal Article] Lack of association between toll-like receptor 4 gene polymor phisms and sarcoidosis-related uveitis in Japan.2009

    • Author(s)
      Asukata Y, Ota M, Meguro A, Katsuyama Y, Ishihara M, Namba K, Kitaichi N, Morimoto S, Kaburaki T, Ando Y, Takenaka S, Inoko H, Ohno S, Mizuki N
    • Journal Title

      Mol Vis VOL.15

      Pages: 2673-2682

    • Related Report
      2009 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Evaluation of PTPN22 polymorphisms and Vogt-Koyanagi-Harada disease in Japanese patients.2009

    • Author(s)
      Horie Y, Kitaichi N, Katsuyama Y, Yoshida K, Miura T, Ota M, Asukata Y, Inoko H, Mizuki N, Ishida S, Ohno S
    • Journal Title

      Mol Vis VOL.15

      Pages: 1115-1119

    • NAID

      120001415121

    • Related Report
      2009 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Association of TLR4 polymorphisms with Behcet's disease in a Korean population.2009

    • Author(s)
      Horie Y, Neguro A Ota M, Kitaichi N, Katsuyama Y, Takemoto Y, Namba K, Yoshida K, Song Y W, Park K S, Lee E B, Inoko H, Mizuki N, Ohno S
    • Journal Title

      Rheumatology VOL.48

      Pages: 638-642

    • Related Report
      2009 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Investigation of the association between the GLC3A locus and normal tension glaucoma in Japanese patients by microsatellite analysis.2009

    • Author(s)
      Kamio M, Meguro A, Ota M, Nomura N, Kashiwagi K, Mabuchi F, Iijima H, Kawase K, Yamamoto T, Nakamura M, Negi A, Sagara T, Nishida T, Inatani M, Tanihara H, Aihara M, Araie M, Fukuchi T, Abe H, Higashide T, Sugiyama K, Kanamoto T, Kiuchi Y, Iwase A, Ohno S, Inoko H, Mizuki N
    • Journal Title

      Clin Ophthalmol VOL.3

      Pages: 183-188

    • Related Report
      2009 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Proliferative diabetic retinopathy with lymphocyte-rich epiretinal membrane associated with poor visual prognosis.2009

    • Author(s)
      Kase S, Saito W, Ohno S, Ishida S
    • Journal Title

      Invest Ophthalmol Vis Sci VOL.50

      Pages: 5909-5912

    • Related Report
      2009 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Low prevalence of juvenile-onset Behcet's diease with uveitis in east/south Asian people.2009

    • Author(s)
      Kitaichi N, Miyazaki A, Stanford MR, Iwata D, Chams H, Ohno S
    • Journal Title

      Br J Ophthalmol VOL.93

      Pages: 1428-1430

    • Related Report
      2009 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Clinical features of intraocular inflammation in Hokkaido, Japan.2009

    • Author(s)
      Kitamei H, Kitaichi N, Namba K, Kotake S, Goda C, Kitamura M, Miyazaki A, Ohno S
    • Journal Title

      Acta Ophthalmol VOL.87

      Pages: 424-428

    • Related Report
      2009 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Association of microsatellite polymorphisms of the GPDS1 locus with normal tension glaucoma in the Japanese population.2009

    • Author(s)
      Nakamura K, Ota M, Meguro A, Nomura N, Kashiwagi K, Mabuchi F, Iijima H, Kawase K, Yamamoto T, Nakamura M, Negi A, Sagara T, Nishida T, Inatani M, Tanihara H, Aihara M, Araie M, Fukuchi T, Abe H, Higashide T, Sugiyama K, Kanamoto T, Kiuchi Y, Iwase A, Ohno S, Inoko H, Mizuki N
    • Journal Title

      Clin Ophthalmol VOL.3

      Pages: 307-312

    • Related Report
      2009 Annual Research Report
    • Peer Reviewed
  • [Journal Article] New susceptibility locus for high myopia is linked to the uromodulin-like 1(UMODL1)gene region on chromosome 21q22.3.2009

    • Author(s)
      Nishizaki R, Ota M, Inoko H, Meguro A, Shiota T, Okada E, Mok J, Oka A, Ohno S, Mizuki N.
    • Journal Title

      Eye. VOL.23

      Pages: 222-229

    • Related Report
      2009 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Investigation of the association between toll-like receptor 2 gene polymorphisms and Behcet's disease in Japanese patients.2009

    • Author(s)
      Tomiyama R, Meguro A, Ota M, Katsuyama Y, Nishide T, Uemoto R, Iijima Y, Ohno S, Inoko H, Mizuki N
    • Journal Title

      Hum Immunol VOL.70

      Pages: 41-44

    • Related Report
      2009 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Anti-inflammatory effect of angiotensin type 1 receptor antagonist on endotoxin-induced uveitis in rats2008

    • Author(s)
      Miyazaki A, Kitaichi N, OhgamiK, Iwata D, Jin XH, Iwabuchi K, Morohashi T, Ohno S, Onoe K
    • Journal Title

      Graefes Arch Clin Exp Ophthalmol VOL. 246

      Pages: 747-757

    • Related Report
      2009 Final Research Report
    • Peer Reviewed
  • [Journal Article] Guidelines for the diagnosis of ocular sarcoidosis2008

    • Author(s)
      Asukata Y, Ishihara M, Hasumi Y, Nakamura S, Hayashi K, Ohno S, Mizuki N
    • Journal Title

      Ocul Immunol Inflamm VOL. 16

      Pages: 77-81

    • Related Report
      2009 Final Research Report
    • Peer Reviewed
  • [Journal Article] Sister cases of Behcet's disease and Vogt-Koyanagi-Harada disease2008

    • Author(s)
      Horie Y, Namba K, Kitaichi N, Ohno S
    • Journal Title

      Br J Ophthalmol VOL. 92

      Pages: 433-434

    • Related Report
      2009 Final Research Report
    • Peer Reviewed
  • [Journal Article] Evaluation of mixed infection cases with both herpes simplex virus types 1 and 22008

    • Author(s)
      Kaneko H, Kawana T, Ishioka K, Ohno S, Aoki K, Suzutani T
    • Journal Title

      J Med Virology VOL. 80

      Pages: 883-887

    • Related Report
      2009 Final Research Report
    • Peer Reviewed
  • [Journal Article] Polymorphism of IFN-gamma gene and Vogt-Koyanagi-Harada disease2008

    • Author(s)
      Horie Y, Kitaichi N, Takemoto Y, Namba K, Yoshida K, Hirose S, Hasumi Y, Ota M, Inoko H, Mizuki N, Ohno S
    • Journal Title

      Mol Vis VOL. 92

      Pages: 2334-2338

    • NAID

      120000947114

    • Related Report
      2009 Final Research Report
    • Peer Reviewed
  • [Journal Article] Block suture for trabpculectomy using only 2 anchors2008

    • Author(s)
      Chin S
    • Journal Title

      Arch Ophthalmol 126

      Pages: 1756-1758

    • Related Report
      2008 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Anti-inflammatory effect of angiotensin type 1 receptor antagonist on endotoxin-induced uveitis in rats2008

    • Author(s)
      Miyazaki A
    • Journal Title

      Graefes Arch Clin Exp Ophthalmol 246

      Pages: 747-757

    • Related Report
      2008 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Guidelines for the diagnosis of ocular sarcoidosis2008

    • Author(s)
      Asukata Y
    • Journal Title

      Ocul Immunol Inflamm 16

      Pages: 77-81

    • Related Report
      2008 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Sister cages of Behcet's disease and Vogt-Koyanagi-Harada disease2008

    • Author(s)
      Horie Y
    • Journal Title

      Br J Ophthalmol 92

      Pages: 433-434

    • Related Report
      2008 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Evaluation of mixed infection cases with both herpes simplex virus types 1 and 22008

    • Author(s)
      Kaneko H
    • Journal Title

      J Med Virology 80

      Pages: 883-887

    • Related Report
      2008 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Macrophage migration inhibitory factor ameliorates UV-induced photokeratitis in mice2008

    • Author(s)
      Kitaichi N
    • Journal Title

      Exp Eye Res 86

      Pages: 929-935

    • Related Report
      2008 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Transgenic mice gererating group, Ono E : Microphthalmia and lack of vitreous body in transgenic mice expressing the first immunoglobulin-like domain of nectin-12008

    • Author(s)
      Yoshida K
    • Journal Title

      Graefes Arch Clin Exp Ophthalmol 246

      Pages: 543-549

    • Related Report
      2008 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Behcet disease in children2008

    • Author(s)
      Kitaichi N
    • Journal Title

      Int Ophthalmol Clin 48

      Pages: 87-91

    • Related Report
      2008 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Association of the toll-like receptor 4 gene polymorphisms with Behcet's disease2008

    • Author(s)
      Meguro A
    • Journal Title

      Ann Rheum Dis 67

      Pages: 725-727

    • Related Report
      2008 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Microsatellite analysis of the GLC1B locus on chromosome 2 points to NCK2 as a new candidate gene for normal tension glaucoma2008

    • Author(s)
      Akiyama M
    • Journal Title

      Br J Ophthalmol 92

      Pages: 1293-1296

    • Related Report
      2008 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Efficacy and complications of intravitreal injection of triamcinolone acetonide for refractory cystoid macular edema associated with intraocular inflammation2008

    • Author(s)
      Zhenyu Dong
    • Journal Title

      Jpn J Ophthalmol 52

      Pages: 374-379

    • Related Report
      2008 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Inhibition of choroidal neovascularization with an anti-inflammatory carotenold astaxanthin2008

    • Author(s)
      Izumi-Nagai K
    • Journal Title

      Invest Ophthalmol Vis Sci 49

      Pages: 1679-1685

    • Related Report
      2008 Annual Research Report
    • Peer Reviewed
  • [Journal Article] 眼科におけるアスタキサンチンの有用性2008

    • Author(s)
      大神一浩
    • Journal Title

      あたらしい眼科 9

      Pages: 1257-1260

    • Related Report
      2008 Annual Research Report
    • Peer Reviewed
  • [Journal Article] 海の幸エビ・カニ・サケは目に良いか? 赤い色の正体は2008

    • Author(s)
      大野重昭
    • Journal Title

      眼科ケア 10

      Pages: 1004-1008

    • Related Report
      2008 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Vbgt-小柳-原田病とスギウラ・サイン2008

    • Author(s)
      北市伸義
    • Journal Title

      日本の眼科 79

      Pages: 1229-1233

    • Related Report
      2008 Annual Research Report
    • Peer Reviewed
  • [Journal Article] H2-D^d-mediated upregulation of IL-4 production by natural killer Tcell and dendritic cell interaction.2008

    • Author(s)
      Mizuuchi K
    • Journal Title

      Int Immunol (In press)

    • Related Report
      2007 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Sister cases of Behcet's disease and Vogt-Koyanagi-Harada disease.2008

    • Author(s)
      Horie Y
    • Journal Title

      Br J Ophthalmol 92

      Pages: 433-434

    • Related Report
      2007 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Association of the Toll-like receptor 4 gene polymorphisms with Behcet's disease.2008

    • Author(s)
      Meguro A
    • Journal Title

      Ann Rheum Dis (In press)

    • Related Report
      2007 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Primary central nervous system lymphoma with intraocular recurrence after optic nerve disorder2007

    • Author(s)
      Horie Y, Saito W, Kase S, Yoshida K, Ohno S
    • Journal Title

      Retinal Cases & Brief Reports VOL. 1

      Pages: 165-168

    • Related Report
      2009 Final Research Report
    • Peer Reviewed
  • [Journal Article] Lack of Association of Toll-like receptor 9 gene polymorphism with Behcet's disease in Japanese patients2007

    • Author(s)
      Ito A, Ota M, Katsuyama Y, Inoko H, Ohno S, Mizuki N
    • Journal Title

      Tissue Antigens VOL. 70

      Pages: 423-426

    • Related Report
      2009 Final Research Report
    • Peer Reviewed
  • [Journal Article] Polymorphism of IFN-gamma gene and Vogt-Koyanagi-Harada disease.2007

    • Author(s)
      Horie Y
    • Journal Title

      Mol Vis 21

      Pages: 2334-2338

    • Related Report
      2007 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Primary central nervous system lymphoma with intraocular recurrence after optic nerve disorder.2007

    • Author(s)
      Horie Y
    • Journal Title

      Retinal Cases & Brief Reports 1

      Pages: 165-168

    • Related Report
      2007 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Lack of Association of Toll-like receptor 9 gene polymorphism with Behcet's disease in Japanese patients.2007

    • Author(s)
      Ito A
    • Journal Title

      Tissue Antigens 70

      Pages: 423-426

    • Related Report
      2007 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Association of major histocompatibility complex class I chain-related gene A and HLA-B alleles with Behcet's disease in Turkey.2007

    • Author(s)
      Mizuki N
    • Journal Title

      Jpn J Ophthalmol 51

      Pages: 431-436

    • NAID

      10020179012

    • Related Report
      2007 Annual Research Report
    • Peer Reviewed
  • [Journal Article] MDRI polymorphisms effect cyclosporine AUC0-4 values in Behcet's disease patients.2007

    • Author(s)
      Katsuyama Y
    • Journal Title

      Clin Ophthalmol 1

      Pages: 297-303

    • Related Report
      2007 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Ocular features of Behcet's disease: an international collaborative study.2007

    • Author(s)
      Kitaichi N
    • Journal Title

      Br J Ophthalmol 91

      Pages: 1579-1582

    • Related Report
      2007 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Neuroprotective effect of geranylgeranylacetone against ischemia-induced retinal injury.2007

    • Author(s)
      Harada C
    • Journal Title

      Mol Vis 7

      Pages: 1601-1607

    • Related Report
      2007 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Indocyanine green angiography in a case of punctate inner choroidopathy associated with acute zonal occult outer retinopathy.2007

    • Author(s)
      Saito A
    • Journal Title

      Jpn J Ophthalmol 51

      Pages: 295-300

    • Related Report
      2007 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Slowly progressive cancer-associated retinopathy.2007

    • Author(s)
      Saito W
    • Journal Title

      Arch Ophthalmol 125

      Pages: 1431-1433

    • Related Report
      2007 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Repeated exacerbations of ocular inflammation with vitreous hemorrhage in a patient with HLA-B27 associated uveitis.2007

    • Author(s)
      Kase S
    • Journal Title

      J Med Invest 54

      Pages: 350-353

    • Related Report
      2007 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Increased osteopontin levels in the vitreous of patients with diabetic retinopathy.2007

    • Author(s)
      Kase S
    • Journal Title

      Ophthalmic Res 39

      Pages: 143-147

    • Related Report
      2007 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Osteopontin aggravates experimental autoimmune uveoretinitis in mice.2007

    • Author(s)
      Kitamura M
    • Journal Title

      J Immunol 178

      Pages: 6567-6572

    • Related Report
      2007 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Genetic polymorphisms in the promoter of the interferon gamma receptor 1 gene are associated with atopic cataracts.2007

    • Author(s)
      Matsuda A
    • Journal Title

      Invest Ophthalmol Vis Sci 48

      Pages: 583-589

    • Related Report
      2007 Annual Research Report
    • Peer Reviewed
  • [Journal Article] High-resolution mapping for essential hypertension using microsatellite markers.2007

    • Author(s)
      Yatsu K
    • Journal Title

      Hypertension 49

      Pages: 446-452

    • Related Report
      2007 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Epidemiological survey of intraocular inflammation in Japan.2007

    • Author(s)
      Goto H
    • Journal Title

      Jpn J Ophthalmol 51

      Pages: 41-44

    • Related Report
      2007 Annual Research Report
    • Peer Reviewed
  • [Journal Article] The positive role of lumbar puncture in the diagnosis of Vogt-Koyanagi-Harada disease: lymphocyte subsets in the aqueous humor and cerebrospinal fluid.2007

    • Author(s)
      Kitaichi
    • Journal Title

      Int Ophthalmol 27

      Pages: 97-103

    • Related Report
      2007 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Anti-TNF therapy in the management of Behcet's disease--review and basis for recommendations.2007

    • Author(s)
      Sfikakis PP
    • Journal Title

      Rheumatology 46

      Pages: 736-741

    • Related Report
      2007 Annual Research Report
    • Peer Reviewed
  • [Journal Article] 【サイトカインの注目すべき作用】オステオポンチンの自己免疫疾患発症への関与2007

    • Author(s)
      北村瑞
    • Journal Title

      臨床免疫・アレルギー科 47

      Pages: 285-289

    • Related Report
      2007 Annual Research Report
    • Peer Reviewed
  • [Journal Article] 炎症性眼疾患の診療 若年性関節リウマチに伴う前部内眼炎2007

    • Author(s)
      北市伸義
    • Journal Title

      臨床眼科 61

      Pages: 488-492

    • Related Report
      2007 Annual Research Report
    • Peer Reviewed
  • [Journal Article] 炎症性眼疾患の診療 結核性内眼炎2007

    • Author(s)
      小竹聡
    • Journal Title

      臨床眼科 61

      Pages: 1380-1382

    • Related Report
      2007 Annual Research Report
    • Peer Reviewed
  • [Journal Article] 炎症性眼疾患の診療 間質性腎炎ぶどう膜炎症候群2007

    • Author(s)
      合田千穂
    • Journal Title

      臨床眼科 61

      Pages: 1598-1601

    • Related Report
      2007 Annual Research Report
    • Peer Reviewed
  • [Journal Article] 【誘導される免疫応答の種類と樹状細胞】CpG反応樹状細胞によるNKT細胞からのIL-4産生誘導2007

    • Author(s)
      水内一臣
    • Journal Title

      臨床免疫・アレルギー科 48

      Pages: 236-242

    • Related Report
      2007 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Intravitreal anti-vascular endothelial growth factor therapy with bevacizumab for tuberous sclerosis with macular oedema

    • Author(s)
      Saito W
    • Journal Title

      Acta Ophthalmol (In press)

    • Related Report
      2008 Annual Research Report
    • Peer Reviewed
  • [Journal Article] New susceptibility locus for high myopia is linked to the uromodulin-like 1 (UMODL1) gene region on chromosome 21q22.3

    • Author(s)
      Nishizaki R
    • Journal Title

      Eye (In press)

    • Related Report
      2008 Annual Research Report
    • Peer Reviewed
  • [Presentation] Ocular Inflammatory Disease : Clinical pictures of sarcoidosis2009

    • Author(s)
      Ohno S.
    • Organizer
      The 12th Seoul National University-Hokkaido University Joint Symposium
    • Place of Presentation
      Seoul, Korea
    • Year and Date
      2009-11-19
    • Related Report
      2009 Final Research Report
  • [Presentation] Clinical features of intraocular inflammation in Asia-Pacific region2009

    • Author(s)
      Ohno S, Namba K, Kitaichi N, Ishida S.
    • Organizer
      The 4th Congress of the Asia-Pacific Vitreo-Retinal Society
    • Place of Presentation
      Taipei, Taiwan
    • Year and Date
      2009-11-12
    • Related Report
      2009 Final Research Report
  • [Presentation] Intraocular inflammation in Asia2009

    • Author(s)
      Ohno S, Kitaichi N, Namba K.
    • Organizer
      The 2nd International Uveitis/The 3rd Asia Pacific Intraocular Inflammation/The 8th Chinese Ocular Immunology Combined Symposium
    • Place of Presentation
      Chongqing, China
    • Year and Date
      2009-11-06
    • Related Report
      2009 Final Research Report
  • [Presentation] Young Investigator Award Lecture : Low prevalence of juvenile-onset Behcet's disease with uveitis in east/south Asian people2009

    • Author(s)
      Kitaichi N, Ohno S.
    • Organizer
      The 2nd International Uveitis Symposium/The 3rd Asia-Pacific Intraocular Inflammation Symposium/The 8th Chinese Ocular Immunology Symposium
    • Place of Presentation
      Chongqing, China
    • Year and Date
      2009-11-06
    • Related Report
      2009 Final Research Report
  • [Presentation] Clinical features of Behcet's disease2009

    • Author(s)
      Ohno S, Lennikov A
    • Organizer
      Meeting in Research Institution of Rheumatology Diseases
    • Place of Presentation
      Moscow, Russia
    • Year and Date
      2009-09-15
    • Related Report
      2009 Final Research Report
  • [Presentation] Vogt-Koyanagi-Harada disease2009

    • Author(s)
      Ohno S.
    • Organizer
      SOE 2009 : The 17th Congress of the European Society of Ophthalmology
    • Place of Presentation
      Amsterdam, The Netherlands
    • Year and Date
      2009-06-13
    • Related Report
      2009 Final Research Report
  • [Presentation] Early systemic corticosteroid therapy may reduce ocular complications in Vogt-Koyanagi-Harada disease2009

    • Author(s)
      Ohno S, Hirose S, Kitaichi N.
    • Organizer
      The 6th International Workshop on Vogt-Koyanagi-Harada disease & sympathetic ophthalmia/The 2nd International workshop on Sarcoidosis
    • Place of Presentation
      Singapore, Singapore
    • Year and Date
      2009-02-28
    • Related Report
      2009 Final Research Report
  • [Presentation] Early systemic corticosteroid therapy may reduce ocular complications in Vogt-Koyanagi-Harada diseas2009

    • Author(s)
      Ohno S
    • Organizer
      6^<th> International Workshop on VKH & Sympathetic Ophthalmia / 2^<nd> International Work shop on Sarcoidosis
    • Place of Presentation
      Grand Copthorne Water-front, Singapore
    • Year and Date
      2009-02-28
    • Related Report
      2008 Annual Research Report
  • [Presentation] Diagnosis of Vogt-Koyanagi-Harada disease2009

    • Author(s)
      Ohno S, Kitaichi N.
    • Organizer
      The 6th International Workshop on Vogt-Koyanagi-Harada disease & sympathetic ophthalmia/The 2nd International workshop on Sarcoidosis
    • Place of Presentation
      Singapore, Singapore
    • Year and Date
      2009-02-27
    • Related Report
      2009 Final Research Report
  • [Presentation] Epidemiology and genetics of Vogt-Koyanagi-Harada disease2009

    • Author(s)
      Ohno S
    • Organizer
      6^<th> International Workshop on VKH & Sympathetic Ophthalmia / 2^<nd> International Works hop on Sarcoidosis
    • Place of Presentation
      Grand Copthorne Water-front, Singapore
    • Year and Date
      2009-02-27
    • Related Report
      2008 Annual Research Report
  • [Presentation] Diagnosis of Vogt-Koyanagi-Harada disease in Japan2009

    • Author(s)
      Ohno S
    • Organizer
      6^<th> International Workshop on VKH & Sympathetic Ophthalmia / 2^<nd> International Works hop on Sarcoidosis
    • Place of Presentation
      Grand Copthorne Water-front, Singapore
    • Year and Date
      2009-02-27
    • Related Report
      2008 Annual Research Report
  • [Presentation] Lumber puncture in Vogt-Koyanagi-Harada disease2009

    • Author(s)
      Ohno S
    • Organizer
      6^<th> International Workshop on VKH & Sympathetic Ophthalmia / 2^<nd> International Works hop on Sarcoidosis
    • Place of Presentation
      Grand Copthorne Water-front, Singapore
    • Year and Date
      2009-02-27
    • Related Report
      2008 Annual Research Report
  • [Presentation] 網膜芽細胞腫関連白内障2008

    • Author(s)
      加瀬諭
    • Organizer
      第62回日本臨床眼科学会
    • Place of Presentation
      東京国際フォーラム, 東京
    • Year and Date
      2008-10-26
    • Related Report
      2008 Annual Research Report
  • [Presentation] 強膜炎に対するシクロスポリン点眼薬の評価2008

    • Author(s)
      西堀宗樹
    • Organizer
      第62回日本臨床眼科学会
    • Place of Presentation
      東京国際フォーラム, 東京
    • Year and Date
      2008-10-26
    • Related Report
      2008 Annual Research Report
  • [Presentation] 加齢性眼疾患予防におけるアスタキサンチンの可能性2008

    • Author(s)
      吉田和彦
    • Organizer
      第62回日本臨床眼科学会
    • Place of Presentation
      東京国際フォーラム, 東京
    • Year and Date
      2008-10-24
    • Related Report
      2008 Annual Research Report
  • [Presentation] アスタキサンチン含有ソフトカプセルの摂取が眼底血流に及ぼす影響2008

    • Author(s)
      吉田和彦
    • Organizer
      第62回日本臨床眼科学会
    • Place of Presentation
      東京国際フォーラム, 東京
    • Year and Date
      2008-10-24
    • Related Report
      2008 Annual Research Report
  • [Presentation] 日本とネパールにおけるChlamydia trachomatisのserovarの比較2008

    • Author(s)
      青木功喜
    • Organizer
      第62回日本臨床眼科学会
    • Place of Presentation
      東京国際フォーラム, 東京
    • Year and Date
      2008-10-24
    • Related Report
      2008 Annual Research Report
  • [Presentation] 国際共同研究から明らかになった小児ベーチェット病の特徴2008

    • Author(s)
      北市伸義
    • Organizer
      第62回日本臨床眼科学会
    • Place of Presentation
      東京国際フォーラム, 東京
    • Year and Date
      2008-10-23
    • Related Report
      2008 Annual Research Report
  • [Presentation] Decrease of Behcet's disease in Japan2008

    • Author(s)
      Ohno S
    • Organizer
      7^<th> International Symposium on Uveitis. Konzil Konstanz
    • Place of Presentation
      Konzil Konstanz, Konstanz, Germany
    • Year and Date
      2008-09-10
    • Related Report
      2008 Annual Research Report
  • [Presentation] An international survey on Behcet's disease with ocular lesions in children2008

    • Author(s)
      Kitaichi N
    • Organizer
      7^<th> International Symposium on Uveitis. Konzil K onstanz
    • Place of Presentation
      Konzil Konstanz, Konstanz, Germany
    • Year and Date
      2008-09-10
    • Related Report
      2008 Annual Research Report
  • [Presentation] Genes and anterior Uveitis : are there more associations than HLA-B272008

    • Author(s)
      Ohno S
    • Organizer
      7^<th> International Symposium on Uveitis. Konzil Konstanz
    • Place of Presentation
      Konzil Konstanz, Konstanz, Germany
    • Year and Date
      2008-09-10
    • Related Report
      2008 Annual Research Report
  • [Presentation] 子どもの目の感染症2008

    • Author(s)
      大野重昭
    • Organizer
      第18回日本外来小児科学会
    • Place of Presentation
      名古屋国際会議場, 名古屋市
    • Year and Date
      2008-08-31
    • Related Report
      2008 Annual Research Report
  • [Presentation] 炎症性外眼部疾患の診断と治療2008

    • Author(s)
      大野重昭
    • Organizer
      群馬県眼科医会学術講演会
    • Place of Presentation
      マーキュリーホテル, 前橋市
    • Year and Date
      2008-07-18
    • Related Report
      2008 Annual Research Report
  • [Presentation] ベーチェット病診療の最近の進歩2008

    • Author(s)
      大野重昭
    • Organizer
      第2回九州ベーチェット病フォーラム
    • Place of Presentation
      ホテル日航福岡、福岡
    • Year and Date
      2008-07-12
    • Related Report
      2008 Annual Research Report
  • [Presentation] 特発性多発性腸潰瘍に伴う両眼性壊死性結膜強膜炎の一例2008

    • Author(s)
      西堀宗樹
    • Organizer
      第42回日本眼炎症学会
    • Place of Presentation
      福岡国際会議場, 福岡
    • Year and Date
      2008-07-05
    • Related Report
      2008 Annual Research Report
  • [Presentation] Effects of astaxanthin on eye fatigue2008

    • Author(s)
      Ohno S
    • Organizer
      The 15th International Symposium on Carotenoids
    • Place of Presentation
      Hotel Moon Beach, Okinawa
    • Year and Date
      2008-06-23
    • Related Report
      2008 Annual Research Report
  • [Presentation] モンゴロイド病とシルクロード病2008

    • Author(s)
      大野重昭
    • Organizer
      第48回日本リンパ網内系学会総会
    • Place of Presentation
      北大学術交流会館, 札幌
    • Year and Date
      2008-06-13
    • Related Report
      2008 Annual Research Report
  • [Presentation] 炎症性眼疾患の基礎と臨床2008

    • Author(s)
      大野重昭
    • Organizer
      熊本眼疾患研究会
    • Place of Presentation
      熊本大学講堂, 熊本
    • Year and Date
      2008-06-06
    • Related Report
      2008 Annual Research Report
  • [Presentation] Intravitreal triamcinolone acetonide for suppression of recurrent ocular inflammatory attacks in Behcet's disease2008

    • Author(s)
      Horie Y
    • Organizer
      第13回国際ベーチェット病学会
    • Place of Presentation
      Congress Center Worther-see, Klagenfurt, Austria
    • Year and Date
      2008-05-24
    • Related Report
      2008 Annual Research Report
  • [Presentation] Functional properties of cationic antimicrobial compounds on the neutrophils and endothelial cells2008

    • Author(s)
      Isogai E
    • Organizer
      第13回国際ベーチェット病学会
    • Place of Presentation
      Congress Center Worther-see, Klagenfurt, Austria
    • Year and Date
      2008-05-24
    • Related Report
      2008 Annual Research Report
  • [Presentation] Protective effects of antimicrobial steroid (CSA-13) against bacterial infection with ocular manifestations2008

    • Author(s)
      Isogai H
    • Organizer
      第13回国際ベーチェット病学会
    • Place of Presentation
      Congress Center Worther-see, Klagenfurt, Austria
    • Year and Date
      2008-05-24
    • Related Report
      2008 Annual Research Report
  • [Presentation] Clinical and basic study for the role of Osteopontin in intraocular inflammation2008

    • Author(s)
      Kitaichi N
    • Organizer
      第13回国際ベーチェット病学会
    • Place of Presentation
      Congress Center Worther-see, Klagenfurt, Austria
    • Year and Date
      2008-05-24
    • Related Report
      2008 Annual Research Report
  • [Presentation] Ocular lesions of Behcet's disease in Japan2008

    • Author(s)
      Ohno S
    • Organizer
      第13回国際ベーチェット病学会
    • Place of Presentation
      Congress Center Worther-see, Klagenfurt, Austria
    • Year and Date
      2008-05-24
    • Related Report
      2008 Annual Research Report
  • [Presentation] An international collaborative study on juvenile Behcet's disease with ocular lesions2008

    • Author(s)
      Ohno S
    • Organizer
      第13回国際ベーチェット病学会
    • Place of Presentation
      Congress Center Worther-see, Klagenfurt, Austria
    • Year and Date
      2008-05-24
    • Related Report
      2008 Annual Research Report
  • [Presentation] Neurological manifestations in Japanese patients with Behcet's disease : A retrospective analysis in Japan2008

    • Author(s)
      Suda A
    • Organizer
      第13回国際ベーチェット病学会
    • Place of Presentation
      Congress Center Worther-see, Klagenfurt, Austria
    • Year and Date
      2008-05-24
    • Related Report
      2008 Annual Research Report
  • [Presentation] 本邦におけるベーチェット病治療の現状と課題2008

    • Author(s)
      大野重昭
    • Organizer
      Infliximab Expert Meeting for Behcet's disease
    • Place of Presentation
      ヨコハマグランドインターコンチネンタルホテル, 横浜
    • Year and Date
      2008-04-17
    • Related Report
      2008 Annual Research Report
  • [Presentation] 韓国のベーチェット病患者におけるHLA-B51遺伝子の検討2008

    • Author(s)
      田川義継
    • Organizer
      第112回日本眼科学会総会
    • Place of Presentation
      パシフィコ横浜, 横浜
    • Year and Date
      2008-04-17
    • Related Report
      2008 Annual Research Report
  • [Presentation] 韓国のベーチェット病患者におけるHLA-B51遺伝子め検討2008

    • Author(s)
      堀江幸弘
    • Organizer
      第112回日本眼科学会総会
    • Place of Presentation
      パシフィコ横浜, 横浜
    • Year and Date
      2008-04-17
    • Related Report
      2008 Annual Research Report
  • [Presentation] Ocular involvement in sarcoidosis.2007

    • Author(s)
      Ohno S
    • Organizer
      The First International Symposium on Uveitis in China
    • Place of Presentation
      Guangzhou Ocean Hotel, Guangzhou, China
    • Year and Date
      2007-12-01
    • Related Report
      2007 Annual Research Report
  • [Presentation] A case of osteonecrosis of the femoral head in a patient with Vogt-Koyanagi-Harada disease treated with systemic corticosteroids2007

    • Author(s)
      Horie Y
    • Organizer
      The First International Symposium on Uveitis in China
    • Place of Presentation
      Guangzhou Ocean Hotel, Guangzhou, China
    • Year and Date
      2007-11-30
    • Related Report
      2007 Annual Research Report
  • [Presentation] Role of osteopontin in endogenous uveitis and intraocular inflammation.2007

    • Author(s)
      Kitaichi N
    • Organizer
      The First International Symposium on Uveitis in China
    • Place of Presentation
      Guangzhou Ocean Hotel, Guangzhou, China
    • Year and Date
      2007-11-30
    • Related Report
      2007 Annual Research Report
  • [Presentation] Anti-TNF therapy2007

    • Author(s)
      Ohno S
    • Organizer
      9th IOIS Congress
    • Place of Presentation
      Meridien Etoile Hotel, Paris, France
    • Year and Date
      2007-09-17
    • Related Report
      2007 Annual Research Report
  • [Presentation] Tyrosinase related proteins and VKH2007

    • Author(s)
      Ohno S
    • Organizer
      Animals models of ocular inflammation, neovascularization, AMD, diabetes, intraocular lymphoma, glaucoma and optic neuritis
    • Place of Presentation
      Meridien Etoile Hotel, Paris, France
    • Year and Date
      2007-09-15
    • Related Report
      2007 Annual Research Report
  • [Presentation] New. treatment of uverits and intraocular inflammation2007

    • Author(s)
      Ohno S
    • Organizer
      日中ぶどう膜炎シンポジウム
    • Place of Presentation
      Zhengzhou International Convention and Exhibition center, 北京,中国
    • Year and Date
      2007-09-01
    • Related Report
      2007 Annual Research Report
  • [Presentation] Uveitis and intraocular inflammation in the 21th century.2007

    • Author(s)
      Ohno S
    • Organizer
      XIVth Afro-Asian Congress of Ophthalmology
    • Place of Presentation
      Palais des Congres, Marrakesh, Morocco
    • Year and Date
      2007-06-23
    • Related Report
      2007 Annual Research Report
  • [Presentation] Recent advances on pathogenesis and treatment of Behcet's disease2007

    • Author(s)
      Ohno S
    • Organizer
      XIVth Afro-Asian Congress of OPhthalmology
    • Place of Presentation
      Palais des Congres, Marrakesh, Morocco
    • Year and Date
      2007-06-21
    • Related Report
      2007 Annual Research Report
  • [Presentation] Effects of astaxanthin on ocular diseases2007

    • Author(s)
      Ohno S
    • Organizer
      33rd Annual Meeting of Indonesian Ophthalmologist Association Annual Meeting
    • Place of Presentation
      Jakarta Convention Center Jakarta, Indonesia
    • Year and Date
      2007-06-17
    • Related Report
      2007 Annual Research Report
  • [Presentation] Microsatellite analysis of the Vogt-Koyanagi-Harada diesase at the tyrosinase gene family loci in Japanese patients2007

    • Author(s)
      Horie Y
    • Organizer
      ARVO
    • Place of Presentation
      Broward County Convention Center, Fort Lauderdale, USA
    • Year and Date
      2007-05-10
    • Related Report
      2007 Annual Research Report
  • [Presentation] Aphase III, non-inferiority study of difluprednate ophthalmic emulsion(DFBA), 0.05% in the treatment of anterior uveitis2007

    • Author(s)
      Ohno S
    • Organizer
      ARVO
    • Place of Presentation
      Broward County Convention Center, Fort Lauderdale, USA
    • Year and Date
      2007-05-10
    • Related Report
      2007 Annual Research Report

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Published: 2007-04-01   Modified: 2016-04-21  

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