| Project/Area Number |
19406031
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| Research Category |
Grant-in-Aid for Scientific Research (B)
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| Allocation Type | Single-year Grants |
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| Section | 海外学術 |
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| Research Field |
Orthodontic/Pediatric dentistry
|
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| Research Institution | Tokyo Medical and Dental University |
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Principal Investigator |
SUDA Naoto Tokyo Medical and Dental University, 歯学部, 教授 (90302885)
|
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| Co-Investigator(Kenkyū-buntansha) |
YAMASHIRO Takashi 岡山大学, 大学院・医歯学総合研究科, 教授 (70294428)
MITOME Masato 徳島大学, ヘルスバイオサイエンス研究部, 教授 (50261318)
FUKUMOTO Satoshi 東北大学, 歯学研究科, 教授 (30264253)
MORIYAMA Keiji 東京医科歯科大学, 大学院・医歯学総合研究科, 教授 (20262206)
OGAWA Takuya 東京医科歯科大学, 大学院・医歯学総合研究科, 助教 (50401360)
TSUJI Michiko 東京医科歯科大学, 大学院・医歯学総合研究科, 助教 (90345281)
|
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| Project Period (FY) |
2007 – 2010
|
| Project Status |
Completed (Fiscal Year 2010)
|
| Budget Amount *help |
¥16,770,000 (Direct Cost: ¥12,900,000、Indirect Cost: ¥3,870,000)
Fiscal Year 2010: ¥3,380,000 (Direct Cost: ¥2,600,000、Indirect Cost: ¥780,000)
Fiscal Year 2009: ¥3,380,000 (Direct Cost: ¥2,600,000、Indirect Cost: ¥780,000)
Fiscal Year 2008: ¥3,640,000 (Direct Cost: ¥2,800,000、Indirect Cost: ¥840,000)
Fiscal Year 2007: ¥6,370,000 (Direct Cost: ¥4,900,000、Indirect Cost: ¥1,470,000)
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| Keywords | 先天性多数歯欠損 / 遺伝子変異 / PAX9 / MSX1 / 多数歯欠損 / PAX / 先天性欠如歯 / アジア |
|---|
| Research Abstract |
It is known that congenital missing of permanent teeth is one of the most popular anomalies in craniofacial region. Lacking of many teeth (oligodontia) causes serious dysfunction to the mastication, pronounciation and food intake. In this study, we identified a novel gene mutation (321_322insG) in a transcription factor, PAX9. This mutaion was unstable and had a shorter half life than wild-type PAX9.
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