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Molecular mechanism of the soft structure of proteins: Analysis of interior cavities and structural changes under pressure

Research Project

Project/Area Number 19500252
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeSingle-year Grants
Section一般
Research Field Bioinformatics/Life informatics
Research InstitutionNagaoka University of Technology

Principal Investigator

SODA Kunitsugu  Nagaoka University of Technology, 工学部, 教授 (10011686)

Co-Investigator(Kenkyū-buntansha) SEKI Yasutaka  長岡技術科学大, 工学部, 助教 (30377220)
Project Period (FY) 2007 – 2008
Project Status Completed (Fiscal Year 2008)
Budget Amount *help
¥4,550,000 (Direct Cost: ¥3,500,000、Indirect Cost: ¥1,050,000)
Fiscal Year 2008: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
Fiscal Year 2007: ¥2,730,000 (Direct Cost: ¥2,100,000、Indirect Cost: ¥630,000)
Keywords柔構造 / 分子動力学 / 原子充填密度 / 分子内空隙 / 圧力効果
Research Abstract

PDB (蛋白質立体構造データベース) に登録されている869種の蛋白質分子立体構造の網羅的解析により, 球状蛋白質は, これ迄広く認められていたよりも有意に低い原子充填密度を持つこと, 及び蛋白質分子水溶液への分子動力学模擬計算法の適用により, 球状蛋白質はTHz域に, 所謂Boson Peak に相当する振動モードを示すことを見出すと共に, その生成の分子機構を明らかにした。

Report

(3 results)
  • 2008 Annual Research Report   Final Research Report ( PDF )
  • 2007 Annual Research Report
  • Research Products

    (13 results)

All 2008 2007

All Journal Article (1 results) (of which Peer Reviewed: 1 results) Presentation (8 results) Book (4 results)

  • [Journal Article] Global Structure Analysis of Acid-Unfolded Myoglobin with Consideration to Effects of Intermolecular Coulomb Repulsion on Solution X-ray Scattering2007

    • Author(s)
      Seki Y, Tomizawa T, Hiragi Y & Soda, K.
    • Journal Title

      Biochemistry

      Pages: 234-244

    • Related Report
      2008 Final Research Report
    • Peer Reviewed
  • [Presentation] Dynamical Properties of Proteins as Analyzed by Molecular Volume Fluctuation2008

    • Author(s)
      Soda, K., Seki, Y., Shimbo, Y., Matsumoto, H., Fujii, J.
    • Organizer
      日本生物物理学会
    • Place of Presentation
      福岡
    • Year and Date
      2008-12-04
    • Related Report
      2008 Annual Research Report
  • [Presentation] J. Soft Structure of Proteins Analyzed by Atomic Packing Density and Volume Fluctuation Dynamics2008

    • Author(s)
      Soda, K, Seki, Y, Mori, K, Shimbo, Y, Matsumoto, H and Fujii
    • Organizer
      International Conference on Protein Science and Human Proteome Organization.(PRICPS-AOHUPO 2008)
    • Place of Presentation
      Cairns, Australia
    • Related Report
      2008 Final Research Report
  • [Presentation] Dynamics of Structural Fluctuations of Proteins and Hydration Effects2008

    • Author(s)
      Soda, K.
    • Organizer
      Third International Workshop on Proteins under Pressure
    • Place of Presentation
      Santa Fe, New Mexico, U.S.A.
    • Related Report
      2008 Final Research Report
  • [Presentation] Solvent- Reorganization Effects on Hydration Thermodynamic Quantities of Nonpolar Molecules by Molecular Dynamics Simulation2008

    • Author(s)
      Shimbo, Y & Soda, K
    • Organizer
      Third International Workshop on Proteins under Pressure
    • Place of Presentation
      Santa Fe, New Mexico, U.S.A.
    • Related Report
      2008 Final Research Report
  • [Presentation] Soft Structure of Proteins Analyzed by Atomic Packing Density and Volume Fluctuation Dynamics2008

    • Author(s)
      Soda, K, Seki, Y, Mori, K, Shimbo, Y, Matsumoto, H, Fujii, J.
    • Organizer
      PRICPS - AOHUPO
    • Place of Presentation
      Cairns, Australia
    • Related Report
      2008 Annual Research Report
  • [Presentation] Dynamics of Structural Fluctuations of Proteins and Hydration Effects2008

    • Author(s)
      Soda, K., Mori, K.& Seki, Y.
    • Organizer
      Intern. Conf, on Proteins Under Pressure
    • Place of Presentation
      Santa Fe, NM, USA
    • Related Report
      2007 Annual Research Report
  • [Presentation] Solvent-Reorganization Effects on Hydration Thermodynamic Quantities of Nonpolar Molecules by Molecular Dynamics Simulation2008

    • Author(s)
      Shimbo, Y. & Soda, K.
    • Organizer
      Intern. Conf, on Proteins Under Pressure
    • Place of Presentation
      Santa Fe, NM, USA
    • Related Report
      2007 Annual Research Report
  • [Presentation] Hydration Effects on Partial Molecular Volume of Proteins2007

    • Author(s)
      Seki, Y., Fujii, J. & Soda, K.
    • Organizer
      Biophys. Soc. Jpn.
    • Place of Presentation
      Yokohama, Jpn
    • Related Report
      2007 Annual Research Report
  • [Book] 疎水効果, 水, 溶液X線散乱. タンパク質の事典(猪飼篤, 伏見譲, 卜部格, 上野川修一, 中村春木, 浜窪隆雄 編)2008

    • Author(s)
      曽田 邦嗣
    • Publisher
      朝倉書店
    • Related Report
      2008 Final Research Report
  • [Book] 「タンパク質の事典」 : 疎水効果, 水, 溶液X線散乱2008

    • Author(s)
      曽田邦嗣
    • Total Pages
      14
    • Publisher
      朝倉書店
    • Related Report
      2008 Annual Research Report
  • [Book] 「生物物理学ハンドブック」 : 水と水和2008

    • Author(s)
      曽田邦嗣
    • Total Pages
      5
    • Publisher
      朝倉書店
    • Related Report
      2008 Annual Research Report
  • [Book] 水と水和. 生物物理学ハンドブック(石渡信一, 桂勲, 桐野豊, 美宅成樹編)2007

    • Author(s)
      曽田 邦嗣
    • Publisher
      朝倉書店
    • Related Report
      2008 Final Research Report

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Published: 2007-04-01   Modified: 2016-04-21  

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