Keap1/Nrf2 System Regulates Neuronal Survival as Revealed through Study of keap1 Gene Knockout Mice

• Project/Area Number: 19500261
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Single-year Grants
• Section: 一般
• Research Field: Neuroscience in general
• Research Institution: Iwate University
• Principal Investigator: SATOH Takumi Iwate University, 工学部, 准教授 (10300831)
• Project Period (FY): 2007 – 2008
• Project Status: Completed (Fiscal Year 2008)
• Budget Amount: ¥4,680,000 (Direct Cost: ¥3,600,000、Indirect Cost: ¥1,080,000); Fiscal Year 2008: ¥780,000 (Direct Cost: ¥600,000、Indirect Cost: ¥180,000); Fiscal Year 2007: ¥3,900,000 (Direct Cost: ¥3,000,000、Indirect Cost: ¥900,000)
• Keywords: Keap1 / Nrf2 / 親電子性物質 / 酸化ストレス

Research Abstract

Keap1/Nrf2システムはニューロンにおいて、酸化ストレスに反応して、抗酸化酵素群を誘導する。この防御機構は、酸化ストレス条件下では、ニューロンの生存を決めると申請者は仮説を立てた。この仮説を、Keap1のノックアウトマスを用いて直接証明した。すなわちKeap1は脳保護剤のターゲットとして最適であることを証明した。

Research Products

• [Journal Article] Simple ortho- and para-hydroquinones as compounds neuroprotective against oxidative stress in a manner associated with specific transcriptional activation (2009)
  • Author(s): Satoh T, Saitoh S, Hosaka M, Kosaka K
  • Journal Title: Biochem Biophys Res Commun 379 Pages: 537-541
  • Peer Reviewed
• [Journal Article] Keap1/Nrf2 system regulates neuronal survival as revealed through study of keap1 gene-knockout mice (2009)
  • Author(s): Satoh T, Harada N, Hosoya T, Tohyama K, Yamamoto M, Itoh K.
  • Journal Title: Biochem Biophys Res Commun 380 Pages: 298-302
  • Peer Reviewed
• [Journal Article] Carnosic acid and carnosol inhibit adipocyte differentiation in mouse 3T3-L1 cells through induction of phase2 enzymes and activation of glutathione metabolism (2009)
  • Author(s): Takahashi T, Tabuchi T, Tamaki Y, Kosaka K, Takikawa Y, Satoh T.
  • Journal Title: Biophys Res Commun 382(3) Pages: 549-554
  • Peer Reviewed
• [Journal Article] Keap1/Nrf2 system regulates neuronal survival as revealed through study of keapl gene-knockout mice (2009)
  • Author(s): Satoh T, et.al.
  • Journal Title: Biochem Biophys Res Comm 380 Pages: 298-302
  • Peer Reviewed
• [Journal Article] Simple ortho- and para-hydroquinones as compounds neuroprotective against oxidative stress in a manner associated with specific transcriptional activation (2009)
  • Author(s): Satoh T, et.al.
  • Journal Title: Biochem Biophys Res Comm 379 Pages: 537-541
  • Peer Reviewed
• [Journal Article] Carnosic acid and carnosol inhibit adipocyte differentiation in mouse 3T3-L1 cells through induction of phase2 enzymes and activation of glutathione metabolism (2009)
  • Author(s): Takahashi, et.al.
  • Journal Title: Biochem iophys Res Comm (In press)
  • Peer Reviewed
• [Journal Article] Carnosic acid protects neuronal HT22 cells- (2008)
  • Author(s): Satoh T, et. al.
  • Journal Title: Neuroscience Letters 434 Pages: 260-265
  • Peer Reviewed
• [Journal Article] Carnosic acid, a catechol-type electrophilic compound, protect- (2008)
  • Author(s): Satoh T, et. al.
  • Journal Title: Journal of Neurochemistry 104 Pages: 1116-1131
  • Peer Reviewed
• [Journal Article] Neuroprotective effects of phenylenediamine derivatives- (2007)
  • Author(s): Satoh T and Izumi M
  • Journal Title: Neuroscience Letters 418 Pages: 102-105
  • Peer Reviewed
• [Presentation] Carnosic acid, a catechol-type electrophilic compound, protects neurons both in vitro and in vivo through activation of the Keap1/Nrf2 pathway via S-alkylation of targeted cysteines (2009)
  • Author(s): Takumi Satoh
  • Organizer: Hirosaki Internatioal Forum of Medical Science
  • Place of Presentation: 弘前大学医学部コミニュケーションセンター
• [Presentation] Stimulation of glutathione metabolism may be critical for the inhibition of adipocyte differentiation by carnosic acid and carnosol (2009)
  • Author(s): Takahito Tabuchi, Toshiyuki Takahashi, Yousei Tamaki, and Takumi Satoh
  • Organizer: Hirosaki Internatioal Forum of Medical Science
  • Place of Presentation: 弘前大学医学部コミニュケーションセンター
• [Presentation] Carnosic acid protected HT22 cells against oxidative stress through the induction of phas2 enzymes and stimulation of glutathione metabolism (2009)
  • Author(s): Yousei Tamaki, Toshiyuki Takahashi, Takahito Tabuchi, and Takumi Satoh
  • Organizer: Hirosaki Internatioal Forum of Medical Science
  • Place of Presentation: 弘前大学医学部コミニュケーションセンター
• [Presentation] Carnosic aicd inhibited adipocytes differentiation through the induction of phase2 enzymes that regulate glutathione metabolism (2009)
  • Author(s): Toshiyuki Takahashi, Takahito Tabuchi, Yousei Tamaki, and Takumi Satoh
  • Organizer: Hirosaki Internatioal Forum of Medical Science
  • Place of Presentation: 弘前大学医学部コミニュケーションセンター
• [Presentation] Carnosic acid, a catechol-type electrophilic compound, protects neurons both in vitro and in vivo through activation of the Keap1/Nrf2 pathway via S-alkylation of targeted cysteines (2008)
  • Author(s): Takumi Satoh
  • Organizer: Lipid peroxidation 2008
  • Place of Presentation: 軽井沢プリンスホテル
• [Remarks]
  • URL: http://www.wel.iwate-u.ac.jp/satoh/
• [Remarks]
  • URL: http://www.wel.iwate-u.ac.jp/satoh/