Investigation of the reorganization of the brain's functional mapduring the sequence learning by serial reaction time task

• Project/Area Number: 19500262
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Single-year Grants
• Section: 一般
• Research Field: Neuroscience in general
• Research Institution: Tohoku University
• Principal Investigator: YOSHIYA Matsuzaka Tohoku University, 大学院・医学系研究科, 助教 (30312557)
• Co-Investigator(Kenkyū-buntansha): SHIMA Keisetsu 東北大学, 大学院・医学系研究科, 助教 (60124583)
• Project Period (FY): 2007 – 2009
• Project Status: Completed (Fiscal Year 2009)
• Budget Amount: ¥4,810,000 (Direct Cost: ¥3,700,000、Indirect Cost: ¥1,110,000); Fiscal Year 2009: ¥650,000 (Direct Cost: ¥500,000、Indirect Cost: ¥150,000); Fiscal Year 2008: ¥650,000 (Direct Cost: ¥500,000、Indirect Cost: ¥150,000); Fiscal Year 2007: ¥3,510,000 (Direct Cost: ¥2,700,000、Indirect Cost: ¥810,000)
• Keywords: 神経科学 / 順序動作 / 機能地図 / 前頭前野 / サル / 内側前頭前野 / ニューロン / 競合解決 / 高次中枢機能 / 補足運動野 / 前補足運動野 / LFP / 系列反応潜時課題 / 一次運動野

Research Abstract

We discovered that the part of the prefrontal cortex of primates is activated when the subjects were required to select the action under the presence of multiple rules, but inactivated when only a single rule is present. Such a context dependent activation and inactivation of a particular brain region suggests that the so-called functional map of brain is not hard-wired, but rather it undergoes flexible reorganization when necessary. Our findings may require the revision of the conventional notion of the fixed functional map of brain.

Research Products

• [Journal Article] Cannula-aided penetration : a simple method to insert structurally weak electrodes into brain through the dura mater (2009)
  • Author(s): Matsuzaka Y, Sakamoto K, Tanaka T, Furusawa Y Mushiake H
  • Journal Title: Neuroscience Research 65 Pages: 126-129
  • Peer Reviewed
• [Journal Article] Interval time coding by neurons in the presupplementary and supplementary motor areas (2009)
  • Author(s): Mita A, Mushiake H, Shima K, Matsuzaka Y, Tanji J
  • Journal Title: Nature Neuroscience 12 Pages: 502-507
  • Peer Reviewed
• [Journal Article] A simple device allowing silicon microelectrode insertion for chronic neural recording in primates (2009)
  • Author(s): Sakamoto K, Matsuzaka Y, Suenaga T, Watanabe H, Kobayashi R, Fukushima T, Katayama N, Tanaka T, Koyanagi M, Mushiake H
  • Journal Title: Neural Engineering, 2009. NER'09. 4th International IEEE/EMBS Conference- Pages: 104-107
• [Journal Article] Development of double-sided Si neural probe with microfluidic channels using wafer direct bonding technique (2009)
  • Author(s): Kobayashi R, Kanno S, Lee S, Fukushima T, Sakamoto K, Matsuzaka Y, Katayama N, Mushiake H, Koyanagi M, Tanaka T
  • Journal Title: Neural Engineering, 2009.NER' 09. 4th International IEEE/EMBS Conference- Pages: 96-99
• [Journal Article] Cannula-aided penetration : a simple method to insert structurally weak electrodes into brain through the dura mater. (2009)
  • Author(s): Yoshiya Matsuzaka, Kazuhiro Sakamoto, Tetsu Tanaka, Yoshihito Furusawa, Hajime Mushiake
  • Journal Title: Neuroscience Research 65 Pages: 126-129
  • Peer Reviewed
• [Journal Article] A simple device allowing silicon microelectrode insertion for chronic neural recording in primates (2009)
  • Author(s): Sakamoto, K.Matsuzaka, Y.Suenaga, T.Watanabe, H.Kobayashi, R.Fukushima, T.Katayama, N.Tanaka, T.Koyanagi, M.Mushiake, H.
  • Journal Title: Neural Engineering Pages: 104-107
• [Journal Article] Development of double-sided Si neural probe with microfluidic channels using wafer direct bonding technique (2009)
  • Author(s): Kobayashi, R., Kanno, S., Lee, S., Fukushima, T., Sakamoto, K., Matsuzaka, Y., Katayama, N., Mushiake, H., Koyanagi, M., Tanaka, T.
  • Journal Title: Neural Engineering Pages: 96-99
• [Journal Article] Interval time coding by neurons in the presupplementary and supplementary motor areas (2009)
  • Author(s): Mita-A, Mushiake-H, Shima-K, Matsuzaka-Y, Tanji-J
  • Journal Title: Nature Neuroscience 12 Pages: 502-507
  • Peer Reviewed
• [Journal Article] Spatial distribution of cingulate cortical cells projecting to the primary motor cortex in the rat (2008)
  • Author(s): Wang Y, Matsuzaka Y, Mushiake H, Shima K
  • Journal Title: Neuroscience Research 60 Pages: 406-411
  • Peer Reviewed
• [Journal Article] Spatial distribution of cingulate cortical cells projecting to the primary motor cortex in the rat (2008)
  • Author(s): Wang-Y, Matsuzaka-Y, Mushiake-H & Shima-K
  • Journal Title: Neuroscience Research 60 Pages: 406-411
  • Peer Reviewed
• [Journal Article] Skill representation in the primary motor cortex after long-term practice (2007)
  • Author(s): Matsuzaka Y, Picard N, Strick PL
  • Journal Title: Journal of Neurophysiology 97 Pages: 1819-1832
  • Peer Reviewed
• [Journal Article] Skill representation in the primary motor cortex after long-term practice (2007)
  • Author(s): Matsuzaka-Y, Picard-N & Strick-PL
  • Journal Title: Journal of Neurophysiology 97 Pages: 1819-1832
  • Peer Reviewed
• [Presentation] Chaos may facilitate decision making in the prefrontal cortex (2010)
  • Author(s): Hirata Y, Matsuzaka Y, Mushiake H, Aihara K
  • Organizer: Computational and Systems Neuroscience 2010
  • Place of Presentation: Saltlake, Utah
  • Year and Date: 2010-02-25
• [Presentation] Chaos may facilitate decision making in the prefrontal cortex (2010)
  • Author(s): Yoshito Hirata, Yoshiya Matsuzaka, Hajime Mushiake, Kazuyuki Aihara
  • Organizer: Computational and Systems Neuroscience 2010
  • Place of Presentation: Saltlake, Utah, USA
  • Year and Date: 2010-02-25
• [Presentation] カニクイサルを用いた視機能評価 (2009)
  • Author(s): 菅野江里子, 富田浩史, 姫志剛, 松坂義哉, 虫明元, 砂金ひとみ, 廣井照, 八尾寛, 玉井信
  • Organizer: 第63回日本臨床眼科学会総会
  • Place of Presentation: 福岡
  • Year and Date: 2009-10-09
• [Presentation] カニクイサルを用いた視機能評価 (2009)
  • Author(s): 菅野江里子, 富田浩史, 姫志剛, 松坂義哉, 虫明元, 砂金ひとみ, 廣井照, 八尾寛, 玉井信
  • Organizer: 第63回日本臨床眼科学会総会
  • Place of Presentation: 福岡市
  • Year and Date: 2009-10-09
• [Presentation] Uncertainty, not the presence, of response conflict activates the primate medial prefrontal cortex during the selection of actions (2009)
  • Author(s): Y.Matsuzaka, H.Mushiake, J.Tanji
  • Organizer: 日本神経科学学会
  • Place of Presentation: 名古屋市
  • Year and Date: 2009-09-19
• [Presentation] 霊長類カニクイサルの視覚評価 (2009)
  • Author(s): 菅野江里子, 富田浩史, 姫志剛, 砂金ひとみ, 松坂義哉, 虫明元, 廣井照, 王卓, 玉井信
  • Organizer: 日本動物学会大80回大会
  • Place of Presentation: 静岡
  • Year and Date: 2009-09-17
• [Presentation] 霊長類カニクイサルの視覚評価 (2009)
  • Author(s): 菅野江里子, 富田浩史, 姫志剛, 砂金ひとみ, 松坂義哉, 虫明元, 廣井照, 王卓, 玉井信
  • Organizer: 日本動物学会大80回大会
  • Place of Presentation: 静岡市
  • Year and Date: 2009-09-17
• [Presentation] Uncertainty, not the presence, of response conflict activates the primate medial prefrontal cortex during the selection of actions (2009)
  • Author(s): Matsuzaka Y, Mushiake H, Tanji J
  • Organizer: 日本神経科学学会
  • Place of Presentation: 名古屋
  • Year and Date: 2009-09-16
• [Presentation] A simple device allowing silicon microelectrode insertion for chronic neural recording in primates (2009)
  • Author(s): Sakamoto K, Matsuzaka Y, Suenaga T, Watanabe H, Kobayashi R, Fukushima T, Katayama N, Tanaka T, Koyanagi M, Mushiake H
  • Organizer: The 4th International IEEE EMBS Conference on Neural Engineering
  • Place of Presentation: Antalya, Turky
  • Year and Date: 2009-04-29
• [Presentation] Development of Double-sided Si Neural Probe with Microfluidic Channels Using Wafer Direct Bonding Technique (2009)
  • Author(s): Kobayashi R, Kanno K, Lee S, Fukushima T, Sakamoto K, Matsuzaka Y, Katayama N, Mushiake H, Tanaka T, Koyanagi M
  • Organizer: The 4th International IEEE EMBS Conference on Neural Engineering
  • Place of Presentation: Antalya, Turky
  • Year and Date: 2009-04-29
• [Presentation] Development of Double-sided Si Neural Probe with Microfluidic Channels Using Wafer Direct Bonding Technique (2009)
  • Author(s): R.Kobayashi, S.Kanno, S.Lee, T.Fukushima, K.Sakamoto, Y.Matsuzaka, N.Katayama, H.Mushiake, T.Tanaka, M.Koyanagi
  • Organizer: The 4th International IEEE EMBS Conference on Neural Engineering
  • Place of Presentation: Antalya, Thrkey
  • Year and Date: 2009-04-29
• [Presentation] Interactions between the medial frontal areas of awake monkeys revealed by the partial directional coherence of local field potentials (2008)
  • Author(s): Hosaka R, Matsuzaka Y, Mushiake H, Aihara K, Tanji J
  • Organizer: Society for Neuroscience Meeting
  • Place of Presentation: Washington DC
  • Year and Date: 2008-11-15
• [Presentation] Interactions between the medial frontal areas of awake monkeys revealed by the partial directional coherence of local field potentials (2008)
  • Author(s): Hosaka-R, Matsuzaka-Y, Mushiake-H, Aihara-K, Tanji-J
  • Organizer: Society for Neuroscience
  • Place of Presentation: Washinton DC, USA
  • Year and Date: 2008-11-15
• [Presentation] Evoked motor response following deep transcranial magnetic stimulation in a cynomolgus monkey (2008)
  • Author(s): Ishii K, Matsuzaka Y, Izumi S, Abe T, Nakazato N, Okita T, Yashima Y, Takagi T, Nagatomi R
  • Organizer: 3rd International Conference on TMS and tDCS
  • Place of Presentation: Goettingen, Germany
  • Year and Date: 2008-10-01
• [Presentation] 電気化学的センサーによる神経回路内における神経伝達物質の計測技術の確立 (2008)
  • Author(s): 松坂義哉, 安川智之, 筒井健一郎
  • Organizer: H20年度ERYS発表会
  • Place of Presentation: 仙台
  • Year and Date: 2008-07-16
• [Presentation] A novel silicon microelectrode holder for chronic neural recording in monkeys(P1 W06) (2008)
  • Author(s): Sakamoto K, Matsuzaka Y, Suenaga T, Watanabe H, Mushiake H
  • Organizer: 日本神経科学会第31回大会
  • Place of Presentation: 東京
  • Year and Date: 2008-07-09
• [Presentation] A novel silicon microelectrode holder for chronic neural recording in monkeys (2008)
  • Author(s): Sakamoto-K, Matsuzaka-Y, Suenaga-T, Watanabe-H, Mushiake-H
  • Organizer: 日本神経科学会第31回大会
  • Place of Presentation: 東京
  • Year and Date: 2008-07-09
• [Presentation] in-vivo神経細胞活動記録用両面電極つきSiプローブの開発(30p-ZL-7) (2008)
  • Author(s): 李相勲, 小林吏悟, 菅野壮一郎, 福島誉史, 坂本一寛, 松坂義哉, 片山統裕, 虫明元, 田中徹, 小柳光正
  • Organizer: 第56回応用物理学関係連合講演会
  • Place of Presentation: つくば市
  • Year and Date: 2008-03-31
• [Presentation] 電気化学的センサーによる神経回路内における神経伝達物質の計測技術の確立 (2007)
  • Author(s): 松坂義哉, 安川智之, 筒井健一郎
  • Organizer: ERYS (若手研究者萌芽育成プログラム) 研究成果発表会
  • Place of Presentation: 仙台
  • Year and Date: 2007-07-20
• [Remarks]
  • URL: http://www.med.tohoku.ac.jp/~2sei/