Development of microcircuits in neocortex

• Project/Area Number: 19500272
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Single-year Grants
• Section: 一般
• Research Field: Neuroscience in general
• Research Institution: Nagoya University
• Principal Investigator: YOSHIMURA Yumiko Nagoya University, 環境医学研究所, 准教授 (10291907)
• Project Period (FY): 2007 – 2008
• Project Status: Completed (Fiscal Year 2008)
• Budget Amount: ¥4,290,000 (Direct Cost: ¥3,300,000、Indirect Cost: ¥990,000); Fiscal Year 2008: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000); Fiscal Year 2007: ¥2,990,000 (Direct Cost: ¥2,300,000、Indirect Cost: ¥690,000)
• Keywords: 視覚野 / 暗室飼育 / 局所回路 / 経験依存的発達 / ラット / 抑制性結合 / 興奮性結合 / 局所神経回路 / 発達 / 神経回路 / 興奮性ニューロン / 抑制性ニューロン

Research Abstract

ラットより作成した大脳皮質視覚野スライス標本を用いて、錐体細胞間抑制性伝達の特性と経験依存的発達を電気生理学的手法により検討した。錐体細胞間抑制性結合は、興奮性結合に比べて高い頻度で観察された。両結合は、発達初期の視覚野では発達後期に比べて低頻度でしか観察されなかった。しかし、興奮性結合の形成は生後直後からの発達後期までの暗室飼育により抑えられたが、抑制性結合は、暗室飼育の方が高頻度で観察された。

Research Products

• [Journal Article] State-dependent bidirectional modification of somatic inhibition in neocortical pyramidal cells (2008)
  • Author(s): Kurotani T, Yamada K, Yoshimura Y, Crair M, Komatsu Y
  • Journal Title: Neuron 57 Pages: 905-916
  • Peer Reviewed
• [Journal Article] Komatsu Y Involvement of T-type Ca^<2+> channels in the potentiation of synaptic and visual responses during the critical period in rat visual cortex (2008)
  • Author(s): Yoshimura Y, Inaba M, Yamada K, Kurotani T, Begum T, Reza F, Maruyama T
  • Journal Title: Eur J Neurosci 28(4) Pages: 730-74
  • Peer Reviewed
• [Journal Article] Involvement of T-type Ca^<2+> channels in the potentiation of synaptic and visual responses during the critical period in rat visual cortex. (2008)
  • Author(s): Yumiko Yoshimura, Mie Inaba, Kazumasa Yamada, Tohru Kurotani, Tahamina Begum, Faruque Reza, Takuro Maruyama, Yukio Komatsu
  • Journal Title: European Journal of Neuroscience 28 (4) Pages: 730-743
  • Peer Reviewed
• [Journal Article] State-dependent bidirectional modification of somatic inhibition in neocortical pyramidal cells. (2008)
  • Author(s): Kurotani T, Yamada K, Yoshimura Y, Crair MC, Komatsu Y
  • Journal Title: Neuron 57(6) Pages: 905-916
  • Peer Reviewed
• [Journal Article] Specialized inhibitory synaptic actions between nearby neocortical pyramidal neurons (2007)
  • Author(s): Ren M, Yoshimura Y, Takada N, Horibe S, Komatsu Y
  • Journal Title: Science 316(758) Pages: 758-761
  • Peer Reviewed
• [Journal Article] Specialized inhibitory synaptic actions between nearby neocortical pyramidal neurons. (2007)
  • Author(s): Ren M, Yoshimura Y, Takada N, Horibe S and Komatsu Y
  • Journal Title: Science 316(758) Pages: 758-761
  • Peer Reviewed
• [Presentation] 大脳皮質における錐体細胞間の新規な抑制性シナプス作用 (2008)
  • Author(s): 吉村由美子
  • Organizer: 第113回日本解剖学会総会・全国学術集会
  • Place of Presentation: 大分県由布市
• [Presentation] excitatory and inhibitory connections between nearby layer 2/3 pyramidal cells using dual whole-cell recording from visual cortex (2008)
  • Author(s): Yoshimura Y
  • Organizer: 7th OIB Symposium "Frontiers of Biological Imaging-Synergy of the Advanced Techniques"
  • Place of Presentation: Techniques
• [Presentation] Characterization of excitatory and inhibitory connections between nearby layer 2/3 pyramidal cells using dual whole-cell recording from visual cortex. (2008)
  • Author(s): Yumiko Yoshimrua
  • Organizer: 7th OTB Symposium "Frontiers of Biological Imaging-Synergy of the Advanced Techniques"
  • Place of Presentation: Okazaki
• [Presentation] 大脳皮質視覚野における抑制性神経回路の発達,Development of pyramidal cell inhibition in visual cortex (2007)
  • Author(s): 吉村由美子, 任鳴, 堀部尚子, 小松由紀夫
  • Organizer: 第30回日本神経科学大会
  • Place of Presentation: 横浜市
  • Year and Date: 2007-09-10
• [Presentation] 大脳皮質視覚野における抑制性神経回路の発達,Development of pyramidal cell inhibition in visual cortex. (2007)
  • Author(s): 吉村由美子, 任鳴, 堀部尚子, 小松由紀夫
  • Organizer: Neuro2007
  • Place of Presentation: Yokohama
  • Year and Date: 2007-09-10