Treatment of a glaucoma model by transplantation of cloned retinal progenitor cells derived from ES cells
| Project/Area Number |
19500280
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Neuroscience in general
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| Research Institution | St.Marianna University School of Medicine |
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Principal Investigator |
KUROKAWA Manae St.Marianna University School of Medicine, 医学部, 准教授 (90301598)
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| Co-Investigator(Kenkyū-buntansha) |
SUZUKI Noboru 聖マリアンナ医科大学, 医学部, 教授 (40235982)
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| Project Period (FY) |
2007 – 2010
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| Project Status |
Completed (Fiscal Year 2010)
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| Budget Amount *help |
¥4,030,000 (Direct Cost: ¥3,100,000、Indirect Cost: ¥930,000)
Fiscal Year 2010: ¥780,000 (Direct Cost: ¥600,000、Indirect Cost: ¥180,000)
Fiscal Year 2009: ¥780,000 (Direct Cost: ¥600,000、Indirect Cost: ¥180,000)
Fiscal Year 2008: ¥780,000 (Direct Cost: ¥600,000、Indirect Cost: ¥180,000)
Fiscal Year 2007: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
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| Keywords | 緑内障 / 網膜神経節細胞 / 胚性幹細胞 / 緑内障治療 / ES細胞 |
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| Research Abstract |
Glaucoma, loss of retinal ganglion cells (RGCs), causes severe visual impairment. We induced RGC-progenitor cells by transfecting pax6 gene to mouse embryonic stem (ES) cells. Transplantation of the RGC-progenitor cells into a glaucoma model, optic nerve-injured mice, successfully reduced the degeneration of optic nerves, and significantly improved light reflex and electroretinogram in the grafted mice. Transplantation of the RGC-progenitor cells induced from ES cells may be useful for treatment of visual impairment in glaucoma.
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Report
(6 results)
Research Products
(169 results)
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[Journal Article] Identification of autoantigens specific for systemic lupus erythematosus with central nervous system involvement.2010
Author(s)
Iizuka N, Okamoto K, Mastushita R, Kimura M, Nagai K, Arito M, Kurokawa MS, Masuko K, Suematsu N, Hirohata S, Kato T
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Related Report
Peer Reviewed
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[Journal Article] Transfection with pax6 gene of mouse ES cells and subsequent cell cloning induced retinal neurin progenitors, including retinal ganglion cell-like cells, in vitro.2010
Author(s)
Kayama M, Kurokawa MS, Ueda Y, Ueno H, Kumagai Y, Takada E, Chiba S, Ueno S, Tadokoro M, Suzuki N
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Journal Title
Ophtalmic Res 43
Pages: 79-91
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Peer Reviewed
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[Journal Article] Transfection with pax6 gene of mouse embryonic stem cells and subsequent cell cloning induced retinal neuron progenitors, including retinal ganglion cell-like cells, in vitro.2010
Author(s)
Kayama M, Kurokawa MS, Ueda Y, Ueno H, Kumagai Y, Chiba S, Takada E, Ueno S, Tadokoro M, Suzuki N.
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Journal Title
Ophthalmic Res 43
Pages: 79-91
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Peer Reviewed
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[Journal Article] Proteomic analysis of the rat cerebellar flocculus during vestibular compensation.2009
Author(s)
Fukasawa M, Okamotoa K, Nakamura M, Mikami K, Shimada S,Tanaka Y, Nagai K, Arito M, Kurokawa MS, Masuko K, Suematsu N, Koizuka I, Kato T
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Journal Title
J Vestib Res 19
Pages: 83-94
Related Report
Peer Reviewed
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[Journal Article] Comprehensive analysis of short peptides in sera from patients with IgA nephropathy.2009
Author(s)
Kaneshiro N, Xiang Y, Nagai K, Kurokawa MS, Okamoto K, Arito M, Masuko K, Yudoh K, Yasuda T, Suematsu N, Kimura K, Kato T
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Journal Title
Rapid Commun Mass Spectrom 23
Pages: 3720-8
NAID
Related Report
Peer Reviewed
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[Journal Article] Implication of GM-CSF Induced neutrophil gelatinase-associated lipocalin in pathogenesis of rheumatoid arthritis revealed by proteome analysis.2009
Author(s)
Katano M, Okamoto K, Arito M, Kawakami Y, Kurokawa MS, Suematsu N, Shimada S, Nakamura H, Xiang Y, Masuko K, Nishioka K, Yudoh K, Kato T
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[Journal Article] Arthritogenicity of annexin VII revealed by phosphoproteomics of rheumatoid synoviocytes.
Author(s)
Matsuo K, Arito M, Noyori K, Nakamura H, Kurokawa MS, Masuko K, Okamoto K, Nagai K, Suematsu N, Yudoh K, Beppu M, Saito T, Kato T
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Journal Title
Annals of the rheumatic diseases (in press)
Related Report
Peer Reviewed
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[Presentation] Subretinal transplantation of embryonic stem cell derived neuroretinal cells to mice with optic nerve injury2008
Author(s)
Kayama M, Kurokawa MS, Ueda Y, Ueno H, Kumagai Y, Masuda C, Takada E, Tago R, Ueno S, Suzuki N.
Organizer
The Association for Research in vision and Ophthalmology
Place of Presentation
Frorida, USA.
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[Presentation] Induction of Differentiation Into Retinal Ganglion Cells of Mouse ES Cells by Pax6 Gene Transfection2007
Author(s)
Kayama M, Kurokawa MS, Ueda Y, Ueno H, Kumagai Y, Masuda C, Takada E, Ueno S, Tadokoro M, Suzuki N.
Organizer
The Association for Research in vision and Ophthalmology
Place of Presentation
Frorida, USA.
Related Report
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