| Project/Area Number |
19500280
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Neuroscience in general
|
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| Research Institution | St.Marianna University School of Medicine |
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Principal Investigator |
KUROKAWA Manae St.Marianna University School of Medicine, 医学部, 准教授 (90301598)
|
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| Co-Investigator(Kenkyū-buntansha) |
SUZUKI Noboru 聖マリアンナ医科大学, 医学部, 教授 (40235982)
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| Project Period (FY) |
2007 – 2010
|
| Project Status |
Completed (Fiscal Year 2010)
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| Budget Amount *help |
¥4,030,000 (Direct Cost: ¥3,100,000、Indirect Cost: ¥930,000)
Fiscal Year 2010: ¥780,000 (Direct Cost: ¥600,000、Indirect Cost: ¥180,000)
Fiscal Year 2009: ¥780,000 (Direct Cost: ¥600,000、Indirect Cost: ¥180,000)
Fiscal Year 2008: ¥780,000 (Direct Cost: ¥600,000、Indirect Cost: ¥180,000)
Fiscal Year 2007: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
|
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| Keywords | 緑内障 / 網膜神経節細胞 / 胚性幹細胞 / 緑内障治療 / ES細胞 |
|---|
| Research Abstract |
Glaucoma, loss of retinal ganglion cells (RGCs), causes severe visual impairment. We induced RGC-progenitor cells by transfecting pax6 gene to mouse embryonic stem (ES) cells. Transplantation of the RGC-progenitor cells into a glaucoma model, optic nerve-injured mice, successfully reduced the degeneration of optic nerves, and significantly improved light reflex and electroretinogram in the grafted mice. Transplantation of the RGC-progenitor cells induced from ES cells may be useful for treatment of visual impairment in glaucoma.
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