Molecular and cellular mechanisms of ocular dominance plasticity in adult induced by serine proteases
| Project/Area Number |
19500285
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Neuroscience in general
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| Research Institution | The Institute of Physical and Chemical Research |
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Principal Investigator |
MATAGA Nobuko The Institute of Physical and Chemical Research, 生体物質分析支援ユニット, 支援ユニットリーダー (20209464)
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| Project Period (FY) |
2007 – 2009
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| Project Status |
Completed (Fiscal Year 2009)
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| Budget Amount *help |
¥4,550,000 (Direct Cost: ¥3,500,000、Indirect Cost: ¥1,050,000)
Fiscal Year 2009: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2008: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2007: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
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| Keywords | 眼優位可塑性 / 臨界期 / 興奮性入力 / スパイン / セリンプロテアーゼ / テレンセファリン / 酵素消化 / 組織型プラスミノーゲンアクチベーター / プラスミン / 培養神経細胞 / マウス / 大脳皮質・視覚野 / シナプス可塑性 / 眼優位性 / 単眼遮蔽 / 細胞外基質タンパク質 / プレシナプス / グルタミン酸トランスポーター / テトロドトキシン |
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| Research Abstract |
To understand the molecular and cellular mechanisms of ocular dominance (OD) plasticity in adulthood, we explored candidate substrates of serine proteases, which are essential for morphological plasticity. Using mice during and after the CP for OD plasticity, we found proteolysis of extracellular matrix proteins and adhesion molecules including telencephalin (TLCN) by plasmin. Interestingly, telencephalin slowed spine maturation while plasmin enhanced synaptic formation, suggesting that there is a negative correlation between the full-length TLCN and plasmin.
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Report
(4 results)
Research Products
(18 results)
