Analysis of neural circuits in reward-related behaviors

• Project/Area Number: 19500297
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Single-year Grants
• Section: 一般
• Research Field: Nerve anatomy/Neuropathology
• Research Institution: Fukushima Medical University
• Principal Investigator: KAI Nobuyuki Fukushima Medical University, 医学部, 助教 (50301750)
• Project Period (FY): 2007 – 2009
• Project Status: Completed (Fiscal Year 2009)
• Budget Amount: ¥4,030,000 (Direct Cost: ¥3,100,000、Indirect Cost: ¥930,000); Fiscal Year 2009: ¥910,000 (Direct Cost: ¥700,000、Indirect Cost: ¥210,000); Fiscal Year 2008: ¥780,000 (Direct Cost: ¥600,000、Indirect Cost: ¥180,000); Fiscal Year 2007: ¥2,340,000 (Direct Cost: ¥1,800,000、Indirect Cost: ¥540,000)
• Keywords: 側坐核 / 報酬行動 / ドパミン受容体 / イムノトキシン細胞標的法 / 神経回路網 / ドーパミン受容体

Research Abstract

Drug addiction is a terrible social problem. To understand which neural circuits are involved in the addiction, mutant mice in which a specific kind of neurons was removed were tested for drug-associated behavior. It was revealed that the loss of a kind of neurons in the Nucleus accumbens shell strengthened drug addiction. Deletion of another kind of neurons in the shell weakened drug addiction.

Research Products

• [Journal Article] Laser capture microdissection and cDNA array analysis for identification of mouse KIAA/FLJ genes differentially expressed in the embryonic dorsal spinal cord. (2009)
  • Author(s): Masuda T, Kai N, Sakuma C, Kobayashi K, Koga H, Yaginuma H.
  • Journal Title: Brain Res. 1249 Pages: 61-67
  • Peer Reviewed
• [Journal Article] Transient silencing of synaptic transmitter release from specific neuronal types by recombinant tetanus toxin light chain fused to antibody variable region. (2008)
  • Author(s): Kobayashi T, Kai N, Kobayashi K, Fujiwara T, Akagawa K, Onda M, Kobayashi K.
  • Journal Title: J Neurosci Methods. Vol.175,No1 Pages: 125-132
  • Peer Reviewed
• [Journal Article] 基底核と記憶 (2008)
  • Author(s): 甲斐信行, 小林和人
  • Journal Title: 分子精神医学 8 Pages: 294-299
• [Journal Article] ドーパミン伝達による行動発現システムの制御 (2008)
  • Author(s): 甲斐信行, 小林和人
  • Journal Title: 蛋白質・核酸・酵素 53 Pages: 565-572
• [Presentation] Conditional ablation of dopamine D2 receptor-containing neurons in the nucleus accumbens shell impairs reward-related behavior (2008)
  • Author(s): 甲斐信行
  • Organizer: Society for Neuroscience
  • Place of Presentation: Washignton DC
  • Year and Date: 2008-11-17
• [Presentation] Roles of two types of dopamine receptor-containing neurons of nucleus accumbens shell in reward-related behavior (2008)
  • Author(s): 甲斐信行
  • Organizer: 第31回日本神経科学大会
  • Place of Presentation: 東京国際フォーラム
  • Year and Date: 2008-07-09
• [Presentation] Conditional ablation of dopamine D2 receptor-containing neurons in the nucleus accumbens shell impairs reward-related behavior (2007)
  • Author(s): 甲斐信行
  • Organizer: 第30回日本分子生物学会年会
  • Place of Presentation: パシフィコ横浜
  • Year and Date: 2007-12-13
• [Remarks]
  • URL: http://www.fmu.ac.jp/cms/molgenet/index_html