Molecular mechanisms for stepwise migratory processes during the cortical plate development.

• Project/Area Number: 19500298
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Single-year Grants
• Section: 一般
• Research Field: Nerve anatomy/Neuropathology
• Research Institution: Keio University
• Principal Investigator: TABATA Hidenori Keio University, 医学部, 講師 (80301761)
• Project Period (FY): 2007 – 2008
• Project Status: Completed (Fiscal Year 2008)
• Budget Amount: ¥4,550,000 (Direct Cost: ¥3,500,000、Indirect Cost: ¥1,050,000); Fiscal Year 2008: ¥2,210,000 (Direct Cost: ¥1,700,000、Indirect Cost: ¥510,000); Fiscal Year 2007: ¥2,340,000 (Direct Cost: ¥1,800,000、Indirect Cost: ¥540,000)
• Keywords: 神経科学 / 脳・神経 / 発生・分化 / 解剖学 / 神経回路 / 細胞移動 / 神経発生 / 軸索伸展 / 細胞間相互作用

Research Abstract

本研究課題では、マウス大脳皮質発生過程において、側脳室に面する脳室帯(VZ)から移動を開始する2つの集団に関して移動様式を検討した。一方はVZ内で最終分裂を終了するもので、約10時間VZ内に留まったのち、分裂を伴わずに多極性細胞へと形態変化し、VZのすぐ表層側に集積する。一方、VZを出発してもまだ分裂能を持つ細胞集団は脳表面側へと伸びる長い突起を有し、前者よりもより表層側へ早く移動し分裂する。

Research Products

• [Journal Article] Differences of migratory behavior between direct progeny of apical progenitors and basal progenitors in the developing cerebral cortex. (2009)
  • Author(s): Hidenori Tabata, Shigeaki Kanatani, Kazunori Nakajima
  • Journal Title: Cereb. Cortex 19(9) Pages: 2092-2105
  • Peer Reviewed
• [Journal Article] Differences of migratory behavior between direct progeny of apical progenitors and basal progenitors in the developing cerebral cortex (2009)
  • Author(s): Hidenori Tabata, et al.
  • Journal Title: Cereb.Cortex 19 Pages: 2092-2105
  • Peer Reviewed
• [Journal Article] COUP-TFII is preferentially expressed in the caudal ganglionic eminence and is involved in the caudal migratory stream (2008)
  • Author(s): Shigeaki Kanatani, Masato Yozu, Hidenori Tabata, Kazunori Nakajima
  • Journal Title: J. Neurosci. 28(50) Pages: 13582-13591
  • Peer Reviewed
• [Journal Article] Cell-autonomous roles of ARX in cell proliferation and neuronal migration during corticogenesis. (2008)
  • Author(s): Gaelle Friocourt, Shigeaki Kanatani, Hidenori Tabata, Masato Yozu, Takao Takahashi, Mary Antypa, Odile Raguenes, Jamel Chelly, Claude Ferec, Kazunori Nakajima, John G. Parnavelas
  • Journal Title: J. Neurosci. 28(22) Pages: 5794-5805
  • Peer Reviewed
• [Journal Article] The cortical subventricular zone-specific molecule Svet1 is part of the nuclear RNA coded by the putative Netrin receptor gene Unc5d and is expressed in multipolar migrating cells. (2008)
  • Author(s): Shinji Sasaki, Hidenori Tabata, Kashiko Tachikawa, Kazunori Nakajima
  • Journal Title: Mol. Cell. Neurosci. 38(4) Pages: 474-483
  • Peer Reviewed
• [Journal Article] Migratory behavior of presumptive interneurons is affected by AMPA receptor activation in slice cultures of embryonic mouse neocortex. (2008)
  • Author(s): Masato Yozu, Hidenori Tabata, Norbert Koenig, Kazunori Nakajima
  • Journal Title: Dev. Neurosci. 30(1-3) Pages: 105-116
  • Peer Reviewed
• [Journal Article] Labeling embryonic mouse CNS cells by in utero electroporation. (2008)
  • Author(s): Hidenori Tabata, Kazunori Nakajima.
  • Journal Title: Develop. Growth Differ. 50(6) Pages: 507-511
  • Peer Reviewed
• [Journal Article] COUP-TFII is preferentially expressed in the caudal ganglionic eminence and is involved in the caudal migratory stream (2008)
  • Author(s): Shigeaki Kanatani, et al.
  • Journal Title: J.Neurosci. 28 Pages: 13582-13591
  • Peer Reviewed
• [Journal Article] Migratory behavior of presumptive interneurons is affected by AMPA receptor activation in slice cultures of embryonic mouse neocortex (2008)
  • Author(s): Masato Yozu, et al.
  • Journal Title: Dev. Neurosci. 30 Pages: 105-116
  • Peer Reviewed
• [Journal Article] Cell-autonomous roles of ARX in cell proliferation and neuronal migrati on during corticogenesis (2008)
  • Author(s): Gaelle Friocourt, et al.
  • Journal Title: J. Neurosci 28 Pages: 5794-5805
  • Peer Reviewed
• [Journal Article] Cdk5 is required for multipolar-to-bipolar transition during radial neuronal migration and proper dendrite development of pyramidal neurons in the cerebral cortex. (2007)
  • Author(s): Toshio Ohshima, Motoyuki Hirasawa, Hidenori Tabata, Tetsuji Mutoh, Tomoko Adachi, Hiromi Suzuki, Keiko Saruta, Takuji Iwasato, Shigeyoshi Itohara, Mitsuhiro Hashimoto, Kazunori Nakajima, Masaharu Ogawa, Ashok B. Kulkarni, Katsuhiko Mikoshiba
  • Journal Title: Development 134(12) Pages: 2273-2282
  • Peer Reviewed
• [Journal Article] Cdk5 is required for multipolar-to-bipolar transition during radial neuronal migration and proper dendrite development of pyramidal neurons in the cerebral cortex (2007)
  • Author(s): Toshio Ohshima, et al.
  • Journal Title: Development 134 Pages: 2273-2282
  • Peer Reviewed
• [Presentation] 仲嶋一範"マウス胎生後期大脳皮質の中間帯で見られる新たな細胞移動様式 (2008)
  • Author(s): 佐々木恵、田畑秀典
  • Organizer: 日本解剖学会関東支部第96回学術集会
  • Place of Presentation: つくば
  • Year and Date: 2008-11-22
• [Presentation] マウス胎生後期大脳皮質の中間帯で見られる新たな細胞移動様式 (2008)
  • Author(s): 佐々木恵, 等
  • Organizer: 日本解剖学会関東支部第96回学術集会
  • Place of Presentation: つくば
  • Year and Date: 2008-11-22
• [Presentation] Expression pattern of Roundabout1 (Robo1) in the developing mouse forebrain(発達期のマウス前脳におけるRoundabout1(Robo1)の発現分布様式) (2008)
  • Author(s): Yuko Gonda, Hidenori Tabata, Kazunori Nakajima, Shigeo Uchino, Shinichi Kohsaka (権田裕子、田畑秀典、仲嶋一範、内野茂夫、高坂新一)
  • Organizer: 第31回日本分子生物学会年会・第81回日本生化学会大会合同大会(BMB2008)
  • Place of Presentation: 神戸
• [Presentation] マウス前脳におけるRobo1の発現様式 (2008)
  • Author(s): 権田裕子、田畑秀典、仲嶋一範、内野茂夫、高坂新一
  • Organizer: 第50回日本神経化学会大会
  • Place of Presentation: 富山
• [Presentation] 発生中大脳皮質におけるリーリンシグナルの役割の解析 (2008)
  • Author(s): 久保健一郎、本田岳夫、富田憲司、田畑秀典、仲嶋一範
  • Organizer: 第50回日本神経化学会大会
  • Place of Presentation: 富山
• [Presentation] Screening of the molecules that regulate the migratory stream from the caudal ganglionic eminence in the developing mouse telencephalon. (2008)
  • Author(s): Shigeaki Kanatani, Masato Yozu, Hidenori Tabata, Kazunori Nakajima
  • Organizer: 第31回日本神経科学大会
  • Place of Presentation: 東京
• [Presentation] Molecular mechanisms that regulate the behavior of multipolar migration neurons in the developing cerebral neocortex (2008)
  • Author(s): Shinji Sasaki, Hidenori Tabata, Kashiko Tachikawa, Kazunori Nakajima
  • Organizer: 第31回日本神経科学大会
  • Place of Presentation: 東京
• [Presentation] The application of the in utero gene transfer system to investigate the role of Reelin in the developing neocortex (2008)
  • Author(s): Ken-ichiro Kubo, Kenji Tomita, Kazuma Kobayashi, Asuka Uto, Takao Honda, Hidenori Tabata, Kazunori Nakajima
  • Organizer: 第31回日本神経科学大会
  • Place of Presentation: 東京
• [Presentation] A novel migration mode observed in the intermediate zone during the late cortical development (2008)
  • Author(s): Hidenori Tabata, Megumi Sasaki, Kazunori Nakajima
  • Organizer: 第31回日本神経科学大会
  • Place of Presentation: 東京
• [Presentation] Investigation of the roles of Reelin on the cortical layer development (2008)
  • Author(s): Ken-ichiro Kubo, Takao Honda, Kenji Tomita, Hidenori Tabata, Kazunori Nakajima
  • Organizer: Cortical Development Meeting 2008
  • Place of Presentation: Crete, Greece
• [Presentation] 大脳後期発生過程に見られる新規移動様式、不軌道性移動の解析 (2008)
  • Author(s): 田畑秀典、佐々木恵、仲嶋一範
  • Organizer: 第113回日本解剖学会全国学術集会
  • Place of Presentation: 大分
• [Presentation] 大脳皮質興奮性ニューロンの移動における髄膜の役割 (2008)
  • Author(s): 森本桂子、滝上紘之、前田卓哉、味岡逸樹、刀川夏詩子、佐々木慎二、本田岳夫、田畑秀典、仲嶋一範
  • Organizer: 第113回日本解剖学会全国学術集会
  • Place of Presentation: 大分
• [Presentation] Molecular mechanisms that regulate the behavior of multipolar migration neurons in the developing cerebral neocaortex (2008)
  • Author(s): Shinji Sasaki, et al.
  • Organizer: 第31回日本神経科学大会
  • Place of Presentation: 東京
• [Presentation] Screening of the molecules that regulate the migratory stream from the caudal ganglionic eminence in the developing mouse telencephalon (2008)
  • Author(s): Shigeaki Kanatani, et al.
  • Organizer: 第31回日本神経科学大会
  • Place of Presentation: 東京
• [Presentation] The analysis of the role of Reelin signaling in the developing neocortex (2008)
  • Author(s): Ken-ichiro Kubo, et al.
  • Organizer: 第50回日本神経化学会大会
  • Place of Presentation: 富山
• [Presentation] Expression profile of Roundabout1(Robo1)in the developing mouse neocortex (2008)
  • Author(s): Yuko Gonda, et al.
  • Organizer: 第50回日本神経化学会大会
  • Place of Presentation: 富山
• [Presentation] Expression pattern of Roundabout1(Robo1)in the developing mouse forebrain (2008)
  • Author(s): Yuko Gonda, et al.
  • Organizer: 第31回日本分子生物学会年会・第81回日本生化学会大会合同大会(BMB2008)
  • Place of Presentation: 神戸
• [Presentation] Screening and functional analyses of the molecules that are preferentially expressed in the caudal ganglionic eminence in the developing mouse brain. (2007)
  • Author(s): Shigeaki Kanatani, Masato Yozu, Hidenori Tabata, Kazunori Nakajima
  • Organizer: Society for Neuroscience, 37th Annual Meeting
  • Place of Presentation: San Diego, CA, U.S.A.
• [Presentation] Cdk5は大脳皮質神経細胞の放射状移動時の多極性-双極性変換に必要である (2007)
  • Author(s): 大島登志男, 平澤基之, 田畑秀典, 岩里琢治, 糸原重美, 仲嶋一範, Ashok Kulkarni, 御子柴克彦
  • Organizer: 第30回日本神経科学大会・第50回日本神経化学会大会・第17回日本神経回路学会大会合同大会(Neuro2007)
  • Place of Presentation: 横浜
• [Presentation] IGFBPL-1は発生期脳において新たに誕生した神経細胞の局在部位に強く発現する傾向を有する (2007)
  • Author(s): 権田裕子、櫻井準、田畑秀典、平田幸男、味岡逸樹、仲嶋一範
  • Organizer: 第30回日本神経科学大会・第50回日本神経化学会大会・第17回日本神経回路学会大会合同大会(Neuro2007)
  • Place of Presentation: 横浜
• [Presentation] 発生期大脳新皮質における多極性移動神経細胞の挙動を制御する分子の検索と解析 (2007)
  • Author(s): 佐々木慎二、田畑秀典、刀川夏詩子、平田幸男, 仲嶋一範
  • Organizer: 第30回日本神経科学大会・第50回日本神経化学会大会・第17回日本神経回路学会大会合同大会(Neuro2007)
  • Place of Presentation: 横浜
• [Presentation] 大脳皮質形成過程におけるNMDA受容体を介した細胞移動の分子基盤 (2007)
  • Author(s): 内野茂夫、福村怜子、田畑秀典、平澤孝枝、服部功太郎、湯浅茂樹、仲嶋一範、高坂新一
  • Organizer: 第30回日本神経科学大会・第50回日本神経化学会大会・第17回日本神経回路学会大会合同大会(Neuro2007)
  • Place of Presentation: 横浜
• [Presentation] Screening and functional analyses of the molecules that are preferentially expressed in the caudal ganglionic eminence in the developing mouse brain (2007)
  • Author(s): Shigeaki Kanatani, et al.
  • Organizer: Society for Neuroscience, 37th Annual Meeting
  • Place of Presentation: San Diego, CA, U. S. A
• [Book] Electroporation and Sonoporation in Developmental Biology(In utero electroporation; assay system for migration of cerebral cortical neurons) (2009)
  • Author(s): Harukazu Nakamura, Hidenori Tabata, Kazunori Nakajima
  • Publisher: Springer