Molecular mechanisms for stepwise migratory processes during the cortical plate development.
| Project/Area Number |
19500298
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Nerve anatomy/Neuropathology
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| Research Institution | Keio University |
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Principal Investigator |
TABATA Hidenori Keio University, 医学部, 講師 (80301761)
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| Project Period (FY) |
2007 – 2008
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| Project Status |
Completed (Fiscal Year 2008)
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| Budget Amount *help |
¥4,550,000 (Direct Cost: ¥3,500,000、Indirect Cost: ¥1,050,000)
Fiscal Year 2008: ¥2,210,000 (Direct Cost: ¥1,700,000、Indirect Cost: ¥510,000)
Fiscal Year 2007: ¥2,340,000 (Direct Cost: ¥1,800,000、Indirect Cost: ¥540,000)
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| Keywords | 神経科学 / 脳・神経 / 発生・分化 / 解剖学 / 神経回路 / 細胞移動 / 神経発生 / 軸索伸展 / 細胞間相互作用 |
|---|
| Research Abstract |
本研究課題では、マウス大脳皮質発生過程において、側脳室に面する脳室帯(VZ)から移動を開始する2つの集団に関して移動様式を検討した。一方はVZ内で最終分裂を終了するもので、約10時間VZ内に留まったのち、分裂を伴わずに多極性細胞へと形態変化し、VZのすぐ表層側に集積する。一方、VZを出発してもまだ分裂能を持つ細胞集団は脳表面側へと伸びる長い突起を有し、前者よりもより表層側へ早く移動し分裂する。
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Report
(3 results)
Research Products
(36 results)
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[Journal Article] Cell-autonomous roles of ARX in cell proliferation and neuronal migration during corticogenesis.2008
Author(s)
Gaelle Friocourt, Shigeaki Kanatani, Hidenori Tabata, Masato Yozu, Takao Takahashi, Mary Antypa, Odile Raguenes, Jamel Chelly, Claude Ferec, Kazunori Nakajima, John G. Parnavelas
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Journal Title
J. Neurosci. 28(22)
Pages: 5794-5805
Related Report
Peer Reviewed
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[Journal Article] Cdk5 is required for multipolar-to-bipolar transition during radial neuronal migration and proper dendrite development of pyramidal neurons in the cerebral cortex.2007
Author(s)
Toshio Ohshima, Motoyuki Hirasawa, Hidenori Tabata, Tetsuji Mutoh, Tomoko Adachi, Hiromi Suzuki, Keiko Saruta, Takuji Iwasato, Shigeyoshi Itohara, Mitsuhiro Hashimoto, Kazunori Nakajima, Masaharu Ogawa, Ashok B. Kulkarni, Katsuhiko Mikoshiba
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Journal Title
Development 134(12)
Pages: 2273-2282
Related Report
Peer Reviewed
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