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Synaptic distribution of dopaminergic inputs to the prefrontal cortex related to working memory

Research Project

Project/Area Number 19500300
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeSingle-year Grants
Section一般
Research Field Nerve anatomy/Neuropathology
Research InstitutionToho University

Principal Investigator

KURODA Masaru  Toho University, 医学部, 教授 (10170135)

Co-Investigator(Kenkyū-buntansha) ODA Satoko  東邦大学, 医学部, 講師 (90224237)
YOKOFUJITA Junko  東邦大学, 医学部, 助教 (80114792)
Project Period (FY) 2007 – 2009
Project Status Completed (Fiscal Year 2009)
Budget Amount *help
¥4,550,000 (Direct Cost: ¥3,500,000、Indirect Cost: ¥1,050,000)
Fiscal Year 2009: ¥650,000 (Direct Cost: ¥500,000、Indirect Cost: ¥150,000)
Fiscal Year 2008: ¥650,000 (Direct Cost: ¥500,000、Indirect Cost: ¥150,000)
Fiscal Year 2007: ¥3,250,000 (Direct Cost: ¥2,500,000、Indirect Cost: ¥750,000)
Keywords前頭前野 / 視床背内側核 / ドーパミン受容体 / 共焦点顕微鏡 / 興奮性ニューロン / 抑制性ニューロン / シナプス / 視床脊内側核 / 電子顕微鏡
Research Abstract

In this study, to identify the precise localization of dopamine receptor D5 (D5R) in the rat prefrontal cortex, we observed the D5R-immunolabeled structures by confocal laser microscopy. As a result, we found that nearly all neurons, both excitatory and inhibitory neurons, contained D5R, and that the intracellular distribution pattern of D5R is markedly different between them. These findings strongly suggested that the differential distribution pattern of D5R may underlie dopaminergic modulation of cognitive functions subserved by the prefrontal cortex.

Report

(4 results)
  • 2009 Annual Research Report   Final Research Report ( PDF )
  • 2008 Annual Research Report
  • 2007 Annual Research Report
  • Research Products

    (15 results)

All 2010 2009 2008 2007

All Journal Article (6 results) (of which Peer Reviewed: 6 results) Presentation (7 results) Book (2 results)

  • [Journal Article] Dopamine D5 receptor immunoreactivity is differentially distributed in GABAergic interneurons and pyramidal cells in the rat prefrontal cortex.2010

    • Author(s)
      Oda S, Funato H, Adachi-Akahane S, Ito M, Okada A, Igarashi H, Yokofujita J, Kuroda M
    • Journal Title

      Brain Res 1329

      Pages: 89-102

    • Related Report
      2009 Final Research Report
    • Peer Reviewed
  • [Journal Article] Dopamine D5 receptor immunoreactivity is differentially distributed in GABAergic interneurons and pyramidal cells in the rat medial prefrontal cortex2010

    • Author(s)
      Oda S, Funato H, Adachi-Akahane S, Ito M, Okada A, Igarashi H, Ykofujita J, Kuroda M
    • Journal Title

      Brain Research(Epub March 11, 2010) 1329

      Pages: 89-102

    • Related Report
      2009 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Synaptic characteristics between cortical cells in the rat prefrontal cortex and axon terminals from the ventral tegmental area that utilize different neurotransmitters.2008

    • Author(s)
      Yokofujita J, Oda S, Igarashi H, Sato F, Kuroda M
    • Journal Title

      Int. J. Neurosci 118

      Pages: 1443-1459

    • Related Report
      2009 Final Research Report
    • Peer Reviewed
  • [Journal Article] Synaptic characteristics between cortical cells in the rat prefrontal cortex and axon terminals from the ventral tegmental area that utilize differentneurotransmitters.2008

    • Author(s)
      Yokofujita J, Oda s, Igarashi H, Sato F, Kuroda M
    • Journal Title

      Int. J. Neurosci. 118

      Pages: 1443-1459

    • Related Report
      2008 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Immunolocalization of muscarinic receptor subtypes in the reticular thalamic nucleus of rats.2007

    • Author(s)
      Oda S, Sato F, Okada A, Akahane S, Igarashi H, Yokofujita J, Yang J, Kuroda M
    • Journal Title

      Brain Res. Bull 74

      Pages: 376-384

    • Related Report
      2009 Final Research Report
    • Peer Reviewed
  • [Journal Article] Immunolocalization of muscarinic receptor subtypes in the reticular thalamic nucleus of rats.2007

    • Author(s)
      Oda S, Sato F, Okada A, Akahane S, Igarashi H, Yang J, Kuroda M
    • Journal Title

      Brain Res. Bull. 74

      Pages: 376-384

    • Related Report
      2007 Annual Research Report
    • Peer Reviewed
  • [Presentation] 前頭前野における抑制性および興奮性神経細胞の細胞内ドーパミンD5受容体分布の比較.2010

    • Author(s)
      小田哲子, 船戸弘正, 五十嵐広明, 横藤田純子, 黒田優
    • Organizer
      第115回日本解剖学会全国学術集会
    • Place of Presentation
      盛岡
    • Year and Date
      2010-03-29
    • Related Report
      2009 Final Research Report
  • [Presentation] ラット内側前頭前野におけるドーパミンD5受容体の局在分布2010

    • Author(s)
      小田哲子, 船戸弘正, 五十嵐広明, 横藤田純子, 黒田優
    • Organizer
      第115回日本解剖学会総会全国学術集会
    • Place of Presentation
      盛岡
    • Year and Date
      2010-03-29
    • Related Report
      2009 Annual Research Report
  • [Presentation] 前頭前野における腹側被蓋野投射線維のシナプス形態について.2009

    • Author(s)
      横藤田純子, 五十嵐広明, 小田哲子, 船戸弘正, 黒田優
    • Organizer
      第97回日本解剖学会関東支部学術集会
    • Place of Presentation
      入間
    • Year and Date
      2009-10-24
    • Related Report
      2009 Final Research Report
  • [Presentation] 前頭前野における腹側被蓋野投射線維のシナプス形態について2009

    • Author(s)
      横藤田純子, 五十嵐広明, 小田哲子, 船戸弘正, 黒田優
    • Organizer
      第97回日本解剖学会関東支部学術集会
    • Place of Presentation
      入間
    • Year and Date
      2009-10-24
    • Related Report
      2009 Annual Research Report
  • [Presentation] Abnormal REM sllep structures of goosecoid-like-deficient mouse. Society for Neuroscience2009

    • Author(s)
      Funato H, Sato M, Sinton C, Williams S-C, Gautron L, Elmquist J-K, Skoultchi A-I, Kuroda M, Yanagisawa M
    • Organizer
      Neuroscience Annual Meeting 2009
    • Place of Presentation
      Chicago, USA
    • Year and Date
      2009-10-19
    • Related Report
      2009 Final Research Report
  • [Presentation] 異なる神経伝達物質を利用するラット腹側被蓋野投射線維と前頭前野細胞間のシナプス形態について.2009

    • Author(s)
      横藤田純子, 小田哲子, 五十嵐広明, 黒田優
    • Organizer
      第114回日本解剖学会全国学術集会
    • Place of Presentation
      岡山
    • Year and Date
      2009-03-30
    • Related Report
      2009 Final Research Report
  • [Presentation] 異なる神経伝達物質を利用するラット腹側被蓋野投射線維と前頭前野細胞間のシナプス形態について2009

    • Author(s)
      横藤田純子, 小田哲子, 五十嵐広明, 佐藤二美, 黒田優
    • Organizer
      第114回日本解剖学会全国学術集会
    • Place of Presentation
      岡山
    • Year and Date
      2009-03-30
    • Related Report
      2008 Annual Research Report
  • [Book] 嗅神経(他19用語)、医学書院医学大辞典第2版2009

    • Author(s)
      黒田優, 他
    • Total Pages
      3560
    • Publisher
      医学書院
    • Related Report
      2009 Final Research Report
  • [Book] 医学書院医学大辞典第2版(伊藤正男他総編)2009

    • Author(s)
      黒田 優(分担)
    • Total Pages
      3560
    • Publisher
      医学書院
    • Related Report
      2008 Annual Research Report

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Published: 2007-04-01   Modified: 2016-04-21  

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