Noninvasive acquisition of ischemic tolerance of brain after spreading depression by transcranial magnetic stimulation

• Project/Area Number: 19500312
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Single-year Grants
• Section: 一般
• Research Field: Nerve anatomy/Neuropathology
• Research Institution: Keio University
• Principal Investigator: KOBAYASHI Masahito Keio University, 医学部, 講師 (60245511)
• Co-Investigator(Kenkyū-buntansha): HORIGUCHI Takashi 慶應義塾大学, 医学部, 講師 (70245520)
• Project Period (FY): 2007 – 2009
• Project Status: Completed (Fiscal Year 2009)
• Budget Amount: ¥4,160,000 (Direct Cost: ¥3,200,000、Indirect Cost: ¥960,000); Fiscal Year 2009: ¥1,040,000 (Direct Cost: ¥800,000、Indirect Cost: ¥240,000); Fiscal Year 2008: ¥1,040,000 (Direct Cost: ¥800,000、Indirect Cost: ¥240,000); Fiscal Year 2007: ¥2,080,000 (Direct Cost: ¥1,600,000、Indirect Cost: ¥480,000)
• Keywords: 脳虚血耐性 / 経頭蓋磁気刺激 / 皮質拡散抑制 / 皮質拡延性抑制 / 脳卒中

Research Abstract

We have established the condition of general anesthesia and chemical stimulation to induce SD in the experimental animal connected to the stereotactic neurosurgical frame. While TMS itself was difficult to induce SD constantly, high-frequency repetitive TMS reduced threshold to induce the SD by chemical stimulation.

Research Products

• [Journal Article] Effect of slow repetitive TMS of the motor cortex on ipsilateral sequential simple finger movements and motor skill learning (2010)
  • Author(s): Masahito Kobayashi
  • Journal Title: Restorative Neurology and Neuroscience (印刷中)
  • Peer Reviewed
• [Journal Article] Suppression of ipsilateral motor cortex facilitates motor skill learning (2009)
  • Author(s): Masahito Kobayashi
  • Journal Title: European Journal of Neuroscience 29巻 Pages: 833-836
  • Peer Reviewed
• [Journal Article] Suppress ion of ipsilateral motor cortex facilitates mot or skill learning. (2009)
  • Author(s): Masahi to Kobayashi
  • Journal Title: European Journal of Neuroscience 29 Pages: 833-836
  • Peer Reviewed
• [Journal Article] Source analysis of the magnetic field evoked during self-paced finger movements (2008)
  • Author(s): Maki Niimi、Masahito Kobayashi
  • Journal Title: Neurological Research 30巻 Pages: 239-243
  • Peer Reviewed
• [Journal Article] Source analysis of the magnetic field evoked during sel f-paced finger movements. (2008)
  • Author(s): Maki Niimi
  • Journal Title: Neurological Research 30 Pages: 239-243
  • Peer Reviewed
• [Presentation] 経頭蓋磁気刺激による脳卒中および頭頚部外傷後慢性期の難治性疼痛の制御 (2009)
  • Author(s): 小林正人
  • Organizer: 第48回日本定位・機能神経外科学会
  • Place of Presentation: 東京
  • Year and Date: 2009-01-23
• [Presentation] 経頭蓋磁気刺激による脳卒中および頭頚部外傷後慢性期の難治性疼痛の制御. (2009)
  • Author(s): 小林 正人
  • Organizer: 第48回日本定位・機能神経外科学会
  • Place of Presentation: 東京
  • Year and Date: 2009-01-23
• [Presentation] 経頭蓋磁気刺激による脳脊髄損傷後慢性期の治療の試み (2008)
  • Author(s): 小林正人
  • Organizer: 第38回日本臨床神経生理学会学術大会
  • Place of Presentation: 神戸
  • Year and Date: 2008-11-13
• [Presentation] 経頭蓋磁気刺激による脳脊髄損傷後慢性期の治療の試み : 脳卒中後の麻痺と頭頚部外傷後の慢性期疼痛に対して. (2008)
  • Author(s): 小林 正人
  • Organizer: 第38回日本臨床神経生理学会学術大会
  • Place of Presentation: 神戸
  • Year and Date: 2008-11-13
• [Presentation] Characteristics of neuronal activation in the primary sensori-motor cortex under chronic ischemia and its change through surgical intervention (2008)
  • Author(s): 秋山武紀、小林正人
  • Organizer: Conference of International Society for the Advancement of Clinical Magnetoencephalography
  • Place of Presentation: Matsushima, Japan
  • Year and Date: 2008-08-30
• [Presentation] Somatosensory evoked field derived by tactile finger stimulation (2008)
  • Author(s): 井麻綾、小林正人
  • Organizer: Conference of International Society for the Advancement of Clinical Magnetoencephalography
  • Place of Presentation: Matsushima, Japan
  • Year and Date: 2008-08-30
• [Presentation] 経頭蓋磁気刺激による頭頸部外傷後の慢性期の疼痛の制御 (2008)
  • Author(s): 小林正人
  • Organizer: 日本定位・機能的脳神経外科学会
  • Place of Presentation: 浜松
  • Year and Date: 2008-01-26
• [Presentation] 3T-MRIを用いた定位脳手術planningの誤差と有用性の検討 (2007)
  • Author(s): 小林正人
  • Organizer: 第25回関東機能的脳外科カンファレンス
  • Place of Presentation: 東京
  • Year and Date: 2007-09-01
• [Presentation] Characteristics of neuronal activation in the primary sensori-motor cortex under chronic ischemia and its change through surgical intervention (2007)
  • Author(s): 秋山 武紀・小林 正人
  • Organizer: Conference of International Society for the Advan cement of Clinical Magnetoencephalography
  • Place of Presentation: 松島
  • Year and Date: 2007-08-30
• [Presentation] Somatosensory evoked field derived by tactile finger stimulation (2007)
  • Author(s): 折居 麻綾・小林 正人
  • Organizer: Conerence of Intemational Society for the Advan cement of Clinical Magnetoencephalography
  • Place of Presentation: 松島
  • Year and Date: 2007-08-30