| Project/Area Number |
19500324
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Neurochemistry/Neuropharmacology
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| Research Institution | Shimane University |
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Principal Investigator |
HASHIMOTO Michio Shimane University, 医学部, 准教授 (70112133)
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| Co-Investigator(Kenkyū-buntansha) |
KATAKURA Masanori 島根大学, 医学部, 助教 (40383179)
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| Co-Investigator(Renkei-kenkyūsha) |
YAMASHITA Kazuya 島根県立大学, 短期大学部, 教授 (30210412)
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| Project Period (FY) |
2007 – 2009
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| Project Status |
Completed (Fiscal Year 2009)
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| Budget Amount *help |
¥4,420,000 (Direct Cost: ¥3,400,000、Indirect Cost: ¥1,020,000)
Fiscal Year 2009: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2008: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2007: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
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| Keywords | 精神・神経疾患の病態と治療 / 神経幹細胞 / n-3系多価不飽和脂肪酸 / 神経新生 / ヒト介入試験 / ドコサヘキサエン酸 / 二重盲検並行群間比較法 / ミニメンタルステートテスト / 前頭葉機能試験 / 健常高齢者 / 認知症予防 / 多価不飽和脂肪酸 / Neurogenesis / 成体脳 |
|---|
| Research Abstract |
1) Docosahexaenoic acid (DHA) and eicosapentaenoic acid, n-3 polyunsaturated fatty acids, promoted neurogenesis of neuronal stem cells (NSCs) isolated from rat embryos and also adult hippocampus. These n-3 fatty acids induce differentiation by causing cell cycle arrest in NSCs.
2) In randomized, double-blind and placebo-controlled trail, preventive effect of DHA supplement for 12 months on cognitive decline rate in elderly people with very mild dementia was observed.
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