Effects of fatty acids on differentiation of neuronal stem cells and the protective and ameliorative effects on dementia.
Project/Area Number |
19500324
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Research Category |
Grant-in-Aid for Scientific Research (C)
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Allocation Type | Single-year Grants |
Section | 一般 |
Research Field |
Neurochemistry/Neuropharmacology
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Research Institution | Shimane University |
Principal Investigator |
HASHIMOTO Michio Shimane University, 医学部, 准教授 (70112133)
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Co-Investigator(Kenkyū-buntansha) |
KATAKURA Masanori 島根大学, 医学部, 助教 (40383179)
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Co-Investigator(Renkei-kenkyūsha) |
YAMASHITA Kazuya 島根県立大学, 短期大学部, 教授 (30210412)
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Project Period (FY) |
2007 – 2009
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Project Status |
Completed (Fiscal Year 2009)
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Budget Amount *help |
¥4,420,000 (Direct Cost: ¥3,400,000、Indirect Cost: ¥1,020,000)
Fiscal Year 2009: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2008: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2007: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
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Keywords | 精神・神経疾患の病態と治療 / 神経幹細胞 / n-3系多価不飽和脂肪酸 / 神経新生 / ヒト介入試験 / ドコサヘキサエン酸 / 二重盲検並行群間比較法 / ミニメンタルステートテスト / 前頭葉機能試験 / 健常高齢者 / 認知症予防 / 多価不飽和脂肪酸 / Neurogenesis / 成体脳 |
Research Abstract |
1) Docosahexaenoic acid (DHA) and eicosapentaenoic acid, n-3 polyunsaturated fatty acids, promoted neurogenesis of neuronal stem cells (NSCs) isolated from rat embryos and also adult hippocampus. These n-3 fatty acids induce differentiation by causing cell cycle arrest in NSCs. 2) In randomized, double-blind and placebo-controlled trail, preventive effect of DHA supplement for 12 months on cognitive decline rate in elderly people with very mild dementia was observed.
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Report
(4 results)
Research Products
(110 results)
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[Journal Article] DHA disrupts in vitro amyloid β1-40 fibrillation and concomitantly inhibits amyloid levels in cerebral cortex tissue of Alzheimer's disease model rats.2008
Author(s)
Michio Hashimoto, Hossain Md Shahdat, Shinji Yamashita, Masanori Katakura, Yoko Tanabe, Hironori Fujiwara, Shuji Gamoh, Teruo Miyazawa, Noriyuki Arai, Toshio Shimada, Osamu Shido.
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Journal Title
Journal of Neurochemistry 107
Pages: 1634-1646
Related Report
Peer Reviewed
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[Journal Article] Effect of amlodipine, a calcium channel antagonist, on cholesterol level in the cerebral cortex and hippocampus of obese and hippocampus of obese and hypertensive SHR. Cg-Lepr^<cp>/NDmcr rats.2007
Author(s)
Michio Hashimoto, Satomi Kagota, Yoko Kubota, Masanori Katakura, Budbazar Enkhjargal, Shuji Gamoh, Haque Md Abdul, Osamu Shido, Masaru Kunitomo, Kazumasa Shinozuka
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Journal Title
Clinical and Experimental Pharmacology and Physiology 34
Related Report
Peer Reviewed
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[Presentation] MECHANISMS OF DIETARY DOCOSAHEXAENOIC ACID-INDUCED PROTECTION AND AMELIORATION ON IMPAIRMENT OF MEMORY LEARNING IN ALZHEIMER'S DISEASE MODEL RATS.2007
Author(s)
Michio Hashimoto, Hossain Md Shahdat, Shinji Yamashita, Masanori Katakura, Yoko Tanabe, Hironori Fujiwara, Shuji Gamoh, Teruo Miyazawa, Noriyuki Arai, Osamu Shido.
Organizer
8th International Conference AD/PD 2007
Place of Presentation
Salzburg, Austria
Related Report
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