MECHANISMS OF MODULATION OF LEARNING AND MEMORY FUNCTION BY NOCICEPTIN

• Project/Area Number: 19500333
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Single-year Grants
• Section: 一般
• Research Field: Neurochemistry/Neuropharmacology
• Research Institution: Meijo University
• Principal Investigator: HIRAMATSU Masayuki Meijo University, 薬学部, 准教授 (10189863)
• Project Period (FY): 2007 – 2009
• Project Status: Completed (Fiscal Year 2009)
• Budget Amount: ¥4,420,000 (Direct Cost: ¥3,400,000、Indirect Cost: ¥1,020,000); Fiscal Year 2009: ¥910,000 (Direct Cost: ¥700,000、Indirect Cost: ¥210,000); Fiscal Year 2008: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000); Fiscal Year 2007: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
• Keywords: 神経機能の可塑性 / ノシセプチン / 細胞内情報伝達系 / ペプチドフラグメント / nociceptin opioid peptide(NOP)受容体 / ERK / MEK経路 / 学習・記憶機能 / 抗認知症薬開発 / Opioid receptor like-1 (ORL1)受容体 / ペプチド作動性神経系 / Opioid receptor like-1 (ORL1) 受容体 / Opioid receptor like-1(ORL1)受容体 / protein kinase A経路 / 抗認知証薬開発

Research Abstract

Low doses of nociceptin attenuated the memory impairment, and this effect was not mediated via nociceptin opioid peptide receptors. We suggested that there is a novel action site or mechanism for these effects, and the sequence of nociceptin (14-17) is a critical structure.

Research Products

• [Journal Article] Nociceptin and its metabolite attenuate U0126-induced memory impairment through a nociceptin opioid peptide (NOP) receptor-independent mechanism. (2010)
  • Author(s): Masaya Miwa, Fumika Horiba, Hiroshi Takeshima, Toshitaka Nabeshima, Masayuki Hiramatsu
  • Journal Title: Neurobiol. Learn. Mem. 93(3) Pages: 396-405
  • Peer Reviewed
• [Journal Article] Nociceptin and its metabolite attenuate U0126-induced memory impairment through a nociceptin opioid peptide(NOP)receptor-independent mechanism (2010)
  • Author(s): Masaya Miwa, Shogo Uchida, Fumika Horiba, Hiroshi Takeshima, Toshitaka Nabeshima, Masayuki Hiramatsu
  • Journal Title: Neurobiol Learn Mem. 93(3) Pages: 396-405
  • Peer Reviewed
• [Journal Article] (2010)
  • Author(s): 平松正行(分担執筆)
  • Journal Title: ストレス百科事典(丸善書店)
• [Journal Article] Distinct effects of nociceptin analogs on scopolamine-induced memory impairment in mice. (2009)
  • Author(s): Masaya Miwa, Chieko Shinki, Shogo Uchida, Masayuki Hiramatsu
  • Journal Title: Eur. J. Pharmacol. 602(2-3) Pages: 328-333
  • Peer Reviewed
• [Journal Article] The long-lasting effects of cross-fostering on the emotional behavior in ICR mice (2009)
  • Author(s): Lingling Lu, Takayoshi Mamiya, Ping Lu, Minae Niwa, Akihiro Mouri, Li-Bo Zou, Taku Nagai, Masayuki Hiramatsu, Toshitaka Nabeshima
  • Journal Title: Behav.Brain Res. 157(7) Pages: 1270-1277
  • Peer Reviewed
• [Journal Article] Silibinin prevents amyloid β peptide-induced memory impairment and oxidative stress in mice (2009)
  • Author(s): Ping Lu, Takayoshi Mamiya, Lingling Lu, Akihiro Mouri, Li-Bo Zou, Taku Nagai, Masayuki Hiramatsu, Takeshi Ikejima, Toshitaka Nabeshima
  • Journal Title: Brit.J.Pharmacol. 157(7) Pages: 1270-1277
  • Peer Reviewed
• [Journal Article] Silibinin attenuates amyloid β 25-35 peptide-induced memory impairments : implication of inducible nitric oxide synthase and tumor necrosis factor-α in mice (2009)
  • Author(s): Ping Lu, Takayoshi Mamiya, Lingling Lu, Akihiro Mouri, Minae Niwa, Masayuki Hiramatsu, Li-Bo Zou, Takeshi Ikejima, Taku Nagai, Toshitaka Nabeshima
  • Journal Title: J.Pharmacol.Exp.Ther 331(1) Pages: 319-326
  • Peer Reviewed
• [Journal Article] Prenatal exposure to phencyclidine produces abnormal behaviour and NMDA receptor expression in postpubertal mice (2009)
  • Author(s): Lu Lingling, Takayoshi Mamiya, Ping Lu, Kazuya Toriumi, Akihiro Mouri, Masayuki Hiramatsu, Hyoung-Chun Kim, Li-Bo Zou, Taku Nagai, Toshitaka Nabeshima
  • Journal Title: Int.J.Neuropsychopharmacol. 19 Pages: 1-13
  • Peer Reviewed
• [Journal Article] Distinct effects of nociceptin analogs on scopolamine-induced memory im pairment in mice (2009)
  • Author(s): Masaya Miwa, Chieko Shinki, Shogo Uchida, Masayuki Hiramatsu
  • Journal Title: Eur. J. Pharmacol. 602(2-3) Pages: 328-333
  • Peer Reviewed
• [Journal Article] Nociceptin/orphanin FQ reverses mecamylamine-induced learning and memory impairment as well as decrease in hippocampal acetylcholine release in the rat. (2008)
  • Author(s): Masayuki Hiramatsu, Masaya Miwa, Kazuki Hashimoto, Satoko Kawai, Nao Nomura
  • Journal Title: Brain Res. 1195 Pages: 96-103
  • Peer Reviewed
• [Journal Article] Nociceptin/orphanin FQ reverses mecamylamine-induced learning and memory impairment as well as reduces hippocampal acetylcholine release in the rat (2008)
  • Author(s): Masayuki Hiramatsu, Masaya Miwa, Kazuki Hashimoto, Satoko Kawai and Nao Nomura
  • Journal Title: Brain Research 1195 Pages: 96-103
  • Peer Reviewed
• [Presentation] 妊娠期ニコチン暴露は出生マウスの感情及び認識行動を障害する (2010)
  • Author(s): Tursun Alkam, 平松正行, 間宮隆吉, 毛利彰宏, 鳥海和也, 鍋島俊隆
  • Organizer: 第83回日本薬理学会年会
  • Place of Presentation: 大阪
  • Year and Date: 2010-03-17
• [Presentation] Pre-/Peri-natal nicotine exposure at different time-windows differentially affected cognition and emotion in offspring of C57BL/6J mice (2010)
  • Author(s): Tursun Alkam, Masayuki Hiramatsu, Takayoshi Mamiya, Toshitaka Nabeshima
  • Organizer: The 56th NIBB Conference "Neocortical Organization"
  • Place of Presentation: 岡崎
  • Year and Date: 2010-03-12
• [Presentation] Nociceptin and its metabolite improve U0126-induced memory impairment through NOP receptor-independent mechanism (2009)
  • Author(s): Masaya Miwa, Fumika Horiba, Shogo Uchida, Toshitaka Nabeshima, Masayuki Hiramatsu
  • Organizer: The 39th annual meeting of the Society for Neuroscience
  • Place of Presentation: Chicago
  • Year and Date: 2009-10-21
• [Presentation] Repeated administration of betaine or catechin prevents lipopolysaccharide-induced memory impairment in mice (2009)
  • Author(s): Masayuki Hiramatsu, Aika Iwata, Mizuki Tsuboi, Masaya Miwa
  • Organizer: The 39th annual meeting of the Society for Neuroscience
  • Place of Presentation: Chicago, U.S.A.
  • Year and Date: 2009-10-21
• [Presentation] Nociceptin and its metabolite improve U0126-induced memory impairment through NOP receptor-independent mechanism (2009)
  • Author(s): Masaya Miwa, Fumika Horiba, Shogo Uchida, Toshitaka Nabeshima, Masayuki Hiramatsu
  • Organizer: The 39th annual meeting of the Society for Neuroscience
  • Place of Presentation: Chicago, U.S.A.
  • Year and Date: 2009-10-21
• [Presentation] 拘束水浸ストレス負荷による記憶障害に対するベタインの作用 (2009)
  • Author(s): 三輪将也, 川村美緒, 高橋ゆか里, 天野杏南, 鍋島俊隆, 平松正行
  • Organizer: 第11回応用薬理シンポジウム
  • Place of Presentation: 静岡
  • Year and Date: 2009-09-18
• [Presentation] Prenatal exposure to phencyclidine produces abnormal behavior and NMDA receptor function in the postpubertal mice (2009)
  • Author(s): Lingling Lu, Takayoshi Mamiya, Ping Lu, Kazuya Toriumi, Akihiro Mouri, Masayuki Hiramatsu, Li-Bo Zou, Toshitaka Nabeshim
  • Organizer: 第6回名古屋南京瀋陽学術シンポジウム
  • Place of Presentation: 名古屋
  • Year and Date: 2009-09-15
• [Presentation] Abnormal behavior and NMDA receptor in the postpubertal mice after prenatal exposure to phencyclidine (2009)
  • Author(s): Lingling Lu, Takayoshi Mamiya, Kazuya Toriumi, Akihiro Mouri, Ping Lu, Masayuki Hiramatsu, Li-Bo Zou, Toshitaka Nabeshima
  • Organizer: 第115回日本薬理学会近畿部会
  • Place of Presentation: 金沢
  • Year and Date: 2009-06-26
• [Presentation] β-amyloid protein (25-35)を用いたアルツハイマー型認知症モデルマウスに対するcilostazolの効果 (2009)
  • Author(s): 滝口修直、西山亜希、森啓真、鍋島俊隆、平松正行
  • Organizer: 第82回日本薬理学会年会
  • Place of Presentation: 横浜
  • Year and Date: 2009-03-17
• [Presentation] ノシセプチン及びノシセプチン代謝物はMEK阻害薬による記憶障害をNOP受容体非依存的に改善する (2009)
  • Author(s): 三輪将也、堀場史加、内田将吾、鍋島俊隆、平松正行
  • Organizer: 第82回日本薬理学会年会
  • Place of Presentation: 横浜
  • Year and Date: 2009-03-17
• [Presentation] β-amyloid protein(25-35)を用いたアルツハイマー型認知症モデルマウスに対するcilostazolの効果 (2009)
  • Author(s): 滝口修直, 西山亜希, 森 啓真, 鍋島俊隆, 平松正行
  • Organizer: 第82回日本薬理学会年会
  • Place of Presentation: 横浜
  • Year and Date: 2009-03-17
• [Presentation] 拘束水浸ストレスによる学習・記憶障害における炎症性サイトカインの関与 (2009)
  • Author(s): 高橋ゆか里, 天野杏南, 川村美緒, 三輪将也, 鍋島俊隆, 平松正行
  • Organizer: 第82回日本薬理学会年会
  • Place of Presentation: 横浜
  • Year and Date: 2009-03-16
• [Presentation] 拘束水浸ストレスによって惹起される記憶障害とその機構 (2009)
  • Author(s): 三輪将也, 天野杏南, 川村美緒, 鍋島俊隆, 平松正行
  • Organizer: 第1回名城大学学術フロンティア推進事業若手研究者シンポジウム
  • Place of Presentation: 名古屋
  • Year and Date: 2009-03-02
• [Presentation] 拘束水浸ストレス負荷による学習・記憶障害とグルタミン酸作動性神経系の関与およびサイトカイン遺伝子の発現変化 (2009)
  • Author(s): 平松正行、高橋ゆか里、川村美緒、鍋島俊隆
  • Organizer: 第13回神経科学領域における分子モニタリングシンポジウム・学術フロンティア報告会共催合同大会
  • Place of Presentation: 名古屋
  • Year and Date: 2009-01-09
• [Presentation] Nociceptin improves long-term memory impairment induced by a MEK inhibitor, but not a PKA inhibitor. (2008)
  • Author(s): Masaya Miwa, Shogo Uchida, Fumika Horiba, Kumi Fujii, Toshitaka Nabeshima, Masayuki Hiramatsu
  • Organizer: International Symposium on Brain Development and Neuropsychiatric Disorders
  • Place of Presentation: Nagoya
  • Year and Date: 2008-09-24
• [Presentation] Learning and memory impairment by water-immersion restraint stress and its underlying molecular mechanism (2008)
  • Author(s): Masayuki Hiramatsu, Yukari Takahashi, Yusuke Kakehi, Anna Amano, Mio Kawamura, Masaya Miwa, Toshitaka Nabeshima
  • Organizer: International Symposium on Brain Development and Neuropsychiatric Disorders
  • Place of Presentation: 名古屋
  • Year and Date: 2008-09-24
• [Presentation] Nociceptin improves long-term memory impairment induced by a MEK inhibitor, but not a PKA inhibitor (2008)
  • Author(s): Masaya Miwa, Shogo Uchida, Fumika Horiba, Kumi Fujii, Toshitaka Nabeshima, Masayuki Hiramatsu
  • Organizer: International Symposium on Brain Development and Neuropsychiatric Disorders
  • Place of Presentation: 名古屋
  • Year and Date: 2008-09-24
• [Presentation] Involvement of inflammatory cytokines on learning and memory impairments induced by water-immersion restraint stress (2008)
  • Author(s): Yukari Takahashi, Anna Amano, Mio Kawamura, Masaya Miwa, Toshitaka Nabeshima, Masayuki Hiramatsu
  • Organizer: International Symposium on Brain Development and Neuropsychiatric Disorders
  • Place of Presentation: 名古屋
  • Year and Date: 2008-09-24
• [Presentation] Effect of cilostazol on learning and memory impairment induced by βa myloid peptide (25-35)in mice (2008)
  • Author(s): Osanao Takiguchi, Syota Seki, Hiromasa Mori, Toshitaka Nabeshima, Masayuki Hiramatsu
  • Organizer: International Symposium on Brain Development and Neuropsychiatric Disorders
  • Place of Presentation: 名古屋
  • Year and Date: 2008-09-24
• [Presentation] 低用量ノシセプチンの海馬内投与による学習・記憶障害改善作用と細胞内情報伝達系の関与 (2008)
  • Author(s): 内田将吾、藤井久美、三輪将也、鍋島俊隆、平松正行
  • Organizer: 第81回日本薬理学会年会
  • Place of Presentation: 横浜
  • Year and Date: 2008-03-19
• [Presentation] リポポリサッカライドによる記憶障害及び炎症性マーカーの遺伝子発現に対するベタインの作用 (2008)
  • Author(s): 三輪将也、坪井美月、野口祐美子、鍋島俊隆、平松正行
  • Organizer: 第81回日本薬理学会年会
  • Place of Presentation: 横浜
  • Year and Date: 2008-03-17
• [Presentation] 拘束水浸ストレスによる学習・記憶障害と関与するメカニズムについて (2008)
  • Author(s): 高橋ゆか里、天野杏南、三輪将也、鍋島俊隆、平松正行
  • Organizer: 第17回神経行動薬理若手研究者の集い
  • Place of Presentation: 横浜
  • Year and Date: 2008-03-16
• [Presentation] Nociceptin improves impairment of learning and memory mediated by MEK/ERK pathway. (2007)
  • Author(s): Masaya Miwa, Shogo Uchida, Masayuki Hiramatsu
  • Organizer: The 37th annual meeting of the Society for Neuroscience
  • Place of Presentation: San Diego
  • Year and Date: 2007-11-05
• [Presentation] Nociceptin improves impairment of learning and memory mediated by MEK/ERK pathway (2007)
  • Author(s): Masaya Miwa, Shogo Uchida and Masayuki Hiramatsu
  • Organizer: The 37th annual meeting of the Society for Neuroscience
  • Place of Presentation: San Diego, U. S. A.
  • Year and Date: 2007-11-05
• [Presentation] ストレス負荷またはリポポリサッカライド(LPS)投与による学習・記憶障害モデルマウスに対するカテキンおよびベタインの効果 (2007)
  • Author(s): 平松正行、三輪将也、内田将吾、筧裕介、岩田合郁
  • Organizer: 第9回応用薬理シンポジウム
  • Place of Presentation: 東京
  • Year and Date: 2007-09-10
• [Presentation] Effects of cilostazole on a mouse Alzheimer's dementia model using β-amyloid peptide(25-35) (2007)
  • Author(s): Masayuki Hiramatsu, Osanao Takiguchi and Hiromasa Mori
  • Organizer: Second Meeting of West European Societies of Biological Psychiatry
  • Place of Presentation: Strasbourg, France
• [Book] GraphPad Prism 5による生物統計学入門 (2010)
  • Author(s): 平松正行
  • Total Pages: 294
  • Publisher: カットシステム