Study of neurite elongation mechanisms of early-late endosome transfer
| Project/Area Number |
19500338
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Neurochemistry/Neuropharmacology
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| Research Institution | Kyushu Institute of Technology (2008-2009)
National Center of Neurology and Psychiatry (2007) |
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Principal Investigator |
AOKI Shunsuke Kyushu Institute of Technology, 大学院・情報工学研究院, 准教授 (30392426)
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| Project Period (FY) |
2007 – 2009
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| Project Status |
Completed (Fiscal Year 2009)
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| Budget Amount *help |
¥3,770,000 (Direct Cost: ¥2,900,000、Indirect Cost: ¥870,000)
Fiscal Year 2009: ¥1,040,000 (Direct Cost: ¥800,000、Indirect Cost: ¥240,000)
Fiscal Year 2008: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000)
Fiscal Year 2007: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
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| Keywords | 神経損傷の再生・修復 / 細胞内小胞輸送 / Solo / class C VPS / HOP / 神経突起伸長 / Rho small GTPaseファミリー / エンドソーム / Rho small GTPase ファミリー |
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| Research Abstract |
We studied on the intracellular mechanisms of neurite elongation controlled by early-late endosome transition modulated by Solo, Rho GTPase and class C VPS/HOPS molecules. We found that Rac is a major downstream signal regulator for neurite elongation induced by Solo and that VPS39 plays an important role in the cellular signal transduction. Moreover, we established a novel in vivo bioassay for neurite elongation/nerve regeneration by ligation of dissected rat facial nerve with silicon tube.
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Report
(4 results)
Research Products
(30 results)
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[Journal Article] Neuroprotective role of bradykinin because of the attenuation of pro-inflammatory cytokine release from activated microglia.2007
Author(s)
Noda M, Kariura Y, Pannasch U, Nishikawa K, Wang L, Seike T, Ifuku M, Kosai Y, Wang B, Nolte C, Aoki S, Kettenmann H, Wada K.
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Journal Title
J Neurochem. 101
Pages: 397-410
Related Report
Peer Reviewed
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[Journal Article] Dopaminergic cell loss in transgenic mice expressing the Parkinson's disease-associated UCH-L1 I93M mutant.2007
Author(s)
Setsuie R, Wang YL, Mochizuki H, Osaka H, Hayakawa H, Ichihara N, Li H, Furuta A, Sato Y, Sun YJ, Kwon J, Kabuta T, Yoshimi K, Aoki S, Mizuno Y, Noda M, Wada K.
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Journal Title
Neurochem Int. 50
Pages: 119-129
Related Report
Peer Reviewed
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